Protein: SREK1
Splicing regulatory glutamine/lysine-rich protein 1 (Serine/arginine-rich-splicing regulatory protein 86) (SRrp86) (Splicing factor, arginine/serine-rich 12) (Splicing regulatory protein 508) (SRrp508)

Gene: SREK1
Organism: Homo sapiens
Interactions: 170
UniProt ID: Q8WXA9

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0005654 - nucleoplasm
GO:0005681 - spliceosomal complex
GO:0006397 - mRNA processing
GO:0008380 - RNA splicing

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

984104

SRS11
Serine/arginine-rich splicing factor 11

4

2

High-throughput

0.904

High

1263302

SRSF8
Serine/arginine-rich splicing factor 8

4

7

Small-scale

0.897

High

267034

SRS10
Serine/arginine-rich splicing factor 10

4

8

Small-scale

0.895

High

942839

SRPK2
SRSF protein kinase 2

3

10

High-throughput

0.882

High

1263300

SRPK1
SRSF protein kinase 1

3

7

Small-scale

0.873

High

1263304

MK67I
MKI67 FHA domain-interacting nucleolar phosphoprotein

3

9

High-throughput

0.861

High

1070573

RNPS1
RNA-binding protein with serine-rich domain 1

3

7

High-throughput

0.855

High

1054465

RBM39
RNA-binding protein 39

3

8

High-throughput

0.843

High

1084349

SRSF7
Serine/arginine-rich splicing factor 7

2

9

Small-scale

0.831

High

964037

SRSF2
Serine/arginine-rich splicing factor 2

2

6

Small-scale

0.807

High

992862

SRSF1
Serine/arginine-rich splicing factor 1

2

12

Small-scale

0.789

High

993782

SRSF4
Serine/arginine-rich splicing factor 4

2

9

Small-scale

0.789

High

1028752

SRSF5
Serine/arginine-rich splicing factor 5

2

10

Small-scale

0.789

High

1029019

SRSF6
Serine/arginine-rich splicing factor 6

2

10

Small-scale

0.789

High

1263311

LN28A
Protein lin-28 homolog A

2

3

High-throughput

0.789

High

952059

SRSF3
Serine/arginine-rich splicing factor 3

2

11

Small-scale

0.768

High

745239

RBMX
RNA-binding motif protein, X chromosome

1

6

Small-scale

0.724

High

931302

YBOX1
Y-box-binding protein 1

1

3

Small-scale

0.724

High

1073536

SAFB1
Scaffold attachment factor B1

1

5

Small-scale

0.724

High

1263287

SREK1
Splicing regulatory glutamine/lysine-rich protein 1

1

3

High-throughput

0.698

High

307840

ZRAB2
Zinc finger Ran-binding domain-containing protein 2

4

2

Small-scale

0.694

High

453876

RU2A
U2 small nuclear ribonucleoprotein A'

