Protein: FURIN
Furin (EC 3.4.21.75) (Dibasic-processing enzyme) (Paired basic amino acid residue-cleaving enzyme) (PACE)

Gene: FURIN
Organism: Homo sapiens
Interactions: 240
UniProt ID: P09958

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0001825 - blastocyst formation
GO:0002020 - protease binding
GO:0002862 - negative regulation of inflammatory response to antigenic stimulus
GO:0004175 - endopeptidase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

488723

PTPRD
Receptor-type tyrosine-protein phosphatase delta

1

2

High-throughput

0.691

High

488706

FURIN
Furin

1

13

High-throughput

0.665

High

488747

MMP14
Matrix metalloproteinase-14

3

2

Small-scale

0.650

High

488827

PXYP1
2-phosphoxylose phosphatase 1

3

0

High-throughput

0.638

High

425162

IPSP
Plasma serine protease inhibitor

2

3

High-throughput

0.628

High

488758

FCGRN
IgG receptor FcRn large subunit p51

2

4

High-throughput

0.628

High

488893

FND3A
Fibronectin type-III domain-containing protein 3A

1

2

High-throughput

0.618

High

488742

5HT3A
5-hydroxytryptamine receptor 3A

2

0

High-throughput

0.602

High

488728

BASI
Basigin

2

1

High-throughput

0.584

High

488872

ISK5
Serine protease inhibitor Kazal-type 5

1

1

Small-scale

0.575

High

164757

GDF8
Growth/differentiation factor 8

2

3

Small-scale

0.552

High

488756

SNAA
Alpha-soluble NSF attachment protein

1

0

Small-scale

0.549

High

450163

GDN
Glia-derived nexin

1

4

High-throughput

0.536

High

488722

LSHR
Lutropin-choriogonadotropic hormone receptor

1

1

High-throughput

0.536

High

488731

BMR1A
Bone morphogenetic protein receptor type-1A

1

1

High-throughput

0.536

High

488776

ATP7A
Copper-transporting ATPase 1

1

1

High-throughput

0.536

High

488778

S20A2
Sodium-dependent phosphate transporter 2

1

1

High-throughput

0.536

High

488800

PRSS8
Prostasin

1

1

High-throughput

0.536

High

488811

BRID5
BRICHOS domain-containing protein 5

1

1

High-throughput

0.536

High

488815

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

2

High-throughput

0.536

High

488834

T106A
Transmembrane protein 106A

1

1

High-throughput

0.536

High

488837

SGTB
Small glutamine-rich tetratricopeptide repeat-containing protein beta

1

5

High-throughput

0.536

High

488846

NEUS
Neuroserpin

1

4

High-throughput

0.536

High

488867

RISC
Retinoid-inducible serine carboxypeptidase

1

1

High-throughput

0.536

High

488901

ORNT1
Mitochondrial ornithine transporter 1

1

4

High-throughput

0.536

High

129963

PGRC1
Membrane-associated progesterone receptor component 1

1

1

High-throughput

0.515

High

413057

P53
Cellular tumor antigen p53

1

1

High-throughput

0.515

High

488716

PFKAL
ATP-dependent 6-phosphofructokinase, liver type

1

1

High-throughput

0.515

High

488740

VDAC2
Non-selective voltage-gated ion channel VDAC2

1

1

High-throughput

0.515

High

488749

SERPH
Serpin H1

1

5

High-throughput

0.515

High

488760

RAB10
Ras-related protein Rab-10

1

2

High-throughput

0.515

High

488774

PFKAP
ATP-dependent 6-phosphofructokinase, platelet type

1

1

High-throughput

0.515

High

488862

MMP28
Matrix metalloproteinase-28

1

2

Small-scale

0.515

High

488883

DJB11
DnaJ homolog subfamily B member 11

1

4

High-throughput

0.515

High

488886

S2513
Electrogenic aspartate/glutamate antiporter SLC25A13, mitochondrial

1

4

High-throughput

0.515

