Protein: MRD1
Multiple RNA-binding domain-containing protein 1

Gene: MRD1
Organism: Saccharomyces cerevisiae S288C
Interactions: 119
UniProt ID: Q06106

Gene Ontology (top 5):
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000472 - endonucleolytic cleavage to generate mature 5'-end of SSU-rRNA from (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0000480 - endonucleolytic cleavage in 5'-ETS of tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0003729 - mRNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

407328

RS3
Small ribosomal subunit protein uS3

2

3

High-throughput

0.789

High

985907

NOP12
Nucleolar protein 12

1

17

Small-scale

0.691

High

811353

NOP9
Nucleolar protein 9

4

2

Small-scale

0.683

High

634773

KRR1
KRR1 small subunit processome component

3

4

Small-scale

0.656

High

748705

ENP1
Essential nuclear protein 1

3

2

High-throughput

0.656

High

792583

UTP10
U3 small nucleolar RNA-associated protein 10

3

2

Small-scale

0.656

High

613755

RS3A2
Small ribosomal subunit protein eS1B

2

5

Small-scale

0.628

High

756788

UTP9
U3 small nucleolar RNA-associated protein 9

2

1

Small-scale

0.628

High

860742

UTP22
U3 small nucleolar RNA-associated protein 22

2

1

Small-scale

0.628

High

767420

UTP7
U3 small nucleolar RNA-associated protein 7

2

3

High-throughput

0.621

High

604619

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

3

High-throughput

0.618

High

648434

NSR1
Nuclear localization sequence-binding protein

1

16

High-throughput

0.618

High

985910

NCBP2
Nuclear cap-binding protein subunit 2

1

18

High-throughput

0.618

High

480324

RS6A
Small ribosomal subunit protein eS6A

2

4

Small-scale

0.611

High

635646

PWP2
Periodic tryptophan protein 2

2

5

Small-scale

0.611

High

700629

RSSA1
Small ribosomal subunit protein uS2A

2

3

High-throughput

0.611

High

985810

UTP21
U3 small nucleolar RNA-associated protein 21

2

6

Small-scale

0.611

High

985911

BMS1
Ribosome biogenesis protein BMS1

2

3

Small-scale

0.611

High

985918

NOP56
Nucleolar protein 56

2

5

Small-scale

0.611

High

366912

HSP82
ATP-dependent molecular chaperone HSP82

2

7

High-throughput

0.608

High

499082

RL4A
Large ribosomal subunit protein uL4A

2

3

Small-scale

0.601

High

512775

SSB1
Ribosome-associated molecular chaperone SSB1

2

10

High-throughput

0.601

High

970468

UTP6
U3 small nucleolar RNA-associated protein 6

2

0

Small-scale

0.585

High

985904

UTP4
U3 small nucleolar RNA-associated protein 4

2

6

Small-scale

0.571

High

383357

RL25
Large ribosomal subunit protein uL23

1

4

High-throughput

0.553

High

409862

NOT2
General negative regulator of transcription subunit 2

1

3

High-throughput

0.536

High

479821

RS4A
Small ribosomal subunit protein eS4A

1

1

Small-scale

0.536

High

535120

RL3
Large ribosomal subunit protein uL3

1

2

Small-scale

0.536

High

549500

FBRL
rRNA 2'-O-methyltransferase fibrillarin

1

3

Small-scale

0.536

High

707139

DCA13
Protein SOF1

1

2

Small-scale

0.536

High

730731

DHR2
Probable ATP-dependent RNA helicase DHR2

1

4

Small-scale

0.536

High

799857

ROK1
ATP-dependent RNA helicase ROK1

1

6

Small-scale

0.536

High

811559

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

1

Small-scale

0.536

High

859432

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

4

Small-scale

0.536

High

973673

UTP17
NET1-associated nuclear protein 1

1

4

Small-scale

0.536

High

976858

HAS1
ATP-dependent RNA helicase HAS1

1

10

Small-scale

0.536

High

979239

UTP15
U3 small nucleolar RNA-associated protein 15

1

3

Small-scale

0.536

High

982873

RRP5
rRNA biogenesis protein RRP5

1

6

Small-scale

0.536

High

985416

UTP13
U3 small nucleolar RNA-associated protein 13

1

9

Small-scale

0.536

High

985914

MAK21
Ribosome biogenesis protein MAK21

1

6

Small-scale

0.536

High

985915

UTP12
U3 small nucleolar RNA-associated protein 12

1

9

Small-scale

0.536

High

861028

UTP8
U3 small nucleolar RNA-associated protein 8

1

0

Small-scale

0.513

High

985902

PIN3
[PSI+] inducibility protein 3

1

4

High-throughput

0.508

High

743684

HMT1
Protein arginine N-methyltransferase 1

1

7

Small-scale

0.501

High

807619

RS10B
Small ribosomal subunit protein eS10B

1

4

High-throughput

0.489

High

141530

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

408131

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

408467

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

1

6

High-throughput

0.479

High

413714

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

480888

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

482465

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

482939

RL35A
Large ribosomal subunit protein uL29A

1

3

High-throughput

0.479

High

524451

CAF20
Cap-associated protein CAF20

1

2

High-throughput

0.479

High

544436

HSC82
ATP-dependent molecular chaperone HSC82

1

7

High-throughput

0.479

High

558261

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

2

High-throughput

0.479

High

