Protein: SYFA
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (CML33) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)

Gene: SYFA, FARSA
Organism: Homo sapiens
Interactions: 201
UniProt ID: Q9Y285

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000287 - magnesium ion binding
GO:0003723 - RNA binding
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1449355

SYFB
Phenylalanine--tRNA ligase beta subunit

10

8

Small-scale

0.975

High

397255

ESR1
Estrogen receptor

3

1

Small-scale

0.641

High

243325

PRKN
E3 ubiquitin-protein ligase parkin

3

4

High-throughput

0.640

High

907632

UBP11
Ubiquitin carboxyl-terminal hydrolase 11

2

2

High-throughput

0.611

High

1114689

CUL3
Cullin-3

2

2

High-throughput

0.611

High

1460257

MD2L2
Mitotic spindle assembly checkpoint protein MAD2B

2

0

High-throughput

0.595

High

872906

SOX2
Transcription factor SOX-2

2

1

High-throughput

0.584

High

1414408

PDC10
Programmed cell death protein 10

2

0

High-throughput

0.580

High

1437042

COG4
Conserved oligomeric Golgi complex subunit 4

2

0

High-throughput

0.580

High

1454444

ABI3
ABI gene family member 3

1

2

High-throughput

0.573

High

401722

RAF1
RAF proto-oncogene serine/threonine-protein kinase

2

1

High-throughput

0.571

High

1198152

RHG29
Rho GTPase-activating protein 29

2

1

High-throughput

0.571

High

831672

CCNF
Cyclin-F

2

0

High-throughput

0.559

High

1453180

WWOX
WW domain-containing oxidoreductase

2

0

High-throughput

0.559

High

530614

TAU
Microtubule-associated protein tau

2

1

High-throughput

0.552

High

290211

OFD1
Centriole and centriolar satellite protein OFD1

2

0

High-throughput

0.547

High

631571

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.547

High

1410344

ECSIT
Evolutionarily conserved signaling intermediate in Toll pathway, mitochondrial

