Protein: PP6R1
Serine/threonine-protein phosphatase 6 regulatory subunit 1 (SAPS domain family member 1)

Gene: PP6R1, PPP6R1
Organism: Homo sapiens
Interactions: 160
UniProt ID: Q9UPN7

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005829 - cytosol
GO:0019888 - protein phosphatase regulator activity
GO:0019903 - protein phosphatase binding
GO:0031267 - small GTPase binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

135515

PPP6
Serine/threonine-protein phosphatase 6 catalytic subunit

10

8

Small-scale

0.758

High

1058321

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

4

7

High-throughput

0.694

High

167044

ANR28
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit A

3

9

Small-scale

0.675

High

1237562

ANR44
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit B

6

9

Small-scale

0.672

High

1239519

ANR52
Serine/threonine-protein phosphatase 6 regulatory ankyrin repeat subunit C

3

9

Small-scale

0.667

High

1224082

TRM2A
tRNA

2

2

High-throughput

0.628

High

1306182

NPAS1
Neuronal PAS domain-containing protein 1

2

4

High-throughput

0.628

High

1185505

MOB1B
MOB kinase activator 1B

2

8

High-throughput

0.621

High

1273302

ARHG2
Rho guanine nucleotide exchange factor 2

2

3

Small-scale

0.621

High

861983

PLK1
Serine/threonine-protein kinase PLK1

2

11

High-throughput

0.611

High

1126062

PP6R3
Serine/threonine-protein phosphatase 6 regulatory subunit 3

2

6

High-throughput

0.611

High

1233350

PNKD
Probable hydrolase PNKD

2

1

High-throughput

0.611

High

533108

PRG2
Bone marrow proteoglycan

3

2

High-throughput

0.609

High

1302151

DCR1C
Protein artemis

3

1

High-throughput

0.599

High

504966

HSP7C
Heat shock cognate 71 kDa protein

2

2

High-throughput

0.588

High

121602

IKBE
NF-kappa-B inhibitor epsilon

2

14

Small-scale

0.584

High

836095

GSK3B
Glycogen synthase kinase-3 beta

2

10

High-throughput

0.584

High

1146965

A16L1
Autophagy-related protein 16-1

2

3

High-throughput

0.584

High

1333713

MOB1A
MOB kinase activator 1A

2

8

High-throughput

0.584

High

436967

ACM4
Muscarinic acetylcholine receptor M4

2

2

High-throughput

0.574

High

944480

PRKDC
DNA-dependent protein kinase catalytic subunit

1

5

Small-scale

0.561

High

380348

HG2A
HLA class II histocompatibility antigen gamma chain

1

1

High-throughput

0.536

High

439377

CATG
Cathepsin G

1

2

High-throughput

0.536

High

804376

NOTC1
Neurogenic locus notch homolog protein 1

1

9

High-throughput

0.536

High

818612

SOX2
Transcription factor SOX-2

1

2

High-throughput

0.536

High

849001

AL3A2
Aldehyde dehydrogenase family 3 member A2

1

1

High-throughput

0.536

High

1173788

ACD11
Acyl-CoA dehydrogenase family member 11

1

2

High-throughput

0.536

High

1245517

ZNRF2
E3 ubiquitin-protein ligase ZNRF2

1

2

High-throughput

0.536

High

1254751

BRSK1
Serine/threonine-protein kinase BRSK1

1

7

High-throughput

0.536

High

1288054

HDA11
Histone deacetylase 11

1

6

High-throughput

0.536

High

1304536

M3K14
Mitogen-activated protein kinase kinase kinase 14

1

5

High-throughput

0.536

High

1344837

DISC1
Disrupted in schizophrenia 1 protein

1

1

High-throughput

0.536

High

1347423

HIF1N
Hypoxia-inducible factor 1-alpha inhibitor

1

4

High-throughput

0.536

High

1357090

ABT1
Activator of basal transcription 1

1

1

High-throughput

0.536

High

1307463

SH3G3
Endophilin-A3

2

6

High-throughput

