Protein: HST1
NAD-dependent protein deacetylase HST1 (EC 2.3.1.286) (Homologous to SIR2 protein 1) (Regulatory protein SIR2 homolog 1)

Gene: HST1
Organism: Saccharomyces cerevisiae S288C
Interactions: 25
UniProt ID: P53685

Gene Ontology (top 5):
GO:0000118 - histone deacetylase complex
GO:0005634 - nucleus
GO:0006357 - regulation of transcription by RNA polymerase II
GO:0006974 - DNA damage response
GO:0009267 - cellular response to starvation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

858413

SUM1
Suppressor of mar1-1 protein

6

1

Small-scale

0.729

High

922632

RFM1
Repression factor of MSEs protein 1

5

1

Small-scale

0.709

High

781776

SET3
SET domain-containing protein 3

5

11

Small-scale

0.706

High

796844

SIF2
SIR4-interacting protein SIF2

4

5

Small-scale

0.687

High

825204

HOS4
Protein HOS4

4

8

Small-scale

0.687

High

550678

SIR4
Regulatory protein SIR4

1

1

Small-scale

0.618

High

672778

SNT1
Probable DNA-binding protein SNT1

2

8

Small-scale

0.612

High

381193

H2B1
Histone H2B.1

1

9

High-throughput

0.575

High

917104

HOS2
Probable histone deacetylase HOS2

1

8

Small-scale

0.515

High

646486

RAD53
Serine/threonine-protein kinase RAD53

1

2

Small-scale

0.501

High

575981

CYPH
Peptidyl-prolyl cis-trans isomerase

1

0

Small-scale

0.493

High

809379

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

745827

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

1

High-throughput

0.479

High

763956

SPT10
Protein SPT10

1

1

High-throughput

0.479

High

805561

SET1
Histone-lysine N-methyltransferase, H3 lysine-4 specific

1

10

Small-scale

0.479

High

916524

SAP4
SIT4-associating protein SAP4

1

3

High-throughput

0.479

High

922629

SIZ1
E3 SUMO-protein ligase SIZ1

1

2

High-throughput

0.479

High

922631

SCC1
Sister chromatid cohesion protein 1

1

2

High-throughput

0.479

High

793184

AKL1
Serine/threonine-protein kinase AKL1

1

2

High-throughput

0.470

High

922630

TOS4
Protein TOS4

1

0

Small-scale

0.458

High

524713

HSP71
Heat shock protein SSA1

1

13

High-throughput

0.445

High

545752

SSB1
Ribosome-associated molecular chaperone SSB1

1

14

High-throughput

0.445

High

605114

TPM1
Tropomyosin-1

1

0

High-throughput

0.269

Low

922633

MPC70
Sporulation-specific protein 21

1

0

High-throughput

0.249

Low

922628

PFD4
Prefoldin subunit 4

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025