Protein: TF2H1
General transcription factor IIH subunit 1 (Basic transcription factor 2 62 kDa subunit) (BTF2 p62) (General transcription factor IIH polypeptide 1) (TFIIH basal transcription factor complex p62 subunit)

Gene: TF2H1, GTF2H1
Organism: Homo sapiens
Interactions: 90
UniProt ID: P32780

Gene Ontology (top 5):
GO:0000079 - regulation of cyclin-dependent protein serine/threonine kinase activity
GO:0000439 - transcription factor TFIIH core complex
GO:0003682 - chromatin binding
GO:0005654 - nucleoplasm
GO:0005675 - transcription factor TFIIH holo complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

622769

ERCC3
General transcription and DNA repair factor IIH helicase/translocase subunit XPB

15

2

Small-scale

0.980

High

744659

TF2H2
General transcription factor IIH subunit 2

10

2

Small-scale

0.972

High

413283

P53
Cellular tumor antigen p53

5

1

Small-scale

0.935

High

708876

T2EA
General transcription factor IIE subunit 1

5

2

Small-scale

0.933

High

611647

ERCC2
General transcription and DNA repair factor IIH helicase subunit XPD

5

2

Small-scale

0.928

High

744667

T2H2L
General transcription factor IIH subunit 2-like protein

4

2

Small-scale

0.895

High

744642

CDK7
Cyclin-dependent kinase 7

13

2

Small-scale

0.758

High

744660

TF2H3
General transcription factor IIH subunit 3

7

1

Small-scale

0.753

High

744657

KLF1
Krueppel-like factor 1

1

0

Small-scale

0.709

High

744652

XPC
DNA repair protein complementing XP-C cells

5

3

Small-scale

0.709

High

744644

MAT1
CDK-activating kinase assembly factor MAT1

4

2

Small-scale

0.694

High

744643

CCNH
Cyclin-H

5

1

Small-scale

0.691

High

704720

ERCC5
DNA excision repair protein ERCC-5

4

2

Small-scale

0.689

High

744670

TF2H5
General transcription factor IIH subunit 5

5

0

Small-scale

0.689

High

744678

TF2H4
General transcription factor IIH subunit 4

4

2

Small-scale

0.689

High

667186

RPB1
DNA-directed RNA polymerase II subunit RPB1

5

0

Small-scale

0.674

High

395581

ESR1
Estrogen receptor

3

4

Small-scale

0.650

High

744682

EAF1
ELL-associated factor 1

3

0

High-throughput

0.620

High

654620

TCEA1
Transcription elongation factor A protein 1

3

0

Small-scale

0.619

High

744651

E2F1
Transcription factor E2F1

2

0

Small-scale

0.603

High

744635

T2FA
General transcription factor IIF subunit 1

2

1

Small-scale

0.584

High

744663

BRD3
Bromodomain-containing protein 3

2

2

High-throughput

0.584

High

744661

FHL2
Four and a half LIM domains protein 2

2

0

High-throughput

0.580

High

371295

MYC
Myc proto-oncogene protein

2

0

High-throughput

0.559

High

588019

RFA2
Replication protein A 32 kDa subunit

2

0

Small-scale

0.559

High

694733

RFA1
Replication protein A 70 kDa DNA-binding subunit

2

0

Small-scale

0.559

High

744666

UVSSA
UV-stimulated scaffold protein A

2

0

Small-scale

0.559

High

621566

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

Small-scale

0.536

High

659374

CRCM
Colorectal mutant cancer protein

1

1

High-throughput

0.536

High

744655

SSRP1
FACT complex subunit SSRP1

1

2

High-throughput

0.536

High

704505

RXRB
Retinoic acid receptor RXR-beta

1

3

Small-scale

0.527

High

211221

HXC11
Homeobox protein Hox-C11

1

0

High-throughput

0.518

High

744647

BRPF1
Peregrin

1

0

High-throughput

0.518

High

744676

JDP2
Jun dimerization protein 2

1

0

High-throughput

0.518

High

132437

CDC7
Cell division cycle 7-related protein kinase

1

0

High-throughput

0.513

High

744637

CETN2
Centrin-2

1

0

High-throughput

0.513

High

744689

PRD11
PR domain-containing protein 11

1

0

High-throughput

0.513

High

744692

NUDC
Nuclear migration protein nudC

1

0

High-throughput

0.513

High

185467

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

1

High-throughput

0.501

High

507589

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

Small-scale

0.501

High

744638

HNF4A
Hepatocyte nuclear factor 4-alpha

1

3