High

421368

A4
Amyloid-beta precursor protein

1

1

High-throughput

0.515

High

48498

ESYT2
Extended synaptotagmin-2

1

0

High-throughput

0.513

High

62891

POTEF
POTE ankyrin domain family member F

1

0

High-throughput

0.513

High

322693

RHBT3
Rho-related BTB domain-containing protein 3

1

0

High-throughput

0.513

High

488743

BAG6
Large proline-rich protein BAG6

1

0

High-throughput

0.513

High

488769

SMAD3
Mothers against decapentaplegic homolog 3

1

0

High-throughput

0.513

High

488821

NRSN1
Neurensin-1

1

0

High-throughput

0.513

High

488822

WDFY3
WD repeat and FYVE domain-containing protein 3

1

0

High-throughput

0.513

High

488830

ELYS
Protein ELYS

1

0

High-throughput

0.513

High

488831

LGAT1
Acyl-CoA:lysophosphatidylglycerol acyltransferase 1

1

0

High-throughput

0.513

High

488868

S38AA
Solute carrier family 38 member 10

1

0

High-throughput

0.513

High

488889

KDIS
Kinase D-interacting substrate of 220 kDa

1

0

High-throughput

0.513

High

488895

MAN1
Inner nuclear membrane protein Man1

1

0

High-throughput

0.513

High

488748

SPB8
Serpin B8

1

3

Small-scale

0.501

High

488836

AP2M1
AP-2 complex subunit mu

1

1

Small-scale

0.501

High

299918

CBPD
Carboxypeptidase D

1

0

High-throughput

0.493

High

321158

ERLN2
Erlin-2

1

0

High-throughput

0.493

High

488745

K2C6C
Keratin, type II cytoskeletal 6C

1

0

High-throughput

0.493

High

488753

HNRPM
Heterogeneous nuclear ribonucleoprotein M

1

0

High-throughput

0.493

High

488804

DHB12
Very-long-chain 3-oxoacyl-CoA reductase

1

0

High-throughput

0.493

High

488802

CL12B
C-type lectin domain family 12 member B

1

2

High-throughput

0.489

High

488873

HELLS
Lymphoid-specific helicase

1

1

High-throughput

0.489

High

488881

RAI14
Ankycorbin

1

2

High-throughput

0.489

High

332075

MRP6
ATP-binding cassette sub-family C member 6

1

1

High-throughput

0.481

High

123564

MYO1C
Unconventional myosin-Ic

1

2

High-throughput

0.479

High

217746

TGON2
Trans-Golgi network integral membrane protein 2

1

2

High-throughput

0.479

High

224591

ACTN4
Alpha-actinin-4

1

2

High-throughput

0.479

High

227773

MYO1B
Unconventional myosin-Ib

1

2

High-throughput

0.479

High

318245

MYO1D
Unconventional myosin-Id

1

2

High-throughput

0.479

High

323656

AP2A2
AP-2 complex subunit alpha-2

1

2

High-throughput

0.479

High

323824

SC31A
Protein transport protein Sec31A

1

4

High-throughput

0.479

High

338279

SC24A
Protein transport protein Sec24A

1

3

High-throughput

0.479

High

344608

AP2A1
AP-2 complex subunit alpha-1

1

2

High-throughput

0.479

High

409229

HLAA
HLA class I histocompatibility antigen, A alpha chain

1

3

High-throughput

0.479

High

418574

GNAI2
Guanine nucleotide-binding protein G(i) subunit alpha-2

1

2

High-throughput

0.479

High

424737

ADT2
ADP/ATP translocase 2

1

4

High-throughput

0.479

High

447649

TPM3
Tropomyosin alpha-3 chain

1

3

High-throughput

0.479

High

475877

GNAI3
Guanine nucleotide-binding protein G(i) subunit alpha-3

1

2

High-throughput

0.479

High

488707

HLAC
HLA class I histocompatibility antigen, C alpha chain

1

3

High-throughput

0.479

High

488709

SPTB1
Spectrin beta chain, erythrocytic

1

3

High-throughput

0.479

High

488710

ADT3
ADP/ATP translocase 3

1

4

High-throughput

0.479

High

488711

ACTN1
Alpha-actinin-1

1

2

