Protein: SN114
Pre-mRNA-splicing factor SNU114 (114 kDa U5 small nuclear ribonucleoprotein component) (Growth inhibitory protein 10)

Gene: SN114, SNU114
Organism: Saccharomyces cerevisiae S288C
Interactions: 117
UniProt ID: P36048

Gene Ontology (top 5):
GO:0000244 - spliceosomal tri-snRNP complex assembly
GO:0000349 - generation of catalytic spliceosome for first transesterification step
GO:0000387 - spliceosomal snRNP assembly
GO:0000388 - spliceosome conformational change to release U4 (or U4atac) and U1 (or U11)
GO:0000398 - mRNA splicing, via spliceosome

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

751724

PRP8
Pre-mRNA-splicing factor 8

10

5

Small-scale

0.976

High

780205

LSM3
LSM complex subunit LSM3

6

14

Small-scale

0.938

High

780210

SMD1
Small nuclear ribonucleoprotein Sm D1

4

2

High-throughput

0.896

High

780179

RSMB
Small nuclear ribonucleoprotein-associated protein B

4

3

High-throughput

0.892

High

780192

LSM8
LSM2-LSM8 complex subunit LSM8

4

15

Small-scale

0.887

High

780182

RUXG
Small nuclear ribonucleoprotein G

4

14

High-throughput

0.881

High

780202

LSM7
LSM complex subunit LSM7

3

14

High-throughput

0.861

High

627845

PRP4
U4/U6 small nuclear ribonucleoprotein PRP4

3

6

High-throughput

0.855

High

780173

LSM2
LSM complex subunit LSM2

3

11

High-throughput

0.855

High

780225

SMD2
Small nuclear ribonucleoprotein Sm D2

3

2

High-throughput

0.855

High

780186

SMD3
Small nuclear ribonucleoprotein Sm D3

3

11

Small-scale

0.839

High

780204

RUXF
Small nuclear ribonucleoprotein F

3

3

High-throughput

0.830

High

780239

RUXE
Small nuclear ribonucleoprotein E

3

2

High-throughput

0.830

High

780180

LSM4
LSM complex subunit LSM4

2

6

High-throughput

0.789

High

780243

PRP46
Pre-mRNA-splicing factor PRP46

2

9

High-throughput

0.789

High

744101

BRR2
Pre-mRNA-splicing helicase BRR2

12

13

Small-scale

0.761

High

780181

LSM5
LSM complex subunit LSM5

2

0

High-throughput

0.761

High

780216

CEF1
Pre-mRNA-splicing factor CEF1

6

2

Small-scale

0.733

High

780215

CWC21
Pre-mRNA-splicing factor CWC21

2

0

Small-scale

0.716

High

780236

CWC2
Pre-mRNA-splicing factor CWC2

4

4

High-throughput

0.699

High

780197

PRP43
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP43

4

9

High-throughput

0.699

High

780193

PRP31
Pre-mRNA-processing factor 31

4

5

High-throughput

0.694

High

780214

PRP3
U4/U6 small nuclear ribonucleoprotein PRP3

4

1

High-throughput

0.694

High

780226

LSM6
LSM complex subunit LSM6

1

3

High-throughput

0.691

High

739127

PRP19
Pre-mRNA-processing factor 19

4

6

Small-scale

0.691

High

780238

CLF1
Pre-mRNA-splicing factor CLF1

4

17

Small-scale

0.691

High

702241

YJU2
Splicing factor YJU2

4

1

Small-scale

0.683

High

780235

RU2A
U2 small nuclear ribonucleoprotein A'

