Protein: HMO1
High mobility group protein 1 (High spontaneous mutagenesis protein 2)

Gene: HMO1
Organism: Saccharomyces cerevisiae S288C
Interactions: 224
UniProt ID: Q03973

Gene Ontology (top 5):
GO:0000400 - four-way junction DNA binding
GO:0000785 - chromatin
GO:0001174 - transcriptional start site selection at RNA polymerase II promoter
GO:0003690 - double-stranded DNA binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1044580

HMO1
High mobility group protein 1

2

17

Small-scale

0.816

High

1039029

IMA1
Importin subunit alpha

1

6

High-throughput

0.698

High

382315

H4
Histone H4

3

12

High-throughput

0.662

High

1044608

SMT3
Ubiquitin-like protein SMT3

3

13

High-throughput

0.648

High

812178

FKHL1
Pre-rRNA-processing protein FHL1

2

20

High-throughput

0.633

High

383881

RS17A
Small ribosomal subunit protein eS17A

2

4

High-throughput

0.611

High

427432

RLA0
Large ribosomal subunit protein uL10

2

8

High-throughput

0.611

High

419859

H2A2
Histone H2A.2

2

20

High-throughput

0.601

High

546139

SSB1
Ribosome-associated molecular chaperone SSB1

2

12

High-throughput

0.601

High

850380

IOC3
ISWI one complex protein 3

2

1

Small-scale

0.601

High

1044588

TFC6
Transcription factor tau 91 kDa subunit

2

2

High-throughput

0.601

High

1044606

YRA1
RNA annealing protein YRA1

2

13

High-throughput

0.601

High

410322

RL25
Large ribosomal subunit protein uL23

2

3

High-throughput

0.584

High

433835

RL26A
Large ribosomal subunit protein uL24A

2

3

High-throughput

0.584

High

1044590

RSC2
Chromatin structure-remodeling complex subunit RSC2

2

20

Small-scale

0.584

High

1044611

CMR1
DNA damage-binding protein CMR1

2

20

High-throughput

0.584

High

1044586

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

2

0

High-throughput

0.576

High

1044582

TAF11
Transcription initiation factor TFIID subunit 11

2

0

Small-scale

0.575

High

561524

TBP
TATA-box-binding protein

1

1

Small-scale

0.573

High

531875

RL4A
Large ribosomal subunit protein uL4A

2

5

High-throughput

0.571

High

570133

RL3
Large ribosomal subunit protein uL3

2

4

High-throughput

0.571

High

712663

RL8B
Large ribosomal subunit protein eL8B

2

6

High-throughput

0.571

High

863876

RL17B
Large ribosomal subunit protein uL22B

2

2

High-throughput

0.571

High

885080

RL4B
Large ribosomal subunit protein uL4B

2

5

High-throughput

0.571

High

814145

SAW1
Single-strand annealing weakened protein 1

2

0

High-throughput

0.563

High

849808

EPL1
Enhancer of polycomb-like protein 1

2

0

Small-scale

0.563

High

858466

TAF1
Transcription initiation factor TFIID subunit 1

1

2

Small-scale

0.552

High

1044604

ELG1
Telomere length regulation protein ELG1

1

11

Small-scale

0.552

High

527587

HSP72
Heat shock protein SSA2

2

12

High-throughput

0.552

High

740752

SRP40
Suppressor protein SRP40

1

4

High-throughput

0.541

High

639062

VPS1
Vacuolar protein sorting-associated protein 1

1

5

High-throughput

0.536

High

734470

BTAF1
TATA-binding protein-associated factor MOT1

1

20

High-throughput

0.536

High

782434

RPF2
Ribosome biogenesis protein RPF2

1

1

High-throughput

0.536

High

794215

ISW1
ISWI chromatin-remodeling complex ATPase ISW1

1

20

High-throughput

0.536

High

850568

RSC8
Chromatin structure-remodeling complex protein RSC8

1

15

High-throughput

0.536

High

923118

BRE5
UBP3-associated protein BRE5

1

10

High-throughput

0.536

High

1044450

RUVB1
RuvB-like protein 1

1

14

High-throughput

0.536

High

1044592

RSC3
Chromatin structure-remodeling complex protein RSC3

1

3

High-throughput

0.536

High

444872

SIR3
Regulatory protein SIR3

1

7

High-throughput

0.515

High

584388

GCN2
eIF-2-alpha kinase GCN2

1

4

High-throughput

0.515

High

632731

DBP4
ATP-dependent RNA helicase HCA4