0.521

High

780329

CCNF
Cyclin-F

1

2

High-throughput

0.515

High

1304438

DNJC2
DnaJ homolog subfamily C member 2

1

3

High-throughput

0.515

High

876094

ECHB
Trifunctional enzyme subunit beta, mitochondrial

1

0

High-throughput

0.513

High

974024

M2OM
Mitochondrial 2-oxoglutarate/malate carrier protein

1

0

High-throughput

0.513

High

1081698

PDCD2
Programmed cell death protein 2

1

0

High-throughput

0.513

High

1272844

FGF14
Fibroblast growth factor 14

1

0

High-throughput

0.513

High

1327435

IQCN
IQ domain-containing protein N

1

0

High-throughput

0.513

High

1307441

SH3G2
Endophilin-A1

1

6

High-throughput

0.508

High

926056

AP2B1
AP-2 complex subunit beta

1

10

High-throughput

0.501

High

50269

HACL2
2-hydroxyacyl-CoA lyase 2

1

2

High-throughput

0.489

High

126659

P2Y10
Putative P2Y purinoceptor 10

1

6

High-throughput

0.489

High

172286

GP182
G-protein coupled receptor 182

1

5

High-throughput

0.489

High

316757

ACSL3
Fatty acid CoA ligase Acsl3

1

2

High-throughput

0.489

High

328414

S1PR4
Sphingosine 1-phosphate receptor 4

1

1

High-throughput

0.489

High

537326

DRD2
D(2) dopamine receptor

1

2

High-throughput

0.489

High

591257

ACM3
Muscarinic acetylcholine receptor M3

1

2

High-throughput

0.489

High

598793

S1PR1
Sphingosine 1-phosphate receptor 1

1

1

High-throughput

0.489

High

599028

FPR1
fMet-Leu-Phe receptor

1

1

High-throughput

0.489

High

778332

ECHA
Trifunctional enzyme subunit alpha, mitochondrial

1

1

High-throughput

0.489

High

1031119

GPR17
Uracil nucleotide/cysteinyl leukotriene receptor

1

4

High-throughput

0.489

High

1067655

P2RY6
P2Y purinoceptor 6

1

6

High-throughput

0.489

High

1202581

CMTD1
Catechol O-methyltransferase domain-containing protein 1

1

1

High-throughput

0.489

High

1202759

P2RY8
P2Y purinoceptor 8

1

4

High-throughput

0.489

High

1357679

GPR55
G-protein coupled receptor 55

1

7

High-throughput

0.489

High

1357681

GPR45
Probable G-protein coupled receptor 45

1

1

High-throughput

0.489

High

163470

XPO1
Exportin-1

1

12

High-throughput

0.479

High

164508

TRI66
Tripartite motif-containing protein 66

1

1

High-throughput

0.479

High

232592

KDM1A
Lysine-specific histone demethylase 1A

1

1

High-throughput

0.479

High

257236

PP6R2
Serine/threonine-protein phosphatase 6 regulatory subunit 2

1

7

High-throughput

0.479

High

295410

RECQ4
ATP-dependent DNA helicase Q4

1

4

High-throughput

0.479

High

305833

ELP1
Elongator complex protein 1

1

1

High-throughput

0.479

High

310418

EPM2A
Laforin

1

1

High-throughput

0.479

High

339139

EGFR
Epidermal growth factor receptor

1

1

High-throughput

0.479

High

409275

K2C8
Keratin, type II cytoskeletal 8

1

1

High-throughput

0.479

High

476577

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

5

High-throughput

0.479

High

547282

EZRI
Ezrin

1

3

High-throughput

0.479

High

714466

HSP74
Heat shock 70 kDa protein 4

1

7

High-throughput

0.479

High

749958

BRCA1
Breast cancer type 1 susceptibility protein

1

5

High-throughput

0.479

High

835569

GSK3A
Glycogen synthase kinase-3 alpha

1

10

High-throughput

0.479

High

840607

VASP
Vasodilator-stimulated phosphoprotein

1

2

High-throughput

0.479

High

909333

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

3

High-throughput

0.479

High

913836

RL7A
Large ribosomal subunit protein eL8

1

1

