HitPredict

Interactor 1: NEB2 (Q6R891)
Neurabin-2 (Neurabin-II) (Protein phosphatase 1 regulatory subunit 9B) (Spinophilin)
Gene: Ppp1r9b

Interactor 2: ACTN1 (Q7TPR4)
Alpha-actinin-1 (Alpha-actinin cytoskeletal isoform) (F-actin cross-linking protein) (Non-muscle alpha-actinin-1)
Gene: ACTN1

Species: Mus musculus

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.56	0.60	0.584

Property	Details
Experiments	30562941, 28634551
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0005886 - plasma membrane GO:0044325 - transmembrane transporter binding GO:0051015 - actin filament binding GO:0098978 - glutamatergic synapse
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 817 Mm			1 892
+	Rn
		204587 NEB2_RAT (1-817): 3.55e-116: 373: 98.90		ACTN1_RAT (1-892): 0: 672: 99.33
+	Mm
		1247217 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		ACTN2_MOUSE (10-892): 0: 613: 80.41
+	Rn
		92871 NEB2_RAT (1-817): 3.55e-116: 373: 98.90		D3ZCV0_RAT (13-892): 0: 608: 80.02
+	Mm
		945622 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		ACTN4_MOUSE (11-892): 0: 613: 86.51
+	Hs
		224780 NEB2_HUMAN (1-817): 4.8e-111: 359: 95.84		ACTN4_HUMAN (11-892): 0: 616: 86.51
+	Hs
		773777 NEB2_HUMAN (1-817): 4.8e-111: 359: 95.84		ACTN2_HUMAN (10-892): 0: 610: 80.07
+	Hs
		555723 LNX1_HUMAN (236-773): 1.12e-33: 140: 11.17		ACTN1_HUMAN (1-892): 0: 671: 99.22
+	Mm
		50271 DLG4_MOUSE (381-806): 6.82e-31: 132: 11.04		A1BN54_MOUSE (1-892): 0: 660: 97.98
+	Hs
		224750 LNX1_HUMAN (236-773): 1.12e-33: 140: 11.17		ACTN4_HUMAN (11-892): 0: 616: 86.51
+	Hs
		1061540 LNX1_HUMAN (236-773): 1.12e-33: 140: 11.17		ACTN3_HUMAN (18-892): 0: 614: 78.06
+	Hs
		773734 DLG1_HUMAN (80-763): 5.27e-34: 142: 9.68		ACTN2_HUMAN (10-892): 0: 610: 80.07
+	Mm
		945621 DLG4_MOUSE (381-806): 6.82e-31: 132: 11.04		ACTN4_MOUSE (11-892): 0: 613: 86.51
+	Hs
		773726 DLG4_HUMAN (438-714): 1.47e-29: 127: 16.03		ACTN2_HUMAN (10-892): 0: 610: 80.07
+	Ce
		111247 DLG1_CAEEL (228-748): 9.75e-25: 112: 11.55		Q9XVU8_CAEEL (6-888): 0: 589: 62.33
+	Ce
		111237 DLG1_CAEEL (228-748): 9.75e-25: 112: 11.55		Q23158_CAEEL (6-888): 0: 573: 60.26
+	Mm
		1223938 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		SPTB2_MOUSE (165-808): 6.08e-11: 68.9: 12.07
+	Mm
		1190041 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		Q3UGX2_MOUSE (247-770): 2.09e-10: 67: 12.12
+	Mm
		1229316 NEB2_MOUSE (1-817): 1.67e-114: 368: 100.00		Q68FG2_MOUSE (242-827): 3.76e-10: 66.2: 11.18
+	Hs
		1028850 LRRC7_HUMAN (15-586): 7.55e-41: 164: 12.93		SPTB2_HUMAN (165-808): 7.57e-11: 68.5: 12.07
+	Mm
		1223545 DLG4_MOUSE (381-806): 6.82e-31: 132: 11.04		SPTB2_MOUSE (165-808): 6.08e-11: 68.9: 12.07