1

0

High-throughput

0.543

High

624182

E2AK2
Interferon-induced, double-stranded RNA-activated protein kinase

1

1

High-throughput

0.536

High

1112805

CUL1
Cullin-1

1

2

High-throughput

0.536

High

1161267

MK06
Mitogen-activated protein kinase 6

1

3

High-throughput

0.536

High

1338647

UBP32
Ubiquitin carboxyl-terminal hydrolase 32

1

2

High-throughput

0.536

High

1253755

RHG36
Rho GTPase-activating protein 36

2

2

High-throughput

0.521

High

1214435

GORAB
RAB6-interacting golgin

1

0

High-throughput

0.518

High

220042

XRCC3
DNA repair protein XRCC3

1

0

High-throughput

0.513

High

867530

CAPZB
F-actin-capping protein subunit beta

1

0

High-throughput

0.513

High

186135

OGT1
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit

1

0

High-throughput

0.480

High

951909

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

132390

WWP2
NEDD4-like E3 ubiquitin-protein ligase WWP2

1

1

Small-scale

0.479

High

138344

PSDE
26S proteasome non-ATPase regulatory subunit 14

1

1

High-throughput

0.479

High

324315

ARHGF
Rho guanine nucleotide exchange factor 15

1

1

High-throughput

0.479

High

346522

STAU1
Double-stranded RNA-binding protein Staufen homolog 1

1

1

High-throughput

0.479

High

350187

SNAI1
Zinc finger protein SNAI1

1

1

High-throughput

0.479

High

508856

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

3

High-throughput

0.479

High

520470

ANDR
Androgen receptor

1

1

High-throughput

0.479

High

578567

BRAF
Serine/threonine-protein kinase B-raf

1

1

High-throughput

0.479

High

584599

VAV
Proto-oncogene vav

1

2

High-throughput

0.479

High

623596

RO52
E3 ubiquitin-protein ligase TRIM21

1

1

High-throughput

0.479

High

643149

KCNA3
Potassium voltage-gated channel subfamily A member 3

1

1

High-throughput

0.479

High

766955

PHB1
Prohibitin 1

1

1

High-throughput

0.479

High

833392

PERI
Peripherin

1

1

High-throughput

0.479

High

861338

MAP1B
Microtubule-associated protein 1B

1

1

High-throughput

0.479

High

930088

UBP14
Ubiquitin carboxyl-terminal hydrolase 14

1

1

High-throughput

0.479

High

1100554

TIF1B
Transcription intermediary factor 1-beta

1

3

High-throughput

0.479

High

1126670

GRB7
Growth factor receptor-bound protein 7

1

2

Small-scale

0.479

High

1197602

PAN2
PAN2-PAN3 deadenylation complex catalytic subunit PAN2

1

1

High-throughput

0.479

High

1215903

RC3H1
Roquin-1

1

1

High-throughput

0.479

High

1227731

A16L1
Autophagy-related protein 16-1

1

3

High-throughput

0.479

High

1256151

TRI67
Tripartite motif-containing protein 67

1

6

High-throughput

0.479

High

1280616

HUWE1
E3 ubiquitin-protein ligase HUWE1

1

1

High-throughput

0.479

High

1363717

TCPW
T-complex protein 1 subunit zeta-2

1

2

High-throughput

0.479

High

1403379

RUFY1
RUN and FYVE domain-containing protein 1

1

1

High-throughput

0.479

High

1433478

Q9H4D1
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.479

High

1434266

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1438089

RC3H2
Roquin-2

1

1

High-throughput

0.479

High

1454234

RHG23
Rho GTPase-activating protein 23

1

1

High-throughput

0.479

High

1459356

ZRAN1
Ubiquitin thioesterase ZRANB1

1

1

High-throughput

0.479

High

1461634

PKHG1
Pleckstrin homology domain-containing family G member 1

1

2

High-throughput

0.479

High

1461915

FZR1
Fizzy-related protein homolog

1

1

High-throughput

0.479

High

1490584

FBW1A
F-box/WD repeat-containing protein 1A

1

1

High-throughput

0.479

High

1490588

ASB4
Ankyrin repeat and SOCS box protein 4

1

2

High-throughput

0.479

High

355051

CHK2
Serine/threonine-protein kinase Chk2

1

0

Small-scale

0.464

High

387481

APOE
Apolipoprotein E

1

0

High-throughput

0.460

High

1429656

RNF32
RING finger protein 32

1

0

