Protein: S15A4
Solute carrier family 15 member 4 (Peptide transporter 4) (Peptide/histidine transporter 1) (hPHT1)

Gene: S15A4, SLC15A4
Organism: Homo sapiens
Interactions: 123
UniProt ID: Q8N697

Gene Ontology (top 5):
GO:0005290 - L-histidine transmembrane transporter activity
GO:0005765 - lysosomal membrane
GO:0005886 - plasma membrane
GO:0006811 - monoatomic ion transport
GO:0015031 - protein transport

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

609745

LEG3
Galectin-3

5

7

Small-scale

0.716

High

1329194

TASL
TLR adapter interacting with SLC15A4 on the lysosome

4

0

Small-scale

0.672

High

163326

TR10B
Tumor necrosis factor receptor superfamily member 10B

3

1

High-throughput

0.667

High

1032617

AT2B2
Plasma membrane calcium-transporting ATPase 2

2

7

High-throughput

0.628

High

1197830

S39AC
Zinc transporter ZIP12

2

7

High-throughput

0.628

High

846082

GLP1R
Glucagon-like peptide 1 receptor

2

4

Small-scale

0.619

High

1313757

S15A3
Solute carrier family 15 member 3

1

2

Small-scale

0.618

High

1329175

S15A4
Solute carrier family 15 member 4

1

2

Small-scale

0.618

High

845523

PI2R
Prostacyclin receptor

2

0

High-throughput

0.602

High

1329183

GPR21
Probable G-protein coupled receptor 21

2

0

High-throughput

0.602

High

1329185

GORS1
Golgi reassembly-stacking protein 1

2

0

High-throughput

0.602

High

130163

PGRC1
Membrane-associated progesterone receptor component 1

2

8

Small-scale

0.601

High

907817

CLCN7
H(+)/Cl(-) exchange transporter 7

2

1

High-throughput

0.588

High

125529

LEG9
Galectin-9

2

7

Small-scale

0.574

High

1110874

IRF5
Interferon regulatory factor 5

1

1

Small-scale

0.554

High

170868

CLGN
Calmegin

2

5

Small-scale

0.549

High

572452

DRD2
D(2) dopamine receptor

1

1

High-throughput

0.541

High

48699

ESYT2
Extended synaptotagmin-2

1

2

Small-scale

0.536

High

127372

LEG8
Galectin-8

1

7

Small-scale

0.536

High

132623

UPK1A
Uroplakin-1a

1

3

High-throughput

0.536

High

140356

SDCB1
Syntenin-1

1

1

Small-scale

0.536

High

164939

TR10C
Tumor necrosis factor receptor superfamily member 10C

1

1

High-throughput

0.536

High

184476

SURF4
Surfeit locus protein 4

1

2

Small-scale

0.536

High

190237

MOT4
Monocarboxylate transporter 4

1

1

Small-scale

0.536

High

328952

RTN3
Reticulon-3

1

1

Small-scale

0.536

High

332363

5HT3B
5-hydroxytryptamine receptor 3B

1

1

High-throughput

0.536

High

338642

AGRL2
Adhesion G protein-coupled receptor L2

1

3

Small-scale

0.536

High

349482

TSN15
Tetraspanin-15

1

2

High-throughput

0.536

High

390668

TFR1
Transferrin receptor protein 1

1

3

Small-scale

0.536

High

417582

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

Small-scale

0.536

High

480851

LEG1
Galectin-1

1

7

Small-scale

0.536

High

869915

ATPO
ATP synthase peripheral stalk subunit OSCP, mitochondrial

1

2

Small-scale

0.536

High

963102

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

1

Small-scale

0.536

High

1139503

S39AE
Metal cation symporter ZIP14

1

7

Small-scale

0.536

High

1153284

AAAT
Neutral amino acid transporter B(0)

