Protein: GMDS
GDP-mannose 4,6 dehydratase (EC 4.2.1.47) (GDP-D-mannose dehydratase) (GMD)

Gene: GMDS
Organism: Homo sapiens
Interactions: 40
UniProt ID: O60547

Gene Ontology (top 5):
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0007219 - Notch signaling pathway
GO:0008446 - GDP-mannose 4,6-dehydratase activity
GO:0019673 - GDP-mannose metabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

251350

GMDS
GDP-mannose 4,6 dehydratase

5

13

High-throughput

0.927

High

251353

TNKS1
Poly [ADP-ribose] polymerase tankyrase-1

4

2

Small-scale

0.696

High

251375

NTAQ1
Protein N-terminal glutamine amidohydrolase

3

0

High-throughput

0.646

High

251383

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

3

0

High-throughput

0.646

High

251378

TNKS2
Poly [ADP-ribose] polymerase tankyrase-2

2

2

High-throughput

0.628

High

216301

KCAB3
Voltage-gated potassium channel subunit beta-3

2

1

High-throughput

0.606

High

251367

NPHP3
Nephrocystin-3

2

0

High-throughput

0.602

High

240229

PRKN
E3 ubiquitin-protein ligase parkin

2

6

High-throughput

0.584

High

239286

MYPT2
Protein phosphatase 1 regulatory subunit 12B

1

3

High-throughput

0.536

High

251351

CCD22
Coiled-coil domain-containing protein 22

1

0

High-throughput

0.513

High

251374

SKA1
SKA complex subunit 1

1

0

High-throughput

0.513

High

251354

BAG3
BAG family molecular chaperone regulator 3

1

1

High-throughput

0.479

High

251358

MERL
Merlin

1

1

High-throughput

0.479

High

251360

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

1

High-throughput

0.479

High

251361

RBX1
E3 ubiquitin-protein ligase RBX1

1

1

High-throughput

0.479

High

251365

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

251366

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.479

High

251384

ZRAN1
Ubiquitin thioesterase ZRANB1

1

2

High-throughput

0.479

High

251352

PAGE4
P antigen family member 4

1

0

High-throughput

0.458

High

251355

HSP7C
Heat shock cognate 71 kDa protein

1

0

High-throughput

0.458

High

251362

CUL3
Cullin-3

1

0

High-throughput

0.458

High

251363

TRI14
Tripartite motif-containing protein 14

1

0

High-throughput

0.458

High

251364

HAPR1
HUWE1-associated protein modifying stress responses 1

1

0

High-throughput

0.458

High

251368

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

0

High-throughput

0.458

High

251371

TOPB1
DNA topoisomerase 2-binding protein 1

1

0

High-throughput

0.458

High

251373

RN166
E3 ubiquitin-protein ligase RNF166

1

0

High-throughput

0.458

High

251376

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

251380

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.458

High

251381

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

251382

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

251379

MLP3A
Microtubule-associated protein 1 light chain 3 alpha

1

1

High-throughput

0.445

High

251370

ZNT5
Proton-coupled zinc antiporter SLC30A5

1

3

High-throughput

0.407

High

251369

CHD1L
Chromodomain-helicase-DNA-binding protein 1-like

1

0

High-throughput

0.279

Low

251372

TSR2
Pre-rRNA-processing protein TSR2 homolog

1

0

High-throughput

0.279

Low

251356

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

251357

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

251359

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

251377

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

251385

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025