Protein: NELFE
Negative elongation factor E (NELF-E) (RNA-binding protein RD)

Gene: NELFE
Organism: Homo sapiens
Interactions: 193
UniProt ID: P18615

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0003729 - mRNA binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

615502

NCBP2
Nuclear cap-binding protein subunit 2

4

13

High-throughput

0.875

High

615532

NCBP1
Nuclear cap-binding protein subunit 1

3

1

High-throughput

0.839

High

615575

NELFB
Negative elongation factor B

13

1

Small-scale

0.762

High

615567

NELFD
Negative elongation factor C/D

10

1

Small-scale

0.758

High

615591

NELFA
Negative elongation factor A

9

1

Small-scale

0.756

High

615488

RPB2
DNA-directed RNA polymerase II subunit RPB2

2

0

High-throughput

0.748

High

615523

SRPK2
SRSF protein kinase 2

1

3

High-throughput

0.710

High

615581

SRPK1
SRSF protein kinase 1

1

2

High-throughput

0.710

High

615530

SRSF1
Serine/arginine-rich splicing factor 1

1

12

High-throughput

0.691

High

615494

SMBP2
DNA-binding protein SMUBP-2

3

3

High-throughput

0.667

High

615504

RPAB4
DNA-directed RNA polymerases I, II, and III subunit RPABC4

1

0

High-throughput

0.656

High

615512

1433G
14-3-3 protein gamma

3

6

High-throughput

0.656

High

615480

RPB1
DNA-directed RNA polymerase II subunit RPB1

3

1

Small-scale

0.640

High

172013

HNRDL
Heterogeneous nuclear ribonucleoprotein D-like

1

11

High-throughput

0.618

High

272794

PHF2
Lysine-specific demethylase PHF2

1

1

High-throughput

0.618

High

285802

SF3B1
Splicing factor 3B subunit 1

1

1

High-throughput

0.618

High

400249

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

1

High-throughput

0.618

High

472446

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

15

High-throughput

0.618

High

615472

NELFE
Negative elongation factor E

1

9

High-throughput

0.618

High

615473

NUCL
Nucleolin

1

6

High-throughput

0.618

High

615500

ROA3
Heterogeneous nuclear ribonucleoprotein A3

1

8

High-throughput

0.618

High

615503

HNRPF
Heterogeneous nuclear ribonucleoprotein F

1

7

High-throughput

0.618

High

615519

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

1

High-throughput

0.618

High

615538

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

10

High-throughput

0.618

High

615540

CHD4
Chromodomain-helicase-DNA-binding protein 4

1

2

High-throughput

0.618

High

615542

PDIA6
Protein disulfide-isomerase A6

1

1

High-throughput

0.618

High

615543

SF3B3
Splicing factor 3B subunit 3

1

1

High-throughput

0.618

High

615546

SRSF7
Serine/arginine-rich splicing factor 7

1

13

High-throughput

0.618

High

615576

RBP56
TATA-binding protein-associated factor 2N

1

4

High-throughput

0.618

High

615586

SRSF8
Serine/arginine-rich splicing factor 8

1

11

High-throughput

0.618

High

615602

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.618

High

615603

PUF60
Poly(U)-binding-splicing factor PUF60

1

5

High-throughput

0.618

High

615604

PTBP2
Polypyrimidine tract-binding protein 2

1

2

High-throughput

0.618

High

615605

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.618

High

130372

SPT5H
Transcription elongation factor SPT5

2

4

High-throughput

0.611

High

615481

1433T
14-3-3 protein theta

2

6

High-throughput

0.611

High

615490

1433B
14-3-3 protein beta/alpha

2

6

High-throughput

0.611

High

615513

1433E
14-3-3 protein epsilon

2

2

High-throughput

0.611

High

615521

1433Z
14-3-3 protein zeta/delta

2

5

High-throughput

0.611

High

615474

RPB3
DNA-directed RNA polymerase II subunit RPB3

