Protein: LCFC1
Sperm-egg fusion protein LLCFC1 (LLLL and CFNLAS motif-containing protein 1) (MSSP-binding protein CTM-1) (Sperm-oocyte fusion required protein 1)

Gene: LCFC1, LLCFC1
Organism: Homo sapiens
Interactions: 120
UniProt ID: Q96L11

Gene Ontology (top 5):
GO:0005576 - extracellular region
GO:0007342 - fusion of sperm to egg plasma membrane involved in single fertilization

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

136960

AGRIN
Agrin [Cleaved into: Agrin N-terminal 110 kDa subunit; Agrin C-terminal 110 kDa subunit; Agrin C-terminal 90 kDa fragment

1

5

High-throughput

0.536

High

144064

MA2B1
Lysosomal alpha-mannosidase

1

2

High-throughput

0.536

High

183291

LAMA5
Laminin subunit alpha-5

1

3

High-throughput

0.536

High

452112

PROS
Vitamin K-dependent protein S

1

7

High-throughput

0.536

High

541642

FGFR1
Fibroblast growth factor receptor 1

1

1

High-throughput

0.536

High

586385

ARSB
Arylsulfatase B

1

5

High-throughput

0.536

High

756580

GALNS
N-acetylgalactosamine-6-sulfatase

1

4

High-throughput

0.536

High

1087073

FSTL1
Follistatin-related protein 1

1

1

High-throughput

0.536

High

1126044

GAS6
Growth arrest-specific protein 6

1

5

High-throughput

0.536

High

1163335

LAMA3
Laminin subunit alpha-3

1

2

High-throughput

0.536

High

1248922

ARSK
Arylsulfatase K

1

4

High-throughput

0.536

High

1293349

CHSS1
Chondroitin sulfate synthase 1

1

2

High-throughput

0.536

High

1311016

SULF2
Extracellular sulfatase Sulf-2

1

4

High-throughput

0.536

High

1324218

VWDE
von Willebrand factor D and EGF domain-containing protein

1

2

High-throughput

0.536

High

1396511

CNTP3
Contactin-associated protein-like 3

1

4

High-throughput

0.536

High

1396525

EGFL7
Epidermal growth factor-like protein 7

1

6

High-throughput

0.536

High

261646

CATL2
Cathepsin L2

1

0

High-throughput

0.513

High

562752

BMP1
Bone morphogenetic protein 1

1

0

High-throughput

0.513

High

774792

TIMP3
Metalloproteinase inhibitor 3

1

0

High-throughput

0.513

High

787832

PEDF
Pigment epithelium-derived factor

1

0

High-throughput

0.513

High

833476

WNT5A
Protein Wnt-5a

1

0

High-throughput

0.513

High

931983

EPHB4
Ephrin type-B receptor 4

1

0

High-throughput

0.513

High

934023

PLTP
Phospholipid transfer protein

1

0

High-throughput

0.513

High

963970

NPC2
NPC intracellular cholesterol transporter 2

1

0

High-throughput

0.513

High

1052169

COEA1
Collagen alpha-1(XIV) chain

1

0

High-throughput

0.513

High

1120550

NID2
Nidogen-2

1

0

High-throughput

0.513

High

1366064

PXDN
Peroxidasin homolog

1

0

High-throughput

0.513

High

1396507

APOL2
Apolipoprotein L2

1

0

High-throughput

0.513

High

1396510

EMIL2
EMILIN-2

1

0

High-throughput

0.513

High

1396524

GAK1A
Golgi-associated kinase 1A

1

0

High-throughput

0.513

High

1396529

HYOU1
Hypoxia up-regulated protein 1

1

0

High-throughput

0.513

High

160830

TOR1B
Torsin-1B

1

3

High-throughput

0.489

High

175415

PLXB2
Plexin-B2

1

2

High-throughput

0.489

High

219823

CHSTA
Carbohydrate sulfotransferase 10

1

1

High-throughput

0.489

High

230837

EXTL3
Exostosin-like 3

1

1

High-throughput

0.489

High

269697

PLXA2
Plexin-A2

1

1

High-throughput

0.489

High

335399

GDF11
Growth/differentiation factor 11

1

1

High-throughput

0.489

High

565448

ITA4
Integrin alpha-4

1

3

High-throughput

0.489

High

603803

ITA2
Integrin alpha-2

1

4

High-throughput

0.489

High

885500

MA2A2
Alpha-mannosidase 2x

1

2

High-throughput

0.489

High

922836

ITA8
Integrin alpha-8 [Cleaved into: Integrin alpha-8 heavy chain; Integrin alpha-8 light chain]

