Protein: RS4A
Small ribosomal subunit protein eS4A (40S ribosomal protein S4-A) (RP5) (S7) (YS6)

Gene: RS4A, RPS4A
Organism: Saccharomyces cerevisiae S288C
Interactions: 226
UniProt ID: P0CX35

Gene Ontology (top 5):
GO:0002181 - cytoplasmic translation
GO:0003723 - RNA binding
GO:0003735 - structural constituent of ribosome
GO:0005737 - cytoplasm
GO:0005829 - cytosol

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

511715

RS24A
Small ribosomal subunit protein eS24A

3

1

Small-scale

0.827

High

511993

RS4A
Small ribosomal subunit protein eS4A

2

6

High-throughput

0.754

High

512120

EIF2A
Eukaryotic translation initiation factor 2A

2

1

Small-scale

0.754

High

512065

ENP1
Essential nuclear protein 1

6

1

Small-scale

0.721

High

512087

RIO2
Serine/threonine-protein kinase RIO2

6

3

Small-scale

0.719

High

512000

SSBP1
Single-stranded nucleic acid-binding protein

4

2

Small-scale

0.680

High

512022

KRR1
KRR1 small subunit processome component

4

1

Small-scale

0.676

High

512160

NOC4
Nucleolar complex protein 4

4

0

Small-scale

0.648

High

392079

HSP82
ATP-dependent molecular chaperone HSP82

3

3

High-throughput

0.640

High

512024

PWP2
Periodic tryptophan protein 2

3

3

Small-scale

0.640

High

512178

NOP58
Nucleolar protein 58

3

1

High-throughput

0.640

High

149516

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.618

High

435499

RS9B
Small ribosomal subunit protein uS4B

1

3

High-throughput

0.618

High

512067

RS20
Small ribosomal subunit protein uS10

1

1

High-throughput

0.618

High

512110

RS12
Small ribosomal subunit protein eS12

1

1

High-throughput

0.618

High

512153

RRP5
rRNA biogenesis protein RRP5

1

1

High-throughput

0.618

High

512001

HSP71
Heat shock protein SSA1

3

0

High-throughput

0.613

High

512100

UTP10
U3 small nucleolar RNA-associated protein 10

3

0

High-throughput

0.613

High

512121

SLX9
Ribosome biogenesis protein SLX9

3

0

Small-scale

0.606

High

512016

SIS1
Protein SIS1

2

1

High-throughput

0.601

High

511891

RS30A
Small ribosomal subunit protein eS30A

1

0

High-throughput

0.586

High

438577

SC160
Protein SCP160

2

6

High-throughput

0.584

High

511994

RS6A
Small ribosomal subunit protein eS6A

2

3

High-throughput

0.584

High

512002

SSB1
Ribosome-associated molecular chaperone SSB1

2

1

High-throughput

0.584

High

512060

GBLP
Small ribosomal subunit protein RACK1

2

5

Small-scale

0.584

High

512103

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.584

High

512128

BRE5
UBP3-associated protein BRE5

2

2

High-throughput

0.584

High

512137

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

2

1

High-throughput

0.584

High

512145

HAS1
ATP-dependent RNA helicase HAS1

2

3

High-throughput

0.584

High

512149

DHR1
Probable ATP-dependent RNA helicase DHR1

2

2

High-throughput

0.584

High

512152

TMA64
Translation machinery-associated protein 64

2

1

High-throughput

0.584

High

512159

RRP9
Ribosomal RNA-processing protein 9

2

5

High-throughput

0.584

High

512164

TSR1
Ribosome biogenesis protein TSR1

2

1

High-throughput

0.584

High

512183

NOP14
Nucleolar complex protein 14

2

1

High-throughput

0.584

High

512106

MPP10
U3 small nucleolar RNA-associated protein MPP10

1

1

Small-scale

0.575

High

512174

RIO1
Serine/threonine-protein kinase RIO1

2

3

Small-scale

0.571

High

512005

CAF20
Cap-associated protein CAF20

2

0

High-throughput

0.559

High

512074

UTP9
U3 small nucleolar RNA-associated protein 9

2

0

High-throughput

0.559

High

512080

IF2P
Eukaryotic translation initiation factor 5B

2

0

High-throughput

0.559

High

512123

UTP22
U3 small nucleolar RNA-associated protein 22

2

0

High-throughput

0.559

High

512131

NAT10
RNA cytidine acetyltransferase

2

0

High-throughput

0.559

High

436280

RS31
Ubiquitin-ribosomal protein eS31 fusion protein [Cleaved into: Ubiquitin; Small ribosomal subunit protein eS31