1

2

High-throughput

0.691

High

1263316

PUF60
Poly(U)-binding-splicing factor PUF60

1

11

High-throughput

0.691

High

1263318

ZN346
Zinc finger protein 346

1

1

High-throughput

0.691

High

1263322

YBOX2
Y-box-binding protein 2

1

3

High-throughput

0.691

High

1263309

PININ
Pinin

4

0

Small-scale

0.673

High

127835

SAP18
Histone deacetylase complex subunit SAP18

1

0

High-throughput

0.656

High

616430

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.656

High

824654

MAPK2
MAP kinase-activated protein kinase 2

1

0

High-throughput

0.656

High

916288

RL23A
Large ribosomal subunit protein uL23

1

0

High-throughput

0.656

High

1157348

JMJD6
Bifunctional arginine demethylase and lysyl-hydroxylase JMJD6

3

0

High-throughput

0.638

High

241334

HNRC1
Heterogeneous nuclear ribonucleoprotein C-like 1

1

2

Small-scale

0.618

High

432831

HNRPC
Heterogeneous nuclear ribonucleoproteins C1/C2

1

4

Small-scale

0.618

High

442343

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

7

High-throughput

0.618

High

453497

ROA1
Heterogeneous nuclear ribonucleoprotein A1

1

4

Small-scale

0.618

High

516607

PABP1
Polyadenylate-binding protein 1

1

5

Small-scale

0.618

High

582406

NUCL
Nucleolin

1

5

Small-scale

0.618

High

609970

ROA2
Heterogeneous nuclear ribonucleoproteins A2/B1

1

5

Small-scale

0.618

High

613531

SFPQ
Splicing factor, proline- and glutamine-rich

1

7

Small-scale

0.618

High

682911

HNRH1
Heterogeneous nuclear ribonucleoprotein H

1

9

Small-scale

0.618

High

852113

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

6

Small-scale

0.618

High

925085

TRA2B
Transformer-2 protein homolog beta

1

9

Small-scale

0.618

High

934346

CSK21
Casein kinase II subunit alpha

1

4

Small-scale

0.618

High

958089

RBM10
RNA-binding protein 10

1

4

Small-scale

0.618

High

1028585

SRSF9
Serine/arginine-rich splicing factor 9

1

9

Small-scale

0.618

High

1031403

PABP4
Polyadenylate-binding protein 4

1

5

Small-scale

0.618

High

1048153

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

8

Small-scale

0.618

High

1073086

SF3B3
Splicing factor 3B subunit 3

1

1

Small-scale

0.618

High

1077428

ELAV1
ELAV-like protein 1

1

5

Small-scale

0.618

High

1263291

KAT6A
Histone acetyltransferase KAT6A

1

2

High-throughput

0.618

High

1263293

CELF1
CUGBP Elav-like family member 1

1

6

High-throughput

0.618

High

1263312

RC3H2
Roquin-2

1

2

High-throughput

0.618

High

418498

NPM
Nucleophosmin

2

2

Small-scale

0.611

High

971288

H11
Histone H1.1

2

3

High-throughput

0.611

High

263757

PR40A
Pre-mRNA-processing factor 40 homolog A

2

4

High-throughput

0.606

High

1018839

SF3A3
Splicing factor 3A subunit 3

1

0

Small-scale

0.586

High

1221418

ZC3H3
Zinc finger CCCH domain-containing protein 3

1

0

High-throughput

0.578

High

608601

H1T
Histone H1t

2

3

High-throughput

0.574

High

814649

CDX1
Homeobox protein CDX-1

2

2

High-throughput

0.574

High

370095

ESR1
Estrogen receptor

2

10

High-throughput

0.571

High

1263292

DDX17
Probable ATP-dependent RNA helicase DDX17

1

3

Small-scale

0.561

High

770651

TXLNA
Alpha-taxilin

2

6

High-throughput

0.553

High

149111

CTRO
Citron Rho-interacting kinase

1

5

High-throughput

0.553

High

267582

RMXL2
RNA-binding motif protein, X-linked-like-2

1

4

Small-scale

0.553

High

1263320

SRPK3
SRSF protein kinase 3

1

9

Small-scale

0.553

High

962887

MDM2
E3 ubiquitin-protein ligase Mdm2

1

0

High-throughput

0.537

High

269818

PRKRA
Interferon-inducible double-stranded RNA-dependent protein kinase activator A

