Protein: HPS6
BLOC-2 complex member HPS6 (Hermansky-Pudlak syndrome 6 protein) (Ruby-eye protein homolog) (Ru)

Gene: HPS6
Organism: Homo sapiens
Interactions: 43
UniProt ID: Q86YV9

Gene Ontology (top 5):
GO:0005654 - nucleoplasm
GO:0005765 - lysosomal membrane
GO:0005769 - early endosome
GO:0005783 - endoplasmic reticulum
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1295658

HPS5
BLOC-2 complex member HPS5

2

1

High-throughput

0.628

High

1295649

HPS3
BLOC-2 complex member HPS3

2

0

High-throughput

0.602

High

908763

MAT1
CDK-activating kinase assembly factor MAT1

1

0

High-throughput

0.518

High

296802

ST1C4
Sulfotransferase 1C4

1

0

High-throughput

0.513

High

483599

CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase

1

0

High-throughput

0.513

High

537459

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.513

High

905611

IRAK1
Interleukin-1 receptor-associated kinase 1

1

0

High-throughput

0.513

High

1147942

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.513

High

1295655

MET14
N(6)-adenosine-methyltransferase non-catalytic subunit METTL14

1

0

High-throughput

0.513

High

839164

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

1

0

High-throughput

0.486

High

1295656

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

0

High-throughput

0.486

High

508239

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

0

High-throughput

0.480

High

964355

SUMO2
Small ubiquitin-related modifier 2

1

0

High-throughput

0.480

High

520183

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

1295648

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

1067487

EP300
Histone acetyltransferase p300

1

0

High-throughput

0.460

High

173028

XPO1
Exportin-1

1

0

High-throughput

0.458

High

242190

PRKN
E3 ubiquitin-protein ligase parkin

1

0

High-throughput

0.458

High

831021

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

942727

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

0

High-throughput

0.458

High

1140512

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

1178234

CL16A
Protein CLEC16A

1

0

High-throughput

0.458

High

1295646

RPTOR
Regulatory-associated protein of mTOR

1

0

High-throughput

0.458

High

1295654

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1295660

TRRAP
Transformation/transcription domain-associated protein

1

0

High-throughput

0.458

High

593153

CREB1
Cyclic AMP-responsive element-binding protein 1

1

0

High-throughput

0.438

High

1148119

PUM3
Pumilio homolog 3

1

0

High-throughput

0.438

High

1295650

MARK4
MAP/microtubule affinity-regulating kinase 4

1

0

High-throughput

0.438

High

258969

DNJA2
DnaJ homolog subfamily A member 2

1

0

High-throughput

0.426

High

347151

BAG2
BAG family molecular chaperone regulator 2

1

0

High-throughput

0.426

High

1227004

A16L1
Autophagy-related protein 16-1

1

0

High-throughput

0.426

High

1234017

S35E4
Solute carrier family 35 member E4

1

0

High-throughput

0.426

High

1295647

S15A4
Solute carrier family 15 member 4

1

0

High-throughput

0.426

High

1295651

DNJC7
DnaJ homolog subfamily C member 7

1

0

High-throughput

0.426

High

352632

TCL1B
T-cell leukemia/lymphoma protein 1B

2

0

High-throughput

0.318

High

296720

TUSC2
Tumor suppressor candidate 2

1

0

High-throughput

0.279

Low

1295652

NPAS1
Neuronal PAS domain-containing protein 1

1

0

High-throughput

0.279

Low

1231757

TTC19
Tetratricopeptide repeat protein 19, mitochondrial

1

0

High-throughput

0.265

Low

293963

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.249

Low

1295653

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

1239511

ZNT6
Zinc transporter 6

1

0

High-throughput

0.232

Low

1295657

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.232

Low

1295659

S27A6
Long-chain fatty acid transport protein 6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025