Protein: RPP40
Ribonuclease P protein subunit p40 (RNaseP protein p40) (RNase P subunit 1)

Gene: RPP40
Organism: Homo sapiens
Interactions: 45
UniProt ID: O75818

Gene Ontology (top 5):
GO:0000172 - ribonuclease MRP complex
GO:0000447 - endonucleolytic cleavage in ITS1 to separate SSU-rRNA from 5.8S rRNA and LSU-rRNA from tricistronic rRNA transcript (SSU-rRNA, 5.8S rRNA, LSU-rRNA)
GO:0001682 - tRNA 5'-leader removal
GO:0004526 - ribonuclease P activity
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

294962

RPP29
Ribonuclease P protein subunit p29

4

0

High-throughput

0.846

High

294976

RPP30
Ribonuclease P protein subunit p30

3

0

High-throughput

0.827

High

294960

RPP14
Ribonuclease P protein subunit p14

3

0

Small-scale

0.813

High

294966

NPM
Nucleophosmin

4

1

High-throughput

0.699

High

294999

RPP21
Ribonuclease P protein subunit p21

4

0

Small-scale

0.669

High

294994

RBM4B
RNA-binding protein 4B

3

1

High-throughput

0.667

High

294996

RPP25
Ribonuclease P protein subunit p25

3

1

High-throughput

0.667

High

294991

POP5
Ribonuclease P/MRP protein subunit POP5

1

0

High-throughput

0.656

High

294997

RBM4
RNA-binding protein 4

2

1

High-throughput

0.628

High

294902

POP7
Ribonuclease P protein subunit p20

3

0

Small-scale

0.616

High

294987

RP25L
Ribonuclease P protein subunit p25-like protein

2

1

High-throughput

0.601

High

294983

NEPRO
Nucleolus and neural progenitor protein

2

0

Small-scale

0.585

High

294963

ESR1
Estrogen receptor

2

1

High-throughput

0.571

High

288555

NPM3
Nucleoplasmin-3

1

1

High-throughput

0.536

High

294982

Q6FHY5
MEOX2 protein

1

1

High-throughput

0.515

High

294961

CBX6
Chromobox protein homolog 6

1

0

High-throughput

0.513

High

294965

LA
Lupus La protein

1

0

High-throughput

0.513

High

294967

RU17
U1 small nuclear ribonucleoprotein 70 kDa

1

0

High-throughput

0.513

High

294968

RU1C
U1 small nuclear ribonucleoprotein C

1

0

High-throughput

0.513

High

294969

IBP5
Insulin-like growth factor-binding protein 5

1

0

High-throughput

0.513

High

294970

RL13A
Large ribosomal subunit protein uL13

1

0

High-throughput

0.513

High

294972

MECP2
Methyl-CpG-binding protein 2

1

0

High-throughput

0.513

High

294975

RACK1
Small ribosomal subunit protein RACK1

1

0

High-throughput

0.513

High

294978

RRP5
Protein RRP5 homolog

1

0

High-throughput

0.513

High

294993

POP1
Ribonucleases P/MRP protein subunit POP1

1

0

Small-scale

0.505

High

294985

MOB3C
MOB kinase activator 3C

1

0

High-throughput

0.493

High

294971

MEOX2
Homeobox protein MOX-2

1

1

High-throughput

0.481

High

294974

PTEN
Phosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN

1

0

High-throughput

0.480

High

294990

ESR2
Estrogen receptor beta

1

1

High-throughput

0.479

High

294977

ILF3
Interleukin enhancer-binding factor 3

1

0

High-throughput

0.458

High

294979

U5S1
116 kDa U5 small nuclear ribonucleoprotein component

1

0

High-throughput

0.458

High

294980

IF16
Gamma-interferon-inducible protein 16

1

0

High-throughput

0.458

High

294989

DOT1L
Histone-lysine N-methyltransferase, H3 lysine-79 specific

1

0

High-throughput

0.458

High

294995

RIOK1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

295000

TE2IP
Telomeric repeat-binding factor 2-interacting protein 1

1

0

High-throughput

0.458

High

295002

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

294973

IMA5
Importin subunit alpha-5

1

0

High-throughput

0.426

High

294964

VTNC
Vitronectin

3

0

High-throughput

0.345

High

294981

CR021
UPF0711 protein C18orf21

3

0

High-throughput

0.345

High

295001

COPG2
Coatomer subunit gamma-2

1

0

High-throughput

0.279

Low

294984

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.249

Low

294986

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.249

Low

294992

DDRGK
DDRGK domain-containing protein 1

1

0

High-throughput

0.249

Low

294998

PKHA4
Pleckstrin homology domain-containing family A member 4

1

0

High-throughput

0.249

Low

294988

ARK74
Aflatoxin B1 aldehyde reductase member 4

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025