Protein: PPOX
Protoporphyrinogen oxidase (PPO) (EC 1.3.3.4)

Gene: PPOX
Organism: Homo sapiens
Interactions: 78
UniProt ID: P50336

Gene Ontology (top 5):
GO:0004729 - oxygen-dependent protoporphyrinogen oxidase activity
GO:0005739 - mitochondrion
GO:0005743 - mitochondrial inner membrane
GO:0005758 - mitochondrial intermembrane space
GO:0006779 - porphyrin-containing compound biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

275267

NDUS7
NADH dehydrogenase [ubiquinone] iron-sulfur protein 7, mitochondrial

2

1

High-throughput

0.628

High

349658

BPNT1
3'(2'),5'-bisphosphate nucleotidase 1

2

0

High-throughput

0.602

High

894475

ACSM5
Acyl-coenzyme A synthetase ACSM5, mitochondrial

2

0

High-throughput

0.602

High

241105

PRKN
E3 ubiquitin-protein ligase parkin

2

4

High-throughput

0.584

High

894460

HAP1
Huntingtin-associated protein 1

1

1

High-throughput

0.541

High

894471

MIC60
MICOS complex subunit MIC60

1

1

High-throughput

0.541

High

844992

EAA3
Excitatory amino acid transporter 3

1

1

High-throughput

0.536

High

894484

IMP1L
Mitochondrial inner membrane protease subunit 1

1

1

High-throughput

0.536

High

894485

IMP2L
Mitochondrial inner membrane protease subunit 2

1

1

High-throughput

0.536

High

894490

LDH6B
L-lactate dehydrogenase A-like 6B

1

1

High-throughput

0.536

High

894493

MTG2
Mitochondrial ribosome-associated GTPase 2

1

1

High-throughput

0.536

High

894497

NPS3A
Protein NipSnap homolog 3A

1

1

High-throughput

0.536

High

216645

HTRA2
Serine protease HTRA2, mitochondrial

1

0

High-throughput

0.513

High

289764

MTU1
Mitochondrial tRNA-specific 2-thiouridylase 1

1

0

High-throughput

0.513

High

690470

KAD4
Adenylate kinase 4, mitochondrial

1

0

High-throughput

0.513

High

842195

THIM
3-ketoacyl-CoA thiolase, mitochondrial

1

0

High-throughput

0.513

High

869143

UCRI
Cytochrome b-c1 complex subunit Rieske, mitochondrial

1

0

High-throughput

0.513

High

894469

TAZ
Tafazzin

1

0

High-throughput

0.513

High

894477

ETKMT
Electron transfer flavoprotein beta subunit lysine methyltransferase

1

0

High-throughput

0.513

High

894483

RT24
Small ribosomal subunit protein uS3m

1

0

High-throughput

0.513

High

894491

GATA
Glutamyl-tRNA(Gln) amidotransferase subunit A, mitochondrial

1

0

High-throughput

0.513

High

894496

RT30
Large ribosomal subunit protein mL65

1

0

High-throughput

0.513

High

894498

AMACR
Alpha-methylacyl-CoA racemase

1

0

High-throughput

0.513

High

894503

SYYM
Tyrosine--tRNA ligase, mitochondrial

1

0

High-throughput

0.513

High

894504

RT02
Small ribosomal subunit protein uS2m

1

0

High-throughput

0.513

High

182493

GP182
G-protein coupled receptor 182

1

1

High-throughput

0.489

High

894459

CRBA4
Beta-crystallin A4

1

1

High-throughput

0.489

High

894466

KLRD1
Natural killer cells antigen CD94

1

1

High-throughput

0.489

High

894482

TRI43
Tripartite motif-containing protein 43

1

5

High-throughput

0.489

High

894494

ANTR1
Anthrax toxin receptor 1

1

1

High-throughput

0.489

High

274992

COQ9
Ubiquinone biosynthesis protein COQ9, mitochondrial

1

1

High-throughput

0.479

High

333638

NDUAA
NADH dehydrogenase [ubiquinone] 1 alpha subcomplex subunit 10, mitochondrial