1

2

Small-scale

0.536

High

1329176

IGSF1
Immunoglobulin superfamily member 1

1

2

Small-scale

0.536

High

1329186

ZNT2
Proton-coupled zinc antiporter SLC30A2

1

2

High-throughput

0.536

High

1329193

GHC1
Mitochondrial glutamate carrier 1

1

4

Small-scale

0.536

High

1329200

RTN4
Reticulon-4

1

1

Small-scale

0.536

High

1329198

GPR35
G-protein coupled receptor 35

1

0

High-throughput

0.518

High

165619

SCAM3
Secretory carrier-associated membrane protein 3

1

0

Small-scale

0.513

High

183947

S22A2
Solute carrier family 22 member 2

1

0

High-throughput

0.513

High

230990

TYOBP
TYRO protein tyrosine kinase-binding protein

1

0

Small-scale

0.513

High

424222

S10A8
Protein S100-A8

1

0

Small-scale

0.513

High

467549

4F2
Amino acid transporter heavy chain SLC3A2

1

0

Small-scale

0.513

High

718714

FCERG
High affinity immunoglobulin epsilon receptor subunit gamma

1

0

Small-scale

0.513

High

749233

CD70
CD70 antigen

1

0

Small-scale

0.513

High

771794

SCN4A
Sodium channel protein type 4 subunit alpha

1

0

High-throughput

0.513

High

851171

ACHA4
Neuronal acetylcholine receptor subunit alpha-4

1

0

High-throughput

0.513

High

894428

MMP14
Matrix metalloproteinase-14

1

0

Small-scale

0.513

High

1195448

NKAI1
Sodium/potassium-transporting ATPase subunit beta-1-interacting protein 1

1

0

High-throughput

0.513

High

1254063

LRC55
Leucine-rich repeat-containing protein 55

1

0

High-throughput

0.513

High

1329178

SIDT2
SID1 transmembrane family member 2

1

0

High-throughput

0.513

High

1329180

CKLF5
CKLF-like MARVEL transmembrane domain-containing protein 5

1

0

High-throughput

0.513

High

1329190

F234A
Protein FAM234A

1

0

Small-scale

0.513

High

1329202

SC5A4
Probable glucose sensor protein SLC5A4

1

0

High-throughput

0.513

High

1329209

FLVC1
Choline/ethanolamine transporter FLVCR1

1

0

Small-scale

0.513

High

1329197

NOD2
Nucleotide-binding oligomerization domain-containing protein 2

1

1

Small-scale

0.479

High

158852

AP3D1
AP-3 complex subunit delta-1

1

8

High-throughput

0.445

High

178331

NPC1
NPC intracellular cholesterol transporter 1

1

2

High-throughput

0.445

High

189709

STX7
Syntaxin-7

1

1

High-throughput

0.445

High

243975

JIP4
C-Jun-amino-terminal kinase-interacting protein 4

1

2

High-throughput

0.445

High

291433

NU155
Nuclear pore complex protein Nup155

1

1

High-throughput

0.445

High

374059

RASN
GTPase NRas

1

6

High-throughput

0.445

High

374764

RASH
GTPase HRas

1

5

High-throughput

0.445

High

698883

CALX
Calnexin

1

5

High-throughput

0.445

High

861684

NEDD4
E3 ubiquitin-protein ligase NEDD4

1

3

High-throughput

0.445

High

888796

VPS41
Vacuolar protein sorting-associated protein 41 homolog

1

1

High-throughput

0.445

High

901389

RAB7A
Ras-related protein Rab-7a

1

5

High-throughput

0.445

High

901942

RAB9A
Ras-related protein Rab-9A

1

4

High-throughput

0.445

High

908032

VAMP7
Vesicle-associated membrane protein 7

1

3

High-throughput

0.445

High

956391

RAB2A
Ras-related protein Rab-2A

1

4

High-throughput

0.445

High

957968

RAB14
Ras-related protein Rab-14

1

4

High-throughput

0.445

High

1133215

STAR3
StAR-related lipid transfer protein 3

1

2

High-throughput

0.445

High

1233352

LTOR1
Ragulator complex protein LAMTOR1

1

2

High-throughput

0.445

High

1234810

RAB12
Ras-related protein Rab-12

1

4

High-throughput

0.445

High

1247370

ATRAP
Type-1 angiotensin II receptor-associated protein

1

1

High-throughput

0.445

High

1256344

AN13D
Ankyrin repeat domain-containing protein 13D

1

3

High-throughput

0.445

High

1278033

MAVS
