Protein: CLPX
ATP-dependent clpX-like chaperone, mitochondrial (EC 3.6.4.10) (ATP-dependent Clp protease ATP-binding subunit clpX-like, mitochondrial) (Caseinolytic mitochondrial matrix peptidase chaperone subunit X)

Gene: CLPX
Organism: Homo sapiens
Interactions: 204
UniProt ID: O76031

Gene Ontology (top 5):
GO:0005524 - ATP binding
GO:0005654 - nucleoplasm
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005759 - mitochondrial matrix

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

301903

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

5

2

Small-scale

0.912

High

301998

FBW1B
F-box/WD repeat-containing protein 11

5

1

High-throughput

0.706

High

302001

FBW1A
F-box/WD repeat-containing protein 1A

3

1

High-throughput

0.675

High

301932

CHC10
Coiled-coil-helix-coiled-coil-helix domain-containing protein 10, mitochondrial

3

1

High-throughput

0.667

High

301968

NDEL1
Nuclear distribution protein nudE-like 1

3

1

High-throughput

0.662

High

301960

THTPA
Thiamine-triphosphatase

3

0

High-throughput

0.638

High

301851

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.618

High

301828

AIFM1
Apoptosis-inducing factor 1, mitochondrial

3

0

High-throughput

0.616

High

301927

ATPF2
ATP synthase mitochondrial F1 complex assembly factor 2

2

0

High-throughput

0.602

High

301942

FXRD1
FAD-dependent oxidoreductase domain-containing protein 1

2

0

High-throughput

0.602

High

61381

VWA8
von Willebrand factor A domain-containing protein 8

1

0

High-throughput

0.586

High

301846

SDHB
Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial

2

0

Small-scale

0.585

High

301896

ICT1
Large ribosomal subunit protein mL62

2

0

High-throughput

0.585

High

301922

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

2

0

High-throughput

0.585

High

301862

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

2

0

High-throughput

0.576

High

301928

ALAT2
Alanine aminotransferase 2

2

0

High-throughput

0.576

High

301985

EXD2
Exonuclease 3'-5' domain-containing protein 2

2

0

High-throughput

0.576

High

301845

GNS
N-acetylglucosamine-6-sulfatase

2

1

High-throughput

0.574

High

301875

H31
Histone H3.1

2

2

High-throughput

0.571

High

240325

PRKN
E3 ubiquitin-protein ligase parkin

2

0

High-throughput

0.559

High

279596

CISY
Citrate synthase, mitochondrial

2

0

High-throughput

0.559

High

301829

TRUB2
Pseudouridylate synthase TRUB2, mitochondrial

2

0

High-throughput

0.559

High

301844

COX41
Cytochrome c oxidase subunit 4 isoform 1, mitochondrial

2

0

High-throughput

0.559

High

301883

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

2

0

Small-scale

0.559

High

301847

FBRL
rRNA 2'-O-methyltransferase fibrillarin

2

0

High-throughput

0.547

High

301891

CUL1
Cullin-1

1

2

High-throughput

0.536

High

301893

CUL4B
Cullin-4B

1

2

High-throughput

0.536

High

301912

FAHD1
Oxaloacetate tautomerase FAHD1, mitochondrial

1

1

High-throughput

0.536

High

301920

NIT1
Deaminated glutathione amidase

1

1

High-throughput

0.536

High

301929

DDX54
ATP-dependent RNA helicase DDX54

1

1

High-throughput

0.536

High

301915

RHG36
Rho GTPase-activating protein 36

2

1

High-throughput

0.521

High

301860

CDN1B
Cyclin-dependent kinase inhibitor 1B

1

0

High-throughput

0.513

High

301874

GRB2
Growth factor receptor-bound protein 2

1

0

High-throughput

0.513

High

301889

G3BP1
Ras GTPase-activating protein-binding protein 1

1

0

High-throughput

0.513

High

301902

MK06
Mitogen-activated protein kinase 6

1

0

High-throughput

0.513

High

301940

TRI43
Tripartite motif-containing protein 43

1

0

High-throughput

0.513

High

301972

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

301974

EHD4
EH domain-containing protein 4

1

0

High-throughput

0.513

High

301989

BABA1
BRISC and BRCA1-A complex member 1

1

0

High-throughput

0.513

High

301990

TRM1
tRNA

1

0

High-throughput

0.513

High

301992

PDP2
[Pyruvate dehydrogenase [acetyl-transferring]]-phosphatase 2, mitochondrial

1

0

High-throughput

0.513

High

301996

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

301997

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.513

High

302003

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

