Protein: WSS1
DNA-dependent metalloprotease WSS1 (EC 3.4.24.-) (DNA damage response protein WSS1) (SUMO-dependent isopeptidase WSS1) (Weak suppressor of SMT3 protein 1)

Gene: WSS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 82
UniProt ID: P38838

Gene Ontology (top 5):
GO:0000324 - fungal-type vacuole
GO:0004222 - metalloendopeptidase activity
GO:0005634 - nucleus
GO:0005635 - nuclear envelope
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

805851

SMT3
Ubiquitin-like protein SMT3

5

0

Small-scale

0.685

High

679658

CDC48
Cell division control protein 48

2

1

Small-scale

0.639

High

805812

WSS1
DNA-dependent metalloprotease WSS1

3

0

Small-scale

0.627

High

779947

DOA1
Protein DOA1

1

1

Small-scale

0.561

High

805813

LIN1
Protein LIN1

1

0

Small-scale

0.486

High

805817

LIS1
Nuclear distribution protein PAC1

1

1

Small-scale

0.481

High

382092

H4
Histone H4

1

0

Small-scale

0.480

High

415222

TOP1
DNA topoisomerase 1

1

0

Small-scale

0.480

High

419425

H2A1
Histone H2A.1

1

0

Small-scale

0.480

High

509543

UBI4P
Polyubiquitin [Cleaved into: Ubiquitin]

