Protein: ISK5
Serine protease inhibitor Kazal-type 5 (Lympho-epithelial Kazal-type-related inhibitor) (LEKTI) [Cleaved into: Hemofiltrate peptide HF6478; Hemofiltrate peptide HF7665]

Gene: ISK5, SPINK5
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q9NQ38

Gene Ontology (top 5):
GO:0002787 - negative regulation of antibacterial peptide production
GO:0004867 - serine-type endopeptidase inhibitor activity
GO:0005576 - extracellular region
GO:0005737 - cytoplasm
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1446735

KLK14
Kallikrein-14

2

8

Small-scale

0.754

High

1446737

KLK5
Kallikrein-5

2

7

Small-scale

0.754

High

1087082

FSTL1
Follistatin-related protein 1

1

6

High-throughput

0.691

High

1367805

TFG
Protein TFG

3

1

High-throughput

0.667

High

469838

CATG
Cathepsin G

1

13

Small-scale

0.618

High

892137

KLK7
Kallikrein-7

1

9

Small-scale

0.618

High

1446736

KLK13
Kallikrein-13

1

10

Small-scale

0.618

High

488872

FURIN
Furin

1

1

Small-scale

0.575

High

370787

FOS
Protein c-Fos

1

3

High-throughput

0.536

High

733443

CCR1
C-C chemokine receptor type 1

1

2

High-throughput

0.536

High

1309825

TEX14
Inactive serine/threonine-protein kinase TEX14

1

5

High-throughput

0.536

High

1351828

CGAT1
Chondroitin sulfate N-acetylgalactosaminyltransferase 1

1

0

High-throughput

0.513

High

390192

ALBU
Albumin

1

1

High-throughput

0.479

High

773036

MYH9
Myosin-9

1

5

High-throughput

0.479

High

872771

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.479

High

1398516

ZDH15
Palmitoyltransferase ZDHHC15

1

4

Small-scale

0.479

High

1010721

DCD
Dermcidin

1

0

Small-scale

0.458

High

729619

CASPE
Caspase-14

1

3

Small-scale

0.445

High

1227510

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.445

High

1249444

OLFM4
Olfactomedin-4

1

6

High-throughput

0.445

High

1241805

PRP8
Pre-mRNA-processing-splicing factor 8

1

1

High-throughput

0.437

High

261285

NSMA
Sphingomyelin phosphodiesterase 2

1

0

High-throughput

0.426

High

1358241

SKA2
Spindle and kinetochore-associated protein 2

1

0

High-throughput

0.426

High

1413253

SYT11
Synaptotagmin-11

1

1

High-throughput

0.407

High

1287736

ISCA2
Iron-sulfur cluster assembly 2 homolog, mitochondrial

1

0

High-throughput

0.279

Low

1330608

PLD5
Inactive phospholipase D5

1

0

High-throughput

0.279

Low

1357570

DCAF4
DDB1- and CUL4-associated factor 4

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025