4

4

Small-scale

0.676

High

624997

PRP6
Pre-mRNA-splicing factor 6

3

13

High-throughput

0.662

High

700091

PRP45
Pre-mRNA-processing protein 45

3

3

High-throughput

0.662

High

780207

NAM8
Protein NAM8

3

3

High-throughput

0.662

High

780190

LSM1
LSM1-LSM7 complex subunit LSM1

1

16

High-throughput

0.656

High

735455

AAR2
A1 cistron-splicing factor AAR2

3

3

Small-scale

0.656

High

780244

SNU66
66 kDa U4/U6.U5 small nuclear ribonucleoprotein component

3

1

Small-scale

0.650

High

780234

NCBP2
Nuclear cap-binding protein subunit 2

3

8

High-throughput

0.640

High

780175

SP381
Pre-mRNA-splicing factor SPP381

3

0

High-throughput

0.634

High

780199

CWC22
Pre-mRNA-splicing factor CWC22

3

0

High-throughput

0.634

High

628202

PRP2
Pre-mRNA-splicing factor ATP-dependent RNA helicase-like protein PRP2

3

11

Small-scale

0.633

High

780200

CWC25
Pre-mRNA-splicing factor CWC25

3

0

Small-scale

0.632

High

584360

GCN2
eIF-2-alpha kinase GCN2

2

6

High-throughput

0.621

High

780233

LUC7
Protein LUC7

2

3

High-throughput

0.621

High

780187

SAD1
Pre-mRNA-splicing factor SAD1

1

5

Small-scale

0.621

High

780185

PRP17
Pre-mRNA-processing factor 17

1

8

High-throughput

0.618

High

739236

PRP21
Pre-mRNA-splicing factor PRP21

2

1

High-throughput

0.611

High

780229

DIB1
Spliceosomal protein DIB1

2

1

High-throughput

0.611

High

780227

SP382
Pre-mRNA-splicing factor SPP382

2

0

High-throughput

0.602

High

664590

PRP22
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP22

2

10

Small-scale

0.595

High

780218

CWC15
Pre-mRNA-splicing factor CWC15

1

0

High-throughput

0.586

High

780223

SN309
Pre-mRNA-splicing factor SNT309

2

0

High-throughput

0.585

High

780241

SNU23
23 kDa U4/U6.U5 small nuclear ribonucleoprotein component

2

0

High-throughput

0.585

High

672048

BUD31
Pre-mRNA-splicing factor BUD31

2

3

Small-scale

0.584

High

780221

SYF1
Pre-mRNA-splicing factor SYF1

2

15

Small-scale

0.584

High

780201

UBP10
Ubiquitin carboxyl-terminal hydrolase 10

1

6

High-throughput

0.541

High

738200

NHP2
H/ACA ribonucleoprotein complex subunit NHP2

2

4

High-throughput

0.537

High

544449

SSB1
Ribosome-associated molecular chaperone SSB1

1

13

High-throughput

0.536

High

780195

CWC23
Pre-mRNA-splicing factor CWC23

1

9

High-throughput

0.536

High

763556

UTP20
U3 small nucleolar RNA-associated protein 20

1

0

High-throughput

0.518

High

740143

RPN2
26S proteasome regulatory subunit RPN2

1

3

High-throughput

0.515

High

780228

URN1
Pre-mRNA-splicing factor URN1

1

0

High-throughput

0.513

High

780183

MSL1
U2 small nuclear ribonucleoprotein B''

