Protein: PE2R3
Prostaglandin E2 receptor EP3 subtype (PGE receptor EP3 subtype) (PGE2 receptor EP3 subtype) (PGE2-R) (Prostanoid EP3 receptor)

Gene: PE2R3, PTGER3
Organism: Homo sapiens
Interactions: 119
UniProt ID: P43115

Gene Ontology (top 5):
GO:0004957 - prostaglandin E receptor activity
GO:0005635 - nuclear envelope
GO:0005886 - plasma membrane
GO:0006954 - inflammatory response
GO:0007186 - G protein-coupled receptor signaling pathway

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

690077

AVR2A
Activin receptor type-2A

3

4

High-throughput

0.861

High

787119

BMR1A
Bone morphogenetic protein receptor type-1A

3

4

High-throughput

0.861

High

845423

AVR2B
Activin receptor type-2B

3

4

High-throughput

0.861

High

845438

PKN3
Serine/threonine-protein kinase N3

3

4

High-throughput

0.770

High

845488

GHRL
Appetite-regulating hormone

1

2

Small-scale

0.724

High

189124

IPO8
Importin-8

3

14

High-throughput

0.667

High

334704

IPO7
Importin-7

3

14

High-throughput

0.667

High

410696

ERBB2
Receptor tyrosine-protein kinase erbB-2

3

8

High-throughput

0.667

High

624607

SL9A1
Sodium/hydrogen exchanger 1

3

3

High-throughput

0.667

High

661235

AT2B4
Plasma membrane calcium-transporting ATPase 4

3

20

High-throughput

0.667

High

777646

VGFR3
Vascular endothelial growth factor receptor 3

3

2

High-throughput

0.667

High

839135

PK3CB
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform

3

9

High-throughput

0.667

High

845411

MFAP3
Microfibril-associated glycoprotein 3

3

1

High-throughput

0.667

High

845424

EI2BA
Translation initiation factor eIF2B subunit alpha

3

10

High-throughput

0.667

High

845425

DIP2A
Disco-interacting protein 2 homolog A

3

1

High-throughput

0.667

High

845439

RHDF2
Inactive rhomboid protein 2

3

1

High-throughput

0.667

High

845443

AN13D
Ankyrin repeat domain-containing protein 13D

3

2

High-throughput

0.667

High

845458

MIGA1
Mitoguardin 1

3

2

High-throughput

0.667

High

845471

IPO9
Importin-9

3

14

High-throughput

0.667

High

845472

MYADM
Myeloid-associated differentiation marker

3

1

High-throughput

0.667

High

845473

PKP4
Plakophilin-4

3

5

High-throughput

0.667

High

845474

PKP2
Plakophilin-2

3

4

High-throughput

0.667

High

845475

GCP2
Gamma-tubulin complex component 2

3

8

High-throughput

0.667

High

845477

OSBL8
Oxysterol-binding protein-related protein 8

3

3

High-throughput

0.667

High

845483

PLCB1
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1

3

2

High-throughput

0.667

High

845487

S39A1
Zinc transporter ZIP1

3

8

High-throughput

0.667

High

845497

TNPO3
Transportin-3

3

12

High-throughput

0.667

High

845432

PKHG4
Puratrophin-1

3

0

High-throughput

0.638

High

845452

C2CD5
C2 domain-containing protein 5

3

0

High-throughput

0.638

High

845479

PININ
Pinin

3

0

High-throughput

0.638

High

845496

DHRS7
Dehydrogenase/reductase SDR family member 7

3

0

High-throughput

0.638

High

303110

RGS20
Regulator of G-protein signaling 20

2

11

High-throughput

0.628

High

845454

CKLF4
CKLF-like MARVEL transmembrane domain-containing protein 4

2

5

High-throughput

0.611

High

845460

CIP2A
Protein CIP2A

2

2

High-throughput

0.611

High

136326

P85B
Phosphatidylinositol 3-kinase regulatory subunit beta

3

14

High-throughput

0.609

High

273170

CAND2
Cullin-associated NEDD8-dissociated protein 2

3

6

High-throughput

0.609

High

845409

EI2BB
