Protein: OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase (EC 2.3.1.234) (N6-L-threonylcarbamoyladenine synthase) (t(6)A synthase) (O-sialoglycoprotein endopeptidase) (hOSGEP) (t(6)A37 threonylcarbamoyladenosine biosynthesis protein OSGEP) (tRNA threonylcarbamoyladenosine biosynthesis protein OSGEP)

Gene: OSGEP
Organism: Homo sapiens
Interactions: 113
UniProt ID: Q9NPF4

Gene Ontology (top 5):
GO:0000408 - EKC/KEOPS complex
GO:0002949 - tRNA threonylcarbamoyladenosine modification
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1129277

LAGE3
EKC/KEOPS complex subunit LAGE3

8

2

Small-scale

0.967

High

1402179

PRPK
EKC/KEOPS complex subunit TP53RK

7

1

Small-scale

0.751

High

1446327

TPRKB
EKC/KEOPS complex subunit TPRKB

4

1

Small-scale

0.694

High

783665

MP2K2
Dual specificity mitogen-activated protein kinase kinase 2

1

2

High-throughput

0.691

High

1038359

MP2K1
Dual specificity mitogen-activated protein kinase kinase 1

1

2

High-throughput

0.691

High

1417405

GON7
EKC/KEOPS complex subunit GON7

5

0

Small-scale

0.682

High

294953

POP7
Ribonuclease P protein subunit p20

4

0

High-throughput

0.661

High

1338983

NUP43
Nucleoporin Nup43

4

0

High-throughput

0.661

High

1395890

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

0

High-throughput

0.656

High

1408479

VRK1
Serine/threonine-protein kinase VRK1

1

0

High-throughput

0.656

High

1446322

ST32B
Serine/threonine-protein kinase 32B

1

0

High-throughput

0.656

High

1446329

STK24
Serine/threonine-protein kinase 24

1

0

High-throughput

0.656

High

1414433

CC28B
Coiled-coil domain-containing protein 28B

3

0

High-throughput

0.646

High

1446319

MBIP1
MAP3K12-binding inhibitory protein 1

3

0

High-throughput

0.634

High

1446318

OSGEP
tRNA N6-adenosine threonylcarbamoyltransferase

1

5

Small-scale

0.618

High

1007609

PRAME
Melanoma antigen preferentially expressed in tumors

2

0

Small-scale

0.585

High

1391054

OTUB1
Ubiquitin thioesterase OTUB1

2

0

High-throughput

0.547

High

63040

POTEF
POTE ankyrin domain family member F

1

2

High-throughput

0.536

High

1331364

ENAH
Protein enabled homolog

1

1

High-throughput

0.536

High

1429162

NAA50
N-alpha-acetyltransferase 50

1

1

High-throughput

0.536

High

727980

DNJA1
DnaJ homolog subfamily A member 1

1

2

High-throughput

0.515

High

171334

MYPT1
Protein phosphatase 1 regulatory subunit 12A

1

0

High-throughput

0.513

High

290987

PPM1B
Protein phosphatase 1B

1

0

High-throughput

0.513

High

564408

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.513

High

877387

IDHP
Isocitrate dehydrogenase [NADP], mitochondrial

1

0

High-throughput

0.513

High

914065

SPSY
Spermine synthase

1

0

High-throughput

0.513

High

958029

RAB14
Ras-related protein Rab-14

1

0

High-throughput

0.513

High

962522

RHOA
Transforming protein RhoA

1

0

High-throughput

0.513

High

982132

RAP1A
Ras-related protein Rap-1A

1

0

High-throughput

0.513

High

1024861

VIGLN
Vigilin

1

0

High-throughput

0.513

High

1026914

FKBP3
Peptidyl-prolyl cis-trans isomerase FKBP3

1

0

High-throughput

0.513

High

1109396

PIN1
Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1

1

0

High-throughput

0.513

High

1119894

CKAP5
Cytoskeleton-associated protein 5

1

0

High-throughput

0.513

High

1123276

DPYL3
Dihydropyrimidinase-related protein 3

1

0

High-throughput

0.513

High

1153739

TOM34
Mitochondrial import receptor subunit TOM34

1

0

High-throughput

0.513

High

1180189

QRIC1
Transcriptional regulator QRICH1

1

0

High-throughput

0.513

High

1187020

TKFC
Triokinase/FMN cyclase

1

0

High-throughput

0.513

High

1278811

HDGR2
Hepatoma-derived growth factor-related protein 2

1

0

High-throughput

0.513

High

1309838

WDFY1
WD repeat and FYVE domain-containing protein 1

1

0

High-throughput

0.513

High

1349945

PNPT1
Polyribonucleotide nucleotidyltransferase 1, mitochondrial

1

0

High-throughput

0.513

High

1365186

NDRG1
Protein NDRG1

1

0

High-throughput

0.513

High

1417194

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.513

High

1420691

FTO
Alpha-ketoglutarate-dependent dioxygenase FTO

1

0

High-throughput

0.513

High

1434388

EHD1
EH domain-containing protein 1

1

0

High-throughput

0.513

High

1446323

CYH4
Cytohesin-4

1

0

High-throughput

0.513

High

1446324

DBNL
Drebrin-like protein

1

0

High-throughput

0.513

High

1446326

RRP44
Exosome complex exonuclease RRP44

1

0

High-throughput

0.513

High

188531

NVL
Nuclear valosin-containing protein-like

1

1

High-throughput

0.508

High

1279757

SPRE1
Sprouty-related, EVH1 domain-containing protein 1

1

1

High-throughput

0.508

High

1437933

SP110
Sp110 nuclear body protein

1

1

High-throughput