High-throughput

0.479

High

488712

XRCC6
X-ray repair cross-complementing protein 6

1

1

High-throughput

0.479

High

488713

XRCC5
X-ray repair cross-complementing protein 5

1

1

High-throughput

0.479

High

488715

ENPL
Endoplasmin

1

5

High-throughput

0.479

High

488717

ARF4
ADP-ribosylation factor 4

1

1

High-throughput

0.479

High

488720

RAB6A
Ras-related protein Rab-6A

1

2

High-throughput

0.479

High

488730

LONM
Lon protease homolog, mitochondrial

1

1

High-throughput

0.479

High

488734

IF2G
Eukaryotic translation initiation factor 2 subunit 3

1

1

High-throughput

0.479

High

488738

LIS1
Platelet-activating factor acetylhydrolase IB subunit beta

1

1

High-throughput

0.479

High

488750

RAB5C
Ras-related protein Rab-5C

1

2

High-throughput

0.479

High

488751

RAB7A
Ras-related protein Rab-7a

1

3

High-throughput

0.479

High

488757

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

1

High-throughput

0.479

High

488759

RAB8A
Ras-related protein Rab-8A

1

2

High-throughput

0.479

High

488761

ABCE1
ATP-binding cassette sub-family E member 1

1

1

High-throughput

0.479

High

488764

GBB2
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-2

1

1

High-throughput

0.479

High

488765

AP2B1
AP-2 complex subunit beta

1

2

High-throughput

0.479

High

488766

GNAI1
Guanine nucleotide-binding protein G(i) subunit alpha-1

1

2

High-throughput

0.479

High

488767

TPM4
Tropomyosin alpha-4 chain

1

3

High-throughput

0.479

High

488771

S25A3
Solute carrier family 25 member 3

1

5

High-throughput

0.479

High

488772

DHSO
Sorbitol dehydrogenase

1

1

High-throughput

0.479

High

488773

LAT1
Large neutral amino acids transporter small subunit 1

1

3

High-throughput

0.479

High

488775

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

7

High-throughput

0.479

High

488785

GOGA4
Golgin subfamily A member 4

1

1

High-throughput

0.479

High

488786

CUL3
Cullin-3

1

2

High-throughput

0.479

High

488787

SPTN1
Spectrin alpha chain, non-erythrocytic 1

1

4

High-throughput

0.479

High

488788

SAFB2
Scaffold attachment factor B2

1

1

High-throughput

0.479

High

488790

GOGB1
Golgin subfamily B member 1

1

2

High-throughput

0.479

High

488791

RB39A
Ras-related protein Rab-39A

1

2

High-throughput

0.479

High

488795

RCN1
Reticulocalbin-1

1

1

High-throughput

0.479

High

488797

SC23A
Protein transport protein Sec23A

1

3

High-throughput

0.479

High

488798

SC23B
Protein transport protein Sec23B

1

3

High-throughput

0.479

High

488799

TRIPB
Thyroid receptor-interacting protein 11

1

2

High-throughput

0.479

High

488818

GCC2
GRIP and coiled-coil domain-containing protein 2

1

2

High-throughput

0.479

High

488819

MIRO1
Mitochondrial Rho GTPase 1

1

3

High-throughput

0.479

High

488824

ARFG2
ADP-ribosylation factor GTPase-activating protein 2

1

2

High-throughput

0.479

High

488848

AIF1L
Allograft inflammatory factor 1-like

1

1

High-throughput

0.479

High

488851

TBB6
Tubulin beta-6 chain

1

2

High-throughput

0.479

High

488855

AP1M1
AP-1 complex subunit mu-1

1

1

High-throughput

0.479

High

488859

LSG1
Large subunit GTPase 1 homolog

1

1

High-throughput

0.479

High

488861

RAB1B
Ras-related protein Rab-1B

1

1

High-throughput

0.479

High

488871

ARFG3
ADP-ribosylation factor GTPase-activating protein 3

1

2

High-throughput

0.479

High

