Protein: HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial (EC 4.1.3.16) (Dihydrodipicolinate synthase-like) (DHDPS-like protein) (Probable 2-keto-4-hydroxyglutarate aldolase) (Probable KHG-aldolase) (Protein 569272)

Gene: HOGA1
Organism: Homo sapiens
Interactions: 27
UniProt ID: Q86XE5

Gene Ontology (top 5):
GO:0005739 - mitochondrion
GO:0005759 - mitochondrial matrix
GO:0008700 - (R,S)-4-hydroxy-2-oxoglutarate aldolase activity
GO:0009436 - glyoxylate catabolic process
GO:0019470 - trans-4-hydroxy-L-proline catabolic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1293588

HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

1

5

High-throughput

0.618

High

539362

ODB2
Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial

1

1

High-throughput

0.536

High

1293599

BTBD2
BTB/POZ domain-containing protein 2

1

1

High-throughput

0.489

High

1293600

BTBD1
BTB/POZ domain-containing protein 1

1

1

High-throughput

0.489

High

1209347

LRRK2
Leucine-rich repeat serine/threonine-protein kinase 2

1

0

High-throughput

0.480

High

1058125

C1QBP
Complement component 1 Q subcomponent-binding protein, mitochondrial

1

0

High-throughput

0.458

High

1092579

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

0

High-throughput

0.458

High

1187249

ADCK5
Uncharacterized aarF domain-containing protein kinase 5

1

0

High-throughput

0.458

High

1217039

LYRM7
Complex III assembly factor LYRM7

1

0

High-throughput

0.458

High

1293459

NIT1
Deaminated glutathione amidase

1

0

High-throughput

0.458

High

1293590

ABHDB
sn-1-specific diacylglycerol lipase ABHD11

1

0

High-throughput

0.458

High

1293591

SPRY4
SPRY domain-containing protein 4

1

0

High-throughput

0.458

High

1293593

COQ2
4-hydroxybenzoate polyprenyltransferase, mitochondrial

1

0

High-throughput

0.458

High

1293594

RCC1L
RCC1-like G exchanging factor-like protein

1

0

High-throughput

0.458

High

1293602

LYRM4
LYR motif-containing protein 4

1

0

High-throughput

0.458

High

653419

HEMH
Ferrochelatase, mitochondrial

1

0

High-throughput

0.426

High

1293595

UBP47
Ubiquitin carboxyl-terminal hydrolase 47

3

0

High-throughput

0.345

High

1293596

CMA1A
Ciliary microtubule associated protein 1A

2

0

High-throughput

0.316

High

326894

ARK73
Aldo-keto reductase family 7 member A3

1

0

High-throughput

0.279

Low

1272476

CSN6
COP9 signalosome complex subunit 6

1

0

High-throughput

0.279

Low

1293589

KLH36
Kelch-like protein 36

1

0

High-throughput

0.279

Low

1293592

ITLN2
Intelectin-2

1

0

High-throughput

0.279

Low

1293597

CSN8
COP9 signalosome complex subunit 8

1

0

High-throughput

0.279

Low

1293598

FND11
Fibronectin type III domain-containing protein 11

1

0

High-throughput

0.279

Low

1293601

CSN7B
COP9 signalosome complex subunit 7b

1

0

High-throughput

0.279

Low

1131195

MESD
LRP chaperone MESD

1

0

High-throughput

0.269

Low


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Last updated: 11Aug2025