Protein: FRG1
Protein FRG1 (FSHD region gene 1 protein)

Gene: FRG1
Organism: Homo sapiens
Interactions: 62
UniProt ID: Q14331

Gene Ontology (top 5):
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0005730 - nucleolus
GO:0006364 - rRNA processing
GO:0007517 - muscle organ development

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

372018

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.584

High

1125833

CWC22
Pre-mRNA-splicing factor CWC22 homolog

1

0

High-throughput

0.549

High

1125825

EXOS8
Exosome complex component RRP43

1

0

High-throughput

0.549

High

429882

JUN
Transcription factor Jun

2

0

High-throughput

0.547

High

998312

H31
Histone H3.1

2

2

High-throughput

0.533

High

396106

ESR1
Estrogen receptor

2

2

High-throughput

0.521

High

854049

KI67
Proliferation marker protein Ki-67

1

0

High-throughput

0.513

High

1125810

SART3
Spliceosome associated factor 3, U4/U6 recycling protein

1

0

High-throughput

0.513

High

1125824

RBPMS
RNA-binding protein with multiple splicing

1

0

High-throughput

0.486

High

406176

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.479

High

472735

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.458

High

799883

COIL
Coilin

1

0

High-throughput

0.458

High

904710

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

979647

H4
Histone H4

1

0

High-throughput

0.458

High

984763

RL31
Large ribosomal subunit protein eL31

1

0

High-throughput

0.458

High

1125812

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1125813

RBBP5
Retinoblastoma-binding protein 5

1

0

High-throughput

0.458

High

1125814

EZH2
Histone-lysine N-methyltransferase EZH2

1

0

High-throughput

0.458

High

1125815

LARP7
La-related protein 7

1

0

High-throughput

0.458

High

1125816

MIDN
Midnolin

1

0

High-throughput

0.458

High

1125819

MEPCE
7SK snRNA methylphosphate capping enzyme

1

0

High-throughput

0.458

High

1125826

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1125830

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1125840

ZN330
Zinc finger protein 330

1

0

High-throughput

0.458

High

883535

CENPA
Histone H3-like centromeric protein A

1

2

High-throughput

0.437

High

1016854

H33
Histone H3.3

1

2

High-throughput

0.437

High

1125823

ESR2
Estrogen receptor beta

1

2

High-throughput

0.437

High

1125838

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

344192

PTBP3
Polypyrimidine tract-binding protein 3

1

0

High-throughput

0.426

High

529795

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

1125832

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

886855

CEBPA
CCAAT/enhancer-binding protein alpha

1

0

High-throughput

0.391

High

1125809

GNMT
Glycine N-methyltransferase

2

0

High-throughput

0.316

High

980765

H2B1C
Histone H2B type 1-C/E/F/G/I

2

0

High-throughput

0.305

High

1125818

K1C40
Keratin, type I cytoskeletal 40

1

0

High-throughput

0.299

High

1125828

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.299

High

1125821

CAND1
Cullin-associated NEDD8-dissociated protein 1

1

0

High-throughput

0.279

Low

129072

MEN1
Menin

1

0

High-throughput

0.249

Low

302522

RNF8
E3 ubiquitin-protein ligase RNF8

1

0

High-throughput

0.249

Low

400831

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.249

Low

588689

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

695448

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

768183

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879083

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

970492

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.249

Low

1045279

TF65
Transcription factor p65

1

0

High-throughput

0.249

Low

1067322

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.249

Low

1087737

NFIA
Nuclear factor 1 A-type

1

0

High-throughput

0.249

Low

1125811

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.249

Low

1125820

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1125822

NUP43
Nucleoporin Nup43

1

0

High-throughput

0.249

Low

1125829

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.249

Low

1125831

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1125834

ANLN
Anillin

1

0

High-throughput

0.249

Low

1125835

HECW2
E3 ubiquitin-protein ligase HECW2

1

0

High-throughput

0.249

Low

1125836

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.249

Low

1125837

XPO7
Exportin-7

1

0

High-throughput

0.249

Low

1125839

FZR1
Fizzy-related protein homolog

1

0

High-throughput

0.249

Low

1125841

HEY1
Hairy/enhancer-of-split related with YRPW motif protein 1

1

0

Small-scale

0.249

Low

1125827

CF418
Cilia- and flagella-associated protein 418

1

0

Small-scale

0.238

Low

563760

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.232

Low

1125817

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025