Protein: TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B (EC 4.1.3.44) (Radical S-adenosyl methionine and flavodoxin domain-containing protein 2) (tRNA wybutosine-synthesizing protein 1 homolog B)

Gene: TYW1B
Organism: Homo sapiens
Interactions: 21
UniProt ID: Q6NUM6

Gene Ontology (top 5):
GO:0010181 - FMN binding
GO:0031591 - wybutosine biosynthetic process
GO:0046872 - metal ion binding
GO:0051539 - 4 iron, 4 sulfur cluster binding
GO:0102521 - tRNA-4-demethylwyosine synthase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1218403

CDKAL
Threonylcarbamoyladenosine tRNA methylthiotransferase

1

0

High-throughput

0.656

High

845436

PE2R3
Prostaglandin E2 receptor EP3 subtype

3

2

High-throughput

0.609

High

251224

RNBP6
Ran-binding protein 6

2

2

High-throughput

0.574

High

1238332

ARL15
ADP-ribosylation factor-like protein 15

2

1

High-throughput

0.574

High

1238334

ENTP4
Ectonucleoside triphosphate diphosphohydrolase 4

2

1

High-throughput

0.574

High

665316

EDNRB
Endothelin receptor type B

1

2

High-throughput

0.489

High

926786

VMAT1
Chromaffin granule amine transporter

1

2

High-throughput

0.489

High

1106785

VPP3
V-type proton ATPase 116 kDa subunit a 3

1

1

High-throughput

0.489

High

1238333

B3GA1
Galactosylgalactosylxylosylprotein 3-beta-glucuronosyltransferase 1

1

1

High-throughput

0.479

High

901311

RAB7A
Ras-related protein Rab-7a

1

6

High-throughput

0.437

High

1238328

TM11B
Transmembrane protease serine 11B

1

3

High-throughput

0.437

High

1238331

SACA1
Sperm acrosome membrane-associated protein 1

3

0

High-throughput

0.347

High

1238330

SG196
Protein O-mannose kinase

2

0

High-throughput

0.318

High

1238336

TX264
Testis-expressed protein 264

2

0

High-throughput

0.318

High

947900

T2R19
Taste receptor type 2 member 19

2

0

High-throughput

0.316

High

230702

NKG2F
NKG2-F type II integral membrane protein

1

0

High-throughput

0.279

Low

407186

CD3D
T-cell surface glycoprotein CD3 delta chain

1

0

High-throughput

0.279

Low

1180920

HFE
Hereditary hemochromatosis protein

1

0

High-throughput

0.279

Low

1238327

HEAT3
HEAT repeat-containing protein 3

1

0

High-throughput

0.279

Low

1238335

KCNE3
Potassium voltage-gated channel subfamily E member 3

1

0

High-throughput

0.279

Low

1238329

IQCF1
IQ domain-containing protein F1

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025