Protein: GPR21
Probable G-protein coupled receptor 21

Gene: GPR21
Organism: Homo sapiens
Interactions: 81
UniProt ID: Q99679

Gene Ontology (top 5):
GO:0004930 - G protein-coupled receptor activity
GO:0005886 - plasma membrane
GO:0007186 - G protein-coupled receptor signaling pathway
GO:0008286 - insulin receptor signaling pathway
GO:0040018 - positive regulation of multicellular organism growth

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1366196

LPAR1
Lysophosphatidic acid receptor 1

2

20

High-throughput

0.811

High

1406358

S1PR5
Sphingosine 1-phosphate receptor 5

2

19

High-throughput

0.811

High

1358614

BT2A2
Butyrophilin subfamily 2 member A2

2

0

High-throughput

0.770

High

1394648

TXD15
Thioredoxin domain-containing protein 15

2

2

High-throughput

0.726

High

956990

CXCR4
C-X-C chemokine receptor type 4

1

18

High-throughput

0.691

High

1111516

MTR1L
Melatonin-related receptor

1

17

High-throughput

0.691

High

1406355

LGR4
Leucine-rich repeat-containing G-protein coupled receptor 4

1

2

High-throughput

0.691

High

250141

ADCY9
Adenylate cyclase type 9

2

1

High-throughput

0.628

High

252710

TSN3
Tetraspanin-3

2

10

High-throughput

0.628

High

321779

AGRL1
Adhesion G protein-coupled receptor L1

2

5

High-throughput

0.628

High

336568

PIGN
GPI ethanolamine phosphate transferase 1

2

3

High-throughput

0.628

High

420038

B3A2
Anion exchange protein 2

2

3

High-throughput

0.628

High

443940

ATPB
ATP synthase F(1) complex subunit beta, mitochondrial

2

6

High-throughput

0.628

High

507332

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

2

7

High-throughput

0.628

High

604173

CXA1
Gap junction alpha-1 protein

2

6

High-throughput

0.628

High

611313

PTN1
Tyrosine-protein phosphatase non-receptor type 1

2

5

High-throughput

0.628

High

1106320

FZD5
Frizzled-5

2

3

High-throughput

0.628

High

1125871

FZD2
Frizzled-2

2

3

High-throughput

0.628

High

1154821

KCNJ8
ATP-sensitive inward rectifier potassium channel 8

2

3

High-throughput

0.628

High

1195379

ANO6
Anoctamin-6

2

2

High-throughput

0.628

High

1281757

T179B
Transmembrane protein 179B

2

1

High-throughput

0.628

High

1333110

AT11C
Phospholipid-transporting ATPase IG

2

4

High-throughput

0.628

High

1358438

LMBR1
Limb region 1 protein homolog

2

2

High-throughput

0.628

High

1369298

EDA
Ectodysplasin-A

2

2

High-throughput

0.628

High

1390779

S47A1
Multidrug and toxin extrusion protein 1

2

1

High-throughput

0.628

High

1406354

S29A1
Equilibrative nucleoside transporter 1

2

1

High-throughput

0.628

High

1406356

S12A9
Solute carrier family 12 member 9

2

8

High-throughput

0.628

High

1406357

ZDHC5
Palmitoyltransferase ZDHHC5

2

4

High-throughput

0.628

High

1406362

FZD3
Frizzled-3

2

3

High-throughput

0.628

High

1406365

CNNM1
Metal transporter CNNM1

2

1

High-throughput

0.628

High

1406367

S12A6
Solute carrier family 12 member 6

2

8

High-throughput

0.628

High

1406368

S12A4
Solute carrier family 12 member 4

2

8

High-throughput

0.628

High

1406374

S12A7
Solute carrier family 12 member 7

2

8

High-throughput

0.628

High

256121

S19A2
Thiamine transporter 1

2

0

High-throughput

0.602

High

296930

DGAT1
Diacylglycerol O-acyltransferase 1

2

0

High-throughput

0.602

High

1212290

TM63B
Mechanosensitive cation channel TMEM63B

2

0

High-throughput

0.602

High

1329183

S15A4
Solute carrier family 15 member 4

2

0

High-throughput

0.602

High

1333591

SIDT2
SID1 transmembrane family member 2

2

0

High-throughput

0.602

High

1406361

VEZA
Vezatin

2

0

High-throughput

0.602

High

246312

MARH6
E3 ubiquitin-protein ligase MARCHF6