1

13

High-throughput

0.515

High

646526

RAD53
Serine/threonine-protein kinase RAD53

1

3

High-throughput

0.515

High

647831

RFA1
Replication factor A protein 1

1

8

High-throughput

0.515

High

650016

SIN3
Transcriptional regulatory protein SIN3

1

5

High-throughput

0.515

High

656995

BUR1
Serine/threonine-protein kinase BUR1

1

10

High-throughput

0.515

High

675349

RAD51
DNA repair protein RAD51

1

1

High-throughput

0.515

High

697395

MIG1
Regulatory protein MIG1

1

7

High-throughput

0.515

High

738251

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

1

6

High-throughput

0.515

High

745669

ORC2
Origin recognition complex subunit 2

1

3

High-throughput

0.515

High

794330

PBP2
PAB1-binding protein 2

1

8

High-throughput

0.515

High

798298

ENP1
Essential nuclear protein 1

1

1

High-throughput

0.515

High

801018

RFC1
Replication factor C subunit 1

1

10

High-throughput

0.515

High

806496

NACA
Nascent polypeptide-associated complex subunit alpha

1

1

High-throughput

0.515

High

917684

LSG1
Large subunit GTPase 1

1

5

High-throughput

0.515

High

919582

YG5B
Uncharacterized RNA-binding protein YGR250C

1

6

High-throughput

0.515

High

963695

H3
Histone H3

1

20

High-throughput

0.515

High

1040708

YMN1
Uncharacterized membrane protein YML131W

1

3

High-throughput

0.515

High

1044584

RRP5
rRNA biogenesis protein RRP5

1

5

High-throughput

0.515

High

1044587

PDP3
NuA3 HAT complex component PDP3

1

8

High-throughput

0.515

High

1044594

PRP11
Pre-mRNA-splicing factor PRP11

1

2

High-throughput

0.515

High

1044609

YRM1
Zinc finger transcription factor YRM1

1

3

High-throughput

0.515

High

864323

NET1
Nucleolar protein NET1

1

0

High-throughput

0.513

High

1044596

NOP6
Nucleolar protein 6

1

0

High-throughput

0.513

High

1044599

BUD20
Bud site selection protein 20

1

0

High-throughput

0.513

High

915395

MSN5
Protein MSN5

1

10

High-throughput

0.508

High

628090

FKBP
FK506-binding protein 1

1

5

Small-scale

0.506

High

1044591

HPA2
Histone acetyltransferase HPA2

1

2

Small-scale

0.501

High

803376

HSE1
Class E vacuolar protein-sorting machinery protein HSE1

1

3

High-throughput

0.494

High

541292

HEM6
Oxygen-dependent coproporphyrinogen-III oxidase

1

0

High-throughput

0.493

High

665202

DPB2
DNA polymerase epsilon subunit B

1

0

High-throughput

0.493

High

673030

YCT3
Uncharacterized protein YCR043C

1

0

High-throughput

0.493

High

735407

MCM10
Minichromosome maintenance protein 10

1

0

High-throughput

0.493

High

738178

NGG1
SAGA complex subunit NGG1

1

0

High-throughput

0.493

High

805525

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.493

High

818094

SLX8
E3 ubiquitin-protein ligase complex SLX5-SLX8 subunit SLX8

1

0

High-throughput

0.493

High

820890

SIP5
Protein SIP5

1

0

High-throughput

0.493

High

826003

ACA2
ATF/CREB activator 2

1

0

High-throughput

0.493

High

874339

HOSC
Homocitrate synthase, cytosolic isozyme

1

0

High-throughput

0.493

High

918812

UTP22
U3 small nucleolar RNA-associated protein 22

1

0

High-throughput

0.493

High

919686

RT102
Regulator of Ty1 transposition protein 102

1

0

High-throughput

0.493

High

1044581

IOC4
ISWI one complex protein 4

1

0

High-throughput

0.493

High

1044593

SWC7
SWR1-complex protein 7

1

0

High-throughput

0.493

High

1044598

SDO1
Ribosome maturation protein SDO1

1

0

High-throughput

0.493

High

1044603

CDC53
Cell division control protein 53

1

6

Small-scale

0.481

High

149942

RS9A
Small ribosomal subunit protein uS4A

1

3

High-throughput

0.479

High

154223

RL36B
Large ribosomal subunit protein eL36B

1

2

High-throughput

0.479

High

383190

RLA4
Large ribosomal subunit protein P2B

1

4

High-throughput

0.479

High