488878

DDX56
Probable ATP-dependent RNA helicase DDX56

1

1

High-throughput

0.479

High

488888

ACINU
Apoptotic chromatin condensation inducer in the nucleus

1

1

High-throughput

0.479

High

488898

HYOU1
Hypoxia up-regulated protein 1

1

1

High-throughput

0.479

High

488796

SAFB1
Scaffold attachment factor B1

1

1

High-throughput

0.470

High

488816

YTHD3
YTH domain-containing family protein 3

1

3

High-throughput

0.470

High

488899

YTHD2
YTH domain-containing family protein 2

1

3

High-throughput

0.470

High

133927

IPO5
Importin-5

1

0

High-throughput

0.458

High

179446

ARPC3
Actin-related protein 2/3 complex subunit 3

1

0

High-throughput

0.458

High

228431

LANC1
Glutathione S-transferase LANCL1

1

0

High-throughput

0.458

High

339407

ACSL3
Fatty acid CoA ligase Acsl3

1

0

High-throughput

0.458

High

389697

FETUA
Alpha-2-HS-glycoprotein

1

0

High-throughput

0.458

High

417223

RPN1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

0

High-throughput

0.458

High

417902

RPN2
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 2

1

0

High-throughput

0.458

High

420314

AT1A1
Sodium/potassium-transporting ATPase subunit alpha-1

1

0

High-throughput

0.458

High

426183

IF2A
Eukaryotic translation initiation factor 2 subunit 1

1

0

High-throughput

0.458

High

470816

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

0

High-throughput

0.458

High

488708

CLUS
Clusterin

1

0

High-throughput

0.458

High

488714

P4HA1
Prolyl 4-hydroxylase subunit alpha-1

1

0

High-throughput

0.458

High

488719

HXK1
Hexokinase-1

1

0

High-throughput

0.458

High

488721

MSH3
DNA mismatch repair protein Msh3

1

0

High-throughput

0.458

High

488725

PRDX6
Peroxiredoxin-6

1

0

High-throughput

0.458

High

488727

KCY
UMP-CMP kinase

1

0

High-throughput

0.458

High

488732

OST48
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunit

1

0

High-throughput

0.458

High

488739

NAMPT
Nicotinamide phosphoribosyltransferase

1

0

High-throughput

0.458

High

488755

AT1B3
Sodium/potassium-transporting ATPase subunit beta-3

1

0

High-throughput

0.458

High

488762

S61A1
Protein transport protein Sec61 subunit alpha isoform 1

1

0

High-throughput

0.458

High

488763

CNBP
CCHC-type zinc finger nucleic acid binding protein

1

0

High-throughput

0.458

High

488768

PRKDC
DNA-dependent protein kinase catalytic subunit

1

0

High-throughput

0.458

High

488779

GOGA3
Golgin subfamily A member 3

1

0

High-throughput

0.458

High

488780

GOGA2
Golgin subfamily A member 2

1

0

High-throughput

0.458

High

488789

FGFP1
Fibroblast growth factor-binding protein 1

1

0

High-throughput

0.458

High

488792

SYK
Lysine--tRNA ligase

1

0

High-throughput

0.458

High

488793

PON2
Serum paraoxonase/arylesterase 2

1

0

High-throughput

0.458

High

488794

IPYR
Inorganic pyrophosphatase

1

0

High-throughput

0.458

High

488801

MIC60
MICOS complex subunit MIC60

1

0

High-throughput

0.458

High

488807

UBR4
E3 ubiquitin-protein ligase UBR4

1

0

High-throughput

0.458

High

488814

RIR2B
Ribonucleoside-diphosphate reductase subunit M2 B

1

0

High-throughput

0.458

High

488825

PDZD8
PDZ domain-containing protein 8

1

0

High-throughput

0.458

High

488826

NUP35
Nucleoporin NUP35

1

0

High-throughput

0.458

High

488835

SYAP1
Synapse-associated protein 1

1

0

High-throughput

0.458

High

