HitPredict

Interactor 1: M9PAY7 (M9PAY7)
Pi3K21B, isoform C (Pi3K21B, isoform D)
Gene: Pi3K21B

Interactor 2: IRS1 (Q9XTN2)
Insulin receptor substrate 1 (dIRS) (Protein chico)
Gene: chico

Species: Drosophila melanogaster

Source: biogrid

Category: High-throughput

Confidence: High

Method score	Annotation score	Interaction score
0.68	0.60	0.640

Property	Details
Experiments	22068330, 26839216, 27626673
Identification Methods	affinity chromatography technology
Interaction Type	physical association

Property	Details
Interacting Pfam domains	-
Common GO terms	GO:0008286 - insulin receptor signaling pathway
Homologous interactions	20

Homologous interactions (Top 20)

Color coding for hit scores

	1 197 Dm			1 968
+	Dm
		198240 O18683_DROME (9-136): 6.74e-30: 116: 22.31		IRS1_DROME (1-968): 0: 1755: 100.00
+	Hs
		440413 FYN_HUMAN (2-192): 6.6e-59: 194: 19.51		IRS1_HUMAN (1-355): 4.8e-140: 451: 29.13
+	Mm
		683092 LYN_MOUSE (3-192): 1.26e-54: 182: 18.00		IRS2_MOUSE (9-357): 2.98e-113: 380: 25.77
+	Hs
		136310 P85B_HUMAN (19-149): 1.39e-26: 107: 23.29		IRS1_HUMAN (1-355): 4.8e-140: 451: 29.13
+	Hs
		599274 PLCG2_HUMAN (13-171): 1.78e-26: 107: 21.91		IRS1_HUMAN (1-355): 4.8e-140: 451: 29.13
+	Hs
		772510 P55G_HUMAN (18-132): 3.8e-25: 102: 25.42		IRS1_HUMAN (1-355): 4.8e-140: 451: 29.13
+	Hs
		699616 P85A_HUMAN (18-132): 4.75e-24: 100: 25.42		IRS1_HUMAN (1-355): 4.8e-140: 451: 29.13
+	Mm
		686938 P85A_MOUSE (24-132): 3.53e-24: 100: 25.89		IRS1_MOUSE (1-355): 6.18e-138: 446: 30.71
+	Hs
		160393 LCK_HUMAN (2-192): 7.61e-56: 186: 21.89		IRS4_HUMAN (7-369): 6.58e-98: 337: 23.53
+	Hs
		160396 LYN_HUMAN (1-192): 2.47e-55: 184: 17.33		IRS4_HUMAN (7-369): 6.58e-98: 337: 23.53
+	Hs
		619141 PLCG1_HUMAN (5-156): 6.56e-28: 111: 20.83		IRS2_HUMAN (9-357): 3.79e-116: 389: 26.17
+	Hs
		1364903 P55G_HUMAN (18-132): 3.8e-25: 102: 25.42		IRS2_HUMAN (9-357): 3.79e-116: 389: 26.17
+	Hs
		699905 P85A_HUMAN (18-132): 4.75e-24: 100: 25.42		IRS2_HUMAN (9-357): 3.79e-116: 389: 26.17
+	Mm
		686950 P85A_MOUSE (24-132): 3.53e-24: 100: 25.89		IRS2_MOUSE (9-357): 2.98e-113: 380: 25.77
+	Rn
		98921 P85A_RAT (24-132): 6.79e-24: 100: 25.89		F1MAL5_RAT (9-357): 1.95e-112: 378: 25.77
+	Hs
		160410 PLCG1_HUMAN (5-156): 6.56e-28: 111: 20.83		IRS4_HUMAN (7-369): 6.58e-98: 337: 23.53
+	Hs
		136230 P85B_HUMAN (19-149): 1.39e-26: 107: 23.29		IRS4_HUMAN (7-369): 6.58e-98: 337: 23.53
+	Hs
		160568 P55G_HUMAN (18-132): 3.8e-25: 102: 25.42		IRS4_HUMAN (7-369): 6.58e-98: 337: 23.53
+	Hs
		160420 P85A_HUMAN (18-132): 4.75e-24: 100: 25.42		IRS4_HUMAN (7-369): 6.58e-98: 337: 23.53
+	Rn
		148123 P85A_RAT (24-132): 6.79e-24: 100: 25.89		O08724_RAT (8-238): 4.55e-88: 292: 30.16