Protein: PLPL2
Patatin-like phospholipase domain-containing protein 2 (EC 3.1.1.3) (Adipose triglyceride lipase) (Calcium-independent phospholipase A2-zeta) (iPLA2-zeta) (EC 3.1.1.4) (Desnutrin) (Pigment epithelium-derived factor receptor) (PEDF-R) (TTS2.2) (Transport-secretion protein 2) (TTS2)

Gene: PLPL2, PNPLA2
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q96AD5

Gene Ontology (top 5):
GO:0004465 - lipoprotein lipase activity
GO:0004623 - phospholipase A2 activity
GO:0004806 - triacylglycerol lipase activity
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

66451

ASB14
Ankyrin repeat and SOCS box protein 14

1

0

High-throughput

0.656

High

692477

G0S2
G0/G1 switch protein 2

3

1

Small-scale

0.656

High

1355974

ABHD5
1-acylglycerol-3-phosphate O-acyltransferase ABHD5

2

2

Small-scale

0.633

High

278930

PEX14
Peroxisomal membrane protein PEX14

2

1

High-throughput

0.628

High

488256

LOX5
Polyunsaturated fatty acid 5-lipoxygenase

2

0

High-throughput

0.602

High

1382805

TRXR2
Thioredoxin reductase 2, mitochondrial

2

0

High-throughput

0.602

High

1382799

FAF2
FAS-associated factor 2

2

0

Small-scale

0.593

High

1363811

GBF1
Golgi-specific brefeldin A-resistance guanine nucleotide exchange factor 1

1

2

Small-scale

0.573

High

1382801

CYH2
Cytohesin-2

1

2

Small-scale

0.552

High

1382809

BIG2
Brefeldin A-inhibited guanine nucleotide-exchange protein 2

1

2

Small-scale

0.552

High

363686

EGFR
Epidermal growth factor receptor

2

0

Small-scale

0.541

High

1106029

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

1

High-throughput

0.536

High

692113

MARK3
MAP/microtubule affinity-regulating kinase 3

1

0

High-throughput

0.518

High

1364759

PHYIP
Phytanoyl-CoA hydroxylase-interacting protein

1

0

High-throughput

0.518

High

261537

B4GT2
Beta-1,4-galactosyltransferase 2

1

0

High-throughput

0.513

High

296673

AL1L1
Cytosolic 10-formyltetrahydrofolate dehydrogenase

1

0

High-throughput

0.513

High

296812

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

366428

FA12
Coagulation factor XII

1

0

High-throughput

0.513

High

1006279

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.513

High

1144113

TEBP
Prostaglandin E synthase 3

1

0

High-throughput

0.513

High

1147990

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.513

High

1382804

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

0

High-throughput

0.513

High

1382807

GIMA2
GTPase IMAP family member 2

1

0

High-throughput

0.513

High

181920

SMAD9
Mothers against decapentaplegic homolog 9

1

1

High-throughput

0.508

High

1258793

UB2R2
Ubiquitin-conjugating enzyme E2 R2

1

0

High-throughput

0.486

High

253100

PLIN3
Perilipin-3

1

3

Small-scale

0.479

High

535382

BIP
Endoplasmic reticulum chaperone BiP

1

4

Small-scale

0.479

High

1028506

PLIN5
Perilipin-5

1

3

Small-scale

0.479

High

1340772

COP1
E3 ubiquitin-protein ligase COP1

1

1

Small-scale

0.479

High

1382802

PLIN2
Perilipin-2

1

3

Small-scale

0.479

High

1382798

CIDEC
Lipid transferase CIDEC

1

0

Small-scale

0.458

High

1382806

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.458

High

1382808

XPO7
Exportin-7

1

0

High-throughput

0.458

High

787830

PEDF
Pigment epithelium-derived factor

2

0

Small-scale

0.320

High

1101399

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

1325815

D2HDH
D-2-hydroxyglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

1382800

ZHX1R
Zinc fingers and homeoboxes protein 1, isoform 2

1

0

High-throughput

0.279

Low

1382803

TIM29
Mitochondrial import inner membrane translocase subunit Tim29

1

0

High-throughput

0.279

Low

1253643

PKHG7
Pleckstrin homology domain-containing family G member 7

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025