Protein: NTH
Endonuclease III-like protein 1 (hNTH1) (EC 3.2.2.-) (EC 4.2.99.18) (Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase) (DNA glycosylase/AP lyase)

Gene: NTH, NTHL1
Organism: Homo sapiens
Interactions: 44
UniProt ID: P78549

Gene Ontology (top 5):
GO:0000703 - oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity
GO:0003684 - damaged DNA binding
GO:0003690 - double-stranded DNA binding
GO:0003906 - DNA-(apurinic or apyrimidinic site) endonuclease activity
GO:0004519 - endonuclease activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1008591

MINY3
Ubiquitin carboxyl-terminal hydrolase MINDY-3

2

0

High-throughput

0.602

High

704735

ERCC5
DNA excision repair protein ERCC-5

2

0

Small-scale

0.577

High

767949

RFA3
Replication protein A 14 kDa subunit

2

0

High-throughput

0.559

High

395889

ESR1
Estrogen receptor

2

0

High-throughput

0.547

High

1008581

NUMA1
Nuclear mitotic apparatus protein 1

1

2

High-throughput

0.536

High

1008586

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

1

High-throughput

0.536

High

156553

C56D2
Transmembrane reductase CYB561D2

1

0

High-throughput

0.513

High

693680

RL10
Large ribosomal subunit protein uL16

1

0

High-throughput

0.513

High

1008576

HMGN5
High mobility group nucleosome-binding domain-containing protein 5

1

0

High-throughput

0.513

High

1008580

EMX2
Homeobox protein EMX2

1

0

High-throughput

0.513

High

1008584

H2B2E
Histone H2B type 2-E

1

0

High-throughput

0.513

High

550980

PCNA
Proliferating cell nuclear antigen

1

2

Small-scale

0.501

High

1006330

SRPK2
SRSF protein kinase 2

1

1

High-throughput

0.501

High

156255

G3PT
Glyceraldehyde-3-phosphate dehydrogenase, testis-specific

1

0

High-throughput

0.493

High

785818

8ODP
Oxidized purine nucleoside triphosphate hydrolase

1

0

High-throughput

0.493

High

961253

RL27
Large ribosomal subunit protein eL27

1

0

High-throughput

0.493

High

1008579

PO4F1
POU domain, class 4, transcription factor 1

1

0

High-throughput

0.493

High

1008592

MRM3
rRNA methyltransferase 3, mitochondrial

1

0

High-throughput

0.493

High

413608

P53
Cellular tumor antigen p53

1

0

Small-scale

0.480

High

588454

RFA2
Replication protein A 32 kDa subunit

1

1

High-throughput

0.479

High

695198

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.479

High

1008582

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1008589

MMS19
MMS19 nucleotide excision repair protein homolog

1

2

High-throughput

0.479

High

556913

MYH7
Myosin-7

1

1

High-throughput

0.470

High

363125

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

400646

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

704937

RBL1
Retinoblastoma-like protein 1

1

0

High-throughput

0.458

High

979490

H4
Histone H4

1

0

High-throughput

0.458

High

1008578

H33
Histone H3.3

1

0

High-throughput

0.458

High

1008583

BRD3
Bromodomain-containing protein 3

1

0

High-throughput

0.458

High

1008594

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1008595

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

0

High-throughput

0.458

High

1008593

HECW2
E3 ubiquitin-protein ligase HECW2

1

3

High-throughput

0.437

High

1008596

MYH4
Myosin-4

1

1

High-throughput

0.437

High

351216

MOT3
Monocarboxylate transporter 3

1

0

High-throughput

0.279

Low

608246

EGLN
Endoglin

1

0

High-throughput

0.279

Low

657223

KALM
Anosmin-1

1

0

High-throughput

0.279

Low

876312

PTSS1
Phosphatidylserine synthase 1

1

0

High-throughput

0.279

Low

1008577

HTRA4
Serine protease HTRA4

1

0

High-throughput

0.279

Low

1008585

RINL
Ras and Rab interactor-like protein

1

0

High-throughput

0.279

Low

1008587

IL31R
Interleukin-31 receptor subunit alpha

1

0

High-throughput

0.279

Low

1008597

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

1008588

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

1008590

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025