415049

RL39
Large ribosomal subunit protein eL39

1

4

High-throughput

0.479

High

432691

RL7A
Large ribosomal subunit protein uL30A

1

6

High-throughput

0.479

High

432911

RL9A
Large ribosomal subunit protein uL6A

1

3

High-throughput

0.479

High

433285

RL17A
Large ribosomal subunit protein uL22A

1

2

High-throughput

0.479

High

434082

RL33A
Large ribosomal subunit protein eL33A

1

1

High-throughput

0.479

High

434274

RL29
Large ribosomal subunit protein eL29

1

2

High-throughput

0.479

High

434437

RL15A
Large ribosomal subunit protein eL15A

1

4

High-throughput

0.479

High

434646

RL22A
Large ribosomal subunit protein eL22A

1

1

High-throughput

0.479

High

435338

RS3
Small ribosomal subunit protein uS3

1

3

High-throughput

0.479

High

436155

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

442097

RS14A
Small ribosomal subunit protein uS11A

1

3

High-throughput

0.479

High

448333

PDE2
3',5'-cyclic-nucleotide phosphodiesterase 2

1

3

High-throughput

0.479

High

455246

RS19A
Small ribosomal subunit protein eS19A

1

4

High-throughput

0.479

High

503223

RS22A
Small ribosomal subunit protein uS8A

1

5

High-throughput

0.479

High

504400

RL31A
Large ribosomal subunit protein eL31A

1

1

High-throughput

0.479

High

511283

RL20B
Large ribosomal subunit protein eL20B

1

3

High-throughput

0.479

High

512633

RS6A
Small ribosomal subunit protein eS6A

1

3

High-throughput

0.479

High

513203

RS8A
Small ribosomal subunit protein eS8A

1

2

High-throughput

0.479

High

513765

RL2A
Large ribosomal subunit protein uL2A

1

4

High-throughput

0.479

High

514358

RL12B
Large ribosomal subunit protein uL11B

1

2

High-throughput

0.479

High

514821

RS18A
Small ribosomal subunit protein uS13A

1

2

High-throughput

0.479

High

515166

RL19B
Large ribosomal subunit protein eL19

1

4

High-throughput

0.479

High

515320

RL35A
Large ribosomal subunit protein uL29A

1

1

High-throughput

0.479

High

569857

RL30
Large ribosomal subunit protein eL30

1

2

High-throughput

0.479

High

594552

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

6

High-throughput

0.479

High

601123

RL8A
Large ribosomal subunit protein eL8A

1

6

High-throughput

0.479

High

644981

RPA2
DNA-directed RNA polymerase I subunit RPA135

1

7

High-throughput

0.479

High

647207

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

7

High-throughput

0.479

High

674820

RS2
Small ribosomal subunit protein uS5

1

4

High-throughput

0.479

High

677545

KRR1
KRR1 small subunit processome component

1

1

High-throughput

0.479

High

684832

RL5
Large ribosomal subunit protein uL18

1

4

High-throughput

0.479

High

689126

RL16A
Large ribosomal subunit protein uL13A

1

2

High-throughput

0.479

High

689645

RS7A
Small ribosomal subunit protein eS7A

1

2

High-throughput

0.479

High

708076

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

735144

RPC3
DNA-directed RNA polymerase III subunit RPC3

1

2

High-throughput

0.479

High

745863

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

7

High-throughput

0.479

High

747562

RSSA1
Small ribosomal subunit protein uS2A

1

6

High-throughput

0.479

High

753569

RS3A1
Small ribosomal subunit protein eS1A

1

5

High-throughput

0.479

High

775988

TCTP
Translationally-controlled tumor protein homolog

1

1

High-throughput

0.479

High

781259

RL14A
Large ribosomal subunit protein eL14A

1

3

High-throughput

0.479

High

792230

GBLP
Small ribosomal subunit protein RACK1

1

11

High-throughput

0.479

High

792571

RL32
Large ribosomal subunit protein eL32

1

2

High-throughput

0.479

High

802374

RS20
Small ribosomal subunit protein uS10

1

4

High-throughput

0.479

High

803435

RL14B
Large ribosomal subunit protein eL14B

1

3

High-throughput

0.479

High

