Protein: HMGN5
High mobility group nucleosome-binding domain-containing protein 5 (Nucleosome-binding protein 1)

Gene: HMGN5
Organism: Homo sapiens
Interactions: 147
UniProt ID: P82970

Gene Ontology (top 5):
GO:0000785 - chromatin
GO:0003682 - chromatin binding
GO:0003723 - RNA binding
GO:0005634 - nucleus
GO:0005654 - nucleoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

979492

H4
Histone H4

3

2

High-throughput

0.656

High

1013095

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

2

1

High-throughput

0.628

High

1013106

CBX8
Chromobox protein homolog 8

2

7

High-throughput

0.628

High

708947

T2EB
Transcription initiation factor IIE subunit beta

2

0

High-throughput

0.602

High

1013086

SNR27
U4/U6.U5 small nuclear ribonucleoprotein 27 kDa protein

2

0

High-throughput

0.602

High

857410

NOTC1
Neurogenic locus notch homolog protein 1

1

1

High-throughput

0.541

High

127931

PSD11
26S proteasome non-ATPase regulatory subunit 11

1

1

High-throughput

0.536

High

128203

PSD12
26S proteasome non-ATPase regulatory subunit 12

1

1

High-throughput

0.536

High

169511

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.536

High

243598

SMCA5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 5

1

3

High-throughput

0.536

High

285212

EED
Polycomb protein EED

1

3

High-throughput

0.536

High

320322

PHF14
PHD finger protein 14

1

3

High-throughput

0.536

High

331991

KAT7
Histone acetyltransferase KAT7

1

1

High-throughput

0.536

High

342155

BRD1
Bromodomain-containing protein 1

1

4

High-throughput

0.536

High

355494

NSD2
Histone-lysine N-methyltransferase NSD2

1

3

High-throughput

0.536

High

487190

PARP1
Poly [ADP-ribose] polymerase 1

1

4

High-throughput

0.536

High

542457

TOP2A
DNA topoisomerase 2-alpha

1

1

High-throughput

0.536

High

610619

TCPA
T-complex protein 1 subunit alpha

1

1

High-throughput

0.536

High

697494

PYR1
Multifunctional protein CAD

1

1

High-throughput

0.536

High

703291

SMCA1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily A member 1

1

3

High-throughput

0.536

High

755686

MCM4
DNA replication licensing factor MCM4

1

3

High-throughput

0.536

High

756151

MCM7
DNA replication licensing factor MCM7

1

3

High-throughput

0.536

High

765384

BMI1
Polycomb complex protein BMI-1

1

2

High-throughput

0.536

High

798986

BRCA1
Breast cancer type 1 susceptibility protein

1

2

High-throughput

0.536

High

887969

MCM2
DNA replication licensing factor MCM2

1

3

High-throughput

0.536

High

899346

TCPD
T-complex protein 1 subunit delta

1

1

High-throughput

0.536

High

936645

BRPF1
Peregrin

1

4

High-throughput

0.536

High

1013041

CBX1
Chromobox protein homolog 1

1

6

High-throughput

0.536

High

1013045

TOP2B
DNA topoisomerase 2-beta

1

1

High-throughput

0.536

High

1013046

KMT2A
Histone-lysine N-methyltransferase 2A

1

3

High-throughput

0.536

High

1013047

RBBP4
Histone-binding protein RBBP4

1

4

High-throughput

0.536

High

1013049

CBX3
Chromobox protein homolog 3

1

6

High-throughput

0.536

High

1013050

MTA1
Metastasis-associated protein MTA1

1

1

High-throughput