488839

CK5P3
CDK5 regulatory subunit-associated protein 3

1

0

High-throughput

0.458

High

488844

CLCC1
Chloride channel CLIC-like protein 1

1

0

High-throughput

0.458

High

488849

NTPCR
Cancer-related nucleoside-triphosphatase

1

0

High-throughput

0.458

High

488850

ALG1
Chitobiosyldiphosphodolichol beta-mannosyltransferase

1

0

High-throughput

0.458

High

488860

DDX47
Probable ATP-dependent RNA helicase DDX47

1

0

High-throughput

0.458

High

488863

SPNS1
Protein spinster homolog 1

1

0

High-throughput

0.458

High

488864

GCP60
Golgi resident protein GCP60

1

0

High-throughput

0.458

High

488865

GORS2
Golgi reassembly-stacking protein 2

1

0

High-throughput

0.458

High

488869

GOPC
Golgi-associated PDZ and coiled-coil motif-containing protein

1

0

High-throughput

0.458

High

488870

TM9S3
Transmembrane 9 superfamily member 3

1

0

High-throughput

0.458

High

488876

MIC19
MICOS complex subunit MIC19

1

0

High-throughput

0.458

High

488877

NSMA3
Sphingomyelin phosphodiesterase 4

1

0

High-throughput

0.458

High

488880

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.458

High

488890

MYO6
Unconventional myosin-VI

1

0

High-throughput

0.458

High

488735

EAA1
Excitatory amino acid transporter 1

1

3

High-throughput

0.445

High

488736

EAA2
Excitatory amino acid transporter 2

1

3

High-throughput

0.445

High

488737

EAA3
Excitatory amino acid transporter 3

1

3

High-throughput

0.445

High

488777

RON
Macrophage-stimulating protein receptor

1

3

Small-scale

0.445

High

488803

S39AC
Zinc transporter ZIP12

1

4

High-throughput

0.445

High

488823

S39AB
Zinc transporter ZIP11

1

4

High-throughput

0.445

High

488853

S12A9
Solute carrier family 12 member 9

1

2

High-throughput

0.445

High

488858

S13A1
Solute carrier family 13 member 1

1

1

High-throughput

0.445

High

488885

LAT2
Large neutral amino acids transporter small subunit 2

1

3

High-throughput

0.445

High

296424

STAM2
Signal transducing adapter molecule 2

1

4

High-throughput

0.437

High

338407

SC24B
Protein transport protein Sec24B

1

3

High-throughput

0.437

High

482819

TPM1
Tropomyosin alpha-1 chain

1

3

High-throughput

0.437

High

488724

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

1

High-throughput

0.437

High

488729

DEK
Protein DEK

1

1

High-throughput

0.437

High

488733

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

3

High-throughput

0.437

High

488741

CBX5
Chromobox protein homolog 5

1

1

High-throughput

0.437

High

488744

SYQ
Glutamine--tRNA ligase

1

1

High-throughput

0.437

High

488782

CAF1B
Chromatin assembly factor 1 subunit B

1

2

High-throughput

0.437

High

488806

RABL3
Rab-like protein 3

1

3

High-throughput

0.437

High

488817

PABP2
Polyadenylate-binding protein 2

1

1

High-throughput

0.437

High

488829

SMAP2
Stromal membrane-associated protein 2

1

2

High-throughput

0.437

High

488832

TFG
Protein TFG

1

2

High-throughput

0.437

High

488833

STAM1
Signal transducing adapter molecule 1

1

3

High-throughput

0.437

High

488838

DNJA3
DnaJ homolog subfamily A member 3, mitochondrial

1

4

High-throughput

0.437

High

488842

RBM14
RNA-binding protein 14

1

1

High-throughput

0.437

High

488852

RBM4
RNA-binding protein 4

1

1

High-throughput

0.437

High

488857

YTHD1
YTH domain-containing family protein 1

1

2

High-throughput