2

0

Small-scale

0.547

High

453877

IF4E
Eukaryotic translation initiation factor 4E

2

0

Small-scale

0.547

High

512003

ERF1
Eukaryotic peptide chain release factor subunit 1

2

0

Small-scale

0.547

High

512051

LTV1
Protein LTV1

2

0

Small-scale

0.547

High

512168

NOB1
20S-pre-rRNA D-site endonuclease NOB1

2

0

Small-scale

0.547

High

512058

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.536

High

512155

MRD1
Multiple RNA-binding domain-containing protein 1

1

1

Small-scale

0.536

High

512007

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

0

High-throughput

0.517

High

364259

CDK1
Cyclin-dependent kinase 1

1

1

High-throughput

0.479

High

383448

RS17A
Small ribosomal subunit protein eS17A

1

2

High-throughput

0.479

High

409668

RL24A
Large ribosomal subunit protein eL24A

1

1

High-throughput

0.479

High

417003

VDAC1
Non-selective voltage-gated ion channel 1

1

1

High-throughput

0.479

High

434492

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.479

High

434728

RS3
Small ribosomal subunit protein uS3

1

1

High-throughput

0.479

High

435699

RS13
Small ribosomal subunit protein uS15

1

1

High-throughput

0.479

High

441634

RS14A
Small ribosomal subunit protein uS11A

1

2

High-throughput

0.479

High

454799

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.479

High

455359

RS19B
Small ribosomal subunit protein eS19B

1

4

High-throughput

0.479

High

502619

RS25B
Small ribosomal subunit protein eS25B

1

1

High-throughput

0.479

High

502696

RS21A
Small ribosomal subunit protein eS21A

1

2

High-throughput

0.479

High

502774

RS22A
Small ribosomal subunit protein uS8A

1

1

High-throughput

0.479

High

503460

RS28B
Small ribosomal subunit protein eS28B

1

1

High-throughput

0.479

High

503970

RL31A
Large ribosomal subunit protein eL31A

1

3

High-throughput

0.479

High

504504

RL31B
Large ribosomal subunit protein eL31B

1

3

High-throughput

0.479

High

511616

RS23B
Small ribosomal subunit protein uS12B

1

1

High-throughput

0.479

High

511995

RS8A
Small ribosomal subunit protein eS8A

1

3

High-throughput

0.479

High

511996

RS11B
Small ribosomal subunit protein uS17B

1

1

High-throughput

0.479

High

511997

RL18B
Large ribosomal subunit protein eL18B

1

1

High-throughput

0.479

High

511998

RS16B
Small ribosomal subunit protein uS9B

1

2

High-throughput

0.479

High

511999

RS18A
Small ribosomal subunit protein uS13A

1

1

High-throughput

0.479

High

512004

NAT1
N-terminal acetyltransferase A complex subunit NAT1

1

1

High-throughput

0.479

High

512006

RS17B
Small ribosomal subunit protein eS17B

1

2

High-throughput

0.479

High

512009

DBP4
ATP-dependent RNA helicase HCA4

1

4

High-throughput

0.479

High

512011

RS3A2
Small ribosomal subunit protein eS1B

1

3

High-throughput

0.479

High

512012

IF5A1
Eukaryotic translation initiation factor 5A-1

1

1

Small-scale

0.479

High

512018

RS2
Small ribosomal subunit protein uS5

1

2

High-throughput

0.479

High

512020

GBP2
Serine/arginine

1

2

High-throughput

0.479

High

512021

SRO9
RNA-binding protein SRO9

1

5

Small-scale

0.479

High

512025

PAT1
Deadenylation-dependent mRNA-decapping factor PAT1

1

1

Small-scale

0.479

High

512026

CDC48
Cell division control protein 48

1

1

High-throughput

0.479

High

512027

SPB4
ATP-dependent rRNA helicase SPB4

1

3

High-throughput

0.479

High

512028

RS5
Small ribosomal subunit protein uS7

1

1

High-throughput

0.479

High

512029

RL16A
Large ribosomal subunit protein uL13A

1

1

High-throughput

0.479

High

512030

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

512033

