Protein: HME1
Homeobox protein engrailed-1 (Homeobox protein en-1) (Hu-En-1)

Gene: HME1, EN1
Organism: Homo sapiens
Interactions: 109
UniProt ID: Q05925

Gene Ontology (top 5):
GO:0000122 - negative regulation of transcription by RNA polymerase II
GO:0000785 - chromatin
GO:0000978 - RNA polymerase II cis-regulatory region sequence-specific DNA binding
GO:0000981 - DNA-binding transcription factor activity, RNA polymerase II-specific
GO:0001227 - DNA-binding transcription repressor activity, RNA polymerase II-specific

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

980587

TLE1
Transducin-like enhancer protein 1

5

20

Small-scale

0.716

High

129973

MEIS1
Homeobox protein Meis1

1

20

High-throughput

0.691

High

773107

PBX2
Pre-B-cell leukemia transcription factor 2

1

20

High-throughput

0.691

High

773161

PBX3
Pre-B-cell leukemia transcription factor 3

1

20

High-throughput

0.691

High

641383

PAX6
Paired box protein Pax-6

1

20

Small-scale

0.647

High

985224

HMBX1
Homeobox-containing protein 1

1

19

High-throughput

0.646

High

980732

TLE3
Transducin-like enhancer protein 3

2

20

High-throughput

0.628

High

980926

TLE4
Transducin-like enhancer protein 4

2

20

High-throughput

0.628

High

985207

TLE5
TLE family member 5

2

20

High-throughput

0.628

High

764631

CUX1
Homeobox protein cut-like 1

1

10

High-throughput

0.618

High

985232

ZFHX4
Zinc finger homeobox protein 4

1

8

High-throughput

0.618

High

985234

MGAP
MAX gene-associated protein

1

19

High-throughput

0.618

High

301778

TRI37
E3 ubiquitin-protein ligase TRIM37

1

3

High-throughput

0.536

High

422503

CENPB
Major centromere autoantigen B

1

1

High-throughput

0.536

High

934120

CSK21
Casein kinase II subunit alpha

1

5

High-throughput

0.536

High

980676

TLE2
Transducin-like enhancer protein 2

1

20

High-throughput

0.536

High

985228

UBN2
Ubinuclein-2

1

15

High-throughput

0.536

High

985244

SIR1
NAD-dependent protein deacetylase sirtuin-1

1

7

High-throughput

0.536

High

985247

TOPK
Lymphokine-activated killer T-cell-originated protein kinase

1

1

High-throughput

0.536

High

985260

RNC
Ribonuclease 3

1

3

High-throughput

0.536

High

985267

FEM1B
Protein fem-1 homolog B

1

16

High-throughput

0.536

High

135109

NFIB
Nuclear factor 1 B-type

1

4

High-throughput

0.515

High

985209

NFIA
Nuclear factor 1 A-type

1

6

High-throughput

0.515

High

985251

NP1L3
Nucleosome assembly protein 1-like 3

1

0

High-throughput

0.513

High

985253

PSF3
DNA replication complex GINS protein PSF3

1

0

High-throughput

0.513

High

985264

E2AK4
eIF-2-alpha kinase GCN2

1

0

High-throughput

0.513

High

985273

ARI1
E3 ubiquitin-protein ligase ARIH1

1

0

High-throughput

0.513

High

958885

TFAM
Transcription factor A, mitochondrial

1

18

High-throughput

0.500

High

985269

SRRM2
Serine/arginine repetitive matrix protein 2

1

9

High-throughput

0.500

High

216500

SAHH2
S-adenosylhomocysteine hydrolase-like protein 1

1

3

High-throughput

0.489

High

826448

FNTB
Protein farnesyltransferase subunit beta

1

1

High-throughput

0.489

High

985212

SCRIB
Protein scribble homolog

1

4

High-throughput

0.489

High

985235

ANKH1
Ankyrin repeat and KH domain-containing protein 1

1

15

High-throughput

0.489

High

985245

SAHH3
Adenosylhomocysteinase 3

1

3

High-throughput

0.489

High

651020

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.479

High

981216

SSBP
Single-stranded DNA-binding protein, mitochondrial

1

0

High-throughput

0.479

High

985231

DHX30
ATP-dependent RNA helicase DHX30

1

0

High-throughput

0.479

High

152633

KMT2D
Histone-lysine N-methyltransferase 2D

1

12

High-throughput

0.479

High

164217

ZN609
Zinc finger protein 609

1

6

High-throughput

0.479

High

167152

ZN536
Zinc finger protein 536

1

5

High-throughput

0.479

High

183107

KDM6A
Lysine-specific demethylase 6A

1

3

High-throughput

0.479

High

231228

ZEB2
Zinc finger E-box-binding homeobox 2

1

5

High-throughput

0.479

High

245592

TBL1X
F-box-like/WD repeat-containing protein TBL1X

1

2

High-throughput

0.479

High

261477

NCOR1
Nuclear receptor corepressor 1

1

11

High-throughput

0.479

High

321761

WIZ
Protein Wiz

1

1

High-throughput

0.479

High

443173

NFIC
Nuclear factor 1 C-type

1

7

High-throughput

0.479

High

473500

ATX1L
Ataxin-1-like

1

4

High-throughput

0.479

High

550372

ZEP1
Zinc finger protein 40

1

2

High-throughput

0.479

High

575395

EGR1
Early growth response protein 1

1

3

High-throughput

0.479

High

741032

ZEB1
Zinc finger E-box-binding homeobox 1

1

6

High-throughput

0.479

High

830933

CTCF
Transcriptional repressor CTCF

1

2

High-throughput

0.479

High

868445

ATX1
Ataxin-1

1

4

High-throughput

0.479

High

975229

KMT2A
Histone-lysine N-methyltransferase 2A

1

11

High-throughput