301826

KLF8
Krueppel-like factor 8

1

1

High-throughput

0.500

High

301965

KLF16
Krueppel-like factor 16

1

1

High-throughput

0.500

High

301961

RCAF1
GEL complex subunit OPTI

1

0

High-throughput

0.493

High

288159

CLC3A
C-type lectin domain family 3 member A

1

2

High-throughput

0.489

High

301993

FXL17
F-box/LRR-repeat protein 17

1

1

Small-scale

0.481

High

185301

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

301871

NKX25
Homeobox protein Nkx-2.5

1

0

High-throughput

0.479

High

301880

HEN1
Helix-loop-helix protein 1

1

0

High-throughput

0.479

High

188753

TMPS2
Transmembrane protease serine 2

1

1

High-throughput

0.479

High

281842

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

283739

NDUS3
NADH dehydrogenase [ubiquinone] iron-sulfur protein 3, mitochondrial

1

1

High-throughput

0.479

High

287214

RF1M
Peptide chain release factor 1, mitochondrial

1

2

High-throughput

0.479

High

288210

KBL
2-amino-3-ketobutyrate coenzyme A ligase, mitochondrial

1

1

High-throughput

0.479

High

301831

OTC
Ornithine transcarbamylase, mitochondrial

1

1

High-throughput

0.479

High

301852

BRCA1
Breast cancer type 1 susceptibility protein

1

1

High-throughput

0.479

High

301853

HSPA9
Stress-70 protein, mitochondrial

1

4

High-throughput

0.479

High

301856

LPPRC
Leucine-rich PPR motif-containing protein, mitochondrial

1

1

High-throughput

0.479

High

301859

IF2M
Translation initiation factor IF-2, mitochondrial

1

5

High-throughput

0.479

High

301865

EFTU
Elongation factor Tu, mitochondrial

1

5

High-throughput

0.479

High

301872

CDC42
Cell division control protein 42 homolog

1

1

High-throughput

0.479

High

301876

RHOG
Rho-related GTP-binding protein RhoG

1

1

High-throughput

0.479

High

301877

H33
Histone H3.3

1

2

High-throughput

0.479

High

301885

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

301887

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

1

High-throughput

0.479

High

301892

CUL3
Cullin-3

1

2

High-throughput

0.479

High

301898

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

2

High-throughput

0.479

High

301918

H32
Histone H3.2

1

2

High-throughput

0.479

High

301919

FAKD5
FAST kinase domain-containing protein 5, mitochondrial

1

2

High-throughput

0.479

High

301921

HSC20
Iron-sulfur cluster co-chaperone protein HscB

1

1

High-throughput

0.479

High

301926

FBXL6
F-box/LRR-repeat protein 6

1

2

High-throughput

0.479

High

301936

FAKD4
FAST kinase domain-containing protein 4

1

2

High-throughput

0.479

High

301937

MCUR1
Mitochondrial calcium uniporter regulator 1

1

1

High-throughput

0.479

High

301946

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

1

High-throughput

0.479

High

301952

EFGM
Elongation factor G, mitochondrial

1

2

High-throughput

0.479

High

301955

RING2
E3 ubiquitin-protein ligase RING2

1

2

High-throughput

0.479

High

301970

CC90B
Coiled-coil domain-containing protein 90B, mitochondrial

1

1

High-throughput

0.479

High

301976

MTRFR
Mitochondrial translation release factor in rescue

1

2

High-throughput

0.479

High

301994

RF1ML
Peptide chain release factor 1-like, mitochondrial

1

2

High-throughput

0.479

High

302002

PDIP2
Polymerase delta-interacting protein 2

1

2

High-throughput

0.479

High

302008

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

1

High-throughput

0.479

High

156790

CTRO
Citron Rho-interacting kinase

1

0

High-throughput

0.458

High

183560

RT12
Small ribosomal subunit protein uS12m

1

0

High-throughput

0.458

High

274952

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

0

High-throughput

0.458

High

292957

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

296173

SCO1
Protein SCO1 homolog, mitochondrial

1

0

High-throughput

0.458

High

301827

BRD1
Bromodomain-containing protein 1

1

0

High-throughput

0.458

High

301832

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

301833

MYC
Myc proto-oncogene protein

1

0

High-throughput

0.458

High

301834

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.458

High

301835

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

301836

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

301839

