Protein: SCS2
Vesicle-associated membrane protein-associated protein SCS2 (VAMP-associated protein SCS2) (Choline sensitivity suppressor protein 2) (VAP homolog 1)

Gene: SCS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 142
UniProt ID: P40075

Gene Ontology (top 5):
GO:0000781 - chromosome, telomeric region
GO:0005635 - nuclear envelope
GO:0005783 - endoplasmic reticulum
GO:0005789 - endoplasmic reticulum membrane
GO:0005886 - plasma membrane

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

818160

SCS2
Vesicle-associated membrane protein-associated protein SCS2

2

8

Small-scale

0.744

High

777233

OSH1
Oxysterol-binding protein homolog 1

6

20

Small-scale

0.734

High

642177

OPI1
Transcriptional repressor OPI1

6

0

Small-scale

0.702

High

818217

OSH2
Oxysterol-binding protein homolog 2

4

20

Small-scale

0.700

High

818186

NUM1
Nuclear migration protein NUM1

4

0

High-throughput

0.676

High

812224

YM11
Uncharacterized protein YMR124W

3

0

Small-scale

0.659

High

802789

OSH3
Oxysterol-binding protein homolog 3

3

20

Small-scale

0.658

High

818180

PIL1
Sphingolipid long chain base-responsive protein PIL1

3

1

High-throughput

0.657

High

579479

HSC82
ATP-dependent molecular chaperone HSC82

3

2

High-throughput

0.633

High

392808

HSP82
ATP-dependent molecular chaperone HSP82

2

2

High-throughput

0.584

High

776365

YET1
Endoplasmic reticulum transmembrane protein 1

2

5

Small-scale

0.584

High

818200

RTN1
Reticulon-like protein 1

2

8

Small-scale

0.584

High

818202

PEX30
Peroxisomal membrane protein PEX30

2

1

Small-scale

0.584

High

679737

CDC48
Cell division control protein 48

2

6

High-throughput

0.571

High

818206

SHS1
Seventh homolog of septin 1

1

0

High-throughput

0.567

High

790360

STT4
Phosphatidylinositol 4-kinase STT4

2

0

High-throughput

0.563

High

801054

FKS1
1,3-beta-glucan synthase component FKS1

2

0

High-throughput

0.563

High

796947

PHO88
SRP-independent targeting protein 3

2

0

Small-scale

0.559

High

818221

ATG40
Autophagy-related protein 40

2

0

Small-scale

0.559

High

818178

CCH1
Calcium-channel protein CCH1

1

1

Small-scale

0.552

High

524090

HSP71
Heat shock protein SSA1

2

3

High-throughput

0.552

High

526810

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

545045

SSB1
Ribosome-associated molecular chaperone SSB1

2

5

High-throughput

0.552

High

600642

FCY2
Purine-cytosine permease FCY2

1

0

High-throughput

0.518

High

818207

NBA1
Protein NBA1

1

0

High-throughput

0.513

High

592281

VATB
V-type proton ATPase subunit B

2

1

High-throughput

0.504

High

818187

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

1

3

High-throughput

0.501

High

817861

IMB4
Importin subunit beta-4

1

1

Small-scale

0.489

High

818191

SKY1
Serine/threonine-protein kinase SKY1

1

3

High-throughput

0.489

High

818198

ERB1
Ribosome biogenesis protein ERB1

1

1

High-throughput

0.489

High

646241

SEC22
Protein transport protein SEC22

1

5

Small-scale

0.481

High

746439

SSO1
