Protein: MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1 (EC 2.7.11.1) (MAP kinase signal-integrating kinase 1) (MAPK signal-integrating kinase 1) (Mnk1)

Gene: MKNK1
Organism: Homo sapiens
Interactions: 69
UniProt ID: Q9BUB5

Gene Ontology (top 5):
GO:0004674 - protein serine/threonine kinase activity
GO:0004683 - calmodulin-dependent protein kinase activity
GO:0005516 - calmodulin binding
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1082627

MK14
Mitogen-activated protein kinase 14

9

20

Small-scale

0.977

High

659040

MK01
Mitogen-activated protein kinase 1

8

20

Small-scale

0.969

High

647670

MK03
Mitogen-activated protein kinase 3

2

20

Small-scale

0.799

High

438484

HS90B
Heat shock protein HSP 90-beta

1

20

High-throughput

0.698

High

1305080

DNJC7
DnaJ homolog subfamily C member 7

1

5

High-throughput

0.698

High

216965

KIF1C
Kinesin-like protein KIF1C

1

5

High-throughput

0.691

High

592465

RAB5A
Ras-related protein Rab-5A

1

2

High-throughput

0.691

High

789131

FRK
Tyrosine-protein kinase FRK

1

13

High-throughput

0.691

High

1078200

MK11
Mitogen-activated protein kinase 11

1

20

High-throughput

0.691

High

1084598

CPSF6
Cleavage and polyadenylation specificity factor subunit 6

1

6

High-throughput

0.691

High

1235193

KKCC1
Calcium/calmodulin-dependent protein kinase kinase 1

1

20

High-throughput

0.691

High

1312689

MKNK1
MAP kinase-interacting serine/threonine-protein kinase 1

1

17

High-throughput

0.691

High

1312690

PAR6B
Partitioning defective 6 homolog beta

1

8

High-throughput

0.691

High

1312694

MKNK2
MAP kinase-interacting serine/threonine-protein kinase 2

1

18

High-throughput

0.691

High

979979

IF4G1
Eukaryotic translation initiation factor 4 gamma 1

3

5

Small-scale

0.681

High

1312691

HIPK2
Homeodomain-interacting protein kinase 2

1

20

High-throughput

0.621

High

1079592

NEDD8
NEDD8

1

2

High-throughput

0.618

High

974406

CREM
cAMP-responsive element modulator

2

10

High-throughput

0.606

High

208186

SPY2
Protein sprouty homolog 2

1

3

Small-scale

0.561

High

1287765

RCN3
Reticulocalbin-3

1

13

High-throughput

0.555

High

944401

PRKDC
DNA-dependent protein kinase catalytic subunit

1

9

High-throughput

0.541

High

1270783

CBP
CREB-binding protein

1

9

High-throughput

0.541

High

165029

SC16A
Protein transport protein Sec16A

1

1

High-throughput

0.536

High

256337

BRE1B
E3 ubiquitin-protein ligase BRE1B

1

15

High-throughput

0.536

High

304315

UBR5
E3 ubiquitin-protein ligase UBR5

1

16

High-throughput

0.536

High

387421

P53
Cellular tumor antigen p53

1

7

High-throughput

0.536

High

727309

NU214
Nuclear pore complex protein Nup214

1

7

High-throughput

0.536

High

780986

ID1
DNA-binding protein inhibitor ID-1

1

2

High-throughput

0.536

High

867250

TCP4
Activated RNA polymerase II transcriptional coactivator p15

1

1

High-throughput

0.536

High

923770

PPIA
Peptidyl-prolyl cis-trans isomerase A

1

2

High-throughput

0.536

High

1068064

PDK1
[Pyruvate dehydrogenase

1

1

High-throughput

0.536

High

1158570

L2GL2
LLGL scribble cell polarity complex component 2

1

1

High-throughput

0.536

High

1217500

AHNK2
Protein AHNAK2

1

2

High-throughput

0.536

High

1244239

BD1L1
Biorientation of chromosomes in cell division protein 1-like 1

1

16

High-throughput

0.536

High

1246690

KI18A
Kinesin-like protein KIF18A

1

6

High-throughput

0.536

High

1272016

RAD50
DNA repair protein RAD50

1

18

High-throughput

0.536

High

1312697

MYH13
Myosin-13

1

11

High-throughput

0.536

High

1312698

AMOL2
Angiomotin-like protein 2

1

19

High-throughput

0.536

High

417023

IF4E
Eukaryotic translation initiation factor 4E

1

4

Small-scale

0.534

High

930977

PP2AA
Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform

1

8

Small-scale

0.515

High

942023

IF4G2
Eukaryotic translation initiation factor 4 gamma 2

1

5

Small-scale

0.515

High

791929

HD
Huntingtin

1

2

High-throughput

0.515

High

868716

ATX1
Ataxin-1

1

2

High-throughput

0.515

High

1287355

OPTN
Optineurin

1

20

High-throughput

0.515

High

1136026

RNH2B
Ribonuclease H2 subunit B

1

0

High-throughput

0.513

High

1312696

ABHDA
Palmitoyl-protein thioesterase ABHD10, mitochondrial

1

0

High-throughput

0.513

High

203408

IF4G3
Eukaryotic translation initiation factor 4 gamma 3

1

5

High-throughput

0.508

High

849426

UB2D1
Ubiquitin-conjugating enzyme E2 D1

1

4

High-throughput

0.508

High

868315

ATX3
Ataxin-3

1

1

High-throughput

0.508

High

1312693

PHAX
Phosphorylated adapter RNA export protein

1

1

High-throughput

0.508

High

395636

A4
Amyloid-beta precursor protein

1

7

High-throughput

0.501

High

591400

TNR1B
Tumor necrosis factor receptor superfamily member 1B

1

1

High-throughput

0.489

High

1229912

PUSL1
tRNA pseudouridine synthase-like 1

1

1

High-throughput

0.489

High

160171

HGS
Hepatocyte growth factor-regulated tyrosine kinase substrate

1

2

High-throughput

0.481

High

163211

XPO1
Exportin-1

1

5

High-throughput

0.479

High

570021

CEBPB
CCAAT/enhancer-binding protein beta

1

4

High-throughput

0.479

High

798993

GATA4
Transcription factor GATA-4

1

2

High-throughput

0.479

High

1312692

EGLN3
Prolyl hydroxylase EGLN3

1

3

High-throughput

0.479

High

326935

DDAH2
Putative hydrolase DDAH2

1

2

High-throughput

0.464

High

176635

FANCA
Fanconi anemia group A protein

1

0

Small-scale

0.460

High

1245155

TNIP2
TNFAIP3-interacting protein 2

1

0

High-throughput

0.460

High

1129786

TDIF2
Deoxynucleotidyltransferase terminal-interacting protein 2

1

0

High-throughput

0.458

High

1156287

RETST
All-trans-retinol 13,14-reductase

1

1

High-throughput

0.437

High

180167

CCL16
C-C motif chemokine 16

1

0

High-throughput

0.279

Low

1013945

GALT2
Polypeptide N-acetylgalactosaminyltransferase 2

1

0

High-throughput

0.279

Low

1172843

CC149
Coiled-coil domain-containing protein 149

1

0

High-throughput

0.279

Low

1256563

PO210
Nuclear pore membrane glycoprotein 210

1

0

High-throughput

0.279

Low

1312695

BPIA1
BPI fold-containing family A member 1

1

0

High-throughput

0.279

Low


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Last updated: 15 Jul 2024