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

301840

CISD3
CDGSH iron-sulfur domain-containing protein 3, mitochondrial

1

0

High-throughput

0.458

High

301841

COX8A
Cytochrome c oxidase subunit 8A, mitochondrial

1

0

High-throughput

0.458

High

301842

CH60
60 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

301849

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

0

High-throughput

0.458

High

301850

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

301854

MDHM
Malate dehydrogenase, mitochondrial

1

0

High-throughput

0.458

High

301855

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

301858

EFTS
Elongation factor Ts, mitochondrial

1

0

High-throughput

0.458

High

301861

MAP1B
Microtubule-associated protein 1B

1

0

High-throughput

0.458

High

301864

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.458

High

301866

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

301867

DNLI3
DNA ligase 3

1

0

High-throughput

0.458

High

301870

RAB9A
Ras-related protein Rab-9A

1

0

High-throughput

0.458

High

301873

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

301879

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

301881

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

301882

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.458

High

301884

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.458

High

301886

GRSF1
G-rich sequence factor 1

1

0

High-throughput

0.458

High

301888

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

301890

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

301895

AUHM
Methylglutaconyl-CoA hydratase, mitochondrial

1

0

High-throughput

0.458

High

301899

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

301900

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

301901

T22D1
TSC22 domain family protein 1

1

0

High-throughput

0.458

High

301904

OXLD1
Oxidoreductase-like domain-containing protein 1

1

0

High-throughput

0.458

High

301905

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

301907

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

301910

MRM1
rRNA methyltransferase 1, mitochondrial

1

0

High-throughput

0.458

High

301913

RICTR
Rapamycin-insensitive companion of mTOR

1

0

High-throughput

0.458

High

301916

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

301930

PTPM1
Phosphatidylglycerophosphatase and protein-tyrosine phosphatase 1

1

0

High-throughput

0.458

High

301934

ESR2
Estrogen receptor beta

1

0

High-throughput

0.458

High

301935

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

301939

CHCH1
Small ribosomal subunit protein mS37

1

0

High-throughput

0.458

High

301941

RUSD4
Pseudouridylate synthase RPUSD4, mitochondrial

1

0

High-throughput

0.458

High

301944

RRFM
Ribosome-recycling factor, mitochondrial

1

0

High-throughput

0.458

High

301945

MTEF3
Transcription termination factor 3, mitochondrial

1

0

High-throughput

0.458

High

301947

KIF12
Kinesin-like protein KIF12

1

0

High-throughput

0.458

High

301948

FMC1
Protein FMC1 homolog

1

0

High-throughput

0.458

High

301949

COX14
Cytochrome c oxidase assembly protein COX14

1

0

High-throughput

0.458

High

301950

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

301951

TEFM
Transcription elongation factor, mitochondrial

1

0

High-throughput

0.458

High

301953

RANB9
Ran-binding protein 9

1

0

High-throughput

0.458

High

301954

IMP2L
Mitochondrial inner membrane protease subunit 2

1

0

High-throughput

0.458

High

301956

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

301957

GDAH
Guanidino acid hydrolase, mitochondrial

1

0

High-throughput

0.458

High

301958

TACO1
Translational activator of cytochrome c oxidase 1

1

0

High-throughput

0.458

High

301959

CQ080
Mitochondrial nucleoid-associated protein 1

1

0

High-throughput

0.458

High

301962

TR61B
tRNA

1

0

High-throughput

0.458

High

301964

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

301966

RT26
Small ribosomal subunit protein mS26

1

0

High-throughput

0.458

High

301969

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

301971

TOLIP
Toll-interacting protein

1

0

High-throughput

0.458

High

301975

IF3M
Translation initiation factor IF-3, mitochondrial

1