0.508

High

347942

BAG3
BAG family molecular chaperone regulator 3

1

0

High-throughput

0.493

High

345008

WIZ
Protein Wiz

1

0

High-throughput

0.486

High

404446

GCR
Glucocorticoid receptor

1

0

High-throughput

0.486

High

711421

SHC1
SHC-transforming protein 1

1

0

High-throughput

0.486

High

1148056

SF3B3
Splicing factor 3B subunit 3

1

0

High-throughput

0.486

High

1209165

RBM48
RNA-binding protein 48

1

0

High-throughput

0.486

High

1218019

MYOME
Myomegalin

1

0

High-throughput

0.486

High

1232771

CPIN1
Anamorsin

1

0

High-throughput

0.486

High

1250047

WDR82
WD repeat-containing protein 82

1

0

High-throughput

0.486

High

1295656

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.486

High

1332642

ZN579
Zinc finger protein 579

1

0

High-throughput

0.486

High

1385085

ZN775
Zinc finger protein 775

1

0

High-throughput

0.486

High

1385262

LENG1
Leukocyte receptor cluster member 1

1

0

High-throughput

0.486

High

1405306

PKP4
Plakophilin-4

1

0

High-throughput

0.486

High

1438327

TENS1
Tensin-1

1

0

High-throughput

0.486

High

294371

CD123
Translation initiation factor eIF2 assembly protein

1

1

High-throughput

0.479

High

935164

TERA
Transitional endoplasmic reticulum ATPase

1

1

High-throughput

0.479

High

940792

LEG4
Galectin-4

1

0

High-throughput

0.460

High

589765

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.458

High

696583

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.458

High

761296

RYK
Tyrosine-protein kinase RYK

1

0

Small-scale

0.458

High

769252

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.458

High

971129

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

1100416

TIF1B
Transcription intermediary factor 1-beta

1

0

High-throughput

0.458

High

1112996

CUL2
Cullin-2

1

0

Small-scale

0.458

High

1147131

ELOC
Elongin-C

1

0

Small-scale

0.458

High

1147285

ELOB
Elongin-B

1

0

Small-scale

0.458

High

1252982

BAKOR
Beclin 1-associated autophagy-related key regulator

1

0

High-throughput

0.458

High

1255657

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1290979

TAXB1
Tax1-binding protein 1

1

0

High-throughput

0.458

High

1335518

MTMRE
Phosphatidylinositol-3,5-bisphosphate 3-phosphatase MTMR14

1

0

High-throughput

0.458

High

1397457

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

1399200

NP1L5
Nucleosome assembly protein 1-like 5

1

0

High-throughput

0.458

High

1429358

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.458

High

1429984

SHRPN
Sharpin

1

0

Small-scale

0.458

High

1433966

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

1438351

NMRL1
NmrA-like family domain-containing protein 1

1

0

High-throughput

0.458

High

1446086

DLRB1
Dynein light chain roadblock-type 1

1

0

High-throughput

0.458

High

1446321

MTMRA
Myotubularin-related protein 10

1

0

High-throughput

0.458

High

1103878

ZN211
Zinc finger protein 211

1

0

High-throughput

0.426

High

1311525

BBS7
BBSome complex member BBS7

1

0

High-throughput

0.426

High

1361484

IFT81
Intraflagellar transport protein 81 homolog

1

0

High-throughput

0.426

High

1387445

CMBL
Carboxymethylenebutenolidase homolog

1

0

High-throughput

0.426

High

1413531

PAGR1
PAXIP1-associated glutamate-rich protein 1

1

0

High-throughput

0.426

High

1429204

UBA5
Ubiquitin-like modifier-activating enzyme 5

1

0

High-throughput

0.426

High

1326746

MIA40
Mitochondrial intermembrane space import and assembly protein 40

1

1

High-throughput

0.407

High

60659

HYKK
Hydroxylysine kinase

3

0

High-throughput

0.347

High

1181212

ANO4
Anoctamin-4

2

0

High-throughput

0.313

High

167721

LIN7A
Protein lin-7 homolog A

1

0

High-throughput

0.279

Low

329368

LETM1
Mitochondrial proton/calcium exchanger protein

1

0

High-throughput

0.279

Low

450274

HYEP
Epoxide hydrolase 1

1

0

High-throughput

0.279

Low

1116978

CD166
CD166 antigen

1

0

High-throughput

0.279

Low

1446320

CYRIB
CYFIP-related Rac1 interactor B

1

0

High-throughput

0.279

Low

1446328

JAM1
Junctional adhesion molecule A

1

0

High-throughput

0.279

Low

901062

RAB5C
Ras-related protein Rab-5C

1

0

High-throughput

0.269

Low

915910

CRIP2
Cysteine-rich protein 2

1

0

High-throughput

0.265

Low

1389336

REX1B
Required for excision 1-B domain-containing protein

1

0

High-throughput

0.265

Low

1446325

MUCEN
Endomucin

1

0

Small-scale

0.261

Low

377737

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

1249234

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

516873

RPAC2
DNA-directed RNA polymerases I and III subunit RPAC2

1

0

High-throughput

0.232

Low

1419160

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025