Protein: SETD6
N-lysine methyltransferase SETD6 (EC 2.1.1.-) (SET domain-containing protein 6)

Gene: SETD6
Organism: Homo sapiens
Interactions: 21
UniProt ID: Q8TBK2

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005829 - cytosol
GO:0016279 - protein-lysine N-methyltransferase activity
GO:0018026 - peptidyl-lysine monomethylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1045552

TF65
Transcription factor p65

2

0

Small-scale

0.633

High

1348912

SETD6
N-lysine methyltransferase SETD6

1

1

Small-scale

0.625

High

276379

LIPA2
Liprin-alpha-2

1

1

High-throughput

0.536

High

927440

ATX1
Ataxin-1

1

0

High-throughput

0.518

High

1348918

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.513

High

1348915

RL36L
Ribosomal protein eL42-like

1

1

High-throughput

0.479

High

317463

GFPT2
Glutamine--fructose-6-phosphate aminotransferase [isomerizing] 2

1

1

High-throughput

0.445

High

1106214

MYO9B
Unconventional myosin-IXb

1

2

High-throughput

0.445

High

1238171

RHBD2
Rhomboid domain-containing protein 2

1

1

High-throughput

0.445

High

341260

ASML
Probable bifunctional dTTP/UTP pyrophosphatase/methyltransferase protein [Includes: dTTP/UTP pyrophosphatase

1

0

High-throughput

0.426

High

1219166

LYPL1
Lysophospholipase-like protein 1

1

0

High-throughput

0.426

High

1348916

SYFA
Phenylalanine--tRNA ligase alpha subunit

1

0

High-throughput

0.426

High

1348917

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.426

High

593600

GDC
Solute carrier family 25 member 16

1

0

High-throughput

0.232

Low

894479

PPOX
Protoporphyrinogen oxidase

1

0

High-throughput

0.232

Low

1245098

RHDF2
Inactive rhomboid protein 2

1

0

High-throughput

0.232

Low

1249469

DHR13
Dehydrogenase/reductase SDR family member 13

1

0

High-throughput

0.232

Low

1331311

S2529
Mitochondrial basic amino acids transporter

1

0

High-throughput

0.232

Low

1348913

TLC3A
TLC domain-containing protein 3A

1

0

High-throughput

0.232

Low

1348914

PMGT1
Protein O-linked-mannose beta-1,2-N-acetylglucosaminyltransferase 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025