HRR25
Casein kinase I homolog HRR25

1

2

High-throughput

0.479

High

512035

XPO1
Exportin-1

1

3

High-throughput

0.479

High

512042

ZUO1
Zuotin

1

2

High-throughput

0.479

High

512044

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.479

High

512046

PRS6A
26S proteasome regulatory subunit 6A

1

3

High-throughput

0.479

High

512048

LHP1
La protein homolog

1

4

High-throughput

0.479

High

512050

RS3A1
Small ribosomal subunit protein eS1A

1

3

High-throughput

0.479

High

512052

SKI2
Antiviral helicase SKI2

1

1

High-throughput

0.479

High

512054

RS27A
Small ribosomal subunit protein eS27A

1

1

High-throughput

0.479

High

512061

MAK5
ATP-dependent RNA helicase MAK5

1

3

High-throughput

0.479

High

512062

HEK2
Heterogeneous nuclear rnp K-like protein 2

1

6

High-throughput

0.479

High

512066

IF5
Eukaryotic translation initiation factor 5

1

2

High-throughput

0.479

High

512068

RS27B
Small ribosomal subunit protein eS27B

1

1

High-throughput

0.479

High

512069

ECM29
Proteasome component ECM29

1

1

High-throughput

0.479

High

512075

HRB1
Serine/arginine

1

2

High-throughput

0.479

High

512077

RS14B
Small ribosomal subunit protein uS11B

1

2

High-throughput

0.479

High

512078

DHH1
ATP-dependent RNA helicase DHH1

1

4

High-throughput

0.479

High

512082

RS26A
Small ribosomal subunit protein eS26A

1

1

High-throughput

0.479

High

512083

RS26B
Small ribosomal subunit protein eS26B

1

1

High-throughput

0.479

High

512094

RLP7
Ribosome biogenesis protein RLP7

1

2

High-throughput

0.479

High

512095

RS29A
Small ribosomal subunit protein uS14A

1

2

High-throughput

0.479

High

512096

RS29B
Small ribosomal subunit protein uS14B

1

2

High-throughput

0.479

High

512099

ELP2
Elongator complex protein 2

1

4

High-throughput

0.479

High

512101

OTU1
Ubiquitin thioesterase OTU1

1

2

High-throughput

0.479

High

512105

RSSA2
Small ribosomal subunit protein uS2B

1

4

High-throughput

0.479

High

512108

RS7B
Small ribosomal subunit protein eS7B

1

2

High-throughput

0.479

High

512114

IMDH4
Inosine-5'-monophosphate dehydrogenase 4

1

1

High-throughput

0.479

High

512115

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

1

High-throughput

0.479

High

512118

VID30
GID complex subunit 1

1

2

High-throughput

0.479

High

512119

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

1

1

High-throughput

0.479

High

512125

YG3A
Uncharacterized protein YGR130C

1

6

Small-scale

0.479

High

512130

CSL4
Exosome complex component CSL4

1

1

High-throughput

0.479

High

512134

FAP1
FKBP12-associated protein 1

1

2

High-throughput

0.479

High

512136

TMA20
Translation machinery-associated protein 20

1

1

High-throughput

0.479

High

512138

NOP3
Serine/arginine

1

4

High-throughput

0.479

High

512139

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

512143

RLI1
Translation initiation factor RLI1

1

2

Small-scale

0.479

High

512144

TOM1
E3 ubiquitin-protein ligase TOM1

1

3

High-throughput

0.479

High

512158

ESF1
Pre-rRNA-processing protein ESF1

1

2

High-throughput

0.479

High

512161

BFR2
Protein BFR2

1

1

High-throughput

0.479

High

512162

YL419
Putative ATP-dependent RNA helicase YLR419W

1

2

High-throughput

0.479

High

512165

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

512170

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

512173

YRA1
RNA annealing protein YRA1

1

1

High-throughput

0.479

High

512176

DBP10
ATP-dependent RNA helicase DBP10

1

3

High-throughput

0.479

High

512180

RS21B
Small ribosomal subunit protein eS21B

1

2

High-throughput

0.479

High

