Protein: CSN8
COP9 signalosome complex subunit 8 (SGN8) (Signalosome subunit 8) (COP9 homolog) (hCOP9) (JAB1-containing signalosome subunit 8)

Gene: CSN8, COPS8
Organism: Homo sapiens
Interactions: 105
UniProt ID: Q99627

Gene Ontology (top 5):
GO:0000338 - protein deneddylation
GO:0005634 - nucleus
GO:0005654 - nucleoplasm
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1406139

CSN3
COP9 signalosome complex subunit 3

17

6

Small-scale

0.986

High

1370320

CSN5
COP9 signalosome complex subunit 5

14

5

Small-scale

0.983

High

1094404

CSN1
COP9 signalosome complex subunit 1

12

7

Small-scale

0.978

High

1272535

CSN6
COP9 signalosome complex subunit 6

11

2

Small-scale

0.978

High

958702

CSN2
COP9 signalosome complex subunit 2

10

10

Small-scale

0.972

High

1406135

CSN7A
COP9 signalosome complex subunit 7a

10

4

Small-scale

0.972

High

1406119

CSN4
COP9 signalosome complex subunit 4

8

2

Small-scale

0.968

High

1406129

CSN7B
COP9 signalosome complex subunit 7b

5

4

Small-scale

0.925

High

1115021

CUL4A
Cullin-4A

10

7

Small-scale

0.755

High

1115380

CUL4B
Cullin-4B

8

7

Small-scale

0.753

High

1114103

CUL3
Cullin-3

7

7

Small-scale

0.742

High

1363080

DDB2
DNA damage-binding protein 2

7

2

Small-scale

0.742

High

1112967

CUL2
Cullin-2

4

7

High-throughput

0.704

High

1157887

DDB1
DNA damage-binding protein 1

4

1

Small-scale

0.696

High

1112675

CUL1
Cullin-1

4

7

Small-scale

0.694

High

1406142

DCAF1
DDB1- and CUL4-associated factor 1

4

0

Small-scale

0.664

High

1371843

CUL5
Cullin-5

3

7

Small-scale

0.656

High

1352262

DCA11
DDB1- and CUL4-associated factor 11

3

0

High-throughput

0.646

High

1396698

LLR1
Leucine-rich repeat protein 1

3

0

High-throughput

0.638

High

1154426

STK11
Serine/threonine-protein kinase STK11

3

0

High-throughput

0.634

High

1357532

DCAF4
DDB1- and CUL4-associated factor 4

2

1

High-throughput

0.628

High

1406121

BTBD2
BTB/POZ domain-containing protein 2

2

5

High-throughput

0.628

High

1406127

BTBD1
BTB/POZ domain-containing protein 1

2

5

High-throughput

0.628

High

1406132

DTL
Denticleless protein homolog

2

1

High-throughput

0.628

High

1098368

ERCC8
DNA excision repair protein ERCC-8

3

0

Small-scale

0.613

High

908222

BMX
Cytoplasmic tyrosine-protein kinase BMX

2

0

High-throughput

0.602

High

1357981

RN138
E3 ubiquitin-protein ligase RNF138

2

0

High-throughput

0.602

High

1365966

APBP2
Amyloid protein-binding protein 2

2

0

High-throughput

0.602

High

1406138

FEM1B
Protein fem-1 homolog B

2

0

High-throughput

0.602

High

1235384

KLH10
Kelch-like protein 10

2

3

High-throughput

0.601

High

1327584

WDTC1
WD and tetratricopeptide repeats protein 1

2

3

High-throughput

0.601

High

1406134

KLH13
Kelch-like protein 13

2

3

High-throughput

0.601

High

1360280

CSN9
COP9 signalosome complex subunit 9

2

0

Small-scale

0.585

High

1391946

DCNL1
DCN1-like protein 1

2

0

Small-scale

0.585

High

1403120

CRBN
Protein cereblon

2

0

Small-scale

0.585

High

1406141

FBX7
F-box only protein 7

2

0

High-throughput

0.576

High

1406116

CSN8
COP9 signalosome complex subunit 8

1

1

Small-scale

0.575

High

507331

UBB
Polyubiquitin-B [Cleaved into: Ubiquitin]

1

1

High-throughput

0.536

High

1150470

NHRF2
Na(+)/H(+) exchange regulatory cofactor NHE-RF2

1

1

High-throughput

0.536

High

1154912

NEDD8
Ubiquitin-like protein NEDD8

1

1

High-throughput

0.536

High

1202227

DCAF6
DDB1- and CUL4-associated factor 6

1

3

High-throughput

0.536

High

1388926

FBX17
F-box only protein 17

1

1

High-throughput

0.536

High

1406118

KLDC3
Kelch domain-containing protein 3

1

4

High-throughput

0.536

High

1406133

KLHL8
Kelch-like protein 8

1

3

High-throughput

0.536

High

1406144

USH1C
Harmonin

1

1

High-throughput

0.536

High

280951

HYPM
Huntingtin-interacting protein M

1

0

High-throughput

0.513

High

484624

DLDH
Dihydrolipoyl dehydrogenase, mitochondrial

1

0

High-throughput

0.513

High

922491

CLH2
Clathrin heavy chain 2

1

0

High-throughput

0.513

High

1272667

DET1
DET1 homolog

1

0

High-throughput

0.513

High

1293804

FBX11
F-box only protein 11

1

0

High-throughput

0.513

High

1359893

PRP31
U4/U6 small nuclear ribonucleoprotein Prp31

1

0

High-throughput

0.513

High

1406117

HCD2
3-hydroxyacyl-CoA dehydrogenase type-2

1

0

High-throughput

0.513

High

938672

ALR
FAD-linked sulfhydryl oxidase ALR

1

0

Small-scale

0.512

High

508498

UBC
Polyubiquitin-C [Cleaved into: Ubiquitin]