High-throughput

0.460

High

123456

BACH
Cytosolic acyl coenzyme A thioester hydrolase

1

0

High-throughput

0.458

High

1397574

CI072
Guanine nucleotide exchange factor C9orf72

1

0

High-throughput

0.458

High

125670

LEG9
Galectin-9

1

0

High-throughput

0.458

High

294546

CD123
Translation initiation factor eIF2 assembly protein

1

0

High-throughput

0.458

High

316178

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

320158

UFL1
E3 UFM1-protein ligase 1

1

0

High-throughput

0.458

High

325173

HEXI1
Protein HEXIM1

1

0

High-throughput

0.458

High

364052

EGFR
Epidermal growth factor receptor

1

0

High-throughput

0.458

High

412836

NTRK1
High affinity nerve growth factor receptor

1

0

High-throughput

0.458

High

414878

P53
Cellular tumor antigen p53

1

0

High-throughput

0.458

High

437395

K2C8
Keratin, type II cytoskeletal 8

1

0

High-throughput

0.458

High

547717

C1TC
C-1-tetrahydrofolate synthase, cytoplasmic

1

0

High-throughput

0.458

High

564582

CFTR
Cystic fibrosis transmembrane conductance regulator

1

0

High-throughput

0.458

High

607237

CEBPB
CCAAT/enhancer-binding protein beta

1

0

High-throughput

0.458

High

621800

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.458

High

703091

DPOD1
DNA polymerase delta catalytic subunit

1

0

High-throughput

0.458

High

765135

CTNB1
Catenin beta-1

1

0

High-throughput

0.458

High

767380

MERL
Merlin

1

0

High-throughput

0.458

High

800177

COIL
Coilin

1

0

High-throughput

0.458

High

837912

LAP2B
Lamina-associated polypeptide 2, isoforms beta/gamma

1

0

High-throughput

0.458

High

888402

MCM2
DNA replication licensing factor MCM2

1

0

High-throughput

0.458

High

905304

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.458

High

971308

UBE2H
Ubiquitin-conjugating enzyme E2 H

1

0

High-throughput

0.458

High

978414

RHOB
Rho-related GTP-binding protein RhoB

1

0

High-throughput

0.458

High

1036005

KIF23
Kinesin-like protein KIF23

1

0

High-throughput

0.458

High

1096662

AIMP2
Aminoacyl tRNA synthase complex-interacting multifunctional protein 2

1

0

High-throughput

0.458

High

1098173

PSMD2
26S proteasome non-ATPase regulatory subunit 2

1

0

High-throughput

0.458

High

1107348

BIRC3
Baculoviral IAP repeat-containing protein 3

1

0

High-throughput

0.458

High

1108298

SQSTM
Sequestosome-1

1

0

High-throughput

0.458

High

1117168

NACA
Nascent polypeptide-associated complex subunit alpha

1

0

High-throughput

0.458

High

1127257

RBM39
RNA-binding protein 39

1

0

High-throughput

0.458

High

1136705

HERP1
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein

1

0

High-throughput

0.458

High

1138772

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

1153620

MLF2
Myeloid leukemia factor 2

1

0

High-throughput

0.458

High

1218704

OTU1
Ubiquitin thioesterase OTU1

1

0

High-throughput

0.458

High

1238510

ZN746
Zinc finger protein 746

1

0

High-throughput

0.458

High

1252301

SYNE3
Nesprin-3

1

0

High-throughput

0.458

High

1288612

ZN598
E3 ubiquitin-protein ligase ZNF598

1

0

High-throughput

0.458

High

1290832

ZCH18
Zinc finger CCCH domain-containing protein 18

1

0

High-throughput

0.458

High

1366632

AKAP1
A-kinase anchor protein 1, mitochondrial

1

0

High-throughput

0.458

High

1380691

FBX32
F-box only protein 32

1

0

High-throughput

0.458

High

1393837

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.458

High

1411386

LZTS2
Leucine zipper putative tumor suppressor 2

1

0

High-throughput

0.458

High

1418845

HOIL1
RanBP-type and C3HC4-type zinc finger-containing protein 1

1

0

High-throughput

0.458

High

1421018

UBE2O
(E3-independent) E2 ubiquitin-conjugating enzyme

1

0

High-throughput

0.458

High

1431349

ATG5
Autophagy protein 5

1

0

High-throughput

