Protein: MLKL
Mixed lineage kinase domain-like protein (hMLKL)

Gene: MLKL
Organism: Homo sapiens
Interactions: 51
UniProt ID: Q8NB16

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1239429

RIPK3
Receptor-interacting serine/threonine-protein kinase 3

9

18

Small-scale

0.963

High

414993

CDK1
Cyclin-dependent kinase 1

1

5

High-throughput

0.698

High

983874

KPCZ
Protein kinase C zeta type

1

9

High-throughput

0.691

High

1137765

OBSCN
Obscurin

1

2

High-throughput

0.691

High

1239411

LRCH3
DISP complex protein LRCH3

1

20

High-throughput

0.691

High

1038283

RIPK1
Receptor-interacting serine/threonine-protein kinase 1

1

17

Small-scale

0.618

High

1239407

MLKL
Mixed lineage kinase domain-like protein

1

18

Small-scale

0.618

High

594586

PSB1
Proteasome subunit beta type-1

2

1

High-throughput

0.606

High

893816

S10AA
Protein S100-A10

2

1

High-throughput

0.606

High

1239413

ITCH
E3 ubiquitin-protein ligase Itchy homolog

1

2

Small-scale

0.578

High

518716

IMDH2
Inosine-5'-monophosphate dehydrogenase 2

1

1

High-throughput

0.536

High

1059326

CASP8
Caspase-8

1

1

High-throughput

0.536

High

1239426

ZN281
Zinc finger protein 281

1

2

High-throughput

0.536

High

1239421

RAD18
E3 ubiquitin-protein ligase RAD18

1

0

High-throughput

0.518

High

1239422

APC11
Anaphase-promoting complex subunit 11

1

0

High-throughput

0.518

High

1039694

SNW1
SNW domain-containing protein 1

1

0

High-throughput

0.513

High

1235319

PAR16
Protein mono-ADP-ribosyltransferase PARP16

1

0

High-throughput

0.513

High

1239409

GSLG1
Golgi apparatus protein 1

1

0

High-throughput

0.513

High

1239419

SRA1
Steroid receptor RNA activator 1

1

0

High-throughput

0.513

High

271146

UBP2
Ubiquitin carboxyl-terminal hydrolase 2

1

5

Small-scale

0.501

High

1239412

THOC3
THO complex subunit 3

1

1

High-throughput

0.494

High

959139

PIPNA
Phosphatidylinositol transfer protein alpha isoform

1

0

High-throughput

0.493

High

317741

STABP
STAM-binding protein

1

0

Small-scale

0.480

High

1239420

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

Small-scale

0.480

High

164427

TRI66
Tripartite motif-containing protein 66

1

7

High-throughput

0.479

High

170424

TIF1A
Transcription intermediary factor 1-alpha

1

7

High-throughput

0.479

High

244668

BRD4
Bromodomain-containing protein 4

1

3

High-throughput

0.479

High

352660

TNFA
Tumor necrosis factor

1

2

Small-scale

0.479

High

617333

SP100
Nuclear autoantigen Sp-100

1

3

High-throughput

0.479

High

631508

BRD2
Bromodomain-containing protein 2

1

5

High-throughput

0.479

High

1020812

TRAF2
TNF receptor-associated factor 2

1

13

Small-scale

0.479

High

1239415

CECR2
Chromatin remodeling regulator CECR2

1

2

High-throughput

0.479

High

1239418

SP110
Sp110 nuclear body protein

1

7

High-throughput

0.479

High

1239424

ZMYD8
MYND-type zinc finger-containing chromatin reader ZMYND8

1

3

High-throughput

0.479

High

1239425

TRI33
E3 ubiquitin-protein ligase TRIM33

1

5

High-throughput

0.479

High

1239428

TRAF6
TNF receptor-associated factor 6

1

14

Small-scale

0.479

High

319270

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

1042052

CUL3
Cullin-3

1

0

High-throughput

0.458

High

1064492

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1239414

TS101
Tumor susceptibility gene 101 protein

1

0

Small-scale

0.458

High

1239416

ZBP1
Z-DNA-binding protein 1

1

0

Small-scale

0.458

High

1239417

MB12B
Multivesicular body subunit 12B

1

0

Small-scale

0.458

High

1239423

VPS28
Vacuolar protein sorting-associated protein 28 homolog

1

0

Small-scale

0.458

High

831496

CEBPA
CCAAT/enhancer-binding protein alpha

1

1

High-throughput

0.408

High

568469

NDUB7
NADH dehydrogenase [ubiquinone] 1 beta subcomplex subunit 7

1

0

High-throughput

0.282

High

1239410

MR1L1
MORF4 family-associated protein 1-like 1

1

0

High-throughput

0.279

Low

1156271

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.249

Low

1157256

ZNT6
Zinc transporter 6

1

0

High-throughput

0.249

Low

1239408

STT3B
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3B

1

0

High-throughput

0.249

Low

1239427

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024