Protein SSO1

1

20

Small-scale

0.481

High

528593

CP51
Lanosterol 14-alpha demethylase CYP51

1

4

Small-scale

0.479

High

554351

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

1

High-throughput

0.479

High

554430

HMDH2
3-hydroxy-3-methylglutaryl-coenzyme A reductase 2

1

1

High-throughput

0.479

High

577144

SEC63
Protein translocation protein SEC63

1

7

Small-scale

0.479

High

636315

ACO1
Acyl-CoA desaturase 1

1

1

Small-scale

0.479

High

677106

EMC1
ER membrane protein complex subunit 1

1

2

Small-scale

0.479

High

726092

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

1

Small-scale

0.479

High

735838

SAC1
Phosphatidylinositol-3-phosphatase SAC1

1

3

Small-scale

0.479

High

745344

EMP24
Endosomal protein P24B

1

8

Small-scale

0.479

High

748413

SC61A
Protein transport protein SEC61

1

1

High-throughput

0.479

High

754626

OSTB
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit WBP1

1

3

Small-scale

0.479

High

754694

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

1

Small-scale

0.479

High

795010

NU170
Nucleoporin NUP170

1

2

High-throughput

0.479

High

795374

ATG8
Autophagy-related protein 8

1

3

High-throughput

0.479

High

803560

RPN1
26S proteasome regulatory subunit RPN1

1

2

High-throughput

0.479

High

809016

STT3
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit STT3

1

2

Small-scale

0.479

High

816191

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

1

Small-scale

0.479

High

818167

OST1
Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1

1

3

Small-scale

0.479

High

818174

STE24
CAAX prenyl protease 1

1

2

Small-scale

0.479

High

818184

TMEDA
Endoplasmic reticulum vesicle protein 25

1

9

Small-scale

0.479

High

818189

PEX29
Peroxisomal membrane protein PEX29

1

1

Small-scale

0.479

High

818190

TCB3
Tricalbin-3

1

7

Small-scale

0.479

High

818195

GPI17
GPI transamidase component GPI17

1

2

Small-scale

0.479

High

818197

MYO5
Myosin-5

1

2

Small-scale

0.479

High

818201

ERP1
Protein ERP1

1

7

Small-scale

0.479

High

818205

YET3
Endoplasmic reticulum transmembrane protein 3

1

5

Small-scale

0.479

High

818215

YOP1
Protein YOP1

1

5

Small-scale

0.479

High

818216

RTN2
Reticulon-like protein 2

1

8

Small-scale

0.479

High

818218

TCB1
Tricalbin-1

1

7

Small-scale

0.479

High

818219

PGA3
Plasma membrane-associated coenzyme Q6 reductase PGA3

1

3

Small-scale

0.479

High

818161

PEA2
Protein PEA2

1

0

Small-scale

0.460

High

818164

SEC9
Protein transport protein SEC9

1

0

Small-scale

0.460

High

818179

SC6B1
Protein transport protein SBH1

1

0

Small-scale

0.460

High

454303

CARP
Saccharopepsin

1

0

Small-scale

0.458

High

569406

DPM1
Dolichol-phosphate mannosyltransferase

1

0

Small-scale

0.458

High

715035

ERG9
Squalene synthase ERG9

1

0

Small-scale

0.458

High

735311

ERG2
C-8 sterol isomerase ERG2

1

0

Small-scale

0.458

High

780759

PSG1
PMA1 stabilization in the Golgi protein 1 [Cleaved into: PSG1-N'; PSG1-C']