0.479

High

985206

RING1
E3 ubiquitin-protein ligase RING1

1

4

High-throughput

0.479

High

985208

EP300
Histone acetyltransferase p300

1

16

High-throughput

0.479

High

985210

FOXC1
Forkhead box protein C1

1

20

High-throughput

0.479

High

985211

PWP1
Periodic tryptophan protein 1 homolog

1

2

High-throughput

0.479

High

985213

SMC1A
Structural maintenance of chromosomes protein 1A

1

1

High-throughput

0.479

High

985218

ARI4B
AT-rich interactive domain-containing protein 4B

1

12

High-throughput

0.479

High

985220

RIF1
Telomere-associated protein RIF1

1

1

High-throughput

0.479

High

985223

NIPBL
Nipped-B-like protein

1

6

High-throughput

0.479

High

985226

MDEAS
Mitotic deacetylase-associated SANT domain protein

1

4

High-throughput

0.479

High

985227

BCOR
BCL-6 corepressor

1

17

High-throughput

0.479

High

985229

PAXI1
PAX-interacting protein 1

1

4

High-throughput

0.479

High

985230

ASXL2
Putative Polycomb group protein ASXL2

1

3

High-throughput

0.479

High

985233

ARI3B
AT-rich interactive domain-containing protein 3B

1

10

High-throughput

0.479

High

985236

YAF2
YY1-associated factor 2

1

1

High-throughput

0.479

High

985237

RYBP
RING1 and YY1-binding protein

1

1

High-throughput

0.479

High

985239

KMT2C
Histone-lysine N-methyltransferase 2C

1

13

High-throughput

0.479

High

985240

KDM2B
Lysine-specific demethylase 2B

1

1

High-throughput

0.479

High

985241

MORC4
MORC family CW-type zinc finger protein 4

1

1

High-throughput

0.479

High

985243

ZBTB9
Zinc finger and BTB domain-containing protein 9

1

3

High-throughput

0.479

High

985249

CIC
Protein capicua homolog

1

20

High-throughput

0.479

High

985252

ARI3A
AT-rich interactive domain-containing protein 3A

1

10

High-throughput

0.479

High

985254

PCGF1
Polycomb group RING finger protein 1

1

4

High-throughput

0.479

High

985256

GTPB4
GTP-binding protein 4

1

3

High-throughput

0.479

High

985257

SP130
Histone deacetylase complex subunit SAP130

1

6

High-throughput

0.479

High

985263

CHD7
Chromodomain-helicase-DNA-binding protein 7

1

1

High-throughput

0.479

High

985265

TRPS1
Zinc finger transcription factor Trps1

1

11

High-throughput

0.479

High

985268

ZN608
Zinc finger protein 608

1

3

High-throughput

0.479

High

985270

SMC3
Structural maintenance of chromosomes protein 3

1

1

High-throughput

0.479

High

985271

ZN148
Zinc finger protein 148

1

1

High-throughput

0.479

High

985274

NCOR2
Nuclear receptor corepressor 2

1

12

High-throughput

0.479

High

836211

TAF6
Transcription initiation factor TFIID subunit 6

1

0

High-throughput

0.458

High

900136

RL37A
Large ribosomal subunit protein eL43

1

0

High-throughput

0.458

High

912432

SMD2
Small nuclear ribonucleoprotein Sm D2

1

0

High-throughput

0.458

High

985215

TAF9
Transcription initiation factor TFIID subunit 9

1

0

High-throughput

0.458

High

985217

ZN260
Zinc finger protein 260

1

0

High-throughput

0.458

High

985219

BRM1L
Breast cancer metastasis-suppressor 1-like protein

1

0

High-throughput

0.458

High

985238

ZN709
Zinc finger protein 709

1

0

High-throughput

0.458

High

985242

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

985258

SHCAF
SIN3-HDAC complex-associated factor

1

0

High-throughput

0.458

High

985266

DACH1
Dachshund homolog 1

1

0

High-throughput

0.458

High

985216

QSER1
Glutamine and serine-rich protein 1

1

15

High-throughput

0.437

High

985248

EP400
E1A-binding protein p400

1

4

High-throughput

0.437

High

840944

MAP2
Methionine aminopeptidase 2

1

0

High-throughput

0.279

Low

985221

2ABD
Serine/threonine-protein phosphatase 2A 55 kDa regulatory subunit B delta isoform

1

0

High-throughput

0.279

Low

985222

UTP25
U3 small nucleolar RNA-associated protein 25 homolog

1

0

High-throughput

0.279

Low

985246

DCAF5
DDB1- and CUL4-associated factor 5

1

0

High-throughput

0.279

Low

985255

THUM3
tRNA

1

0

High-throughput

0.279

Low

985259

SSU72
RNA polymerase II subunit A C-terminal domain phosphatase SSU72

1

0

High-throughput

0.279

Low

985261

ATG3
Ubiquitin-like-conjugating enzyme ATG3

1

0

High-throughput

0.279

Low

985262

DCA16
DDB1- and CUL4-associated factor 16

1

0

High-throughput

0.279

Low

838785

EMD
Emerin

1

0

High-throughput

0.261

Low

985250

PEO1
Twinkle mtDNA helicase

1

0

High-throughput

0.261

Low

603149

PIMT
Protein-L-isoaspartate(D-aspartate) O-methyltransferase

1

0

High-throughput

0.249

Low

985214

GSE1
Genetic suppressor element 1

1

0

High-throughput

0.249

Low

985225

MSD2
Myb/SANT-like DNA-binding domain-containing protein 2

1

0

High-throughput

0.249

Low

985272

RT17
Small ribosomal subunit protein uS17m

1

0

High-throughput

0.249

Low


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Last updated: 15 Jul 2024