Protein: PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28 (EC 3.6.4.13) (Helicase CA8)

Gene: PRP28
Organism: Saccharomyces cerevisiae S288C
Interactions: 36
UniProt ID: P23394

Gene Ontology (top 5):
GO:0000384 - first spliceosomal transesterification activity
GO:0000395 - mRNA 5'-splice site recognition
GO:0000398 - mRNA splicing, via spliceosome
GO:0003723 - RNA binding
GO:0003724 - RNA helicase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

657960

PRP8
Pre-mRNA-splicing factor 8

3

6

Small-scale

0.827

High

657978

RUVB2
RuvB-like protein 2

2

5

High-throughput

0.759

High

594202

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

1

High-throughput

0.618

High

657959

BRR2
Pre-mRNA-splicing helicase BRR2

1

18

Small-scale

0.618

High

419361

H2A1
Histone H2A.1

2

4

High-throughput

0.588

High

657955

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

12

Small-scale

0.575

High

657970

RUVB1
RuvB-like protein 1

1

5

High-throughput

0.575

High

657972

TOS4
Protein TOS4

2

0

High-throughput

0.563

High

523106

HSP71
Heat shock protein SSA1

2

9

High-throughput

0.552

High

543867

SSB1
Ribosome-associated molecular chaperone SSB1

2

9

High-throughput

0.552

High

657962

RV167
Reduced viability upon starvation protein 167

1

3

High-throughput

0.515

High

657977

SWM1
Anaphase-promoting complex subunit SWM1

1

0

High-throughput

0.513

High

657956

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

657957

IRE1
Serine/threonine-protein kinase/endoribonuclease IRE1

1

5

High-throughput

0.479

High

657961

SN114
Pre-mRNA-splicing factor SNU114

1

6

Small-scale

0.479

High

657969

NOP3
Serine/arginine

1

18

Small-scale

0.479

High

657974

SCC1
Sister chromatid cohesion protein 1

1

1

High-throughput

0.479

High

657975

YRA1
RNA annealing protein YRA1

1

12

High-throughput

0.479

High

657976

CLF1
Pre-mRNA-splicing factor CLF1

1

16

Small-scale

0.479

High

657971

RU1C
U1 small nuclear ribonucleoprotein C

1

0

Small-scale

0.458

High

657973

YG11A
Transposon Ty1-GR1 Gag polyprotein

1

0

High-throughput

0.458

High

381886

H4
Histone H4

1

8

High-throughput

0.445

High

394255

EF1A
Elongation factor 1-alpha

1

2

High-throughput

0.445

High

432491

RL7A
Large ribosomal subunit protein uL30A

1

3

High-throughput

0.445

High

525960

HSP72
Heat shock protein SSA2

1

9

High-throughput

0.445

High

657958

HSP7F
Heat shock protein homolog SSE1

1

11

High-throughput

0.445

High

657963

SSB2
Ribosome-associated molecular chaperone SSB2

1

9

High-throughput

0.445

High

657964

RL13B
Large ribosomal subunit protein eL13B

1

2

High-throughput

0.445

High

657967

RL4B
Large ribosomal subunit protein uL4B

1

2

High-throughput

0.445

High

453430

PYR1
Multifunctional protein URA2

1

0

High-throughput

0.426

High

592023

VATB
V-type proton ATPase subunit B

1

0

High-throughput

0.426

High

657966

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.426

High

657968

IMDH3
Inosine-5'-monophosphate dehydrogenase 3

1

0

High-throughput

0.426

High

655394

RS3A2
Small ribosomal subunit protein eS1B

1

3

High-throughput

0.407

High

657965

COQ7
5-demethoxyubiquinone hydroxylase, mitochondrial

1

0

High-throughput

0.279

Low


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Last updated: 11Aug2025