0.458

High

1433134

CHM4B
Charged multivesicular body protein 4b

1

0

High-throughput

0.458

High

1435473

EGLN3
Prolyl hydroxylase EGLN3

1

0

High-throughput

0.458

High

1446448

BRD7
Bromodomain-containing protein 7

1

0

High-throughput

0.458

High

1447025

CYLD
Ubiquitin carboxyl-terminal hydrolase CYLD

1

0

High-throughput

0.458

High

1447462

ANLN
Anillin

1

0

High-throughput

0.458

High

1448335

FBX6
F-box only protein 6

1

0

High-throughput

0.458

High

1451325

PIHD1
PIH1 domain-containing protein 1

1

0

High-throughput

0.458

High

1458556

HDAC6
Protein deacetylase HDAC6

1

0

High-throughput

0.458

High

1490587

FBX7
F-box only protein 7

1

0

High-throughput

0.458

High

61682

VWA8
von Willebrand factor A domain-containing protein 8

1

1

High-throughput

0.445

High

64918

RCCD1
RCC1 domain-containing protein 1

1

1

High-throughput

0.445

High

430528

JUN
Transcription factor Jun

1

1

High-throughput

0.445

High

457782

TBB5
Tubulin beta chain

1

1

High-throughput

0.445

High

766028

BMI1
Polycomb complex protein BMI-1

1

1

High-throughput

0.445

High

898155

LRBA
Lipopolysaccharide-responsive and beige-like anchor protein

1

2

High-throughput

0.445

High

944104

RIPK4
Receptor-interacting serine/threonine-protein kinase 4

1

1

High-throughput

0.445

High

983619

GBB1
Guanine nucleotide-binding protein G(I)/G(S)/G(T) subunit beta-1

1

1

High-throughput

0.445

High

1118639

TBB2A
Tubulin beta-2A chain

1

1

High-throughput

0.445

High

1207816

Q5JYA6
PLEKHG1

1

2

High-throughput

0.445

High

1209809

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

1

High-throughput

0.445

High

1253184

NBEL2
Neurobeachin-like protein 2

1

2

High-throughput

0.445

High

1360187

RUFY2
RUN and FYVE domain-containing protein 2

1

1

High-throughput

0.445

High

1410638

TBA1C
Tubulin alpha-1C chain

1

1

High-throughput

0.445

High

1449720

MDN1
Midasin

1

1

High-throughput

0.445

High

214983

HNRPR
Heterogeneous nuclear ribonucleoprotein R

1

0

High-throughput

0.438

High

260630

BRD4
Bromodomain-containing protein 4

1

2

High-throughput

0.437

High

472369

CFAH
Complement factor H

1

1

Small-scale

0.437

High

832840

BCL6
B-cell lymphoma 6 protein

1

1

High-throughput

0.437

High

1027973

ECT2L
Epithelial cell-transforming sequence 2 oncogene-like

1

3

High-throughput

0.437

High

1186161

ANR55
Ankyrin repeat domain-containing protein 55

1

2

High-throughput

0.437

High

1260644

ASXL2
Putative Polycomb group protein ASXL2

1

1

High-throughput

0.437

High

1312449

ASXL1
Polycomb group protein ASXL1

1

1

High-throughput

0.437

High

1326810

ARG39
Rho guanine nucleotide exchange factor 39

1

3

High-throughput

0.437

High

1382425

MFRN2
Mitoferrin-2

1

1

High-throughput

0.437

High

1401459

CIC
Protein capicua homolog

1

1

High-throughput

0.437

High

1461709

HECD1
E3 ubiquitin-protein ligase HECTD1

1

1

High-throughput

0.437

High

228115

PM34
Peroxisomal membrane protein PMP34

1

0

High-throughput

0.426

High

354808

PAK4
Serine/threonine-protein kinase PAK 4

1

0

High-throughput

0.426

High

626410

NFKB1
Nuclear factor NF-kappa-B p105 subunit

1

0

High-throughput

0.426

High

967038

1433G
14-3-3 protein gamma

1

0

High-throughput

0.426

High

1130533

RRP1B
Ribosomal RNA processing protein 1 homolog B

1

0

High-throughput

0.426

High

1309505

CEP97
Centrosomal protein of 97 kDa

1

0

High-throughput

0.426

High

1323376

VPS52
Vacuolar protein sorting-associated protein 52 homolog

1

0

High-throughput

0.426

High

1326158

RYBP
RING1 and YY1-binding protein

1

0

High-throughput

0.426

High

1348916

SETD6
N-lysine methyltransferase SETD6

1

0

High-throughput

0.426

High

1350620

GTR12
Solute carrier family 2, facilitated glucose transporter member 12