0

High-throughput

0.458

High

301977

MTG2
Mitochondrial ribosome-associated GTPase 2

1

0

High-throughput

0.458

High

301979

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

301980

MET17
Ribosome assembly protein METTL17, mitochondrial

1

0

High-throughput

0.458

High

301981

ACAD9
Complex I assembly factor ACAD9, mitochondrial

1

0

High-throughput

0.458

High

301982

NGRN
Neugrin

1

0

High-throughput

0.458

High

301983

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

301984

TOM22
Mitochondrial import receptor subunit TOM22 homolog

1

0

High-throughput

0.458

High

301986

RMND1
Required for meiotic nuclear division protein 1 homolog

1

0

High-throughput

0.458

High

301987

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

0

High-throughput

0.458

High

301988

AKIP
Small ribosomal subunit protein mS38

1

0

High-throughput

0.458

High

301991

MRES1
Mitochondrial transcription rescue factor 1

1

0

High-throughput

0.458

High

301995

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

302000

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.458

High

302004

RM11
Large ribosomal subunit protein uL11m

1

0

High-throughput

0.458

High

302005

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

302006

DJC15
DnaJ homolog subfamily C member 15

1

0

High-throughput

0.458

High

301837

HEPS
Serine protease hepsin

1

1

High-throughput

0.445

High

301897

FAKD3
FAST kinase domain-containing protein 3, mitochondrial

1

2

Small-scale

0.445

High

301925

FXL16
F-box/LRR-repeat protein 16

1

2

High-throughput

0.445

High

302007

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

1

High-throughput

0.445

High

301931

CLC4D
C-type lectin domain family 4 member D

1

1

High-throughput

0.437

High

301978

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

301999

CLC4E
C-type lectin domain family 4 member E

1

1

High-throughput

0.437

High

863

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.426

High

248815

GSDME
Gasdermin-E

1

0

High-throughput

0.426

High

301843

PIM1
Serine/threonine-protein kinase pim-1

1

0

High-throughput

0.426

High

301848

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

301868

ERF
ETS domain-containing transcription factor ERF

1

0

High-throughput

0.426

High

301869

PPT1
Palmitoyl-protein thioesterase 1

1

0

High-throughput

0.426

High

301908

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.426

High

301909

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

301911

ARMC6
Armadillo repeat-containing protein 6

1

0

High-throughput

0.426

High

301967

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

301973

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.407

High

297043

DHRS3
Short-chain dehydrogenase/reductase 3

1

0

High-throughput

0.279

Low

301938

ARRD3
Arrestin domain-containing protein 3

1

0

High-throughput

0.279

Low

301963

LS14B
Protein LSM14 homolog B

1

0

High-throughput

0.279

Low

179774

BET1
BET1 homolog

1

0

High-throughput

0.249

Low

277300

TP4A3
Protein tyrosine phosphatase type IVA 3

1

0

High-throughput

0.249

Low

301825

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

0

High-throughput

0.249

Low

301830

TOP3B
DNA topoisomerase 3-beta-1

1

0

High-throughput

0.249

Low

301857

MAGA3
Melanoma-associated antigen 3

1

0

Small-scale

0.249

Low

301863

TNFL6
Tumor necrosis factor ligand superfamily member 6

1

0

High-throughput

0.249

Low

301878

VIGLN
Vigilin

1

0

High-throughput

0.249

Low

301894

PTC1
Protein patched homolog 1

1

0

Small-scale

0.249

Low

301906

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.249

Low

301917

CC062
Uncharacterized protein C3orf62

1

0

High-throughput

0.249

Low

301924

RHG24
Rho GTPase-activating protein 24

1

0

High-throughput

0.249

Low

301943

KCD12
BTB/POZ domain-containing protein KCTD12

1

0

Small-scale

0.249

Low

301838

ACM4
Muscarinic acetylcholine receptor M4

1

0

High-throughput

0.232

Low

301914

ZNT10
Calcium/manganese antiporter SLC30A10

1

0

High-throughput

0.232

Low

301923

S15A3
Solute carrier family 15 member 3

1

0

High-throughput

0.232

Low

301933

LPAR1
Lysophosphatidic acid receptor 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025