1

0

Small-scale

0.480

High

554345

HMDH1
3-hydroxy-3-methylglutaryl-coenzyme A reductase 1

1

0

Small-scale

0.480

High

805831

H1
Histone H1

1

0

Small-scale

0.480

High

805833

H3
Histone H3

1

0

Small-scale

0.480

High

750941

PRS7
26S proteasome regulatory subunit 7 homolog

1

2

Small-scale

0.479

High

805830

RPN14
26S proteasome regulatory subunit RPN14

1

1

Small-scale

0.479

High

739300

KAR9
Karyogamy protein KAR9

1

0

Small-scale

0.460

High

745470

SLX5
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX5

1

0

Small-scale

0.460

High

805820

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

Small-scale

0.460

High

805821

PP4R3
Serine/threonine-protein phosphatase 4 regulatory subunit 3

1

0

Small-scale

0.460

High

805832

TOF1
Topoisomerase 1-associated factor 1

1

0

Small-scale

0.460

High

805835

SLT2
Mitogen-activated protein kinase SLT2/MPK1

1

0

High-throughput

0.460

High

449286

RAD10
DNA repair protein RAD10

1

0

Small-scale

0.458

High

454656

RAD2
DNA repair protein RAD2

1

0

Small-scale

0.458

High

636661

PSA1
Proteasome subunit alpha type-1

1

0

Small-scale

0.458

High

645169

PSB4
Proteasome subunit beta type-4

1

0

Small-scale

0.458

High

647102

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

0

Small-scale

0.458

High

667057

CG21
G2/mitotic-specific cyclin-1

1

0

Small-scale

0.458

High

700100

PRP45
Pre-mRNA-processing protein 45

1

0

Small-scale

0.458

High

712919

PAP
Poly(A) polymerase

1

0

Small-scale

0.458

High

748129

RPC6
DNA-directed RNA polymerase III subunit RPC6

1

0

Small-scale

0.458

High

782649

PXL1
Paxillin-like protein 1

1

0

Small-scale

0.458

High

803749

RRM3
ATP-dependent DNA helicase RRM3

1

0

Small-scale

0.458

High

805178

TRA1
SAGA complex/NuA4 acetyltransferase complex subunit TRA1

1

0

Small-scale

0.458

High

805814

CENPN
Inner kinetochore subunit CHL4

1

0

Small-scale

0.458

High

805824

SMC3
Structural maintenance of chromosomes protein 3

1

0

Small-scale

0.458

High

805826

DPOD3
DNA polymerase delta subunit 3

1

0

Small-scale

0.458

High

805828

MSN5
Protein MSN5

1

0

Small-scale

0.458

High

805834

SEN1
Helicase SEN1

1

0

Small-scale

0.458

High

805837

XRN2
5'-3' exoribonuclease 2

1

0

Small-scale

0.458

High

805839

MSH6
DNA mismatch repair protein MSH6

1

0

Small-scale

0.458

High

805840

SCC2
Sister chromatid cohesion protein 2

1

0

Small-scale

0.458

High

805847

DIA2
Protein DIA2

1

0

Small-scale

0.458

High

805849

THP3
Protein THP3

1

0

Small-scale

0.458

High

734332

DGR2
2-deoxy-glucose resistant protein 2

1

1

Small-scale

0.437

High

805843

IMH1
Golgin IMH1

1

1

Small-scale

0.437

High

804151

SSZ1
Ribosome-associated complex subunit SSZ1

1

0

High-throughput

0.426

High

805829

RTA1
Protein RTA1

1

0

High-throughput

0.265

Low

805838

SNO1
Pyridoxal 5'-phosphate synthase subunit SNO1

1

0

High-throughput

0.265

Low

548202

BIK1
Nuclear fusion protein BIK1

1

0

Small-scale

0.251

Low

780261

EBP2
rRNA-processing protein EBP2

1

0

Small-scale

0.251

Low

805818

BIM1
Protein BIM1

1

0

Small-scale

0.251

Low

805823

STU2
Protein STU2

1

0

Small-scale

0.251

Low

433201

RL17A
Large ribosomal subunit protein uL22A

1

0

Small-scale

0.249

Low

477558

MYO1
Myosin-1

1

0

Small-scale

0.249

Low

541280

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

Small-scale

0.249

Low

592765

ERD1
Protein ERD1

1

0

Small-scale

0.249

Low

654781

URE2
Transcriptional regulator URE2

1

0

Small-scale

0.249

Low

673013

YCT3
Uncharacterized protein YCR043C

1

0

Small-scale

0.249

Low

673563

NLE1
Ribosome assembly protein 4

1

0

Small-scale

0.249

Low

673659

USO1
Intracellular protein transport protein USO1

1

0

Small-scale

0.249

Low

676837

DCC1
Sister chromatid cohesion protein DCC1

1

0

Small-scale

0.249

Low

680579

CYPC
Peptidyl-prolyl cis-trans isomerase C, mitochondrial

1

0

Small-scale

0.249

Low

698106

PEP3
Vacuolar membrane protein PEP3

1

0

Small-scale

0.249

Low

704681

PRR1
Serine/threonine-protein kinase PRR1

1

0

Small-scale

0.249

Low

743982

RAD23
UV excision repair protein RAD23

1

0

Small-scale

0.249

Low

746430

SSO1
Protein SSO1

1

0

Small-scale

0.249

Low

796918

PHO88
SRP-independent targeting protein 3

1

0

Small-scale

0.249

Low

805815

SEC72
Translocation protein SEC72

1

0

Small-scale

0.249

Low

805816

PAC2
Protein PAC2

1

0

Small-scale

0.249

Low

805819

FIR1
Factor interacting with REF2

1

0

Small-scale

0.249

Low

805822

UBP6
Ubiquitin carboxyl-terminal hydrolase 6

1

0

Small-scale

0.249

Low

805825

YJB6
Uncharacterized protein YJL016W

1

0

Small-scale

0.249

Low

805827

ARP3
Actin-related protein 3

1

0

Small-scale

0.249

Low

805836

RSC4
Chromatin structure-remodeling complex subunit RSC4

1

0

Small-scale

0.249

Low

805841

EMI2
Putative glucokinase-2

1

0

Small-scale

0.249

Low

805842

YD306
F-box protein YDR306C

1

0

Small-scale

0.249

Low

805844

NVJ2
Nucleus-vacuole junction protein 2

1

0

Small-scale

0.249

Low

805845

TRM3
tRNA

1

0

Small-scale

0.249

Low

805846

TYW4
tRNA wybutosine-synthesizing protein 4

1

0

Small-scale

0.249

Low

805848

ENV7
Serine/threonine-protein kinase ENV7

1

0

Small-scale

0.249

Low

805850

CSF1
Protein CSF1

1

0

Small-scale

0.249

Low


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Last updated: 11Aug2025