Translation initiation factor eIF2B subunit beta

3

10

High-throughput

0.609

High

845422

EI2BE
Translation initiation factor eIF2B subunit epsilon

3

8

High-throughput

0.609

High

845436

TYW1B
S-adenosyl-L-methionine-dependent tRNA 4-demethylwyosine synthase TYW1B

3

2

High-throughput

0.609

High

845440

TMED8
Protein TMED8

3

4

High-throughput

0.609

High

845447

PKHH3
Pleckstrin homology domain-containing family H member 3

3

1

High-throughput

0.609

High

845450

ZCH18
Zinc finger CCCH domain-containing protein 18

3

2

High-throughput

0.609

High

845457

ARL10
ADP-ribosylation factor-like protein 10

3

9

High-throughput

0.609

High

845478

XPO4
Exportin-4

3

10

High-throughput

0.609

High

845481

CWC22
Pre-mRNA-splicing factor CWC22 homolog

3

2

High-throughput

0.609

High

845484

EI2BG
Translation initiation factor eIF2B subunit gamma

3

7

High-throughput

0.609

High

845486

FIRRM
FIGNL1-interacting regulator of recombination and mitosis

3

2

High-throughput

0.609

High

845491

EI2BD
Translation initiation factor eIF2B subunit delta

3

10

High-throughput

0.609

High

300733

KRT38
Keratin, type I cuticular Ha8

2

4

High-throughput

0.590

High

845445

NT2NA
Notch homolog 2 N-terminal-like protein A

2

3

High-throughput

0.573

High

845419

REL
Proto-oncogene c-Rel

1

1

High-throughput

0.573

High

845489

RGS17
Regulator of G-protein signaling 17

1

11

High-throughput

0.573

High

450223

HYEP
Epoxide hydrolase 1

2

2

High-throughput

0.558

High

845455

VPS8
Vacuolar protein sorting-associated protein 8 homolog

2

1

High-throughput

0.558

High

348075

M4K4
Mitogen-activated protein kinase kinase kinase kinase 4

1

1

High-throughput

0.553

High

221093

SPY2
Protein sprouty homolog 2

1

0

High-throughput

0.549

High

522616

PTPRF
Receptor-type tyrosine-protein phosphatase F

1

5

High-throughput

0.536

High

351513

FBLN4
EGF-containing fibulin-like extracellular matrix protein 2

1

1

High-throughput

0.523

High

587021

ITF2
Transcription factor 4

1

1

High-throughput

0.523

High

845414

KR107
Keratin-associated protein 10-7

1

4

High-throughput

0.523

High

845415

KR108
Keratin-associated protein 10-8

1

4

High-throughput

0.523

High

845416

KR109
Keratin-associated protein 10-9

1

4

High-throughput

0.523

High

845427

K1H1
Keratin, type I cuticular Ha1

1

4

High-throughput

0.523

High

845434

K1C40
Keratin, type I cytoskeletal 40

1

3

High-throughput

0.523

High

845442

ATL4
ADAMTS-like protein 4

1

1

High-throughput

0.523

High

845453

TRI42
Tripartite motif-containing protein 42

1

2

High-throughput

0.523

High

351086

ECD
Protein ecdysoneless homolog

2

1

High-throughput

0.521

High

828340

PEX19
Peroxisomal biogenesis factor 19

1

0

High-throughput

0.513

High

845429

SP6
Transcription factor Sp6

1

1

High-throughput

0.489

High

845465

NGBR
Dehydrodolichyl diphosphate synthase complex subunit NUS1

1

1

High-throughput

0.489

High

126070

AP3B1
AP-3 complex subunit beta-1

1

4

High-throughput

0.479

High

168827

PLD2
Phospholipase D2

1

2

High-throughput

0.479

High

480740

LEG1
Galectin-1

1

2

High-throughput

0.479

High

699635

P85A
Phosphatidylinositol 3-kinase regulatory subunit alpha

1

9

High-throughput

0.479

High

845412

GEMI4
Gem-associated protein 4

1

1

High-throughput

0.479

High

845428

CP51A
Lanosterol 14-alpha demethylase

1

1

High-throughput

0.479

High

845441

LRIG3
