Protein: CN37
2',3'-cyclic-nucleotide 3'-phosphodiesterase (CNP) (CNPase) (EC 3.1.4.37)

Gene: CN37, CNP
Organism: Homo sapiens
Interactions: 205
UniProt ID: P09543

Gene Ontology (top 5):
GO:0003723 - RNA binding
GO:0004113 - 2',3'-cyclic-nucleotide 3'-phosphodiesterase activity
GO:0005615 - extracellular space
GO:0005737 - cytoplasm
GO:0005874 - microtubule

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

483651

SIR3
NAD-dependent protein deacetylase sirtuin-3, mitochondrial

3

2

High-throughput

0.599

High

483531

HD
Huntingtin

2

1

High-throughput

0.588

High

483532

MUC18
Cell surface glycoprotein MUC18

1

0

High-throughput

0.586

High

483559

CXAR
Coxsackievirus and adenovirus receptor

1

0

High-throughput

0.586

High

483566

NMI
N-myc-interactor

2

0

High-throughput

0.585

High

240554

PRKN
E3 ubiquitin-protein ligase parkin

2

2

High-throughput

0.584

High

375109

RASK
GTPase KRas

2

5

High-throughput

0.584

High

483505

LAMP1
Lysosome-associated membrane glycoprotein 1

2

2

High-throughput

0.584

High

483557

RHOB
Rho-related GTP-binding protein RhoB

2

5

High-throughput

0.584

High

395358

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

483600

ZDH17
Palmitoyltransferase ZDHHC17

1

5

High-throughput

0.568

High

483503

TAU
Microtubule-associated protein tau

2

3

Small-scale

0.552

High

436584

KPCB
Protein kinase C beta type

2

0

High-throughput

0.547

High

457184

TBB5
Tubulin beta chain

1

1

High-throughput

0.536

High

465372

IGF1R
Insulin-like growth factor 1 receptor

1

6

High-throughput

0.536

High

483501

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

2

High-throughput

0.536

High

483533

GRK6
G protein-coupled receptor kinase 6

1

1

High-throughput

0.536

High

483537

SOX2
Transcription factor SOX-2

1

1

High-throughput

0.536

High

483542

IRAK1
Interleukin-1 receptor-associated kinase 1

1

1

High-throughput

0.536

High

483544

LIMK2
LIM domain kinase 2

1

1

High-throughput

0.536

High

483567

ILK
Scaffold protein ILK

1

1

High-throughput

0.536

High

483572

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.536

High

483623

PSKH2
Serine/threonine-protein kinase H2

1

1

High-throughput

0.536

High

370992

MYC
Myc proto-oncogene protein

2

1

High-throughput

0.533

High

411231

NTRK1
High affinity nerve growth factor receptor

2

5

High-throughput

0.533

High

483583

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

2

0

High-throughput

0.528

High

483614

ESR2
Estrogen receptor beta

2

1

High-throughput

0.521

High

170472

RAB7L
Ras-related protein Rab-7L1

1

4

High-throughput

0.515

High

161935

MP2K7
Dual specificity mitogen-activated protein kinase kinase 7

1

0

High-throughput

0.513

High

483524

PCKGC
Phosphoenolpyruvate carboxykinase, cytosolic [GTP]