2

0

Small-scale

0.585

High

615475

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

2

0

High-throughput

0.585

High

615607

RRP44
Exosome complex exonuclease RRP44

2

0

High-throughput

0.585

High

371118

MYC
Myc proto-oncogene protein

2

4

High-throughput

0.584

High

468050

HS90B
Heat shock protein HSP 90-beta

2

5

Small-scale

0.584

High

571867

TRI27
Zinc finger protein RFP

1

1

High-throughput

0.573

High

615553

MTUS2
Microtubule-associated tumor suppressor candidate 2

1

1

High-throughput

0.573

High

615487

PPIF
Peptidyl-prolyl cis-trans isomerase F, mitochondrial

1

1

High-throughput

0.553

High

595921

H12
Histone H1.2

1

1

High-throughput

0.536

High

615527

FABP5
Fatty acid-binding protein 5

1

1

High-throughput

0.536

High

615529

1433F
14-3-3 protein eta

1

6

High-throughput

0.536

High

615551

CCD57
Coiled-coil domain-containing protein 57

1

1

High-throughput

0.523

High

615544

VAMP3
Vesicle-associated membrane protein 3

1

0

High-throughput

0.518

High

615557

KANK2
KN motif and ankyrin repeat domain-containing protein 2

1

3

High-throughput

0.515

High

445120

S10A6
Protein S100-A6

1

0

High-throughput

0.513

High

615476

C5AR1
C5a anaphylatoxin chemotactic receptor 1

1

0

High-throughput

0.513

High

615478

LORI
Loricrin

1

0

High-throughput

0.513

High

615509

RPAB2
DNA-directed RNA polymerases I, II, and III subunit RPABC2

1

0

High-throughput

0.513

High

615559

INT5
Integrator complex subunit 5

1

0

High-throughput

0.513

High

615573

WDR48
WD repeat-containing protein 48

1

0

High-throughput

0.513

High

278232

NCOR1
Nuclear receptor corepressor 1

1

1

Small-scale

0.508

High

332385

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

1

0

Small-scale

0.480

High

128764

MEN1
Menin

1

2

High-throughput

0.479

High

131722

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

High-throughput

0.479

High

240704

PRKN
E3 ubiquitin-protein ligase parkin

1

4

High-throughput

0.479

High

243534

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

1

High-throughput

0.479

High

259414

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.479

High

318613

RHBT1
Rho-related BTB domain-containing protein 1

1

3

High-throughput

0.479

High

345351

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

2

High-throughput

0.479

High

385442

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

2

High-throughput

0.479

High

405239

OAT
Ornithine aminotransferase, mitochondrial

1

1

High-throughput

0.479

High

411323

NTRK1
High affinity nerve growth factor receptor

1

2

High-throughput

0.479

High

442997

PTMA
Prothymosin alpha [Cleaved into: Prothymosin alpha, N-terminally processed; Thymosin alpha-1]

1

1

High-throughput

0.479

High

445726

ENOA
Alpha-enolase

1

2

High-throughput

0.479

High

456599

ANXA2
Annexin A2

1

2

High-throughput

0.479

High

461127

HS90A
Heat shock protein HSP 90-alpha

1

5

High-throughput

0.479

High

479109

ENOG
Gamma-enolase

1

2

High-throughput

0.479

High

481082

HMGB1
High mobility group protein B1

1

6

High-throughput

0.479

High

486940

PARP1
Poly [ADP-ribose] polymerase 1

1

2

Small-scale

0.479

High

519728

ANDR
Androgen receptor

1

4

High-throughput

0.479

High

557844

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

562553

RINI
Ribonuclease inhibitor

1

1

High-throughput

0.479

High

568999

ENOB
Beta-enolase

1

2

High-throughput

0.479

High

574139

RSMB
Small nuclear ribonucleoprotein-associated proteins B and B'