1

9

High-throughput

0.508

High

780196

ATG1
Serine/threonine-protein kinase ATG1

1

3

Small-scale

0.501

High

381065

H2B1
Histone H2B.1

1

2

High-throughput

0.479

High

381488

H2B2
Histone H2B.2

1

2

High-throughput

0.479

High

382029

H4
Histone H4

1

2

High-throughput

0.479

High

590191

PRP16
Pre-mRNA-splicing factor ATP-dependent RNA helicase PRP16

1

11

High-throughput

0.479

High

594311

RPB3
DNA-directed RNA polymerase II subunit RPB3

1

3

Small-scale

0.479

High

625088

PRP9
Pre-mRNA-splicing factor PRP9

1

1

High-throughput

0.479

High

638056

ISY1
Pre-mRNA-splicing factor ISY1

1

3

High-throughput

0.479

High

657961

PRP28
Pre-mRNA-splicing ATP-dependent RNA helicase PRP28

1

6

Small-scale

0.479

High

672643

BPH1
Beige protein homolog 1

1

2

High-throughput

0.479

High

694124

CDC15
Cell division control protein 15

1

3

High-throughput

0.479

High

706773

TF2B
Transcription initiation factor IIB

1

4

High-throughput

0.479

High

709694

BMH1
Protein BMH1

1

2

High-throughput

0.479

High

738813

NAB2
Nuclear polyadenylated RNA-binding protein NAB2

1

1

High-throughput

0.479

High

740864

PUB1
Nuclear and cytoplasmic polyadenylated RNA-binding protein PUB1

1

7

High-throughput

0.479

High

757476

NCBP1
Nuclear cap-binding protein complex subunit 1

1

1

High-throughput

0.479

High

780174

SLT11
Pre-mRNA-splicing factor SLT11

1

2

High-throughput

0.479

High

780178

LAA1
AP-1 accessory protein LAA1

1

1

High-throughput

0.479

High

780184

DSN1
Kinetochore-associated protein DSN1

1

1

High-throughput

0.479

High

780191

MPS3
Spindle pole body assembly component MPS3

1

1

High-throughput

0.479

High

780194

SF3B1
U2 snRNP component HSH155

1

9

High-throughput

0.479

High

780203

APJ1
J domain-containing protein APJ1

1

10

High-throughput

0.479

High

780206

H3
Histone H3

1

2

High-throughput

0.479

High

780209

RU17
U1 small nuclear ribonucleoprotein 70 kDa homolog

1

10

Small-scale

0.479

High

780212

CUS1
Cold sensitive U2 snRNA suppressor 1

1

2

High-throughput

0.479

High

780219

PRP42
U1 small nuclear ribonucleoprotein component PRP42

1

16

High-throughput

0.479

High

780220

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

780222

RSE1
Pre-mRNA-splicing factor RSE1

1

3

High-throughput

0.479

High

780231

PRP11
Pre-mRNA-splicing factor PRP11

1

1

High-throughput

0.479

High

780232

VAM6
Vacuolar morphogenesis protein 6

1

1

High-throughput

0.479

High

780237

YRA1
RNA annealing protein YRA1

1

4

High-throughput

0.479

High

780245

HSH49
Protein HSH49

1

5

High-throughput

0.479

High

743517

RU1A
U1 small nuclear ribonucleoprotein A

1

0

High-throughput

0.458

High

780171

NTR2
Pre-mRNA-splicing factor NTR2

1

0

High-throughput

0.458

High

780176

NTC20
Pre-mRNA-splicing factor NTC20

1

0

High-throughput

0.458

High

780177

AIM4
Altered inheritance of mitochondria protein 4

1

0

High-throughput

0.458

High

780188

CWC26
Pre-mRNA-splicing factor CWC26

1

0

High-throughput

0.458

High

780198

SYF2
Pre-mRNA-splicing factor SYF2

1

0

High-throughput

0.458

High

780208

PRP38
Pre-mRNA-splicing factor 38

1

0

High-throughput

0.458

High

780213

SLU7
Pre-mRNA-splicing factor SLU7

1

0

High-throughput

0.458

High

780224

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

780230

RDS3
Pre-mRNA-splicing factor RDS3

1

0

High-throughput

0.458

High

392549

HSP82
ATP-dependent molecular chaperone HSP82

1

10

High-throughput

0.445

High

523593

HSP71
Heat shock protein SSA1

1

14

High-throughput

0.445

High

526391

HSP72
Heat shock protein SSA2

1

14

High-throughput

0.445

High

670570

SIS1
Protein SIS1

1

12

High-throughput

0.445

High

675904

MAS5
Mitochondrial protein import protein MAS5

1

9

High-throughput

0.445

High

741340

HSP7F
Heat shock protein homolog SSE1

1

20

High-throughput

0.445

High

752118

HSP78
Heat shock protein 78, mitochondrial

1

7

High-throughput

0.445

High

780189

JJJ2
J protein JJJ2

1

9

High-throughput

0.445

High

743451

SEC17
Alpha-soluble NSF attachment protein

1

0

High-throughput

0.438

High

739595

SPT16
FACT complex subunit SPT16

1

1

High-throughput

0.437

High

780242

DBP10
ATP-dependent RNA helicase DBP10

1

14

High-throughput

0.437

High

780211

SPP2
Pre-mRNA-splicing factor SPP2

1

0

Small-scale

0.426

High

780172

TXTP
Tricarboxylate transport protein

1

4

High-throughput

0.407

High

780240

UTP23
rRNA-processing protein UTP23

1

0

High-throughput

0.282

High

780217

PML39
Pre-mRNA leakage protein 39

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025