1

10

High-throughput

0.536

High

445482

RSSA
Small ribosomal subunit protein uS2

1

2

High-throughput

0.536

High

489179

H14
Histone H1.4

1

3

High-throughput

0.536

High

559862

H12
Histone H1.2

1

3

High-throughput

0.536

High

595334

LMNB1
Lamin-B1

1

4

High-throughput

0.536

High

898409

RS3A
Small ribosomal subunit protein eS1

1

1

High-throughput

0.536

High

922641

RL10A
Large ribosomal subunit protein uL1

1

1

High-throughput

0.536

High

951672

RL19
Large ribosomal subunit protein eL19

1

1

High-throughput

0.536

High

1041115

CUL1
Cullin-1

1

4

High-throughput

0.536

High

1263301

CDC5L
Cell division cycle 5-like protein

1

3

High-throughput

0.536

High

1263307

PAIP1
Polyadenylate-binding protein-interacting protein 1

1

4

High-throughput

0.536

High

166752

CE290
Centrosomal protein of 290 kDa

2

6

High-throughput

0.521

High

2732

A0A0C4DG62
ADP-ribosylation factor-like protein 6-interacting protein 4

1

1

High-throughput

0.515

High

448755

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

550877

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.513

High

642485

RL13
Large ribosomal subunit protein eL13

1

0

High-throughput

0.513

High

759756

RS19
Small ribosomal subunit protein eS19

1

0

High-throughput

0.513

High

773474

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

790484

RL35
Large ribosomal subunit protein uL29

1

0

High-throughput

0.513

High

807456

RS10
Small ribosomal subunit protein eS10

1

0

High-throughput

0.513

High

900214

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.513

High

907424

RS8
Small ribosomal subunit protein eS8

1

0

High-throughput

0.513

High

916727

RS6
Small ribosomal subunit protein eS6

1

0

High-throughput

0.513

High

922279

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.513

High

1065843

RRS1
Ribosome biogenesis regulatory protein homolog

1

0

High-throughput

0.513

High

1263290

DGCR8
Microprocessor complex subunit DGCR8

1

0

High-throughput

0.513

High

1263298

NEIL1
Endonuclease 8-like 1

1

0

High-throughput

0.513

High

1263317

PURG
Purine-rich element-binding protein gamma

1

0

High-throughput

0.513

High

1263325

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.513

High

180392

MAGB2
Melanoma-associated antigen B2

1

2

High-throughput

0.489

High

470477

H2A1
Histone H2A type 1

1

2

High-throughput

0.489

High

796147

MAGA9
Melanoma-associated antigen 9

1

2

High-throughput

0.489

High

1231398

CT197
Putative uncharacterized protein encoded by LINC02910

1

1

High-throughput

0.489

High

1252843

ZCH10
Zinc finger CCHC domain-containing protein 10

1

1

High-throughput

0.489

High

884336

PCBP3
Poly(rC)-binding protein 3

1

6

High-throughput

0.481

High

1146430

AR6P4
ADP-ribosylation factor-like protein 6-interacting protein 4

1

1

High-throughput

0.481

High

122904

MEN1
Menin

1

2

High-throughput

0.479

High

134136

DDX3X
ATP-dependent RNA helicase DDX3X

1

3

Small-scale

0.479

High

304266

UBR5
E3 ubiquitin-protein ligase UBR5

1

3

High-throughput

0.479

High

319946

HERC2
E3 ubiquitin-protein ligase HERC2

1

4

High-throughput

0.479

High

322930

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

10

High-throughput

0.479

High

347446

MYC
Myc proto-oncogene protein

1

5

High-throughput

0.479

High

455701

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.479

High

553295

RFA2
Replication protein A 32 kDa subunit

1

3

High-throughput

0.479

High

636383

DNJB1
DnaJ homolog subfamily B member 1

1

1

High-throughput

0.479

High

651800

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

3

High-throughput

0.479

High

721024

RFA3
Replication protein A 14 kDa subunit

1

3

High-throughput

0.479

High

824225

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.479

High

904055

HNRPK
Heterogeneous nuclear ribonucleoprotein K

1

6

Small-scale

0.479

High

912340

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

Small-scale

0.479

High

912687

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

Small-scale

0.479

High

929589

RACK1
Small ribosomal subunit protein RACK1

1

5

Small-scale

0.479

