Protein: GNAS1
Guanine nucleotide-binding protein G(s) subunit alpha isoforms XLas (EC 3.6.5.-) (Adenylate cyclase-stimulating G alpha protein) (Extra large alphas protein) (XLalphas)

Gene: GNAS1, GNAS
Organism: Homo sapiens
Interactions: 25
UniProt ID: Q5JWF2

Gene Ontology (top 5):
GO:0003924 - GTPase activity
GO:0003925 - G protein activity
GO:0005159 - insulin-like growth factor receptor binding
GO:0005525 - GTP binding
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1207497

AGRF1
Adhesion G-protein coupled receptor F1

1

9

Small-scale

0.618

High

882507

ARRB1
Beta-arrestin-1

1

1

Small-scale

0.589

High

626254

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

5

High-throughput

0.575

High

1030653

ANK2
Ankyrin-2

1

4

High-throughput

0.575

High

911932

JAK3
Tyrosine-protein kinase JAK3

2

8

High-throughput

0.552

High

328679

VAMP5
Vesicle-associated membrane protein 5

1

3

High-throughput

0.445

High

399979

CATA
Catalase

1

1

High-throughput

0.445

High

529931

TAU
Microtubule-associated protein tau

1

16

High-throughput

0.445

High

563873

CFTR
Cystic fibrosis transmembrane conductance regulator

1

5

High-throughput

0.445

High

637555

FLNA
Filamin-A

1

2

High-throughput

0.445

High

948854

CD81
CD81 antigen

1

7

Small-scale

0.445

High

1097682

STK3
Serine/threonine-protein kinase 3

1

5

High-throughput

0.445

High

1207496

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

4

High-throughput

0.445

High

1207499

PIM3
Serine/threonine-protein kinase pim-3

1

6

High-throughput

0.445

High

1207501

THOC2
THO complex subunit 2

1

5

High-throughput

0.445

High

1207502

TBCK
TBC domain-containing protein kinase-like protein

1

5

High-throughput

0.445

High

1207503

HASP
Serine/threonine-protein kinase haspin

1

5

High-throughput

0.445

High

1207504

CDKL2
Cyclin-dependent kinase-like 2

1

1

High-throughput

0.445

High

1207505

SYGP1
Ras/Rap GTPase-activating protein SynGAP

1

16

High-throughput

0.445

High

1207506

PAK5
Serine/threonine-protein kinase PAK 5

1

13

High-throughput

0.445

High

1207507

ITM2B
Integral membrane protein 2B

1

9

High-throughput

0.445

High

1207508

MB212
Protein mab-21-like 2

1

1

High-throughput

0.445

High

166665

BCKD
Branched-chain alpha-ketoacid dehydrogenase kinase

1

4

High-throughput

0.407

High

1207498

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

1

High-throughput

0.407

High

1207500

MOT11
Monocarboxylate transporter 11

1

5

High-throughput

0.407

High


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Last updated: 11Aug2025