1

3

High-throughput

0.479

High

587879

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

606191

CEBPB
CCAAT/enhancer-binding protein beta

1

3

High-throughput

0.479

High

615482

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

615483

RABP2
Cellular retinoic acid-binding protein 2

1

1

High-throughput

0.479

High

615484

PML
Protein PML

1

2

High-throughput

0.479

High

615485

PRDX6
Peroxiredoxin-6

1

1

High-throughput

0.479

High

615486

PRDX3
Thioredoxin-dependent peroxide reductase, mitochondrial

1

1

High-throughput

0.479

High

615492

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.479

High

615493

RL4
Large ribosomal subunit protein uL4

1

1

High-throughput

0.479

High

615495

FEN1
Flap endonuclease 1

1

1

High-throughput

0.479

High

615496

YAP1
Transcriptional coactivator YAP1

1

3

High-throughput

0.479

High

615497

SOX9
Transcription factor SOX-9

1

7

High-throughput

0.479

High

615501

IMA1
Importin subunit alpha-1

1

1

High-throughput

0.479

High

615507

CTBP2
C-terminal-binding protein 2

1

1

High-throughput

0.479

High

615514

SMD1
Small nuclear ribonucleoprotein Sm D1

1

3

High-throughput

0.479

High

615515

SMD3
Small nuclear ribonucleoprotein Sm D3

1

3

High-throughput

0.479

High

615518

RAN
GTP-binding nuclear protein Ran

1

2

High-throughput

0.479

High

615520

AP2B1
AP-2 complex subunit beta

1

4

High-throughput

0.479

High

615524

VIGLN
Vigilin

1

8

High-throughput

0.479

High

615525

CLH1
Clathrin heavy chain 1

1

1

High-throughput

0.479

High

615526

SET
Protein SET

1

1

High-throughput

0.479

High

615531

SSRP1
FACT complex subunit SSRP1

1

4

High-throughput

0.479

High

615533

EP300
Histone acetyltransferase p300

1

2

High-throughput

0.479

High

615534

TRAP1
Heat shock protein 75 kDa, mitochondrial

1

2

High-throughput

0.479

High

615537

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

2

High-throughput

0.479

High

615541

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

615548

H2A2C
Histone H2A type 2-C

1

1

High-throughput

0.479

High

615549

H2B2E
Histone H2B type 2-E

1

1

High-throughput

0.479

High

615552

BRDT
Bromodomain testis-specific protein

1

3

High-throughput

0.479

High

615554

CYTSB
Cytospin-B

1

1

High-throughput

0.479

High

615555

H2B2F
Histone H2B type 2-F

1

1

High-throughput

0.479

High

615562

H2AV
Histone H2A.V

1

2

High-throughput

0.479

High

615563

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

1

High-throughput

0.479

High

615566

H2A2B
Histone H2A type 2-B

1

1

High-throughput

0.479

High

615569

SMC5
Structural maintenance of chromosomes protein 5

1

3

High-throughput

0.479

High

615577

FUBP2
Far upstream element-binding protein 2

1

8

High-throughput

0.479

High

615579

RSRC1
Serine/Arginine-related protein 53

1

1

High-throughput

0.479

High

615592

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

615596

DDX21
Nucleolar RNA helicase 2

1

7

High-throughput

0.479

High

615599

BCLF1
Bcl-2-associated transcription factor 1

1

1

High-throughput

0.479

High

615600

H2AW
Core histone macro-H2A.2

1

2

High-throughput

0.479

High

615608

TR150
Thyroid hormone receptor-associated protein 3

1

1

High-throughput

0.479

High

615611

LC7L2
Putative RNA-binding protein Luc7-like 2

1

1

High-throughput

0.479

High

615574

CATIN
Splicing factor Cactin

1

0

Small-scale

0.460

High

192783

RPB4
DNA-directed RNA polymerase II subunit RPB4

1

0

High-throughput

0.458

High

207436

DHX15
ATP-dependent RNA helicase DHX15

1

0

High-throughput

0.458

High

221779

SNAI2
Zinc finger protein SNAI2

1

0

High-throughput

0.458

High

262015

NBN
Nibrin

1

0

High-throughput

0.458

High

439942

LCK
Tyrosine-protein kinase Lck

1

0

High-throughput

0.458

High

446627

NPM
Nucleophosmin

1

0

High-throughput

0.458

High

459449

PROF1
Profilin-1

1

0

High-throughput

0.458

High

534607

BIP
Endoplasmic reticulum chaperone BiP

1

0

High-throughput

0.458

High

550828

PCNA
Proliferating cell nuclear antigen

1

0

High-throughput

0.458

High

615479

COF1
Cofilin-1

1

0

High-throughput

0.458

High

615489

DNJA1
DnaJ homolog subfamily A member 1

1

0

High-throughput

0.458

High

615505