High

962244

HNRPU
Heterogeneous nuclear ribonucleoprotein U

1

2

Small-scale

0.479

High

996794

SSRP1
FACT complex subunit SSRP1

1

8

Small-scale

0.479

High

1019575

ILF2
Interleukin enhancer-binding factor 2

1

1

Small-scale

0.479

High

1043479

CUL4B
Cullin-4B

1

4

High-throughput

0.479

High

1046118

DX39B
Spliceosome RNA helicase DDX39B

1

9

Small-scale

0.479

High

1064529

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

3

Small-scale

0.479

High

1081342

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1127658

PRC2B
Protein PRRC2B

1

5

High-throughput

0.479

High

1136197

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1221600

SMC5
Structural maintenance of chromosomes protein 5

1

4

High-throughput

0.479

High

1244398

NUP43
Nucleoporin Nup43

1

3

High-throughput

0.479

High

1263288

DNJC9
DnaJ homolog subfamily C member 9

1

1

High-throughput

0.479

High

1263297

SNR40
U5 small nuclear ribonucleoprotein 40 kDa protein

1

3

High-throughput

0.479

High

1263303

DDX23
Probable ATP-dependent RNA helicase DDX23

1

6

High-throughput

0.479

High

1263310

ECT2
Protein ECT2

1

2

High-throughput

0.479

High

1263314

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

2

High-throughput

0.479

High

1263315

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1263323

TR150
Thyroid hormone receptor-associated protein 3

1

4

Small-scale

0.479

High

1263326

SP16H
FACT complex subunit SPT16

1

1

Small-scale

0.479

High

64870

SRRM4
Serine/arginine repetitive matrix protein 4

1

0

High-throughput

0.460

High

1033045

TARB1
Probable methyltransferase TARBP1

1

0

Small-scale

0.460

High

1263305

RM37
Large ribosomal subunit protein mL37

1

0

High-throughput

0.460

High

1263308

NAT10
RNA cytidine acetyltransferase

1

0

High-throughput

0.460

High

1263313

SHLB2
Endophilin-B2

1

0

Small-scale

0.460

High

278848

DNJC8
DnaJ homolog subfamily C member 8

1

0

High-throughput

0.458

High

722465

RL22
Large ribosomal subunit protein eL22

1

0

High-throughput

0.458

High

760200

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.458

High

990205

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

Small-scale

0.458

High

1263306

IN80B
INO80 complex subunit B

1

0

High-throughput

0.458

High

1263324

LC7L2
Putative RNA-binding protein Luc7-like 2

1

0

High-throughput

0.458

High

844653

RAB5C
Ras-related protein Rab-5C

1

1

High-throughput

0.439

High

385243

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.437

High

908887

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

2

High-throughput

0.437

High

1067069

BRD3
Bromodomain-containing protein 3

1

5

High-throughput

0.437

High

1171007

TRI67
Tripartite motif-containing protein 67

1

3

High-throughput

0.437

High

47445

RPSA2
Small ribosomal subunit protein uS2B

1

2

High-throughput

0.407

High

1263296

GASP2
G-protein coupled receptor-associated sorting protein 2

2

0

High-throughput

0.316

High

1145860

CP135
Centrosomal protein of 135 kDa

2

0

High-throughput

0.298

High

1263321

ADIP
Afadin- and alpha-actinin-binding protein

2

0

High-throughput

0.298

High

456180

IFI6
Interferon alpha-inducible protein 6

1

0

High-throughput

0.279

Low

1054869

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.279

Low

1139297

SPAT1
Spermatogenesis-associated protein 1

1

0

High-throughput

0.279

Low

1263289

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

1

0

High-throughput

0.279

Low

1263294

FGF13
Fibroblast growth factor 13

1

0

High-throughput

0.279

Low

1263295

I27L1
Interferon alpha-inducible protein 27-like protein 1

1

0

High-throughput

0.279

Low

1263299

ZN668
Zinc finger protein 668

1

0

High-throughput

0.279

Low

1263319

PAI2B
Polyadenylate-binding protein-interacting protein 2B

1

0

High-throughput

0.279

Low

1086887

DGKD
Diacylglycerol kinase delta

1

0

Small-scale

0.251

Low

1262648

CKAP2
Cytoskeleton-associated protein 2

1

0

High-throughput

0.251

Low

547581

FOLR1
Folate receptor alpha

1

0

High-throughput

0.249

Low

1243864

FBX22
F-box only protein 22

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024