Protein: ERF1
Eukaryotic peptide chain release factor subunit 1 (Eukaryotic release factor 1) (eRF1) (Omnipotent suppressor protein 1)

Gene: ERF1, SUP45
Organism: Saccharomyces cerevisiae S288C
Interactions: 135
UniProt ID: P12385

Gene Ontology (top 5):
GO:0002184 - cytoplasmic translational termination
GO:0003747 - translation release factor activity
GO:0004045 - peptidyl-tRNA hydrolase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

430756

ERF3
Eukaryotic peptide chain release factor GTP-binding subunit

20

3

Small-scale

0.989

High

553647

RLI1
Translation initiation factor RLI1

3

3

Small-scale

0.864

High

522872

HSP71
Heat shock protein SSA1

3

2

High-throughput

0.624

High

525762

HSP72
Heat shock protein SSA2

3

2

High-throughput

0.624

High

553643

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

2

High-throughput

0.601

High

553633

ROM2
RHO1 GDP-GTP exchange protein 2

2

0

High-throughput

0.595

High

553609

ECM29
Proteasome component ECM29

2

1

High-throughput

0.588

High

553620

IMB4
Importin subunit beta-4

2

1

High-throughput

0.588

High

553592

RENT1
ATP-dependent helicase NAM7

2

2

Small-scale

0.586

High

553590

RS7A
Small ribosomal subunit protein eS7A

2

0

High-throughput

0.585

High

553583

SIS1
Protein SIS1

2

2

High-throughput

0.584

High

553593

HOG1
Mitogen-activated protein kinase HOG1

2

1

High-throughput

0.584

High

553628

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

394163

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.575

High

392113

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.571

High

553587

MAS5
Mitochondrial protein import protein MAS5

2

1

High-throughput

0.571

High

553595

HSP7F
Heat shock protein homolog SSE1

2

3

High-throughput

0.571

High

553650

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

2

0

Small-scale

0.569

High

553605

ATR
Serine/threonine-protein kinase MEC1

2

1

High-throughput

0.567

High

481960

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

2

0

High-throughput

0.563

High

553601

UTP20
U3 small nucleolar RNA-associated protein 20

2

0

High-throughput

0.563

High

553606

EIF3A
Eukaryotic translation initiation factor 3 subunit A

2

0

High-throughput

0.563

High

553630

YJB6
Uncharacterized protein YJL016W

2

0

High-throughput

0.563

High

553649

CLU
Clustered mitochondria protein 1

2

0

High-throughput

0.563

High

434758

RS3
Small ribosomal subunit protein uS3

2

0

Small-scale

0.559

High

553579

DBP5
ATP-dependent RNA helicase DBP5

2

0

Small-scale

0.559

High

553604

GBLP
Small ribosomal subunit protein RACK1

2

0

Small-scale

0.559

High

553670

GLE1
mRNA export factor GLE1

1

0

Small-scale

0.554

High

409893

RL25
Large ribosomal subunit protein uL23

2

0

Small-scale

0.547

High

512003

RS4A
Small ribosomal subunit protein eS4A

2

0

Small-scale

0.547

High

553580

RPA2
DNA-directed RNA polymerase I subunit RPA135

2

2

High-throughput

0.537

High

154128

RL36B
Large ribosomal subunit protein eL36B

1

0

High-throughput

0.513

High

449385

SPT2
Protein SPT2

1

0

High-throughput

0.513

High

553602

OSH1
Oxysterol-binding protein homolog 1

1

0

High-throughput

0.513

High

553607

SHE3
SWI5-dependent HO expression protein 3

1

0

High-throughput

0.513

High

553634

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

1

0

High-throughput

0.513

High

553653

EIF3G
Eukaryotic translation initiation factor 3 subunit G

1

1

Small-scale

0.501

High

553656

ITT1
E3 ubiquitin-protein ligase ITT1

1

2

Small-scale

0.501

High

553576

CSK21
Casein kinase II subunit alpha

1

0

High-throughput

0.493

High

553623

EIF3I
Eukaryotic translation initiation factor 3 subunit I

1

0

Small-scale

0.480

High

383472

RS17A
Small ribosomal subunit protein eS17A

1

1

High-throughput

0.479

High

553575

HSC82
ATP-dependent molecular chaperone HSC82

1

2

High-throughput

0.479

High

553596

ECM32
Putative ATP-dependent RNA helicase ECM32

1

2

Small-scale

0.479

High

553640

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

2

High-throughput

0.479

High

553648

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

367666

ENO1
Enolase 1

1

0

High-throughput

0.458

High

435723

RS13
Small ribosomal subunit protein uS15

1

0

High-throughput

0.458

High

438596

SC160
Protein SCP160

1

0

High-throughput

0.458

High

454823

RS19A
Small ribosomal subunit protein eS19A

1

0

High-throughput

0.458

High

464534

PBS2
MAP kinase kinase PBS2

1

0

High-throughput

0.458

High

502799

RS22A
Small ribosomal subunit protein uS8A

1

0

High-throughput

0.458

High

503996

RL31A
Large ribosomal subunit protein eL31A

1

0

High-throughput

0.458

High

512211

RS6A
Small ribosomal subunit protein eS6A

1

0

High-throughput

0.458

High

518179

IF4A
ATP-dependent RNA helicase eIF4A

1

0

High-throughput

0.458

High

531219

METK1
S-adenosylmethionine synthase 1

1

0

High-throughput

0.458

High

553571

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

553581

XRN1
5'-3' exoribonuclease 1

1

0

High-throughput

0.458

High

553584

RNQ1
[PIN+] prion protein RNQ1

1

0

High-throughput

0.458

High

553586

RS2
Small ribosomal subunit protein uS5

1

0

High-throughput

0.458

High

553588

CDC48
Cell division control protein 48

1

0

High-throughput

0.458

High

553589

RL16A
Large ribosomal subunit protein uL13A

1

0

High-throughput

0.458

High

553597

RSSA1
Small ribosomal subunit protein uS2A

1

0

High-throughput

0.458

High

553598