0.536

High

1013051

CUL4A
Cullin-4A

1

1

High-throughput

0.536

High

1013052

MCM6
DNA replication licensing factor MCM6

1

3

High-throughput

0.536

High

1013053

TRIPC
E3 ubiquitin-protein ligase TRIP12

1

1

High-throughput

0.536

High

1013054

MDC1
Mediator of DNA damage checkpoint protein 1

1

5

High-throughput

0.536

High

1013055

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.536

High

1013056

CBX2
Chromobox protein homolog 2

1

7

High-throughput

0.536

High

1013058

NUMA1
Nuclear mitotic apparatus protein 1

1

1

High-throughput

0.536

High

1013062

RBBP5
Retinoblastoma-binding protein 5

1

4

High-throughput

0.536

High

1013064

EZH2
Histone-lysine N-methyltransferase EZH2

1

3

High-throughput

0.536

High

1013071

NIPBL
Nipped-B-like protein

1

2

High-throughput

0.536

High

1013074

ATAD2
ATPase family AAA domain-containing protein 2

1

3

High-throughput

0.536

High

1013075

SRCAP
Helicase SRCAP

1

3

High-throughput

0.536

High

1013076

H32
Histone H3.2

1

2

High-throughput

0.536

High

1013077

POGZ
Pogo transposable element with ZNF domain

1

1

High-throughput

0.536

High

1013079

RAI1
Retinoic acid-induced protein 1

1

4

High-throughput

0.536

High

1013084

Z280C
Zinc finger protein 280C

1

1

High-throughput

0.536

High

1013087

PHIP
PH-interacting protein

1

4

High-throughput

0.536

High

1013090

KAT6A
Histone acetyltransferase KAT6A

1

5

High-throughput

0.536

High

1013091

RAD50
DNA repair protein RAD50

1

2

High-throughput

0.536

High

1013093

CHAP1
Chromosome alignment-maintaining phosphoprotein 1

1

1

High-throughput

0.536

High

1013098

PWP2A
PWWP domain-containing protein 2A

1

2

High-throughput

0.536

High

1013099

MPP8
M-phase phosphoprotein 8

1

2

High-throughput

0.536

High

1013100

SCAFB
Protein SCAF11

1

1

High-throughput

0.536

High

1013101

BARD1
BRCA1-associated RING domain protein 1

1

3

High-throughput

0.536

High

1013103

SCAPE
S phase cyclin A-associated protein in the endoplasmic reticulum

1

2

High-throughput

0.536

High

1013105

WDR76
WD repeat-containing protein 76

1

5

High-throughput

0.536

High

1013107

BRD7
Bromodomain-containing protein 7

1

6

High-throughput

0.536

High

1013108

INCE
Inner centromere protein

1

2

High-throughput

0.536

High

1013110

BAZ1A
Bromodomain adjacent to zinc finger domain protein 1A

1

5

High-throughput

0.536

High

1013111

UBQL4
Ubiquilin-4

1

1

High-throughput

0.536

High

1013115

H2AW
Core histone macro-H2A.2

1

2

High-throughput

0.536

High

1013117

PARP2
Poly [ADP-ribose] polymerase 2

1

2

High-throughput

0.536

High

1013118

BAZ1B
Tyrosine-protein kinase BAZ1B

1

3

High-throughput

0.536

High

1013119

RCOR1
REST corepressor 1

1

1

High-throughput

0.536

High

1013120

ATD2B
ATPase family AAA domain-containing protein 2B

1

3

High-throughput

0.536

High

1013043

FGD1
FYVE, RhoGEF and PH domain-containing protein 1

2

2

High-throughput

0.521

High

1013082

ARHGJ
Rho guanine nucleotide exchange factor 19

2

2

High-throughput

0.521

High

65735

SMHD1
Structural maintenance of chromosomes flexible hinge domain-containing protein 1