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

0

High-throughput

0.458

High

615506

P5CS
Delta-1-pyrroline-5-carboxylate synthase

1

0

High-throughput

0.458

High

615510

CH10
10 kDa heat shock protein, mitochondrial

1

0

High-throughput

0.458

High

615516

RPB7
DNA-directed RNA polymerase II subunit RPB7

1

0

High-throughput

0.458

High

615517

H4
Histone H4

1

0

High-throughput

0.458

High

615528

TF65
Transcription factor p65

1

0

High-throughput

0.458

High

615535

FOXC1
Forkhead box protein C1

1

0

High-throughput

0.458

High

615536

CBX3
Chromobox protein homolog 3

1

0

High-throughput

0.458

High

615539

NBR1
Next to BRCA1 gene 1 protein

1

0

High-throughput

0.458

High

615545

RBBP7
Histone-binding protein RBBP7

1

0

High-throughput

0.458

High

615547

DECR
2,4-dienoyl-CoA reductase [(3E)-enoyl-CoA-producing], mitochondrial

1

0

High-throughput

0.458

High

615561

H32
Histone H3.2

1

0

High-throughput

0.458

High

615564

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.458

High

615568

RPAP2
Putative RNA polymerase II subunit B1 CTD phosphatase RPAP2

1

0

High-throughput

0.458

High

615570

CMTR1
Cap-specific mRNA

1

0

High-throughput

0.458

High

615583

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

615584

BAG1
BAG family molecular chaperone regulator 1

1

0

High-throughput

0.458

High

615585

TRIR
Telomerase RNA component interacting RNase

1

0

High-throughput

0.458

High

615588

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

615589

NUCKS
Nuclear ubiquitous casein and cyclin-dependent kinase substrate 1

1

0

High-throughput

0.458

High

615593

CAPAM
mRNA

1

0

High-throughput

0.458

High

615595

WDR76
WD repeat-containing protein 76

1

0

High-throughput

0.458

High

615597

INT13
Integrator complex subunit 13

1

0

High-throughput

0.458

High

615598

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

615601

IBTK
Inhibitor of Bruton tyrosine kinase

1

0

High-throughput

0.458

High

615606

RUVB1
RuvB-like 1

1

0

High-throughput

0.458

High

615612

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.458

High

615508

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.437

High

615522

ACTC
Actin, alpha cardiac muscle 1

1

3

High-throughput

0.437

High

615558

A16L1
Autophagy-related protein 16-1

1

1

High-throughput

0.437

High

615560

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

615582

ACON
Aconitate hydratase, mitochondrial

1

1

High-throughput

0.437

High

615587

CNTP4
Contactin-associated protein-like 4

1

1

High-throughput

0.437

High

615609

ACOT9
Acyl-coenzyme A thioesterase 9, mitochondrial

1

1

High-throughput

0.437

High

615550

KNOP1
Lysine-rich nucleolar protein 1

1

0

High-throughput

0.426

High

615580

S45A3
Solute carrier family 45 member 3

1

0

High-throughput

0.426

High

615498

CEBPA
CCAAT/enhancer-binding protein alpha

1

3

High-throughput

0.408

High

116549

H7C5Q0
Arginine and serine rich coiled-coil 1

1

1

High-throughput

0.407

High

615572

TRI58
E3 ubiquitin-protein ligase TRIM58

1

1

High-throughput

0.407

High

615477

HEMH
Ferrochelatase, mitochondrial

2

0

High-throughput

0.328

High

615491

TRY3
Trypsin-3

1

0

High-throughput

0.279

Low

615499

CP2J2
Cytochrome P450 2J2

1

0

High-throughput

0.279

Low

615556

KPLCE
Protein KPLCE

1

0

High-throughput

0.279

Low

615565

XYLT1
Xylosyltransferase 1

1

0

High-throughput

0.279

Low

125932

SMAP
Small acidic protein

1

0

High-throughput

0.249

Low

447668

TPM3
Tropomyosin alpha-3 chain

1

0

High-throughput

0.249

Low

485838

COX6C
Cytochrome c oxidase subunit 6C

1

0

High-throughput

0.249

Low

532207

ESTD
S-formylglutathione hydrolase

1

0

High-throughput

0.249

Low

615511

LYSC
Lysozyme C

1

0

High-throughput

0.249

Low

615571

TTC29
Tetratricopeptide repeat protein 29

1

0

High-throughput

0.249

Low

615578

TM141
Transmembrane protein 141

1

0

High-throughput

0.249

Low

615590

IPYR2
Inorganic pyrophosphatase 2, mitochondrial

1

0

High-throughput

0.249

Low

615594

ACSS3
Acyl-CoA synthetase short-chain family member 3, mitochondrial

1

0

High-throughput

0.249

Low

615610

STA10
START domain-containing protein 10

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025