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

553599

RS3A1
Small ribosomal subunit protein eS1A

1

0

High-throughput

0.458

High

553603

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

553608

RS20
Small ribosomal subunit protein uS10

1

0

High-throughput

0.458

High

553612

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.458

High

553614

ASPG1
L-asparaginase 1

1

0

High-throughput

0.458

High

553616

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

553619

TPA1
Prolyl 3,4-dihydroxylase TPA1

1

0

Small-scale

0.458

High

553624

TM108
Protein TMA108

1

0

High-throughput

0.458

High

553631

RS12
Small ribosomal subunit protein eS12

1

0

High-throughput

0.458

High

553638

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

553639

TR112
Multifunctional methyltransferase subunit TRM112

1

0

Small-scale

0.458

High

553644

RS15
Small ribosomal subunit protein uS19

1

0

High-throughput

0.458

High

553646

ESP1
Separin

1

0

High-throughput

0.458

High

553652

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.458

High

553654

PDS5
Sister chromatid cohesion protein PDS5

1

0

High-throughput

0.458

High

553657

SYRC
Arginine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.458

High

553658

EIF3J
Eukaryotic translation initiation factor 3 subunit J

1

0

Small-scale

0.458

High

553663

SUB2
ATP-dependent RNA helicase SUB2

1

0

High-throughput

0.458

High

553664

MCA1
Metacaspase-1

1

0

High-throughput

0.458

High

553665

RS10A
Small ribosomal subunit protein eS10A

1

0

High-throughput

0.458

High

553667

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

553669

RIO1
Serine/threonine-protein kinase RIO1

1

0

High-throughput

0.458

High

553673

CMR1
DNA damage-binding protein CMR1

1

0

High-throughput

0.458

High

403325

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

1

Small-scale

0.445

High

432468

RL7A
Large ribosomal subunit protein uL30A

1

1

Small-scale

0.445

High

543616

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

553573

RS17B
Small ribosomal subunit protein eS17B

1

1

High-throughput

0.445

High

553594

ZUO1
Zuotin

1

2

High-throughput

0.445

High

553611

SSZ1
Ribosome-associated complex subunit SSZ1

1

1

High-throughput

0.445

High

553618

HSP7E
Heat shock protein SSC3, mitochondrial

1

1

High-throughput

0.445

High

553621

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

553582

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

2

High-throughput

0.437

High

553627

RLP7
Ribosome biogenesis protein RLP7

1

1

High-throughput

0.437

High

553651

RUVB1
RuvB-like protein 1

1

1

High-throughput

0.437

High

553671

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

553672

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

364893

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

444408

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.426

High

453384

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

453886

IF4E
Eukaryotic translation initiation factor 4E

1

0

Small-scale

0.426

High

531576

RL4A
Large ribosomal subunit protein uL4A

1

0

High-throughput

0.426

High

553572

RL3
Large ribosomal subunit protein uL3

1

0

High-throughput

0.426

High

553574

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

High-throughput

0.426

High

553615

YM11
Uncharacterized protein YMR124W

1

0

High-throughput

0.426

High

553617

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

Small-scale

0.426

High

553622

RL13B
Large ribosomal subunit protein eL13B

1

0

High-throughput

0.426

High

553629

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

553585

USO1
Intracellular protein transport protein USO1

2

0

High-throughput

0.324

High

553625

TAO3
Cell morphogenesis protein PAG1

2

0

High-throughput

0.324

High

553645

SEN54
tRNA-splicing endonuclease subunit SEN54

2

0

High-throughput

0.324

High

553661

CORO
Coronin-like protein

2

0

High-throughput

0.324

High

553662

VAC14
Vacuole morphology and inheritance protein 14

2

0

High-throughput

0.324

High

553632

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.279

Low

506423

U5072
UPF0507 protein YML002W

1

0

Small-scale

0.251

Low

553577

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.249

Low

553578

HEMH
Ferrochelatase, mitochondrial

1

0

Small-scale

0.249

Low

553591

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

553610

PHS
Putative pterin-4-alpha-carbinolamine dehydratase

1

0

High-throughput

0.249

Low

553626

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.249

Low

553635

MLC1
Myosin light chain 1

1

0

Small-scale

0.249

Low

553636

EIF2A
Eukaryotic translation initiation factor 2A

1

0

High-throughput

0.249

Low

553637

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

553641

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

553642

H3
Histone H3

1

0

High-throughput

0.249

Low

553655

POB3
FACT complex subunit POB3

1

0

High-throughput

0.249

Low

553659

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

553660

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

553666

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

553668

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

553600

SPT7
SAGA complex subunit SPT7

1

0

High-throughput

0.232

Low

553613

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

553674

SET6
Potential protein lysine methyltransferase SET6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025