1

3

High-throughput

0.489

High

928806

CA2D1
Voltage-dependent calcium channel subunit alpha-2/delta-1

1

1

High-throughput

0.489

High

945905

INHBE
Inhibin beta E chain

1

1

High-throughput

0.489

High

1006216

CNTP1
Contactin-associated protein 1

1

5

High-throughput

0.489

High

1108668

TBB3
Tubulin beta-3 chain

1

1

High-throughput

0.489

High

1116736

ITA7
Integrin alpha-7 [Cleaved into: Integrin alpha-7 heavy chain; Integrin alpha-7 light chain; Integrin alpha-7 70 kDa form]

1

3

High-throughput

0.489

High

1127591

FAT1
Protocadherin Fat 1

1

3

High-throughput

0.489

High

1157389

EXT1
Exostosin-1

1

1

High-throughput

0.489

High

1162150

MA2A1
Alpha-mannosidase 2

1

2

High-throughput

0.489

High

1191937

TBB8
Tubulin beta-8 chain

1

1

High-throughput

0.489

High

1250360

FAT4
Protocadherin Fat 4

1

3

High-throughput

0.489

High

1259426

TBA1A
Tubulin alpha-1A chain

1

1

High-throughput

0.489

High

1278471

PLGT3
Protein O-glucosyltransferase 3

1

1

High-throughput

0.489

High

1311063

SULF1
Extracellular sulfatase Sulf-1

1

4

High-throughput

0.489

High

1315946

CHSS2
Chondroitin sulfate synthase 2

1

2

High-throughput

0.489

High

1333651

PGLT1
Protein O-glucosyltransferase 1

1

1

High-throughput

0.489

High

1365491

EDEM1
ER degradation-enhancing alpha-mannosidase-like protein 1

1

1

High-throughput

0.489

High

1395500

PCD16
Protocadherin-16

1

3

High-throughput

0.489

High

1396506

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.489

High

1396508

LRFN3
Leucine-rich repeat and fibronectin type-III domain-containing protein 3

1

1

High-throughput

0.489

High

1396513

EDEM3
ER degradation-enhancing alpha-mannosidase-like protein 3

1

1

High-throughput

0.489

High

1396514

TOR3A
Torsin-3A

1

3

High-throughput

0.489

High

1396515

CHSTC
Carbohydrate sulfotransferase 12

1

1

High-throughput

0.489

High

1396517

CA2D2
Voltage-dependent calcium channel subunit alpha-2/delta-2

1

1

High-throughput

0.489

High

1396518

CELR3
Cadherin EGF LAG seven-pass G-type receptor 3

1

3

High-throughput

0.489

High

1396520

TEN3
Teneurin-3

1

2

High-throughput

0.489

High

1396521

CHPF2
Chondroitin sulfate glucuronyltransferase

1

2

High-throughput

0.489

High

1396522

DNJB9
DnaJ homolog subfamily B member 9

1

1

High-throughput

0.489

High

1396523

CATF
Cathepsin F

1

1

High-throughput

0.489

High

1324233

TOR2X
Prosalusin

1

3

High-throughput

0.479

High

1207200

TOR2A
Torsin-2A

1

3

High-throughput

0.407

High

517692

ZBT48
Zinc finger and BTB domain-containing protein 48

1

0

High-throughput

0.282

High

564226

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.282

High

63012

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.279

Low

298948

DNJB5
DnaJ homolog subfamily B member 5

1

0

High-throughput

0.279

Low

302264

STC2
Stanniocalcin-2

1

0

High-throughput

0.279

Low

424997

ADT2
ADP/ATP translocase 2

1

0

High-throughput

0.279

Low

599126

CBPE
Carboxypeptidase E

1

0

High-throughput

0.279

Low

604407

ASM
Sphingomyelin phosphodiesterase

1

0

High-throughput

0.279

Low

648306

ENPP1
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1

1

0

High-throughput

0.279

Low

771675

IDUA
Alpha-L-iduronidase

1

0

High-throughput

