Protein: SPRY4
SPRY domain-containing protein 4

Gene: SPRY4, SPRYD4
Organism: Homo sapiens
Interactions: 45
UniProt ID: Q8WW59

Gene Ontology (top 5):
GO:0005634 - nucleus
GO:0005739 - mitochondrion

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1359070

SPRY4
SPRY domain-containing protein 4

1

15

High-throughput

0.618

High

1162447

CLPP
ATP-dependent Clp protease proteolytic subunit, mitochondrial

2

0

High-throughput

0.559

High

665471

EF1B
Elongation factor 1-beta

2

1

High-throughput

0.553

High

1254821

TRI67
Tripartite motif-containing protein 67

1

17

High-throughput

0.553

High

607622

PTN2
Tyrosine-protein phosphatase non-receptor type 2

1

3

High-throughput

0.536

High

724917

HXD3
Homeobox protein Hox-D3

1

16

High-throughput

0.536

High

883294

UB2R1
Ubiquitin-conjugating enzyme E2 R1

1

20

High-throughput

0.536

High

1359075

ZNG1A
Zinc-regulated GTPase metalloprotein activator 1A

1

1

High-throughput

0.536

High

1293451

NUD13
NAD(P)H pyrophosphatase NUDT13, mitochondrial

1

0

High-throughput

0.513

High

1324777

CIART
Circadian-associated transcriptional repressor

1

0

High-throughput

0.513

High

562902

CCL5
C-C motif chemokine 5

1

2

High-throughput

0.489

High

889316

NUMB
Protein numb homolog

1

3

High-throughput

0.489

High

1043642

COAA1

1

1

High-throughput

0.489

High

1063479

GOGA2
Golgin subfamily A member 2

1

9

High-throughput

0.489

High

1359073

FMNL2
Formin-like protein 2

1

3

High-throughput

0.489

High

223211

PRC1
Protein regulator of cytokinesis 1

1

4

High-throughput

0.479

High

279844

CISY
Citrate synthase, mitochondrial

1

2

High-throughput

0.479

High

282021

MPPB
Mitochondrial-processing peptidase subunit beta

1

2

High-throughput

0.479

High

331186

KI20A
Kinesin-like protein KIF20A

1

17

High-throughput

0.479

High

471152

ODPA
Pyruvate dehydrogenase E1 component subunit alpha, somatic form, mitochondrial

1

1

High-throughput

0.479

High

532812

CH60
60 kDa heat shock protein, mitochondrial

1

4

High-throughput

0.479

High

554818

ODBA
2-oxoisovalerate dehydrogenase subunit alpha, mitochondrial

1

1

High-throughput

0.479

High

575174

IDE
Insulin-degrading enzyme

1

3

High-throughput

0.479

High

680444

ATPA
ATP synthase F(1) complex subunit alpha, mitochondrial

1

3

High-throughput

0.479

High

987799

GRB2
Growth factor receptor-bound protein 2

1

16

Small-scale

0.479

High

1083683

MPPA
Mitochondrial-processing peptidase subunit alpha

1

2

High-throughput

0.479

High

1092604

ECH1
Delta(3,5)-Delta(2,4)-dienoyl-CoA isomerase, mitochondrial

1

5

High-throughput

0.479

High

1234465

MRM1
rRNA methyltransferase 1, mitochondrial

1

1

High-throughput

0.479

High

1359074

CRBN
Protein cereblon

1

1

Small-scale

0.479

High

784670

ATPG
ATP synthase F(1) complex subunit gamma, mitochondrial

1

0

High-throughput

0.458

High

938858

SCOT1
Succinyl-CoA:3-ketoacid coenzyme A transferase 1, mitochondrial

1

0

High-throughput

0.458

High

940676

ATP5I
ATP synthase F(0) complex subunit e, mitochondrial

1

0

High-throughput

0.458

High

1142608

PDK1
[Pyruvate dehydrogenase

1

0

High-throughput

0.458

High

1205123

COQ5
2-methoxy-6-polyprenyl-1,4-benzoquinol methylase, mitochondrial

1

0

High-throughput

0.458

High

1293591

HOGA1
4-hydroxy-2-oxoglutarate aldolase, mitochondrial

1

0

High-throughput

0.458

High

1359071

ATPMK
ATP synthase F(0) complex subunit k, mitochondrial

1

0

High-throughput

0.458

High

1359076

TR61B
tRNA

1

0

High-throughput

0.458

High

1359077

CHCH2
Coiled-coil-helix-coiled-coil-helix domain-containing protein 2

1

0

High-throughput

0.458

High

1238060

S18B1
MFS-type transporter SLC18B1

1

2

High-throughput

0.407

High

708992

T2EB
Transcription initiation factor IIE subunit beta

1

0

High-throughput

0.279

Low

1208940

DCA10
DDB1- and CUL4-associated factor 10

1

0

High-throughput

0.279

Low

1309050

ZDH21
Palmitoyltransferase ZDHHC21

1

0

High-throughput

0.279

Low

1359072

SPTCS
Spatacsin

1

0

High-throughput

0.279

Low

446450

G6PI
Glucose-6-phosphate isomerase

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025