1

0

High-throughput

0.513

High

483573

CDK13
Cyclin-dependent kinase 13

1

0

High-throughput

0.513

High

483599

HPS6
BLOC-2 complex member HPS6

1

0

High-throughput

0.513

High

483610

F174A
Membrane protein FAM174A

1

0

High-throughput

0.513

High

483637

IL25
Interleukin-25

1

0

High-throughput

0.513

High

483649

DYRK4
Dual specificity tyrosine-phosphorylation-regulated kinase 4

1

0

High-throughput

0.513

High

483650

LATS2
Serine/threonine-protein kinase LATS2

1

0

High-throughput

0.513

High

483658

DBNL
Drebrin-like protein

1

0

High-throughput

0.513

High

483659

INTU
Protein inturned

1

0

High-throughput

0.513

High

483502

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

2

High-throughput

0.501

High

483513

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

0

High-throughput

0.493

High

483515

DPP4
Dipeptidyl peptidase 4

1

0

High-throughput

0.493

High

483540

ACOT2
Acyl-coenzyme A thioesterase 2, mitochondrial

1

1

High-throughput

0.489

High

483588

PKN3
Serine/threonine-protein kinase N3

1

1

High-throughput

0.489

High

483593

ERN2
Serine/threonine-protein kinase/endoribonuclease IRE2

1

1

High-throughput

0.489

High

483596

ACOT1
Acyl-coenzyme A thioesterase 1

1

1

High-throughput

0.489

High

483630

STK33
Serine/threonine-protein kinase 33

1

2

High-throughput

0.489

High

483642

CIA2A
Cytosolic iron-sulfur assembly component 2A

1

2

High-throughput

0.489

High

483669

RPKL1
Ribosomal protein S6 kinase-like 1

1

2

High-throughput

0.489

High

483553

PP1A
Serine/threonine-protein phosphatase PP1-alpha catalytic subunit

1

0

Small-scale

0.486

High

278800

PEX14
Peroxisomal membrane protein PEX14

1

1

Small-scale

0.484

High

404631

PRIO
Major prion protein

1

0

Small-scale

0.480

High

159477

DVL2
Segment polarity protein dishevelled homolog DVL-2

1

1

High-throughput

0.479

High

302733

CIAO1
Probable cytosolic iron-sulfur protein assembly protein CIAO1

1

3

High-throughput

0.479

High

345285

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

362643

EGFR
Epidermal growth factor receptor

1

3

High-throughput

0.479

High

373739

RASN
GTPase NRas

1

5

High-throughput

0.479

High

374353

RASH
GTPase HRas

1

3

High-throughput

0.479

High

410542

ERBB2
Receptor tyrosine-protein kinase erbB-2

1

3

High-throughput

0.479

High

439915

LCK
Tyrosine-protein kinase Lck

1

1

High-throughput

0.479

High

463290

LYN
Tyrosine-protein kinase Lyn

1

1

High-throughput

0.479

High

466077

RHOC
Rho-related GTP-binding protein RhoC

1

4

High-throughput

0.479

High

483506

FGFR1
Fibroblast growth factor receptor 1

1

7

High-throughput

0.479

High

483507

IFM1
Interferon-induced transmembrane protein 1

1

1

High-throughput

0.479

High

483508

LAMP2
Lysosome-associated membrane glycoprotein 2

1

2

High-throughput

0.479

High

483510

RHOQ
Rho-related GTP-binding protein RhoQ

1

6

High-throughput

0.479

High

483512

VGFR1
Vascular endothelial growth factor receptor 1

1

5

High-throughput

0.479

High

483518

LTK
Leukocyte tyrosine kinase receptor

1

6

High-throughput

0.479

High

483520

UFO
Tyrosine-protein kinase receptor UFO

1

3

High-throughput

0.479

High

483526

VGFR3
Vascular endothelial growth factor receptor 3

1

5

High-throughput

0.479

High

483535

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

483541

RAB9A
Ras-related protein Rab-9A

1

2

High-throughput

0.479

High

483548

CDC42
Cell division control protein 42 homolog

1

6

High-throughput

0.479

High

483549

RAB2A
Ras-related protein Rab-2A

1

1

High-throughput

0.479

High

483550

RHOA
Transforming protein RhoA

1

4

High-throughput

0.479

High

483558

RAC1
Ras-related C3 botulinum toxin substrate 1

1

5

High-throughput

0.479

High

483561

ROR1
Inactive tyrosine-protein kinase transmembrane receptor ROR1

1

8

High-throughput

0.479

High

483569

SQSTM
Sequestosome-1

1

1

High-throughput

0.479

High

483574

SCRB2
Lysosome membrane protein 2

1

1

High-throughput

0.479

High

483577

RAB35
Ras-related protein Rab-35

1

1

High-throughput

0.479

High

483578

RHOH
Rho-related GTP-binding protein RhoH

1

6

High-throughput

0.479

High

483579

DUS7
Dual specificity protein phosphatase 7

1

1

High-throughput

0.479

High

483586

LTOR1
Ragulator complex protein LAMTOR1

1

1

High-throughput

0.479

High

483589

LMTK1
Serine/threonine-protein kinase LMTK1

1

6

High-throughput

0.479

High

483590

TRI67
Tripartite motif-containing protein 67

1

1

High-throughput

0.479

High

483591

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.479

High

483595

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.479