Small-scale

0.501

High

744645

RD23A
UV excision repair protein RAD23 homolog A

1

2

Small-scale

0.501

High

280522

PR40A
Pre-mRNA-processing factor 40 homolog A

1

0

High-throughput

0.493

High

744664

TOM34
Mitochondrial import receptor subunit TOM34

1

1

High-throughput

0.489

High

519785

ANDR
Androgen receptor

1

4

Small-scale

0.479

High

654093

XPA
DNA repair protein complementing XP-A cells

1

1

Small-scale

0.479

High

674089

BRD2
Bromodomain-containing protein 2

1

1

High-throughput

0.479

High

744640

CLK2
Dual specificity protein kinase CLK2

1

3

High-throughput

0.479

High

744641

CLK3
Dual specificity protein kinase CLK3

1

3

High-throughput

0.479

High

744646

RD23B
UV excision repair protein RAD23 homolog B

1

3

Small-scale

0.479

High

744677

ESR2
Estrogen receptor beta

1

4

High-throughput

0.479

High

138636

IMA4
Importin subunit alpha-4

1

0

High-throughput

0.460

High

744662

TNIP1
TNFAIP3-interacting protein 1

1

0

High-throughput

0.460

High

464361

ERCC1
DNA excision repair protein ERCC-1

1

0

Small-scale

0.458

High

606315

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

744636

PRS7
26S proteasome regulatory subunit 7

1

0

Small-scale

0.458

High

744648

ANM2
Protein arginine N-methyltransferase 2

1

0

High-throughput

0.458

High

744653

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

744656

TP53B
TP53-binding protein 1

1

0

High-throughput

0.458

High

744658

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

0

High-throughput

0.458

High

744672

SLN11
Schlafen family member 11

1

0

High-throughput

0.458

High

744679

KAT6A
Histone acetyltransferase KAT6A

1

0

High-throughput

0.458

High

744680

XPF
DNA repair endonuclease XPF

1

0

Small-scale

0.458

High

744681

FUBP1
Far upstream element-binding protein 1

1

0

Small-scale

0.458

High

744684

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

Small-scale

0.458

High

744690

ANLN
Anillin

1

0

High-throughput

0.458

High

744691

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

744674

USBP1
Harmonin-binding protein USHBP1

1

1

High-throughput

0.439

High

130387

SPT5H
Transcription elongation factor SPT5

1

0

High-throughput

0.438

High

744639

CLK1
Dual specificity protein kinase CLK1

1

3

High-throughput

0.437

High

744671

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.426

High

744654

FGL1
Fibrinogen-like protein 1

3

0

High-throughput

0.347

High

744685

LZTS2
Leucine zipper putative tumor suppressor 2

2

0

High-throughput

0.328

High

744668

ATRAP
Type-1 angiotensin II receptor-associated protein

2

0

High-throughput

0.316

High

744688

TRXR2
Thioredoxin reductase 2, mitochondrial

1

0

Small-scale

0.299

High

744665

OBF1
POU domain class 2-associating factor 1

1

0

High-throughput

0.282

High

744675

ZSCA1
Zinc finger and SCAN domain-containing protein 1

1

0

High-throughput

0.282

High

744687

CCSE2
Serine-rich coiled-coil domain-containing protein 2

1

0

High-throughput

0.282

High

718370

CD6
T-cell differentiation antigen CD6

1

0

High-throughput

0.279

Low

720437

AMRP
Alpha-2-macroglobulin receptor-associated protein

1

0

High-throughput

0.279

Low

744649

PRPS1
Ribose-phosphate pyrophosphokinase 1

1

0

High-throughput

0.279

Low

744673

TTC9C
Tetratricopeptide repeat protein 9C

1

0

High-throughput

0.279

Low

561915

LAMP2
Lysosome-associated membrane glycoprotein 2

1

0

High-throughput

0.268

Low

744693

SHLB1
Endophilin-B1

1

0

High-throughput

0.268

Low

555615

ACTN1
Alpha-actinin-1

1

0

High-throughput

0.251

Low

744650

REEP5
Receptor expression-enhancing protein 5

1

0

High-throughput

0.251

Low

744686

TARA
TRIO and F-actin-binding protein

1

0

High-throughput

0.251

Low

744669

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

744694

RNF11
RING finger protein 11

1

0

Small-scale

0.249

Low

744683

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025