Protein: SPI1
Transcription factor PU.1 (31 kDa-transforming protein)

Gene: SPI1
Organism: Homo sapiens
Interactions: 77
UniProt ID: P17947

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000976 - transcription cis-regulatory region binding
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

539457

ITAM
Integrin alpha-M

5

2

Small-scale

0.706

High

609922

IRF8
Interferon regulatory factor 8

4

10

Small-scale

0.699

High

609903

GATA2
Endothelial transcription factor GATA-2

3

14

Small-scale

0.690

High

378542

IL1B
Interleukin-1 beta

4

3

Small-scale

0.676

High

609931

IRF4
Interferon regulatory factor 4

3

10

Small-scale

0.650

High

577401

ETS1
Protein C-ets-1

1

18

Small-scale

0.647

High

578286

ETS2
Protein C-ets-2

1

17

Small-scale

0.647

High

609916

ETV1
ETS translocation variant 1

1

18

Small-scale

0.647

High

609921

SPIB
Transcription factor Spi-B

1

17

Small-scale

0.647

High

429266

JUN
Transcription factor Jun

3

20

Small-scale

0.646

High

590379

GATA1
Erythroid transcription factor

3

14

Small-scale

0.646

High

609927

HDAC1
Histone deacetylase 1

3

9

Small-scale

0.646

High

533871

IRF1
Interferon regulatory factor 1

2

10

Small-scale

0.646

High

609898

TBP
TATA-box-binding protein

2

5

Small-scale

0.634

High

609917

MECP2
Methyl-CpG-binding protein 2

2

3

Small-scale

0.629

High

540802

ERG
Transcriptional regulator ERG

1

17

Small-scale

0.618

High

609926

FOXC1
Forkhead box protein C1

1

12

High-throughput

0.618

High

416948

CY24B
NADPH oxidase 2

2

1

Small-scale

0.601

High

609913

CEBPA
CCAAT/enhancer-binding protein alpha

2

15

Small-scale

0.595

High

609909

FUS
RNA-binding protein FUS

1

6

Small-scale

0.586

High

456131

CSF1R
Macrophage colony-stimulating factor 1 receptor

2

2

Small-scale

0.584

High

609907

C2TA
MHC class II transactivator

2

2

Small-scale

0.584

High

442580

RB
Retinoblastoma-associated protein

1

2

Small-scale

0.578

High

609938

GFI1
Zinc finger protein Gfi-1

1

4

Small-scale

0.578

High

555334

SKI
Ski oncogene

1

1

Small-scale

0.561

High

609910

BCL6
B-cell lymphoma 6 protein

1

2

Small-scale

0.561

High

609915

GSK3B
Glycogen synthase kinase-3 beta

1

3

Small-scale

0.561

High

609930

NONO
Non-POU domain-containing octamer-binding protein

1

5

Small-scale

0.561

High

609933

FBXW7
F-box/WD repeat-containing protein 7

1

4

Small-scale

0.561

High

609937

SIN3A
Paired amphipathic helix protein Sin3a

1

5

Small-scale

0.561

High

609940

DNM3B
DNA

1

2

Small-scale

0.561

High

609944

DNM3A
DNA

1

2

Small-scale

0.561

High

609919

PRKDC
DNA-dependent protein kinase catalytic subunit

1

7

Small-scale

0.550

High

609929

Q15156
Protein PML

1

14

Small-scale

0.536

High

609906

HXA10
Homeobox protein Hox-A10

1

13

Small-scale

0.534

High

609914

CEBPD
CCAAT/enhancer-binding protein delta

1

20

Small-scale

0.515

High

269089

MITF
Microphthalmia-associated transcription factor

1

3

Small-scale

0.501

High

370548

FOS
Protein c-Fos

1

19

Small-scale

0.501

High

571551

IRF2
Interferon regulatory factor 2

1

10

Small-scale

0.501

High

606185

CEBPB
CCAAT/enhancer-binding protein beta

1

15

Small-scale

0.501

High

609897

ATF1
Cyclic AMP-dependent transcription factor ATF-1

1

10

Small-scale

0.501

High

609902

NFYA
Nuclear transcription factor Y subunit alpha

1

1

Small-scale

0.501

High

609904

GATA3
Trans-acting T-cell-specific transcription factor GATA-3

1

14

Small-scale

0.501

High

609912

MK08
Mitogen-activated protein kinase 8

1

11

Small-scale

0.501

High

609918

CSK21
Casein kinase II subunit alpha

1

2

Small-scale

0.501

High

609920

RUNX1
Runt-related transcription factor 1

1

5

Small-scale

0.501

High

609923

CREM
cAMP-responsive element modulator

1

8

Small-scale

0.501

High

609939

TMX1
Thioredoxin-related transmembrane protein 1

1

1

High-throughput

0.494

High

609935

YTDC1
YTH domain-containing protein 1

1

0

High-throughput

0.493

High

126291

TLR4
Toll-like receptor 4

1

5

Small-scale

0.479

High

169938

AURKA
Aurora kinase A

1

3

High-throughput

0.479

High

188165

HDAC3
Histone deacetylase 3

1

9

Small-scale

0.479

High

425298

ISG15
Ubiquitin-like protein ISG15

1

2

Small-scale

0.479

High

520509

RARA
Retinoic acid receptor alpha

1

10

Small-scale

0.479

High

609900

NF1
Neurofibromin

1

1

Small-scale

0.479

High

609901

IL10
Interleukin-10

1

2

Small-scale

0.479

High

609905

PML
Protein PML

1

18

Small-scale

0.479

High

609911

CATK
Cathepsin K

1

2

Small-scale

0.479

High

609924

KPCD
Protein kinase C delta type

1

3

Small-scale

0.479

High

609932

CEBPE
CCAAT/enhancer-binding protein epsilon

1

16

Small-scale

0.479

High

609941

LIMD1
LIM domain-containing protein 1

1

7

Small-scale

0.479

High

584464

VAV
Proto-oncogene vav

1

2

Small-scale

0.470

High

609908

CD68
Macrosialin

1

3

Small-scale

0.470

High

549427

CD20
B-lymphocyte antigen CD20

1

0

Small-scale

0.458

High

609934

DCPS
m7GpppX diphosphatase

1

0

High-throughput

0.458

High

609936

ZN300
Zinc finger protein 300

1

0

Small-scale

0.458

High

609943

UBP22
Ubiquitin carboxyl-terminal hydrolase 22

1

0

Small-scale

0.458

High

486938

PARP1
Poly [ADP-ribose] polymerase 1

1

4

Small-scale

0.445

High

557842

XRCC6
X-ray repair cross-complementing protein 6

1

11

Small-scale

0.445

High

559212

XRCC5
X-ray repair cross-complementing protein 5

1

11

Small-scale

0.445

High

456091

FES
Tyrosine-protein kinase Fes/Fps

1

4

Small-scale

0.437

High

609899

ITAX
Integrin alpha-X

1

2

Small-scale

0.437

High

609928

AGRE1
Adhesion G protein-coupled receptor E1

1

1

Small-scale

0.437

High

609925

SSRP1
FACT complex subunit SSRP1

1

17

Small-scale

0.381

High

567795

PRG2
Bone marrow proteoglycan

1

0

Small-scale

0.249

Low

609942

EVL
Ena/VASP-like protein

1

0

Small-scale

0.249

Low

609945

LY96
Lymphocyte antigen 96

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025