1

0

High-throughput

0.458

High

796658

IST2
Increased sodium tolerance protein 2

1

0

Small-scale

0.458

High

805789

NSG1
Protein NSG1

1

0

High-throughput

0.458

High

818171

MPS3
Spindle pole body assembly component MPS3

1

0

High-throughput

0.458

High

818199

GSF2
Glucose-signaling factor 2

1

0

Small-scale

0.458

High

818220

SEY1
Protein SEY1

1

0

Small-scale

0.458

High

818222

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.458

High

359015

G3P2
Glyceraldehyde-3-phosphate dehydrogenase 2

1

2

High-throughput

0.445

High

359244

G3P3
Glyceraldehyde-3-phosphate dehydrogenase 3

1

2

High-throughput

0.445

High

818162

SSB2
Ribosome-associated molecular chaperone SSB2

1

5

High-throughput

0.445

High

818204

VPS74
Vacuolar protein sorting-associated protein 74

1

2

High-throughput

0.445

High

818212

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

1

High-throughput

0.445

High

818173

GPI14
GPI mannosyltransferase 1

1

0

High-throughput

0.438

High

661522

PSA2
Proteasome subunit alpha type-2

1

1

High-throughput

0.437

High

678524

TAH1
TPR repeat-containing protein associated with Hsp90

1

1

Small-scale

0.437

High

707223

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

708743

TF3B
Transcription factor IIIB 70 kDa subunit

1

1

High-throughput

0.437

High

727065

HS104
Heat shock protein 104

1

1

High-throughput

0.437

High

737873

HOG1
Mitogen-activated protein kinase HOG1

1

2

High-throughput

0.437

High

750679

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.437

High

812340

LAA1
AP-1 accessory protein LAA1

1

2

High-throughput

0.437

High

818169

UTP10
U3 small nucleolar RNA-associated protein 10

1

1

High-throughput

0.437

High

818175

VATG
V-type proton ATPase subunit G

1

1

High-throughput

0.437

High

818183

ORC1
Origin recognition complex subunit 1

1

5

High-throughput

0.437

High

818188

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.437

High

818196

DHR1
Probable ATP-dependent RNA helicase DHR1

1

1

High-throughput

0.437

High

818214

DBP10
ATP-dependent RNA helicase DBP10

1

4

High-throughput

0.437

High

358233

ADH1
Alcohol dehydrogenase 1

1

0

High-throughput

0.426

High

365062

KPYK1
Pyruvate kinase 1

1

0

High-throughput

0.426

High

367976

ENO2
Enolase 2

1

0

High-throughput

0.426

High

757699

EDE1
EH domain-containing and endocytosis protein 1

1

0

High-throughput

0.426

High

818192

ESC1
Silent chromatin protein ESC1

1

0

High-throughput

0.426

High

818182

CRZ1
Transcriptional regulator CRZ1

1

1

High-throughput

0.417

High

386726

TBB
Tubulin beta chain

1

3

High-throughput

0.407

High

616426

SEC18
Vesicular-fusion protein SEC18

1

6

High-throughput

0.407

High

676036

MAS5
Mitochondrial protein import protein MAS5

1

1

High-throughput

0.407

High

701533

IDH2
Isocitrate dehydrogenase [NAD] subunit 2, mitochondrial

1

2

High-throughput

0.407

High

705769

IDH1
Isocitrate dehydrogenase [NAD] subunit 1, mitochondrial

1

2

High-throughput

0.407

High

760592

TSA1
Peroxiredoxin TSA1

1

2

High-throughput

0.407

High

818166

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

1

High-throughput

0.407

High

818177

RL4B
Large ribosomal subunit protein uL4B

1

1

High-throughput

0.407

High

818185

ACT
Actin

1

1

High-throughput

0.407

High

806725

RPN10
26S proteasome regulatory subunit RPN10

3

0

High-throughput

0.335

High

818170

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.305

High

818209

PBI1
PSTB2-interacting protein 1

1

0

Small-scale

0.282

High

806526

UTP9
U3 small nucleolar RNA-associated protein 9

1

0

High-throughput

0.279

Low

818165

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.269

Low

647124

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

High-throughput

0.249

Low

677416

KRR1
KRR1 small subunit processome component

1

0

High-throughput

0.249

Low

779243

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

818163

VID27
Vacuolar import and degradation protein 27

1

0

High-throughput

0.249

Low

818176

TOM22
Mitochondrial import receptor subunit TOM22

1

0

High-throughput

0.249

Low

818181

PESC
Pescadillo homolog

1

0

High-throughput

0.249

Low

818193

GIS1
Transcriptional activator/repressor GIS1

1

0

High-throughput

0.249

Low

818194

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

818203

TFC6
Transcription factor tau 91 kDa subunit

1

0

High-throughput

0.249

Low

818208

MCA1
Metacaspase-1

1

0

High-throughput

0.249

Low

818210

YL11B
Transposon Ty1-LR1 Gag-Pol polyprotein

1

0

High-throughput

0.249

Low

818211

SIZ2
E3 SUMO-protein ligase SIZ2

1

0

Small-scale

0.249

Low

368680

PMG1
Phosphoglycerate mutase 1

1

0

High-throughput

0.232

Low

450597

FAS1
Fatty acid synthase subunit beta

1

0

High-throughput

0.232

Low

453622

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.232

Low

618591

FAS2
Fatty acid synthase subunit alpha

1

0

High-throughput

0.232

Low

626757

HSP60
Heat shock protein 60, mitochondrial

1

0

High-throughput

0.232

Low

639554

RIR3
Ribonucleoside-diphosphate reductase large chain 2

1

0

High-throughput

0.232

Low

644787

CLH
Clathrin heavy chain

1

0

High-throughput

0.232

Low

645829

VATE
V-type proton ATPase subunit E

1

0

High-throughput

0.232

Low

743688

VATD
V-type proton ATPase subunit D

1

0

High-throughput

0.232

Low

800639

YGP1
Protein YGP1

1

0

High-throughput

0.232

Low

818168

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low

818172

TCPQ
T-complex protein 1 subunit theta

1

0

High-throughput

0.232

Low

818213

RPN6
26S proteasome regulatory subunit RPN6

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025