812115

DHH1
ATP-dependent RNA helicase DHH1

1

16

High-throughput

0.479

High

812624

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

814033

IF2P
Eukaryotic translation initiation factor 5B

1

4

High-throughput

0.479

High

820957

RL13B
Large ribosomal subunit protein eL13B

1

3

High-throughput

0.479

High

823030

ATAD2
ATPase histone chaperone YTA7

1

4

High-throughput

0.479

High

825904

RL34B
Large ribosomal subunit protein eL34B

1

3

High-throughput

0.479

High

826069

ULP2
Ubiquitin-like-specific protease 2

1

6

High-throughput

0.479

High

826799

DSN1
Kinetochore-associated protein DSN1

1

2

High-throughput

0.479

High

835884

RL10
Large ribosomal subunit protein uL16

1

3

High-throughput

0.479

High

844346

ELP2
Elongator complex protein 2

1

14

High-throughput

0.479

High

874512

RS12
Small ribosomal subunit protein eS12

1

3

High-throughput

0.479

High

879841

RL37A
Large ribosomal subunit protein eL37A

1

1

High-throughput

0.479

High

897498

UBC9
SUMO-conjugating enzyme UBC9

1

9

High-throughput

0.479

High

902672

RL9B
Large ribosomal subunit protein uL6B

1

3

High-throughput

0.479

High

918330

RL26B
Large ribosomal subunit protein uL24B

1

3

High-throughput

0.479

High

918523

RSC1
Chromatin structure-remodeling complex subunit RSC1

1

20

Small-scale

0.479

High

923870

GIS2
Zinc finger protein GIS2

1

1

High-throughput

0.479

High

924057

JJJ1
J protein JJJ1

1

12

High-throughput

0.479

High

932224

ORC1
Origin recognition complex subunit 1

1

7

High-throughput

0.479

High

1018153

RL34A
Large ribosomal subunit protein eL34A

1

3

High-throughput

0.479

High

1033546

RS15
Small ribosomal subunit protein uS19

1

4

High-throughput

0.479

High

1036288

RL6A
Large ribosomal subunit protein eL6A

1

2

High-throughput

0.479

High

1038395

RL21A
Large ribosomal subunit protein eL21A

1

2

High-throughput

0.479

High

1038743

XRN2
5'-3' exoribonuclease 2

1

3

High-throughput

0.479

High

1044583

POB3
FACT complex subunit POB3

1

6

High-throughput

0.479

High

1044595

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

1044602

RS10A
Small ribosomal subunit protein eS10A

1

2

High-throughput

0.479

High

1044605

SCC1
Sister chromatid cohesion protein 1

1

4

Small-scale

0.479

High

1044610

DBP10
ATP-dependent RNA helicase DBP10

1

14

High-throughput

0.479

High

1044613

RL13A
Large ribosomal subunit protein eL13A

1

3

High-throughput

0.479

High

1044614

H2AZ
Histone H2A.Z

1

20

High-throughput

0.479

High

1044615

RL11B
Large ribosomal subunit protein uL5B

1

5

High-throughput

0.479

High

745386

EMP24
Endosomal protein P24B

1

1

High-throughput

0.470

High

797447

MKAR
Very-long-chain 3-oxoacyl-CoA reductase

1

1

High-throughput

0.470

High

802015

MSC7
Putative aldehyde dehydrogenase-like protein YHR039C

1

4

High-throughput

0.470

High

813609

ERP2
Protein ERP2

1

2

High-throughput

0.470

High

932628

TMEDA
Endoplasmic reticulum vesicle protein 25

1

2

High-throughput

0.470

High

1044589

CORO
Coronin-like protein

1

18

High-throughput

0.470

High

808550

TEM1
Protein TEM1

1

6

High-throughput

0.464

High

511483

RL43B
Large ribosomal subunit protein eL43B

1

0

High-throughput

0.458

High

515384

RS32B
Small ribosomal subunit protein eS32B

1

0

High-throughput

0.458

High

553559

PDR1
Transcription factor PDR1

1

0

High-throughput

0.458

High

558857

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

617815

SNF6
Transcription regulatory protein SNF6

1

0

Small-scale

0.458

High

752686

HSP78
Heat shock protein 78, mitochondrial

1

0

High-throughput

0.458

High

778519

RS27A
Small ribosomal subunit protein eS27A

1

0

High-throughput

0.458

High

792935

ANM1
Protein arginine N-methyltransferase 1

1

0

High-throughput