512181

RS25A
Small ribosomal subunit protein eS25A

1

1

High-throughput

0.479

High

512182

RS28A
Small ribosomal subunit protein eS28A

1

1

High-throughput

0.479

High

512034

RENT1
ATP-dependent helicase NAM7

1

0

Small-scale

0.460

High

512102

BUD27
Bud site selection protein 27

1

0

Small-scale

0.460

High

454681

KAPR
cAMP-dependent protein kinase regulatory subunit

1

0

Small-scale

0.458

High

458948

LYS2
L-2-aminoadipate reductase

1

0

High-throughput

0.458

High

481942

C1TM
C-1-tetrahydrofolate synthase, mitochondrial

1

0

High-throughput

0.458

High

512014

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.458

High

512015

DBP2
ATP-dependent RNA helicase DBP2

1

0

High-throughput

0.458

High

512019

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.458

High

512023

BUD23
18S rRNA

1

0

High-throughput

0.458

High

512036

HS104
Heat shock protein 104

1

0

High-throughput

0.458

High

512037

SYKM
Lysine--tRNA ligase, mitochondrial

1

0

High-throughput

0.458

High

512039

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

0

High-throughput

0.458

High

512040

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

0

High-throughput

0.458

High

512043

FIMB
Fimbrin

1

0

Small-scale

0.458

High

512045

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

512047

CBF5
H/ACA ribonucleoprotein complex subunit CBF5

1

0

High-throughput

0.458

High

512053

OSH1
Oxysterol-binding protein homolog 1

1

0

High-throughput

0.458

High

512056

YKH1
Uncharacterized oxidoreductase YKL071W

1

0

High-throughput

0.458

High

512057

LAS1
Protein LAS1

1

0

Small-scale

0.458

High

512063

EIF3A
Eukaryotic translation initiation factor 3 subunit A

1

0

High-throughput

0.458

High

512064

GID4
GID complex substrate-recognition subunit 4

1

0

High-throughput

0.458

High

512070

OTU2
OTU domain-containing protein 2

1

0

High-throughput

0.458

High

512071

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

512072

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.458

High

512076

STM1
Suppressor protein STM1

1

0

High-throughput

0.458

High

512079

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

512081

IF4F1
Eukaryotic initiation factor 4F subunit p150

1

0

High-throughput

0.458

High

512084

ARB1
ABC transporter ATP-binding protein ARB1

1

0

High-throughput

0.458

High

512090

TM108
Protein TMA108

1

0

High-throughput

0.458

High

512098

KRI1
Protein KRI1

1

0

High-throughput

0.458

High

512104

SCD6
Protein SCD6

1

0

Small-scale

0.458

High

512109

NOL10
Ribosome biogenesis protein ENP2

1

0

High-throughput

0.458

High

512112

RL38
Large ribosomal subunit protein eL38

1

0

High-throughput

0.458

High

512113

PSD10
Probable 26S proteasome regulatory subunit p28

1

0

Small-scale

0.458

High

512117

DXO
Decapping nuclease RAI1

1

0

Small-scale

0.458

High

512122

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

512124

PESC
Pescadillo homolog

1

0

High-throughput

0.458

High

512127

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

Small-scale

0.458

High

512129

GIS2
Zinc finger protein GIS2

1

0

High-throughput

0.458

High

512132

NST1
Stress response protein NST1

1

0

High-throughput

0.458

High

512141

XRN2
5'-3' exoribonuclease 2

1

0

High-throughput

0.458

High

512142

ELP3
Elongator complex protein 3

1

0

High-throughput

0.458

High

512147

FIN1
Filament protein FIN1

1

0

Small-scale

0.458

High

512148

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

512150

BUD22
Bud site selection protein 22

1

0

High-throughput

0.458

High

512157

TMA10