628482

SIS1
Protein SIS1

1

4

High-throughput

0.479

High

632096

RS2
Small ribosomal subunit protein uS5

1

3

High-throughput

0.479

High

645136

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

645657

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

663353

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

688428

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

1

High-throughput

0.479

High

691425

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

4

High-throughput

0.479

High

706495

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

730120

RS27A
Small ribosomal subunit protein eS27A

1

2

High-throughput

0.479

High

743002

GBLP
Small ribosomal subunit protein RACK1

1

6

High-throughput

0.479

High

752674

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

773999

MLP2
Protein MLP2

1

8

High-throughput

0.479

High

820179

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

865618

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

9

High-throughput

0.479

High

866479

APJ1
J domain-containing protein APJ1

1

2

High-throughput

0.479

High

866616

IMP4
U3 small nucleolar ribonucleoprotein protein IMP4

1

1

High-throughput

0.479

High

967766

RS15
Small ribosomal subunit protein uS19

1

3

High-throughput

0.479

High

972634

XRN2
5'-3' exoribonuclease 2

1

5

High-throughput

0.479

High

979715

UTP14
U3 small nucleolar RNA-associated protein 14

1

1

High-throughput

0.479

High

984211

HRQ1
ATP-dependent helicase HRQ1

1

10

Small-scale

0.479

High

985901

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.479

High

985903

NOC4
Nucleolar complex protein 4

1

6

High-throughput

0.479

High

985908

SGO1
Shugoshin

1

2

High-throughput

0.479

High

985912

TMA46
Translation machinery-associated protein 46

1

1

High-throughput

0.479

High

985913

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

1

High-throughput

0.479

High

985919

NOP58
Nucleolar protein 58

1

5

High-throughput

0.479

High

985920

EFG1P
rRNA-processing protein EFG1

1

1

High-throughput

0.479

High

985921

NOP14
Nucleolar complex protein 14

1

1

Small-scale

0.479

High

630260

RRP43
Exosome complex component RRP43

1

0

High-throughput

0.458

High

630540

RRP7
Ribosomal RNA-processing protein 7

1

0

High-throughput

0.458

High

774152

TM108
Protein TMA108

1

0

High-throughput

0.458

High

861623

YG5X
Putative methyltransferase YGR283C

1

0

High-throughput

0.458

High

979409

BUD22
Bud site selection protein 22

1

0

High-throughput

0.458

High

985905

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

985906

CMS1
Protein CMS1

1

0

High-throughput

0.458

High

985916

SMT3
Ubiquitin-like protein SMT3

1

0

High-throughput

0.458

High

368415

EF1A
Elongation factor 1-alpha

1

9

High-throughput

0.445

High

399638

RLA0
Large ribosomal subunit protein uL10

1

2

High-throughput

0.445

High

404707

RL7A
Large ribosomal subunit protein uL30A

1

6

High-throughput

0.445

High

492470

HSP71
Heat shock protein SSA1

1

8

High-throughput

0.445

High

494987

HSP72
Heat shock protein SSA2

1

8

High-throughput

0.445

High

641068

RL5
Large ribosomal subunit protein uL18

1

3

High-throughput

0.445

High

680999

HS104
Heat shock protein 104

1

4

High-throughput

0.445

High

695549

HSP7F
Heat shock protein homolog SSE1

1

10

High-throughput

0.445

High

754716

SSZ1
Ribosome-associated complex subunit SSZ1

1

6

High-throughput

0.445

High

866157

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

1

High-throughput

0.445

High

985917

UTP23
rRNA-processing protein UTP23

1

1

High-throughput

0.445

High

358263

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.437

High

405837

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.437

High

426157

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.437

High

471262

RS22A
Small ribosomal subunit protein uS8A

1

2

High-throughput

0.437

High

472398

RL31A
Large ribosomal subunit protein eL31A

1

4

High-throughput

0.437

High

481826

RS16B
Small ribosomal subunit protein uS9B

1

4

High-throughput

0.437

High

762571

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

959875

NUM1
Nuclear migration protein NUM1

1

7

High-throughput

0.437

High

985909

RS10A
Small ribosomal subunit protein eS10A

1

4

High-throughput

0.437

High

424716

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

454465

TBA1
Tubulin alpha-1 chain

1

0

High-throughput

0.426

High

785219

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

667281

RL8B
Large ribosomal subunit protein eL8B

1

4

High-throughput

0.407

High

707935

GCN1
eIF-2-alpha kinase activator GCN1

1

6

High-throughput

0.407

High

748061

GDT1
Divalent cation/proton antiporter GDT1

1

0

High-throughput

0.269

Low

478991

RL20B
Large ribosomal subunit protein eL20B

1

0

High-throughput

0.249

Low

760957

TCPD
T-complex protein 1 subunit delta

1

0

High-throughput

0.232

Low


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Last updated: 15 Jul 2024