1

1

High-throughput

0.501

High

1152220

MARE1
Microtubule-associated protein RP/EB family member 1

1

0

Small-scale

0.480

High

947261

NLRP6
NACHT, LRR and PYD domains-containing protein 6

1

1

High-throughput

0.479

High

1156830

E2F4
Transcription factor E2F4

1

1

High-throughput

0.479

High

1406125

KLHL4
Kelch-like protein 4

1

3

High-throughput

0.479

High

1406128

PKHA4
Pleckstrin homology domain-containing family A member 4

1

1

High-throughput

0.479

High

1406130

FBX6
F-box only protein 6

1

1

High-throughput

0.479

High

1406140

NOD1
Nucleotide-binding oligomerization domain-containing protein 1

1

1

Small-scale

0.479

High

218674

TGON2
Trans-Golgi network integral membrane protein 2

1

0

High-throughput

0.458

High

315930

RECQ4
ATP-dependent DNA helicase Q4

1

0

High-throughput

0.458

High

764988

CTNB1
Catenin beta-1

1

0

Small-scale

0.458

High

775462

DDIT3
DNA damage-inducible transcript 3 protein

1

0

Small-scale

0.458

High

883668

CENPA
Histone H3-like centromeric protein A

1

0

Small-scale

0.458

High

945589

FBXW4
F-box/WD repeat-containing protein 4

1

0

Small-scale

0.458

High

957488

UBC12
NEDD8-conjugating enzyme Ubc12

1

0

High-throughput

0.458

High

983950

RBX1
E3 ubiquitin-protein ligase RBX1

1

0

High-throughput

0.458

High

1007771

RAE1L
mRNA export factor RAE1

1

0

High-throughput

0.458

High

1110882

IRF5
Interferon regulatory factor 5

1

0

Small-scale

0.458

High

1147258

ELOB
Elongin-B

1

0

High-throughput

0.458

High

1255219

TRI67
Tripartite motif-containing protein 67

1

0

High-throughput

0.458

High

1338335

FBX22
F-box only protein 22

1

0

High-throughput

0.458

High

1340791

COP1
E3 ubiquitin-protein ligase COP1

1

0

High-throughput

0.458

High

1359690

PHIP
PH-interacting protein

1

0

Small-scale

0.458

High

1364547

BAP1
Ubiquitin carboxyl-terminal hydrolase BAP1

1

0

High-throughput

0.458

High

1368360

REQU
Zinc finger protein ubi-d4

1

0

High-throughput

0.458

High

1406120

DDA1
DET1- and DDB1-associated protein 1

1

0

High-throughput

0.458

High

1406122

PINK1
Serine/threonine-protein kinase PINK1, mitochondrial

1

0

Small-scale

0.458

High

1406124

AMRA1
Activating molecule in BECN1-regulated autophagy protein 1

1

0

Small-scale

0.458

High

1406126

MLP3B
Microtubule-associated protein 1 light chain 3 beta

1

0

High-throughput

0.458

High

1406136

ZRAN1
Ubiquitin thioesterase ZRANB1

1

0

High-throughput

0.458

High

1406137

DS13B
Dual specificity protein phosphatase 13B

1

0

High-throughput

0.458

High

1406143

MAFB
Transcription factor MafB

1

0

High-throughput

0.458

High

1215352

DCAF8
DDB1- and CUL4-associated factor 8

1

3

High-throughput

0.445

High

1406131

DISC1
Disrupted in schizophrenia 1 protein

1

0

High-throughput

0.438

High

1241938

FBX42
F-box only protein 42

1

2

High-throughput

0.437

High

1332550

DC4L2
DDB1- and CUL4-associated factor 4-like protein 2

1

1

Small-scale

0.437

High

530270

TAU
Microtubule-associated protein tau

1

0

High-throughput

0.426

High

664899

RAE1
Rab proteins geranylgeranyltransferase component A 1

1

0

High-throughput

0.426

High

935042

TERA
Transitional endoplasmic reticulum ATPase

1

0

High-throughput

0.426

High

1136938

ABRX2
BRISC complex subunit Abraxas 2

1

0

Small-scale

0.426

High

1406123

ZDHC5
Palmitoyltransferase ZDHHC5

1

0

High-throughput

0.426

High

615195

PACA
Pituitary adenylate cyclase-activating polypeptide

2

0

High-throughput

0.318

High

907184

SUOX
Sulfite oxidase, mitochondrial

2

0

High-throughput

0.316

High

922395

CRBA4
Beta-crystallin A4

2

0

High-throughput

0.313

High

1330064

USBP1
Harmonin-binding protein USHBP1

1

0

High-throughput

0.299

High

1200326

ANR39
Ankyrin repeat domain-containing protein 39

1

0

High-throughput

0.279

Low

1293597

HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

1

0

High-throughput

0.279

Low

1327151

FBXL6
F-box/LRR-repeat protein 6

1

0

High-throughput

0.269

Low

318864

RHBT1
Rho-related BTB domain-containing protein 1

1

0

High-throughput

0.249

Low

1395387

NEUL4
Neuralized-like protein 4

1

0

High-throughput

0.232

Low

1397960

MF14A
Hippocampus abundant transcript 1 protein

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025