Protein: IRAK3
Interleukin-1 receptor-associated kinase 3 (IRAK-3) (IL-1 receptor-associated kinase M) (IRAK-M) (Inactive IL-1 receptor-associated kinase 3)

Gene: IRAK3
Organism: Homo sapiens
Interactions: 39
UniProt ID: Q9Y616

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0001819 - positive regulation of cytokine production
GO:0001960 - negative regulation of cytokine-mediated signaling pathway
GO:0002755 - MyD88-dependent toll-like receptor signaling pathway
GO:0004674 - protein serine/threonine kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

905721

IRAK1
Interleukin-1 receptor-associated kinase 1

4

19

Small-scale

0.899

High

210216

IRAK2
Interleukin-1 receptor-associated kinase-like 2

2

19

Small-scale

0.789

High

1407687

MYD88
Myeloid differentiation primary response protein MyD88

2

20

Small-scale

0.776

High

1106150

FKBP5
Peptidyl-prolyl cis-trans isomerase FKBP5

1

5

High-throughput

0.691

High

1459853

TBK1
Serine/threonine-protein kinase TBK1

1

4

High-throughput

0.691

High

1491430

TRAF6
TNF receptor-associated factor 6

4

11

Small-scale

0.689

High

1157126

NTRK3
NT-3 growth factor receptor

1

20

High-throughput

0.621

High

462087

HS90A
Heat shock protein HSP 90-alpha

1

6

High-throughput

0.618

High

468961

HS90B
Heat shock protein HSP 90-beta

1

6

High-throughput

0.618

High

1451576

IRAK4
Interleukin-1 receptor-associated kinase 4

1

20

High-throughput

0.618

High

1491792

IRAK3
Interleukin-1 receptor-associated kinase 3

1

20

Small-scale

0.618

High

471571

CD14
Monocyte differentiation antigen CD14

1

0

High-throughput

0.589

High

1144517

NONO
Non-POU domain-containing octamer-binding protein

1

0

High-throughput

0.589

High

921841

COPB
Coatomer subunit beta

1

1

High-throughput

0.541

High

502190

H2AZ
Histone H2A.Z

1

1

High-throughput

0.536

High

937141

CASP6
Caspase-6

1

1

Small-scale

0.536

High

1460798

HSPB8
Heat shock protein beta-8

1

1

High-throughput

0.536

High

583351

FOLR1
Folate receptor alpha

1

0

High-throughput

0.518

High

1159440

ECM1
Extracellular matrix protein 1

1

0

High-throughput

0.518

High

1390557

CDCA5
Sororin

1

0

High-throughput

0.518

High

1404145

VATO
V-type proton ATPase 21 kDa proteolipid subunit c''

1

0

High-throughput

0.518

High

591408

CD44
CD44 antigen

1

0

High-throughput

0.513

High

1162938

H2A2C
Histone H2A type 2-C

1

0

High-throughput

0.513

High

1250399

DPP8
Dipeptidyl peptidase 8

1

0

High-throughput

0.513

High

437049

K1C18
Keratin, type I cytoskeletal 18

1

0

High-throughput

0.493

High

437405

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.493

High

484829

HXB7
Homeobox protein Hox-B7

1

1

High-throughput

0.481

High

1294151

TCAM2
TIR domain-containing adapter molecule 2

1

1

Small-scale

0.479

High

358052

ADH1B
All-trans-retinol dehydrogenase [NAD(+)] ADH1B

1

0

High-throughput

0.460

High

1287943

LDB1
LIM domain-binding protein 1

1

0

High-throughput

0.460

High

404577

GCR
Glucocorticoid receptor

1

0

High-throughput

0.458

High

430567

JUN
Transcription factor Jun

1

0

Small-scale

0.458

High

591433

NQO2
Ribosyldihydronicotinamide dehydrogenase [quinone]

1

0

High-throughput

0.458

High

945529

GSDMD
Gasdermin-D

1

0

Small-scale

0.458

High

1331295

RN152
E3 ubiquitin-protein ligase RNF152

1

5

Small-scale

0.437

High

1491135

TMED7
Transmembrane emp24 domain-containing protein 7

1

1

Small-scale

0.437

High

338221

NSA2
Ribosome biogenesis protein NSA2 homolog

1

0

High-throughput

0.251

Low

301276

RL1D1
Ribosomal L1 domain-containing protein 1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025