0.279

Low

844224

ECE1
Endothelin-converting enzyme 1

1

0

High-throughput

0.279

Low

906336

GPC3
Glypican-3

1

0

High-throughput

0.279

Low

931283

AT12A
Potassium-transporting ATPase alpha chain 2

1

0

High-throughput

0.279

Low

932385

ANAG
Alpha-N-acetylglucosaminidase

1

0

High-throughput

0.279

Low

981923

RL23
Large ribosomal subunit protein uL14

1

0

High-throughput

0.279

Low

1028111

B4GN1
Beta-1,4 N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.279

Low

1067035

MGT5A
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase A

1

0

High-throughput

0.279

Low

1089123

HYAL2
Hyaluronidase-2

1

0

High-throughput

0.279

Low

1127855

ERG1
Squalene monooxygenase

1

0

High-throughput

0.279

Low

1129970

MELK
Maternal embryonic leucine zipper kinase

1

0

High-throughput

0.279

Low

1131486

MBTP1
Membrane-bound transcription factor site-1 protease

1

0

High-throughput

0.279

Low

1143660

NOMO1
BOS complex subunit NOMO1

1

0

High-throughput

0.279

Low

1175828

T132A
Transmembrane protein 132A

1

0

High-throughput

0.279

Low

1195487

PLCH1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1

1

0

High-throughput

0.279

Low

1205473

EMC4
ER membrane protein complex subunit 4

1

0

High-throughput

0.279

Low

1208459

EOGT
EGF domain-specific O-linked N-acetylglucosamine transferase

1

0

High-throughput

0.279

Low

1228399

SE1L3
Protein sel-1 homolog 3

1

0

High-throughput

0.279

Low

1248281

MOXD1
DBH-like monooxygenase protein 1

1

0

High-throughput

0.279

Low

1259223

TMUB2
Transmembrane and ubiquitin-like domain-containing protein 2

1

0

High-throughput

0.279

Low

1293642

DYR2
Dihydrofolate reductase 2, mitochondrial

1

0

High-throughput

0.279

Low

1294929

ERO1B
ERO1-like protein beta

1

0

High-throughput

0.279

Low

1324500

NLGN1
Neuroligin-1

1

0

High-throughput

0.279

Low

1325548

LARG2
Xylosyl- and glucuronyltransferase LARGE2

1

0

High-throughput

0.279

Low

1361346

BRI3B
BRI3-binding protein

1

0

High-throughput

0.279

Low

1364136

TM131
Transmembrane protein 131

1

0

High-throughput

0.279

Low

1385188

SARAF
Store-operated calcium entry-associated regulatory factor

1

0

High-throughput

0.279

Low

1390777

S47A1
Multidrug and toxin extrusion protein 1

1

0

High-throughput

0.279

Low

1396389

LMLN
Leishmanolysin-like peptidase

1

0

High-throughput

0.279

Low

1396503

HPLN3
Hyaluronan and proteoglycan link protein 3

1

0

High-throughput

0.279

Low

1396504

S29A1
Equilibrative nucleoside transporter 1

1

0

High-throughput

0.279

Low

1396505

SEM3C
Semaphorin-3C

1

0

High-throughput

0.279

Low

1396509

ABHEA
Protein ABHD14A

1

0

High-throughput

0.279

Low

1396512

ABCA2
ATP-binding cassette sub-family A member 2

1

0

High-throughput

0.279

Low

1396516

KLH11
Kelch-like protein 11

1

0

High-throughput

0.279

Low

1396519

EMC3
ER membrane protein complex subunit 3

1

0

High-throughput

0.279

Low

1396526

CEIP2
Cell surface hyaluronidase CEMIP2

1

0

High-throughput

0.279

Low

1396527

METRN
Meteorin

1

0

High-throughput

0.279

Low

1396528

CCPG1
Cell cycle progression protein 1

1

0

High-throughput

0.279

Low

1396530

FLVC1
Choline/ethanolamine transporter FLVCR1

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025