Mitochondrial antiviral-signaling protein

1

2

High-throughput

0.445

High

1294788

STX12
Syntaxin-12

1

1

High-throughput

0.445

High

1315810

AN13A
Ankyrin repeat domain-containing protein 13A

1

4

High-throughput

0.445

High

1323491

S11IP
Serine/threonine-protein kinase 11-interacting protein

1

1

High-throughput

0.445

High

1329196

VEZA
Vezatin

1

1

High-throughput

0.445

High

1329199

RAB9B
Ras-related protein Rab-9B

1

4

High-throughput

0.445

High

1329201

T106B
Transmembrane protein 106B

1

2

High-throughput

0.445

High

1329204

VPS18
Vacuolar protein sorting-associated protein 18 homolog

1

1

High-throughput

0.445

High

1329208

RAP2C
Ras-related protein Rap-2c

1

3

High-throughput

0.445

High

209068

CYB5B
Cytochrome b5 type B

1

0

High-throughput

0.426

High

256483

TOM1
Target of Myb1 membrane trafficking protein

1

0

High-throughput

0.426

High

291680

XRP2
Protein XRP2

1

0

High-throughput

0.426

High

933030

SNAA
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.426

High

987113

RS27A
Ubiquitin-ribosomal protein eS31 fusion protein

1

0

High-throughput

0.426

High

1125543

FKBP8
Peptidyl-prolyl cis-trans isomerase FKBP8

1

0

High-throughput

0.426

High

1179107

TECT1
Tectonic-1

1

0

High-throughput

0.426

High

1286690

PP4P1
Type 1 phosphatidylinositol 4,5-bisphosphate 4-phosphatase

1

0

High-throughput

0.426

High

1295647

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.426

High

1314512

TM192
Transmembrane protein 192

1

0

High-throughput

0.426

High

1329182

WRIP1
ATPase WRNIP1

1

0

High-throughput

0.426

High

1329184

TS101
Tumor susceptibility gene 101 protein

1

0

High-throughput

0.426

High

1329188

TTYH3
Protein tweety homolog 3

1

0

High-throughput

0.426

High

1329191

VPS16
Vacuolar protein sorting-associated protein 16 homolog

1

0

High-throughput

0.426

High

1329192

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.426

High

1329195

RRAGC
Ras-related GTP-binding protein C

1

0

High-throughput

0.426

High

1329203

TMEM9
Proton-transporting V-type ATPase complex assembly regulator TMEM9

1

0

High-throughput

0.426

High

1329205

VTI1B
Vesicle transport through interaction with t-SNAREs homolog 1B

1

0

High-throughput

0.426

High

231505

ORC4
Origin recognition complex subunit 4

1

1

High-throughput

0.407

High

298749

ATP5H
ATP synthase peripheral stalk subunit d, mitochondrial

1

2

Small-scale

0.407

High

648202

NDKB
Nucleoside diphosphate kinase B

1

1

High-throughput

0.407

High

948104

AP3S2
AP-3 complex subunit sigma-2

1

2

High-throughput

0.407

High

981316

RAB1A
Ras-related protein Rab-1A

1

2

High-throughput

0.407

High

1329177

XXLT1
Xyloside xylosyltransferase 1

1

1

High-throughput

0.407

High

1329181

FXL20
F-box/LRR-repeat protein 20

1

1

High-throughput

0.407

High

1329187

T106C
Transmembrane protein 106C

1

2

High-throughput

0.407

High

1329189

RAB1B
Ras-related protein Rab-1B

1

1

High-throughput

0.407

High

1329207

PLAP
Phospholipase A-2-activating protein

1

2

High-throughput

0.407

High

168294

HAT1
Histone acetyltransferase type B catalytic subunit

2

0

Small-scale

0.313

High

347171

BAG2
BAG family molecular chaperone regulator 2

1

0

Small-scale

0.279

Low

415722

HSPB1
Heat shock protein beta-1

1

0

Small-scale

0.279

Low

1035775

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.249

Low

219332

B4GA1
Beta-1,4-glucuronyltransferase 1

1

0

High-throughput

0.232

Low

1329179

HPS3
BLOC-2 complex member HPS3

1

0

High-throughput

0.232

Low

1329206

EPDR1
Mammalian ependymin-related protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025