1

0

High-throughput

0.426

High

1360628

MADD
MAP kinase-activating death domain protein

1

0

High-throughput

0.426

High

1391083

OTUB1
Ubiquitin thioesterase OTUB1

1

0

High-throughput

0.426

High

1409807

SIN1
Target of rapamycin complex 2 subunit MAPKAP1

1

0

High-throughput

0.426

High

1453711

NDUF4
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex assembly factor 4

1

0

High-throughput

0.426

High

1490589

ORNT1
Mitochondrial ornithine transporter 1

1

0

High-throughput

0.426

High

369785

A2MG
Alpha-2-macroglobulin

1

0

High-throughput

0.282

High

561398

TDGF1
Protein Cripto

1

0

High-throughput

0.282

High

484688

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.279

Low

724221

SDHA
Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial

1

0

High-throughput

0.279

Low

1431016

UN93B
Protein unc-93 homolog B1

1

0

High-throughput

0.269

Low

106877

APRIO
Alternative prion protein

1

0

High-throughput

0.249

Low

176102

KDM6B
Lysine-specific demethylase 6B

1

0

Small-scale

0.249

Low

194400

R113A
E3 ubiquitin-protein ligase RNF113A

1

0

High-throughput

0.249

Low

276195

NIPS2
Protein NipSnap homolog 2

1

0

Small-scale

0.249

Low

318919

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

377785

INS
Insulin [Cleaved into: Insulin B chain; Insulin A chain]

1

0

High-throughput

0.249

Low

576701

GBRA1
Gamma-aminobutyric acid receptor subunit alpha-1

1

0

High-throughput

0.249

Low

590067

RFA2
Replication protein A 32 kDa subunit

1

0

High-throughput

0.249

Low

696901

RFA1
Replication protein A 70 kDa DNA-binding subunit

1

0

High-throughput

0.249

Low

769550

RFA3
Replication protein A 14 kDa subunit

1

0

High-throughput

0.249

Low

879633

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

0

High-throughput

0.249

Low

965344

WDR5
WD repeat-containing protein 5

1

0

High-throughput

0.249

Low

1126215

GRM2
Metabotropic glutamate receptor 2

1

0

High-throughput

0.249

Low

1218371

OTUD1
OTU domain-containing protein 1

1

0

High-throughput

0.249

Low

1233586

LTOR1
Ragulator complex protein LAMTOR1

1

0

High-throughput

0.249

Low

1249341

LMBRL
Protein LMBR1L

1

0

High-throughput

0.249

Low

1276990

PARPT
Protein mono-ADP-ribosyltransferase TIPARP

1

0

High-throughput

0.249

Low

1327282

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

1348256

TIP
T-cell immunomodulatory protein

1

0

High-throughput

0.249

Low

1429402

SPRTN
DNA-dependent metalloprotease SPRTN

1

0

High-throughput

0.249

Low

1453558

PD1L1
Programmed cell death 1 ligand 1

1

0

High-throughput

0.249

Low

1490586

AAR2
Protein AAR2 homolog

1

0

High-throughput

0.249

Low

1165

SIM26
Small integral membrane protein 26

1

0

High-throughput

0.232

Low

653662

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.232

Low

1104166

RM49
Large ribosomal subunit protein mL49

1

0

High-throughput

0.232

Low

1165263

RTL8B
Retrotransposon Gag-like protein 8B

1

0

High-throughput

0.232

Low

1253212

TIFAB
TRAF-interacting protein with FHA domain-containing protein B

1

0

High-throughput

0.232

Low

1278673

CF120
UPF0669 protein C6orf120

1

0

High-throughput

0.232

Low

1324290

LYPD1
Ly6/PLAUR domain-containing protein 1

1

0

High-throughput

0.232

Low

1335787

MOT11
Monocarboxylate transporter 11

1

0

High-throughput

0.232

Low

1414120

TMM70
Transmembrane protein 70, mitochondrial

1

0

High-throughput

0.232

Low

1452609

UTP6
U3 small nucleolar RNA-associated protein 6 homolog

1

0

High-throughput

0.232

Low

1454045

SENP1
Sentrin-specific protease 1

1

0

High-throughput

0.232

Low

1459128

CS025
UPF0449 protein C19orf25

1

0

High-throughput

0.232

Low

1490585

ZN281
Zinc finger protein 281

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025