High

483605

FBXW8
F-box/WD repeat-containing protein 8

1

2

High-throughput

0.479

High

483615

FBXW7
F-box/WD repeat-containing protein 7

1

1

High-throughput

0.479

High

483627

ANM1
Protein arginine N-methyltransferase 1

1

2

High-throughput

0.479

High

483631

TRI55
Tripartite motif-containing protein 55

1

3

High-throughput

0.479

High

483632

TRI31
E3 ubiquitin-protein ligase TRIM31

1

2

High-throughput

0.479

High

483634

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

2

High-throughput

0.479

High

483640

RHOJ
Rho-related GTP-binding protein RhoJ

1

6

High-throughput

0.479

High

483641

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

483644

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

483647

BRD7
Bromodomain-containing protein 7

1

2

High-throughput

0.479

High

483655

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

483663

CIA2B
Cytosolic iron-sulfur assembly component 2B

1

2

High-throughput

0.479

High

483664

TRAF6
TNF receptor-associated factor 6

1

2

High-throughput

0.479

High

483668

OAS3
2'-5'-oligoadenylate synthase 3

1

1

High-throughput

0.479

High

179804

BET1
BET1 homolog

1

0

High-throughput

0.458

High

189388

STX7
Syntaxin-7

1

0

High-throughput

0.458

High

247621

NUPR1
Nuclear protein 1

1

0

High-throughput

0.458

High

293096

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

319326

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

377371

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.458

High

400166

RAF1
RAF proto-oncogene serine/threonine-protein kinase

1

0

High-throughput

0.458

High

483504

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

483511

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

483519

MARCS
Myristoylated alanine-rich C-kinase substrate

1

0

High-throughput

0.458

High

483521

STIP1
Stress-induced-phosphoprotein 1

1

0

High-throughput

0.458

High

483522

PHB1
Prohibitin 1

1

0

High-throughput

0.458

High

483525

BASI
Basigin

1

0

High-throughput

0.458

High

483529

SYUA
Alpha-synuclein

1

0

High-throughput

0.458

High

483530

CCNF
Cyclin-F

1

0

High-throughput

0.458

High

483534

IF2M
Translation initiation factor IF-2, mitochondrial

1

0

High-throughput

0.458

High

483539

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

483555

ARF6
ADP-ribosylation factor 6

1

0

High-throughput

0.458

High

483556

RB11A
Ras-related protein Rab-11A

1

0

High-throughput

0.458

High

483562

CAV1
Caveolin-1

1

0

High-throughput

0.458

High

483565

TADBP
TAR DNA-binding protein 43

1

0

Small-scale

0.458

High

483568

NFAC2
Nuclear factor of activated T-cells, cytoplasmic 2

1

0

High-throughput

0.458

High

483570

CUL3
Cullin-3

1

0

High-throughput

0.458

High

483575

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

483576

KIF14
Kinesin-like protein KIF14

1

0

High-throughput

0.458

High

483581

CRY2
Cryptochrome-2

1

0

High-throughput

0.458

High

483584

RC3H1
Roquin-1

1

0

High-throughput

0.458

High

483585

VIR
Protein virilizer homolog

1

0

High-throughput

0.458

High

483607

CGAS
Cyclic GMP-AMP synthase

1

0

High-throughput

0.458

High

483608

RN149
E3 ubiquitin-protein ligase RNF149

1

0

High-throughput

0.458

High

483612

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

483616

CK052
Uncharacterized protein C11orf52

1

0

High-throughput

0.458

High

483620

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

483622

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

483625

RUFY1
RUN and FYVE domain-containing protein 1

1

0

High-throughput

0.458

High

483626

MMS19
MMS19 nucleotide excision repair protein homolog

1

0

High-throughput

0.458

High

483628

HINT2
Adenosine 5'-monophosphoramidase HINT2

1

0

High-throughput

0.458

High

483629

ACE2
Angiotensin-converting enzyme 2

1

0

High-throughput

0.458

High

483636

CCDC8
Coiled-coil domain-containing protein 8

1

0

High-throughput

0.458

High

483638

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

483652

MCUB
Calcium uniporter regulatory subunit MCUb, mitochondrial

1

0

High-throughput

0.458

High

483654

WWOX
WW domain-containing oxidoreductase

1

0

High-throughput

0.458

High

483546

BCAR1
Breast cancer anti-estrogen resistance protein 1

1

1

High-throughput

0.445

High

483547

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.445

High

483587

PKHA7
Pleckstrin homology domain-containing family A member 7

1

3

High-throughput

0.445

High

483633

ZDHC5
Palmitoyltransferase ZDHHC5

1

1

High-throughput

0.445

High

483662

ITM2B
Integral membrane protein 2B

1

1

High-throughput

0.445

High