1

0

High-throughput

0.513

High

216412

SUV91
Histone-lysine N-methyltransferase SUV39H1

1

0

High-throughput

0.513

High

238491

RAD21
Double-strand-break repair protein rad21 homolog

1

0

High-throughput

0.513

High

246532

KDM1A
Lysine-specific histone demethylase 1A

1

0

High-throughput

0.513

High

271500

ATG13
Autophagy-related protein 13

1

0

High-throughput

0.513

High

285633

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.513

High

344916

WIZ
Protein Wiz

1

0

High-throughput

0.513

High

359633

DHE3
Glutamate dehydrogenase 1, mitochondrial

1

0

High-throughput

0.513

High

416007

CP1A1
Cytochrome P450 1A1

1

0

High-throughput

0.513

High

446520

DPOLB
DNA polymerase beta

1

0

High-throughput

0.513

High

455746

H10
Histone H1.0

1

0

High-throughput

0.513

High

559307

XRCC5
X-ray repair cross-complementing protein 5

1

0

High-throughput

0.513

High

607573

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

0

High-throughput

0.513

High

611831

RL35A
Large ribosomal subunit protein eL33

1

0

High-throughput

0.513

High

616299

RCC1
Regulator of chromosome condensation

1

0

High-throughput

0.513

High

617682

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.513

High

621858

RPAB1
DNA-directed RNA polymerases I, II, and III subunit RPABC1

1

0

High-throughput

0.513

High

667269

RPB1
DNA-directed RNA polymerase II subunit RPB1

1

0

High-throughput

0.513

High

722939

RPB2
DNA-directed RNA polymerase II subunit RPB2

1

0

High-throughput

0.513

High

814509

FEN1
Flap endonuclease 1

1

0

High-throughput

0.513

High

881149

FAS
Fatty acid synthase

1

0

High-throughput

0.513

High

892543

DNLI3
DNA ligase 3

1

0

High-throughput

0.513

High

892841

MRE11
Double-strand break repair protein MRE11

1

0

High-throughput

0.513

High

906500

PSMD7
26S proteasome non-ATPase regulatory subunit 7

1

0

High-throughput

0.513

High

920783

ACLY
ATP-citrate synthase

1

0

High-throughput

0.513

High

930847

HSP72
Heat shock-related 70 kDa protein 2

1

0

High-throughput

0.513

High

975377

PRS10
26S proteasome regulatory subunit 10B

1

0

High-throughput

0.513

High

986984

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.513

High

1008576

NTH
Endonuclease III-like protein 1

1

0

High-throughput

0.513

High

1013044

XPC
DNA repair protein complementing XP-C cells

1

0

High-throughput

0.513

High

1013048

PRDM2
PR domain zinc finger protein 2

1

0

High-throughput

0.513

High

1013057

KIF22
Kinesin-like protein KIF22

1

0

High-throughput

0.513

High

1013059

CND2
Condensin complex subunit 2

1

0

High-throughput

0.513

High

1013060

SUZ12
Polycomb protein SUZ12

1

0

High-throughput

0.513

High

1013065

DDB1
DNA damage-binding protein 1

1

0

High-throughput

0.513

High

1013066

GLYR1
Cytokine-like nuclear factor N-PAC

1

0

High-throughput

0.513

High

1013067

HP1B3
Heterochromatin protein 1-binding protein 3

1

0

High-throughput

0.513

High

1013070

INT3
Integrator complex subunit 3

1

0

High-throughput

0.513

High

1013072

NEPRO
Nucleolus and neural progenitor protein

1

0

High-throughput

0.513

High

1013073

RSBNL
Lysine-specific demethylase RSBN1L

1

0

High-throughput

0.513

High

1013081

NAA40
N-alpha-acetyltransferase 40

1

0

High-throughput

0.513

High

1013085

PPHLN
Periphilin-1

1

0

High-throughput

0.513

High

1013088

ING5
Inhibitor of growth protein 5

1

0

High-throughput

0.513

High

1013089

H1X
Histone H1.10

1

0

High-throughput

0.513

High

1013092

SMCE1
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily E member 1

1

0

High-throughput

0.513

High

1013094

LCOR
Ligand-dependent corepressor

1

0

High-throughput

0.513

High

1013097

ZN512
Zinc finger protein 512

1

0

High-throughput

0.513

High

1013104

WNK3
Serine/threonine-protein kinase WNK3

1

0

High-throughput

0.513

High

1013109

CHRC1
Chromatin accessibility complex protein 1

1

0

High-throughput

0.513

High

1013112

ABC3C
DNA dC->dU-editing enzyme APOBEC-3C

1

0

High-throughput

0.513

High

1013113

MBIP1
MAP3K12-binding inhibitory protein 1

1

0

High-throughput

0.513

High

1013116

KDM5B
Lysine-specific demethylase 5B

1

0

High-throughput

0.513

High

1013122

KLH20
Kelch-like protein 20

1

0

High-throughput

0.513

High

1013124

MTF2
Metal-response element-binding transcription factor 2

1

0

High-throughput

0.513

High

74462

HNRC2
Heterogeneous nuclear ribonucleoprotein C-like 2

1

0

High-throughput

0.493

High

898997

TCPQ
T-complex protein 1 subunit theta

1

4

High-throughput

0.489

High

1013102

TCPH
T-complex protein 1 subunit eta

1

2

High-throughput

0.489

High

256832

H2B1K
Histone H2B type 1-K

1

2

High-throughput

0.479

High

449706

H2B1J
Histone H2B type 1-J

1

2

High-throughput

0.479

High

610296

PRS6A
26S proteasome regulatory subunit 6A

1

2

High-throughput

0.479

High

878962

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

3

High-throughput

0.479

High

998206

H31
Histone H3.1

1

2

High-throughput

0.479

High

1013042

H33
Histone H3.3

1

2

High-throughput

0.479

High

1013061

TNIP1
TNFAIP3-interacting protein 1

1

2

High-throughput

0.479

High

1013080

FGD2
FYVE, RhoGEF and PH domain-containing protein 2

1

1

High-throughput

0.479

High

1013123

RL36
Large ribosomal subunit protein eL36

1

0

High-throughput

0.458

High

1013063

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.445

High

1013078

EMSY
BRCA2-interacting transcriptional repressor EMSY

1

2

High-throughput

0.445

High

1013083

BAP18
BPTF-associated chromatin complex component 1

1

0

High-throughput

0.426

High

97076

E9PMD8
Proteasome 26S subunit, ATPase 3

1

3

High-throughput

0.407

High

1013068

ZMYM4
Zinc finger MYM-type protein 4

1

0

High-throughput

0.279

Low

1013069

F91A1
Protein FAM91A1

1

0

High-throughput

0.279

Low

1013114

FBX28
F-box only protein 28

1

0

High-throughput

0.279

Low

1013125

SERC
Phosphoserine aminotransferase

1

0

High-throughput

0.279

Low

1013121

DLGP4
Disks large-associated protein 4

1

0

High-throughput

0.269

Low

1013096

SNX27
Sorting nexin-27

1

0

High-throughput

0.249

Low

229184

B3GT2
Beta-1,3-galactosyltransferase 2

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025