Protein: HEM6
Oxygen-dependent coproporphyrinogen-III oxidase (COX) (Coprogen oxidase) (Coproporphyrinogenase) (EC 1.3.3.3)

Gene: HEM6, HEM13
Organism: Saccharomyces cerevisiae S288C
Interactions: 42
UniProt ID: P11353

Gene Ontology (top 5):
GO:0004109 - coproporphyrinogen oxidase activity
GO:0005737 - cytoplasm
GO:0005829 - cytosol
GO:0006782 - protoporphyrinogen IX biosynthetic process
GO:0006783 - heme biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

541267

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

2

High-throughput

0.656

High

541286

TAF6
SAGA complex/transcription factor TFIID complex subunit TAF6

2

0

High-throughput

0.595

High

481446

HSP73
Heat shock protein SSA3

2

3

High-throughput

0.588

High

541282

HSP7E
Heat shock protein SSC3, mitochondrial

2

1

High-throughput

0.588

High

525748

HSP72
Heat shock protein SSA2

2

3

High-throughput

0.552

High

445305

CDC31
Cell division control protein 31

1

0

High-throughput

0.493

High

541273

PDC6
Pyruvate decarboxylase isozyme 3

1

0

High-throughput

0.493

High

541275

EF2
Elongation factor 2

1

0

High-throughput

0.493

High

541288

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.493

High

541292

HMO1
High mobility group protein 1

1

0

High-throughput

0.493

High

541294

CRM2
Homeostatic regulator of DAG

1

0

High-throughput

0.493

High

541270

ESS1
Peptidyl-prolyl cis-trans isomerase ESS1

1

0

High-throughput

0.480

High

541271

HAL4
Serine/threonine-protein kinase HAL4/SAT4

1

0

High-throughput

0.480

High

541284

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.480

High

541285

SET2
Histone-lysine N-methyltransferase, H3 lysine-36 specific

1

0

High-throughput

0.480

High

514922

YA11A
Transposon Ty1-A Gag polyprotein

1

1

High-throughput

0.479

High

541293

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

1

High-throughput

0.479

High

541281

KOG1
Target of rapamycin complex 1 subunit KOG1

1

0

High-throughput

0.460

High

541279

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

541287

TAN1
tRNA acetyltransferase TAN1

1

0

High-throughput

0.458

High

541290

FDC1
Ferulic acid decarboxylase 1

1

0

High-throughput

0.458

High

522856

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

541268

SSB1
Ribosome-associated molecular chaperone SSB1

1

3

High-throughput

0.445

High

541276

HSP7F
Heat shock protein homolog SSE1

1

4

High-throughput

0.445

High

541283

SSB2
Ribosome-associated molecular chaperone SSB2

1

3

High-throughput

0.445

High

394155

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

453379

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

541272

MAS5
Mitochondrial protein import protein MAS5

1

0

High-throughput

0.426

High

381375

H2B2
Histone H2B.2

1

0

High-throughput

0.269

Low

381819

H4
Histone H4

1

0

High-throughput

0.269

Low

419565

H2A2
Histone H2A.2

1

0

High-throughput

0.269

Low

456493

ARD1
N-terminal acetyltransferase A complex catalytic subunit ARD1

1

0

High-throughput

0.269

Low

541269

PDI
Protein disulfide-isomerase

1

0

High-throughput

0.269

Low

541289

SED1
Cell wall protein SED1

1

0

High-throughput

0.265

Low

541277

PRP40
Pre-mRNA-processing protein PRP40

1

0

High-throughput

0.261

Low

439498

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

1

0

High-throughput

0.249

Low

541274

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

541280

WSS1
DNA-dependent metalloprotease WSS1

1

0

Small-scale

0.249

Low

541291

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.249

Low

541295

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.249

Low

541278

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025