High-throughput

0.479

High

952896

FOXK1
Forkhead box protein K1

1

5

High-throughput

0.479

High

1021382

FOXL1
Forkhead box protein L1

1

4

High-throughput

0.479

High

1038825

HDAC1
Histone deacetylase 1

1

4

High-throughput

0.479

High

1039478

IRF5
Interferon regulatory factor 5

1

2

High-throughput

0.479

High

1042848

CUL3
Cullin-3

1

3

High-throughput

0.479

High

1043641

CUL4B
Cullin-4B

1

3

High-throughput

0.479

High

1044274

DYR1A
Dual specificity tyrosine-phosphorylation-regulated kinase 1A

1

6

High-throughput

0.479

High

1051519

DCTN1
Dynactin subunit 1

1

1

High-throughput

0.479

High

1064841

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

1

High-throughput

0.479

High

1081174

CCDC6
Coiled-coil domain-containing protein 6

1

4

High-throughput

0.479

High

1101380

CL16A
Protein CLEC16A

1

1

High-throughput

0.479

High

1119095

AMOT
Angiomotin

1

7

High-throughput

0.479

High

1140855

RN123
E3 ubiquitin-protein ligase RNF123

1

3

High-throughput

0.479

High

1174334

MOB3C
MOB kinase activator 3C

1

8

High-throughput

0.479

High

1200760

NAA40
N-alpha-acetyltransferase 40

1

2

High-throughput

0.479

High

1231641

STK40
Serine/threonine-protein kinase 40

1

5

Small-scale

0.479

High

1243146

FXL13
F-box and leucine-rich repeat protein 13

1

1

Small-scale

0.479

High

1269939

ESR2
Estrogen receptor beta

1

6

High-throughput

0.479

High

1285991

MOB3A
MOB kinase activator 3A

1

8

High-throughput

0.479

High

1299487

ZN363
RING finger and CHY zinc finger domain-containing protein 1

1

1

High-throughput

0.479

High

1304043

PFD5
Prefoldin subunit 5

1

1

High-throughput

0.479

High

1332778

EGLN3
Prolyl hydroxylase EGLN3

1

2

High-throughput

0.479

High

1347314

PIHD1
PIH1 domain-containing protein 1

1

1

High-throughput

0.479

High

1354874

ZRAN1
Ubiquitin thioesterase ZRANB1

1

4

High-throughput

0.479

High

1355356

TBK1
Serine/threonine-protein kinase TBK1

1

5

High-throughput

0.479

High

1355597

PFD2
Prefoldin subunit 2

1

1

High-throughput

0.479

High

1357261

MYO6
Unconventional myosin-VI

1

5

High-throughput

0.479

High

1357506

CC14A
Dual specificity protein phosphatase CDC14A

1

5

High-throughput

0.479

High

1357606

TTF2
Transcription termination factor 2

1

1

High-throughput

0.479

High

1173834

UBP49
Ubiquitin carboxyl-terminal hydrolase 49

1

4

High-throughput

0.470

High

61499

CNOT1
CCR4-NOT transcription complex subunit 1

1

0

High-throughput

0.458

High

841535

KNTC1
Kinetochore-associated protein 1

1

0

High-throughput

0.458

High

1039363

DCTN2
Dynactin subunit 2

1

0

High-throughput

0.458

High

1135164

ACBD5
Acyl-CoA-binding domain-containing protein 5

1

0

High-throughput

0.458

High

1205958

C2CD5
C2 domain-containing protein 5

1

0

High-throughput

0.458

High

1271276

GOGA1
Golgin subfamily A member 1

1

0

High-throughput

0.458

High

1334116

CNO10
CCR4-NOT transcription complex subunit 10

1

0

High-throughput

0.458

High

1355408

UBQL2
Ubiquilin-2

1

0

High-throughput

0.458

High

1356491

RCOR1
REST corepressor 1

1

0

High-throughput

0.458

High

1356715

AGO1
Protein argonaute-1

1

0

High-throughput

0.458

High

370718

ESR1
Estrogen receptor

1

6

High-throughput

0.445

High

529918

CFTR
Cystic fibrosis transmembrane conductance regulator

1

1

High-throughput

0.445

High

787332

PK3CA
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform

1

3

High-throughput

0.445

High

171700

PFD6
Prefoldin subunit 6

1

1

High-throughput

0.437

High

206173

TGON2
Trans-Golgi network integral membrane protein 2

1

5

High-throughput

0.437

High

385725

NTRK1
High affinity nerve growth factor receptor

1

3

High-throughput

0.437

High

721789

RFA3
Replication protein A 14 kDa subunit

1

2

High-throughput

0.437

High

1159473

FBX42
F-box only protein 42

1

1

High-throughput

0.437

High

1166072

LMBRL
Protein LMBR1L

1

1

High-throughput

0.437

High

1172283

TRI67
Tripartite motif-containing protein 67

1

4

High-throughput

0.437

High

1285396

PF21A
PHD finger protein 21A

1

3

High-throughput

0.437

High

1296119

DNJC1
DnaJ homolog subfamily C member 1

1

7

High-throughput

0.437

High

1297947

HS12B
Heat shock 70 kDa protein 12B

1

1

High-throughput

0.437

High

1301662

RB40C
Ras-related protein Rab-40C

1

4

Small-scale

0.437

High

1319338

CEP44
Centrosomal protein of 44 kDa

1

2

High-throughput

0.437

High

1328890

DJC25
DnaJ homolog subfamily C member 25

1

2

High-throughput

0.437

High

1330883

Q9H4D1
Protein kinase

1

13

High-throughput

0.437

High

1331639

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.437

High

1346558

DJC11
DnaJ homolog subfamily C member 11

1

6

High-throughput

0.437

High

1354260

KS6B2
Ribosomal protein S6 kinase beta-2

1

4

High-throughput

0.437

High

207672

AKA10
A-kinase anchor protein 10, mitochondrial

1

0

High-throughput

0.426

High

1233265

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1163

SIM26
Small integral membrane protein 26

1

1

High-throughput

0.407

High

380157

MAS
Proto-oncogene Mas

1

3

Small-scale

0.407

High

883672

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

13

High-throughput

0.407

High

1233846

CBPA6
Carboxypeptidase A6

2

0

High-throughput

0.328

High

61727

CDHR4
Cadherin-related family member 4

1

0

High-throughput

0.279

Low

315090

SGPL1
Sphingosine-1-phosphate lyase 1

1

0

High-throughput

0.279

Low

438890

SRPRA
Signal recognition particle receptor subunit alpha

1

0

High-throughput

0.279

Low

1055365

KPRA
Phosphoribosyl pyrophosphate synthase-associated protein 1

1

0

High-throughput

0.279

Low

1231782

FA43A
Protein FAM43A

1

0

High-throughput

0.279

Low

1246249

HUS1B
Checkpoint protein HUS1B

1

0

High-throughput

0.279

Low

1254687

HUMMR
Protein MGARP

1

0

High-throughput

0.279

Low

1265971

CLC2B
C-type lectin domain family 2 member B

1

0

High-throughput

0.279

Low

1292453

PLPR2
Phospholipid phosphatase-related protein type 2

1

0

High-throughput

0.279

Low

1328638

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.279

Low

1356537

TF3C4
General transcription factor 3C polypeptide 4

1

0

High-throughput

0.279

Low

1357680

SRPRB
Signal recognition particle receptor subunit beta

1

0

High-throughput

0.279

Low

825764

MTR1B
Melatonin receptor type 1B

1

0

High-throughput

0.265

Low

1231506

PLD6
Mitochondrial cardiolipin hydrolase

1

0

High-throughput

0.249

Low

1282733

UTP4
U3 small nucleolar RNA-associated protein 4 homolog

1

0

High-throughput

0.249

Low

1288002

TIM14
Mitochondrial import inner membrane translocase subunit TIM14

1

0

High-throughput

0.249

Low

1292784

BORC6
BLOC-1-related complex subunit 6

1

0

High-throughput

0.249

Low


Service provided by Combinatics, Japan

Last updated: 15 Jul 2024