Protein: PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase (EC 2.7.8.11) (Phosphatidylinositol synthase) (PI synthase) (PIS) (PtdIns synthase)

Gene: PIS, PIS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: P06197

Gene Ontology (top 5):
GO:0000139 - Golgi membrane
GO:0003881 - CDP-diacylglycerol-inositol 3-phosphatidyltransferase activity
GO:0005739 - mitochondrion
GO:0005741 - mitochondrial outer membrane
GO:0005783 - endoplasmic reticulum

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

439493

PIS
CDP-diacylglycerol--inositol 3-phosphatidyltransferase

2

0

High-throughput

0.751

High

439530

MPS3
Spindle pole body assembly component MPS3

2

0

High-throughput

0.575

High

439502

GAP1
General amino-acid permease GAP1

1

1

Small-scale

0.552

High

439499

HSC82
ATP-dependent molecular chaperone HSC82

2

0

High-throughput

0.547

High

439500

NCPR
NADPH--cytochrome P450 reductase

1

1

High-throughput

0.541

High

439514

GCS1
ADP-ribosylation factor GTPase-activating protein GCS1

1

1

High-throughput

0.541

High

439536

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.541

High

439544

ERP1
Protein ERP1

1

2

High-throughput

0.541

High

439495

HSP71
Heat shock protein SSA1

2

1

High-throughput

0.533

High

439497

CP51
Lanosterol 14-alpha demethylase CYP51

1

0

High-throughput

0.518

High

439507

PPZ1
Serine/threonine-protein phosphatase PP-Z1

1

0

High-throughput

0.518

High

439513

RER2
Dehydrodolichyl diphosphate synthase complex subunit RER2

1

0

High-throughput

0.518

High

439518

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.518

High

439520

SSH1
Sec sixty-one protein homolog

1

0

High-throughput

0.518

High

439521

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

0

High-throughput

0.518

High

439527

AYR1
NADPH-dependent 1-acyldihydroxyacetone phosphate reductase

1

0

High-throughput

0.518

High

439528

EMC5
ER membrane protein complex subunit 5

1

0

High-throughput

0.518

High

439535

ERG5
C-22 sterol desaturase ERG5

1

0

High-throughput

0.518

High

439538

OSH6
Oxysterol-binding protein homolog 6

1

0

High-throughput

0.518

High

439539

SHR3
Secretory component protein SHR3

1

0

High-throughput

0.518

High

439542

TCB3
Tricalbin-3

1

0

High-throughput

0.518

High

439546

TMS1
Membrane protein TMS1

1

0

High-throughput

0.518

High

439547

SEY1
Protein SEY1

1

0

High-throughput

0.518

High

439524

MST28
Multicopy suppressor of SEC21 protein 28

1

1

High-throughput

0.508

High

439515

SIS2
Phosphopantothenoylcysteine decarboxylase subunit SIS2

1

1

High-throughput

0.494

High

439516

CAB3
Coenzyme A biosynthesis protein 3

1

1

High-throughput

0.494

High

439505

SEC14
SEC14 cytosolic factor

1

0

High-throughput

0.486

High

439529

GST1
Glutathione S-transferase 1

1

0

High-throughput

0.486

High

439541

PEX29
Peroxisomal membrane protein PEX29

1

0

High-throughput

0.486

High

439543

USA1
U1 SNP1-associating protein 1

1

0

High-throughput

0.486

High

439545

LAM6
Membrane-anchored lipid-binding protein LAM6

1

0

High-throughput

0.486

High

439496

HSP72
Heat shock protein SSA2

1

1

High-throughput

0.479

High

439508

PMT2
Dolichyl-phosphate-mannose--protein mannosyltransferase 2

1

1

High-throughput

0.479

High

439511

EMP24
Endosomal protein P24B

1

1

High-throughput

0.479

High

439512

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

1

High-throughput

0.479

High

439532

COPA
Coatomer subunit alpha

1

1

High-throughput

0.479

High

439523

UIP3
ULP1-interacting protein 3

1

1

High-throughput

0.464

High

439501

VATA
V-type proton ATPase catalytic subunit A

1

0

High-throughput

0.458

High

439503

ACO1
Acyl-CoA desaturase 1

1

0

High-throughput

0.458

High

439504

PSA1
Proteasome subunit alpha type-1

1

0

High-throughput

0.458

High

439506

CWH43
Protein CWH43

1

0

High-throughput

0.458

High

439522

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.458

High

439525

SPF1
Endoplasmic reticulum transmembrane helix translocase

1

0

High-throughput

0.458

High

439533

ALG9
Alpha-1,2-mannosyltransferase ALG9

1

0

High-throughput

0.458

High

439534

APJ1
J domain-containing protein APJ1

1

0

High-throughput

0.458

High

439531

ERV29
ER-derived vesicles protein ERV29

1

0

High-throughput

0.438

High

439537

UBC7
Ubiquitin-conjugating enzyme E2 7

1

0

High-throughput

0.438

High

439517

NU170
Nucleoporin NUP170

1

1

High-throughput

0.437

High

439510

HSP7F
Heat shock protein homolog SSE1

1

2

High-throughput

0.407

High

439509

NDC1
Nucleoporin NDC1

1

0

High-throughput

0.282

High

439540

ROD1
Protein ROD1

1

0

High-throughput

0.282

High

439519

NTM1
Alpha N-terminal protein methyltransferase 1

1

0

High-throughput

0.265

Low

439494

DED1
ATP-dependent RNA helicase DED1

1

0

High-throughput

0.249

Low

439498

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.249

Low

439526

SSB2
Ribosome-associated molecular chaperone SSB2

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025