340973

DIRA3
GTP-binding protein Di-Ras3

1

1

High-throughput

0.437

High

405712

MYCN
N-myc proto-oncogene protein

1

1

High-throughput

0.437

High

483514

FGFR3
Fibroblast growth factor receptor 3

1

7

High-throughput

0.437

High

483516

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

483517

EPHA2
Ephrin type-A receptor 2

1

4

High-throughput

0.437

High

483523

RFA3
Replication protein A 14 kDa subunit

1

1

High-throughput

0.437

High

483527

VGFR2
Vascular endothelial growth factor receptor 2

1

5

High-throughput

0.437

High

483528

FLT3
Receptor-type tyrosine-protein kinase FLT3

1

5

High-throughput

0.437

High

483551

RND3
Rho-related GTP-binding protein RhoE

1

6

High-throughput

0.437

High

483552

WDR5
WD repeat-containing protein 5

1

2

High-throughput

0.437

High

483554

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.437

High

483560

IFM3
Interferon-induced transmembrane protein 3

1

1

High-throughput

0.437

High

483592

ASXL2
Putative Polycomb group protein ASXL2

1

2

High-throughput

0.437

High

483594

RHOU
Rho-related GTP-binding protein RhoU

1

7

High-throughput

0.437

High

483601

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

483603

MKX
Homeobox protein Mohawk

1

1

High-throughput

0.437

High

483613

RND1
Rho-related GTP-binding protein Rho6

1

6

High-throughput

0.437

High

483621

SNX27
Sorting nexin-27

1

1

High-throughput

0.437

High

483624

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

483639

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

2

High-throughput

0.437

High

483661

LAMP3
Lysosome-associated membrane glycoprotein 3

1

2

High-throughput

0.437

High

294650

PR15A
Protein phosphatase 1 regulatory subunit 15A

1

0

High-throughput

0.426

High

483646

LN28A
Protein lin-28 homolog A

1

0

High-throughput

0.426

High

483667

SIR4
NAD-dependent protein lipoamidase sirtuin-4, mitochondrial

1

2

High-throughput

0.407

High

483536

MTR1A
Melatonin receptor type 1A

2

0

Small-scale

0.313

High

105174

APRIO
Alternative prion protein

2

0

Small-scale

0.310

High

66865

SPDE4
Speedy protein E4

1

0

High-throughput

0.279

Low

483563

TFCP2
Alpha-globin transcription factor CP2

1

0

High-throughput

0.279

Low

483564

SNF5
SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1

1

0

High-throughput

0.279

Low

483597

ST32C
Serine/threonine-protein kinase 32C

1

0

High-throughput

0.279

Low

483598

TMM25
Transmembrane protein 25

1

0

High-throughput

0.279

Low

483618

RMC1
Regulator of MON1-CCZ1 complex

1

0

High-throughput

0.279

Low

483619

AURKB
Aurora kinase B

1

0

High-throughput

0.279

Low

483645

MED20
Mediator of RNA polymerase II transcription subunit 20

1

0

High-throughput

0.279

Low

483656

MRM2
rRNA methyltransferase 2, mitochondrial

1

0

High-throughput

0.279

Low

483657

ZF69B
Zinc finger protein 69 homolog B

1

0

High-throughput

0.279

Low

483660

MED23
Mediator of RNA polymerase II transcription subunit 23

1

0

High-throughput

0.279

Low

483665

NUBP2
Cytosolic Fe-S cluster assembly factor NUBP2

1

0

High-throughput

0.279

Low

483666

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

217744

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.249

Low

385384

LMNA
Prelamin-A/C [Cleaved into: Lamin-A/C

1

0

High-throughput

0.249

Low

483509

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

483538

UBE2A
Ubiquitin-conjugating enzyme E2 A

1

0

High-throughput

0.249

Low

483545

FOXA1
Hepatocyte nuclear factor 3-alpha

1

0

High-throughput

0.249

Low

483571

APR
Phorbol-12-myristate-13-acetate-induced protein 1

1

0

High-throughput

0.249

Low

483580

CL16A
Protein CLEC16A

1

0

High-throughput

0.249

Low

483582

SYAM
Alanine--tRNA ligase, mitochondrial

1

0

High-throughput

0.249

Low

483602

TM192
Transmembrane protein 192

1

0

High-throughput

0.249

Low

483604

CXD3
Gap junction delta-3 protein

1

0

High-throughput

0.249

Low

483606

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

483609

DPTOR
DEP domain-containing mTOR-interacting protein

1

0

Small-scale

0.249

Low

483611

CLC4D
C-type lectin domain family 4 member D

1

0

High-throughput

0.249

Low

483617

CLUA1
Clusterin-associated protein 1

1

0

High-throughput

0.249

Low

483635

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

483643

ANTR1
Anthrax toxin receptor 1

1

0

Small-scale

0.249

Low

483648

ANLN
Anillin

1

0

High-throughput

0.249

Low

483653

B3GN2
N-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase 2

1

0

High-throughput

0.249

Low

483543

GPC3
Glypican-3

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025