2

1

High-throughput

0.574

High

248616

FADS1
Acyl-CoA

2

1

High-throughput

0.574

High

397809

ATP8
ATP synthase F(0) complex subunit 8

2

1

High-throughput

0.574

High

665681

AT5F1
ATP synthase peripheral stalk subunit b, mitochondrial

2

2

High-throughput

0.574

High

1010521

EREP3
Protein ENTREP3

2

1

High-throughput

0.574

High

1142926

EBP
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase

2

2

High-throughput

0.574

High

1153731

TOM34
Mitochondrial import receptor subunit TOM34

2

2

High-throughput

0.574

High

1187372

HSDL1
Inactive hydroxysteroid dehydrogenase-like protein 1

2

1

High-throughput

0.574

High

1216913

TM164
Transmembrane protein 164

2

1

High-throughput

0.574

High

1251741

CERS6
Ceramide synthase 6

2

6

High-throughput

0.574

High

1275401

ERMP1
Endoplasmic reticulum metallopeptidase 1

2

3

High-throughput

0.574

High

1291469

RETR3
Reticulophagy regulator 3

2

3

High-throughput

0.574

High

1329513

FITM2
Acyl-coenzyme A diphosphatase FITM2

2

1

High-throughput

0.574

High

1340555

MFSD8
Major facilitator superfamily domain-containing protein 8

2

4

High-throughput

0.574

High

1398466

TLCD4
TLC domain-containing protein 4

2

1

High-throughput

0.574

High

1398781

MBOA7
Membrane-bound acylglycerophosphatidylinositol O-acyltransferase MBOAT7

2

5

High-throughput

0.574

High

1406366

ELOV2
Very long chain fatty acid elongase 2

2

3

High-throughput

0.574

High

1406370

ZDHC9
Palmitoyltransferase ZDHHC9

2

3

High-throughput

0.574

High

1406372

RHBD3
Rhomboid domain-containing protein 3

2

4

High-throughput

0.574

High

560994

GP1BB
Platelet glycoprotein Ib beta chain

1

2

High-throughput

0.536

High

680476

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

6

High-throughput

0.536

High

727539

SC6A6
Sodium- and chloride-dependent taurine transporter

1

4

High-throughput

0.536

High

1232912

IPIL1
Inositol 1,4,5-trisphosphate receptor-interacting protein-like 1

1

1

High-throughput

0.536

High

506650

GPHRB
Golgi pH regulator B

2

7

High-throughput

0.533

High

1406360

XKR8
XK-related protein 8

1

0

High-throughput

0.513

High

85394

GPHRA
Golgi pH regulator A

2

7

High-throughput

0.504

High

1406363

AT132
Polyamine-transporting ATPase 13A2

1

20

Small-scale

0.494

High

1085372

SCAP
Sterol regulatory element-binding protein cleavage-activating protein

1

4

High-throughput

0.489

High

1197271

MBRL
Membralin

1

2

High-throughput

0.489

High

1248650

LCLT1
Lysocardiolipin acyltransferase 1

1

4

High-throughput

0.489

High

1366712

ALG3
Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

1

1

High-throughput

0.489

High

1406371

PTH2
Peptidyl-tRNA hydrolase 2, mitochondrial

1

1

High-throughput

0.489

High

1399543

MIA2
Melanoma inhibitory activity protein 2

1

5

High-throughput

0.407

High

49689

T120B
Transmembrane protein 120B

2

0

High-throughput

0.328

High

295867

FACE1
CAAX prenyl protease 1 homolog

2

0

High-throughput

0.328

High

299680

ATP5L
ATP synthase F(0) complex subunit g, mitochondrial

2

0

High-throughput

0.328

High

1273061

OTU6A
OTU domain-containing protein 6A

2

0

High-throughput

0.328

High

1406359

SG196
Protein O-mannose kinase

2

0

High-throughput

0.328

High

1406364

ST7
Suppressor of tumorigenicity 7 protein

2

0

High-throughput

0.328

High

1406369

CIA30
Complex I intermediate-associated protein 30, mitochondrial

2

0

High-throughput

0.328

High

654670

TCEA1
Transcription elongation factor A protein 1

1

0

High-throughput

0.279

Low

1406373

T184B
Transmembrane protein 184B

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025