0.458

High

813718

ECM1
Shuttling pre-60S factor ECM1

1

0

High-throughput

0.458

High

865742

MOG1
Nuclear import protein MOG1

1

0

High-throughput

0.458

High

1044305

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

0

High-throughput

0.458

High

1044585

RQC1
Ribosome quality control complex subunit 1

1

0

High-throughput

0.458

High

1044601

SGO1
Shugoshin

1

0

High-throughput

0.458

High

1044612

RQC2
Ribosome quality control complex subunit 2

1

0

High-throughput

0.458

High

394877

EF1A
Elongation factor 1-alpha

1

3

High-throughput

0.445

High

453775

PYR1
Multifunctional protein URA2

1

4

High-throughput

0.445

High

525036

HSP71
Heat shock protein SSA1

1

12

High-throughput

0.445

High

536049

SEC7
ADP-ribosylation factor guanine nucleotide-exchange factor SEC7

1

1

High-throughput

0.445

High

550079

RAP1
DNA-binding protein RAP1

1

2

High-throughput

0.445

High

676311

MAS5
Mitochondrial protein import protein MAS5

1

7

High-throughput

0.445

High

734197

EF2
Elongation factor 2

1

5

High-throughput

0.445

High

742322

HSP7F
Heat shock protein homolog SSE1

1

15

High-throughput

0.445

High

755165

GCN1
eIF-2-alpha kinase activator GCN1

1

7

High-throughput

0.445

High

805138

YNG2
Chromatin modification-related protein YNG2

1

18

Small-scale

0.445

High

819694

SSB2
Ribosome-associated molecular chaperone SSB2

1

12

High-throughput

0.445

High

826482

DJP1
DnaJ-like protein 1

1

8

High-throughput

0.445

High

864368

SMC3
Structural maintenance of chromosomes protein 3

1

8

Small-scale

0.445

High

1025170

SEN1
Helicase SEN1

1

6

Small-scale

0.445

High

1044600

RRP44
Exosome complex exonuclease DIS3

1

2

High-throughput

0.445

High

1044607

RL7B
Large ribosomal subunit protein uL30B

1

6

High-throughput

0.445

High

427747

RLA2
Large ribosomal subunit protein P2A

1

4

High-throughput

0.437

High

528865

RLA3
Large ribosomal subunit protein P1B

1

1

High-throughput

0.437

High

745198

CDC13
Cell division control protein 13

1

1

Small-scale

0.437

High

785969

LONM
Lon protease homolog, mitochondrial

1

5

High-throughput

0.437

High

815330

IF4F2
Eukaryotic initiation factor 4F subunit p130

1

15

High-throughput

0.437

High

925383

SAM50
Sorting assembly machinery 50 kDa subunit

1

1

High-throughput

0.437

High

1044597

TEN1
Telomere length regulation protein TEN1

1

1

Small-scale

0.437

High

570813

ABF1
ARS-binding factor 1

1

0

High-throughput

0.426

High

816626

EAF5
Chromatin modification-related protein EAF5

1

0

Small-scale

0.426

High

858549

AP3B
AP-3 complex subunit beta

1

0

High-throughput

0.426

High

734576

MSS51
Protein MSS51, mitochondrial

1

0

High-throughput

0.269

Low

754720

PMT1
Dolichyl-phosphate-mannose--protein mannosyltransferase 1

1

0

High-throughput

0.269

Low

825673

COPE
Coatomer subunit epsilon

1

0

High-throughput

0.269

Low

1044252

PKR1
V-type ATPase assembly factor PKR1

1

0

High-throughput

0.269

Low

826299

PDR11
ATP-dependent permease PDR11

1

0

High-throughput

0.265

Low

575516

GFA1
Glutamine--fructose-6-phosphate aminotransferase [isomerizing]

1

0

High-throughput

0.249

Low

635988

ODO1
2-oxoglutarate dehydrogenase, mitochondrial

1

0

High-throughput

0.249

Low

748533

SC61A
Protein transport protein SEC61

1

0

High-throughput

0.249

Low

797045

PHO88
SRP-independent targeting protein 3

1

0

High-throughput

0.249

Low

808273

STN1
Protein STN1

1

0

Small-scale

0.249

Low

1044616

ENV10
SRP-independent targeting protein 2

1

0

High-throughput

0.249

Low

843231

ZIM17
Mitochondrial protein import protein ZIM17

1

0

High-throughput

0.238

Low

864063

MRX5
MIOREX complex component 5

1

0

High-throughput

0.238

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025