1

2

High-throughput

0.479

High

894462

PO5F1
POU domain, class 5, transcription factor 1

1

5

High-throughput

0.479

High

844738

EAA1
Excitatory amino acid transporter 1

1

1

High-throughput

0.445

High

330766

KI20A
Kinesin-like protein KIF20A

1

3

High-throughput

0.437

High

878785

NR2C2
Nuclear receptor subfamily 2 group C member 2

1

7

High-throughput

0.437

High

888442

TSP3
Thrombospondin-3

1

2

High-throughput

0.437

High

894474

VIR
Protein virilizer homolog

1

1

High-throughput

0.437

High

894476

TRI67
Tripartite motif-containing protein 67

1

11

High-throughput

0.437

High

894495

NANOG
Homeobox protein NANOG

1

1

High-throughput

0.437

High

449596

KLK1
Kallikrein-1

1

2

High-throughput

0.407

High

894473

A16L1
Autophagy-related protein 16-1

1

5

High-throughput

0.407

High

894489

S17A9
Voltage-gated purine nucleotide uniporter SLC17A9

1

1

High-throughput

0.407

High

894502

ITM2B
Integral membrane protein 2B

1

2

High-throughput

0.407

High

631122

RAB5A
Ras-related protein Rab-5A

2

0

High-throughput

0.298

High

260742

RAMP2
Receptor activity-modifying protein 2

1

0

High-throughput

0.279

Low

268917

FCG3B
Low affinity immunoglobulin gamma Fc region receptor III-B

1

0

High-throughput

0.279

Low

280906

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.279

Low

519596

LYAG
Lysosomal alpha-glucosidase

1

0

High-throughput

0.279

Low

608238

EGLN
Endoglin

1

0

High-throughput

0.279

Low

655985

CAH6
Carbonic anhydrase 6

1

0

High-throughput

0.279

Low

841531

I12R1
Interleukin-12 receptor subunit beta-1

1

0

High-throughput

0.279

Low

879992

DNSL1
Deoxyribonuclease-1-like 1

1

0

High-throughput

0.279

Low

894458

LIMK2
LIM domain kinase 2

1

0

High-throughput

0.279

Low

894461

CTG1B
Cancer/testis antigen 1

1

0

High-throughput

0.279

Low

894463

NAAA
N-acylethanolamine-hydrolyzing acid amidase

1

0

High-throughput

0.279

Low

894465

FMOD
Fibromodulin

1

0

High-throughput

0.279

Low

894467

SG2A2
Mammaglobin-A

1

0

High-throughput

0.279

Low

894470

UPP1
Uridine phosphorylase 1

1

0

High-throughput

0.279

Low

894472

TECT1
Tectonic-1

1

0

High-throughput

0.279

Low

894478

FA83F
Protein FAM83F

1

0

High-throughput

0.279

Low

894481

SNX21
Sorting nexin-21

1

0

High-throughput

0.279

Low

894486

NAA38
N-alpha-acetyltransferase 38, NatC auxiliary subunit

1

0

High-throughput

0.279

Low

894492

ADAM7
Disintegrin and metalloproteinase domain-containing protein 7

1

0

High-throughput

0.279

Low

894499

CLC4E
C-type lectin domain family 4 member E

1

0

High-throughput

0.279

Low

894500

PCDAC
Protocadherin alpha-12

1

0

High-throughput

0.279

Low

894501

DHDH
Trans-1,2-dihydrobenzene-1,2-diol dehydrogenase

1

0

High-throughput

0.279

Low

894505

GPR45
Probable G-protein coupled receptor 45

1

0

High-throughput

0.279

Low

894480

CSN5
COP9 signalosome complex subunit 5

1

0

High-throughput

0.265

Low

894468

HNRPD
Heterogeneous nuclear ribonucleoprotein D0

1

0

High-throughput

0.251

Low

154804

ISLR
Immunoglobulin superfamily containing leucine-rich repeat protein

1

0

High-throughput

0.249

Low

582316

ARSA
Arylsulfatase A

1

0

High-throughput

0.249

Low

830352

CCNF
Cyclin-F

1

0

High-throughput

0.249

Low

894464

UPAR
Urokinase plasminogen activator surface receptor

1

0

High-throughput

0.249

Low

894487

CAB45
45 kDa calcium-binding protein

1

0

High-throughput

0.249

Low

894488

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

0

High-throughput

0.249

Low

239024

ZNRD2
Protein ZNRD2

1

0

High-throughput

0.232

Low

894479

SETD6
N-lysine methyltransferase SETD6

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025