0.437

High

488866

WDR41
WD repeat-containing protein 41

1

1

High-throughput

0.437

High

488882

SAE1
SUMO-activating enzyme subunit 1

1

1

High-throughput

0.437

High

488884

SAE2
SUMO-activating enzyme subunit 2

1

1

High-throughput

0.437

High

488891

SNX6
Sorting nexin-6

1

1

High-throughput

0.437

High

139172

UPK2
Uroplakin-2

1

0

High-throughput

0.426

High

488874

S22AB
Solute carrier family 22 member 11

1

0

High-throughput

0.426

High

332278

ATE1
Arginyl-tRNA--protein transferase 1

2

0

High-throughput

0.324

High

488813

MPRIP
Myosin phosphatase Rho-interacting protein

1

0

High-throughput

0.279

Low

488843

PP1RA
Serine/threonine-protein phosphatase 1 regulatory subunit 10

1

0

High-throughput

0.279

Low

488847

CDC6
Cell division control protein 6 homolog

1

0

High-throughput

0.279

Low

488892

ZC3H4
Zinc finger CCCH domain-containing protein 4

1

0

High-throughput

0.279

Low

488896

CIA30
Complex I intermediate-associated protein 30, mitochondrial

1

0

High-throughput

0.279

Low

488812

PACS1
Phosphofurin acidic cluster sorting protein 1

1

0

Small-scale

0.275

Low

488781

SSRP1
FACT complex subunit SSRP1

1

0

High-throughput

0.269

Low

137626

NDUA4
Cytochrome c oxidase subunit NDUFA4

1

0

High-throughput

0.249

Low

285569

BAF
Barrier-to-autointegration factor

1

0

High-throughput

0.249

Low

488718

XRCC1
DNA repair protein XRCC1

1

0

High-throughput

0.249

Low

488726

ATPD
ATP synthase F(1) complex subunit delta, mitochondrial

1

0

High-throughput

0.249

Low

488746

DNLI3
DNA ligase 3

1

0

High-throughput

0.249

Low

488752

ZNF80
Zinc finger protein 80

1

0

High-throughput

0.249

Low

488754

SYYC
Tyrosine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.249

Low

488770

TFAM
Transcription factor A, mitochondrial

1

0

High-throughput

0.249

Low

488783

ROA0
Heterogeneous nuclear ribonucleoprotein A0

1

0

High-throughput

0.249

Low

488784

CTBP1
C-terminal-binding protein 1

1

0

High-throughput

0.249

Low

488805

ZN326
DBIRD complex subunit ZNF326

1

0

High-throughput

0.249

Low

488809

RM14
Large ribosomal subunit protein uL14m

1

0

High-throughput

0.249

Low

488810

SFXN4
Sideroflexin-4

1

0

High-throughput

0.249

Low

488820

M21D2
Nucleotidyltransferase MB21D2

1

0

High-throughput

0.249

Low

488828

SMCR8
Guanine nucleotide exchange protein SMCR8

1

0

High-throughput

0.249

Low

488840

ZFR
Zinc finger RNA-binding protein

1

0

High-throughput

0.249

Low

488841

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.249

Low

488845

RBM15
RNA-binding protein 15

1

0

High-throughput

0.249

Low

488854

SRRT
Serrate RNA effector molecule homolog

1

0

High-throughput

0.249

Low

488856

PDIP3
Polymerase delta-interacting protein 3

1

0

High-throughput

0.249

Low

488875

RM16
Large ribosomal subunit protein uL16m

1

0

High-throughput

0.249

Low

488879

TMOD3
Tropomodulin-3

1

0

High-throughput

0.249

Low

488887

MRT4
mRNA turnover protein 4 homolog

1

0

High-throughput

0.249

Low

488894

TPPC8
Trafficking protein particle complex subunit 8

1

0

High-throughput

0.249

Low

488897

NOC2L
Nucleolar complex protein 2 homolog

1

0

High-throughput

0.249

Low

488900

SP16H
FACT complex subunit SPT16

1

0

High-throughput

0.249

Low

488808

PRAM5
PRAME family member 5

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025