Translation machinery-associated protein 10

1

0

High-throughput

0.458

High

512163

ELP1
Elongator complex protein 1

1

0

High-throughput

0.458

High

512166

NOP6
Nucleolar protein 6

1

0

High-throughput

0.458

High

512167

RCL1
rRNA processing protein RCL1

1

0

High-throughput

0.458

High

512169

SGO1
Shugoshin

1

0

High-throughput

0.458

High

512172

TMA46
Translation machinery-associated protein 46

1

0

High-throughput

0.458

High

512179

RRP12
Ribosomal RNA-processing protein 12

1

0

High-throughput

0.458

High

403314

PABP
Polyadenylate-binding protein, cytoplasmic and nuclear

1

2

Small-scale

0.445

High

512041

PRP19
Pre-mRNA-processing factor 19

1

5

Small-scale

0.445

High

512086

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

380927

H2B1
Histone H2B.1

1

2

High-throughput

0.437

High

381808

H4
Histone H4

1

1

High-throughput

0.437

High

419557

H2A2
Histone H2A.2

1

1

High-throughput

0.437

High

512008

SKI3
Superkiller protein 3

1

1

High-throughput

0.437

High

512010

REB1
DNA-binding protein REB1

1

1

High-throughput

0.437

High

512032

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

512038

BTAF1
TATA-binding protein-associated factor MOT1

1

2

High-throughput

0.437

High

512059

YC16
UPF0743 protein YCR087C-A

1

1

High-throughput

0.437

High

512089

MLP2
Protein MLP2

1

4

High-throughput

0.437

High

512092

ULP2
Ubiquitin-like-specific protease 2

1

1

Small-scale

0.437

High

512135

ORC1
Origin recognition complex subunit 1

1

1

High-throughput

0.437

High

512140

PRS8
26S proteasome regulatory subunit 8 homolog

1

2

Small-scale

0.437

High

512146

ESC1
Silent chromatin protein ESC1

1

1

High-throughput

0.437

High

512175

SMT3
Ubiquitin-like protein SMT3

1

1

High-throughput

0.437

High

512177

RUVB2
RuvB-like protein 2

1

1

High-throughput

0.437

High

512097

DIM1
Dimethyladenosine transferase

1

0

High-throughput

0.426

High

512184

PNO1
Pre-rRNA-processing protein PNO1

1

0

Small-scale

0.426

High

512093

DSN1
Kinetochore-associated protein DSN1

2

0

High-throughput

0.305

High

456487

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

0

High-throughput

0.249

Low

512013

PSA2
Proteasome subunit alpha type-2

1

0

High-throughput

0.249

Low

512017

BUD31
Pre-mRNA-splicing factor BUD31

1

0

Small-scale

0.249

Low

512031

PEX3
Peroxisomal biogenesis factor 3

1

0

High-throughput

0.249

Low

512049

MFT1
THO complex subunit MFT1

1

0

High-throughput

0.249

Low

512055

EAP1
Protein EAP1

1

0

High-throughput

0.249

Low

512085

NSA2
Ribosome biogenesis protein NSA2

1

0

High-throughput

0.249

Low

512088

JEM1
DnaJ-like chaperone JEM1

1

0

High-throughput

0.249

Low

512091

FIS1
Mitochondrial fission 1 protein

1

0

Small-scale

0.249

Low

512107

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.249

Low

512111

GNP1
High-affinity glutamine permease

1

0

High-throughput

0.249

Low

512116

CWH41
Mannosyl-oligosaccharide glucosidase

1

0

High-throughput

0.249

Low

512126

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.249

Low

512133

SAM50
Sorting assembly machinery 50 kDa subunit

1

0

High-throughput

0.249

Low

512151

UTP14
U3 small nucleolar RNA-associated protein 14

1

0

High-throughput

0.249

Low

512154

YL278
Uncharacterized transcriptional regulatory protein YLR278C

1

0

High-throughput

0.249

Low

512156

YP114
Uncharacterized TLC domain-containing protein YPR114W

1

0

High-throughput

0.249

Low

512171

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

512073

RPF1
Ribosome production factor 1

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025