Leucine-rich repeats and immunoglobulin-like domains protein 3

1

1

High-throughput

0.479

High

845444

DYM
Dymeclin

1

3

High-throughput

0.479

High

845468

CREL1
Protein disulfide isomerase CRELD1

1

3

High-throughput

0.479

High

845469

EXOC2
Exocyst complex component 2

1

4

High-throughput

0.479

High

845482

RAB18
Ras-related protein Rab-18

1

4

High-throughput

0.479

High

845492

IPO11
Importin-11

1

14

High-throughput

0.479

High

845418

EREP3
Protein ENTREP3

1

0

High-throughput

0.458

High

845437

RETST
All-trans-retinol 13,14-reductase

1

0

High-throughput

0.458

High

845449

KTN1
Kinectin

1

0

High-throughput

0.458

High

845451

LSR
Lipolysis-stimulated lipoprotein receptor

1

0

High-throughput

0.458

High

845462

LMBR1
Limb region 1 protein homolog

1

0

High-throughput

0.458

High

845485

ST7
Suppressor of tumorigenicity 7 protein

1

0

High-throughput

0.458

High

845494

VANG2
Vang-like protein 2

1

0

High-throughput

0.458

High

845413

KR103
Keratin-associated protein 10-3

1

4

High-throughput

0.439

High

164544

TNPO2
Transportin-2

1

8

High-throughput

0.437

High

521577

H14
Histone H1.4

1

1

High-throughput

0.437

High

845435

PHLB3
Pleckstrin homology-like domain family B member 3

1

1

High-throughput

0.437

High

845459

TBC15
TBC1 domain family member 15

1

1

High-throughput

0.437

High

845461

STAG1
Cohesin subunit SA-1

1

3

High-throughput

0.437

High

845476

FACD2
Fanconi anemia group D2 protein

1

2

High-throughput

0.437

High

845490

ARMX3
Armadillo repeat-containing X-linked protein 3

1

10

High-throughput

0.437

High

845431

RHG29
Rho GTPase-activating protein 29

1

4

High-throughput

0.407

High

845495

PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1

1

1

High-throughput

0.407

High

845446

HEAT3
HEAT repeat-containing protein 3

4

0

High-throughput

0.360

High

320543

FARP2
FERM, ARHGEF and pleckstrin domain-containing protein 2

3

0

High-throughput

0.347

High

604616

UBF1
Nucleolar transcription factor 1

3

0

High-throughput

0.347

High

845421

TMM94
Transmembrane protein 94

3

0

High-throughput

0.347

High

845448

NOP9
Nucleolar protein 9

3

0

High-throughput

0.347

High

845463

PBIP1
Pre-B-cell leukemia transcription factor-interacting protein 1

3

0

High-throughput

0.347

High

845464

EVI5L
EVI5-like protein

3

0

High-throughput

0.347

High

845466

HOOK2
Protein Hook homolog 2

3

0

High-throughput

0.347

High

845467

SAAL1
Protein SAAL1

3

0

High-throughput

0.347

High

845470

DOCK7
Dedicator of cytokinesis protein 7

3

0

High-throughput

0.347

High

845426

RNPS1
RNA-binding protein with serine-rich domain 1

2

0

High-throughput

0.318

High

733838

CDD
Cytidine deaminase

1

0

High-throughput

0.299

High

845410

MEOX2
Homeobox protein MOX-2

1

0

High-throughput

0.299

High

845420

INCA1
Protein INCA1

1

0

High-throughput

0.299

High

845433

PR15B
Protein phosphatase 1 regulatory subunit 15B

2

0

High-throughput

0.288

High

845480

SMYD3
Histone-lysine N-methyltransferase SMYD3

1

0

High-throughput

0.279

Low

845493

MKLN1
Muskelin

1

0

Small-scale

0.275

Low

845430

MGT5B
Alpha-1,6-mannosylglycoprotein 6-beta-N-acetylglucosaminyltransferase B

1

0

High-throughput

0.251

Low

845456

CCD33
Coiled-coil domain-containing protein 33

1

0

High-throughput

0.251

Low

845417

UBP46
Ubiquitin carboxyl-terminal hydrolase 46

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025