Protein: GSH1
Glutamate--cysteine ligase catalytic subunit (EC 6.3.2.2) (GCS heavy chain) (Gamma-ECS) (Gamma-glutamylcysteine synthetase)

Gene: GSH1, GCLC
Organism: Homo sapiens
Interactions: 21
UniProt ID: P48506

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004357 - glutamate-cysteine ligase activity
GO:0005524 - ATP binding
GO:0005739 - mitochondrion
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

819391

GSH0
Glutamate--cysteine ligase regulatory subunit

4

5

Small-scale

0.704

High

226816

PRKN
E3 ubiquitin-protein ligase parkin

2

1

High-throughput

0.584

High

819401

ZRAN1
Ubiquitin thioesterase ZRANB1

2

0

High-throughput

0.559

High

819393

CUL3
Cullin-3

1

1

High-throughput

0.479

High

819395

NF2L2
Nuclear factor erythroid 2-related factor 2

1

1

Small-scale

0.479

High

322323

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

0

High-throughput

0.458

High

401619

JUN
Transcription factor Jun

1

0

Small-scale

0.458

High

435008

SP1
Transcription factor Sp1

1

0

High-throughput

0.458

High

764339

FEN1
Flap endonuclease 1

1

0

High-throughput

0.458

High

819392

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.458

High

819394

CUL4A
Cullin-4A

1

1

High-throughput

0.437

High

819397

TYW3
tRNA wybutosine-synthesizing protein 3 homolog

2

0

High-throughput

0.328

High

134727

CCL22
C-C motif chemokine 22

1

0

High-throughput

0.282

High

819400

NMD3
60S ribosomal export protein NMD3

1

0

High-throughput

0.279

Low

819396

LARGN
Protein Largen

1

0

High-throughput

0.269

Low

552194

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

575329

EGR1
Early growth response protein 1

1

0

High-throughput

0.249

Low

650633

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

719935

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

819398

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

819399

PAXI1
PAX-interacting protein 1

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024