Protein: CUL8
Cullin-8 (Cullin-C) (Regulator of Ty1 transposition protein 101)

Gene: CUL8, RTT101
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: P47050

Gene Ontology (top 5):
GO:0004842 - ubiquitin-protein transferase activity
GO:0005634 - nucleus
GO:0005737 - cytoplasm
GO:0006275 - regulation of DNA replication
GO:0006281 - DNA repair

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

864615

RBX1
RING-box protein HRT1

4

20

Small-scale

0.703

High

864611

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

5

0

Small-scale

0.692

High

805980

RT107
Regulator of Ty1 transposition protein 107

4

1

Small-scale

0.687

High

864612

MMS1
E3 ubiquitin-protein ligase linker protein MMS1

5

0

Small-scale

0.682

High

574808

UBC3
Ubiquitin-conjugating enzyme E2-34 kDa

3

20

Small-scale

0.664

High

739680

SPT16
FACT complex subunit SPT16

2

7

Small-scale

0.624

High

864614

CRT10
Protein CRT10

3

0

Small-scale

0.622

High

382191

H4
Histone H4

2

7

Small-scale

0.612

High

864605

H3
Histone H3

2

7

Small-scale

0.612

High

590666

HSP26
Heat shock protein 26

2

1

High-throughput

0.588

High

721321

PSB7
Proteasome subunit beta type-7

1

10

Small-scale

0.541

High

722057

XPO1
Exportin-1

1

10

High-throughput

0.536

High

864606

CTF4
DNA polymerase alpha-binding protein

1

20

Small-scale

0.536

High

864604

ORC5
Origin recognition complex subunit 5

1

0

Small-scale

0.525

High

864613

ESC2
Protein ESC2

1

0

Small-scale

0.525

High

419794

H2A2
Histone H2A.2

1

15

High-throughput

0.515

High

864617

YP216
Putative ISWI chromatin-remodeling complex subunit YPL216W

1

1

High-throughput

0.515

High

757929

YEL1
Guanine-nucleotide exchange factor YEL1

1

0

High-throughput

0.493

High

809354

STM1
Suppressor protein STM1

1

0

High-throughput

0.493

High

817785

RT105
Regulator of Ty1 transposition protein 105

1

0

Small-scale

0.480

High

435196

RS3
Small ribosomal subunit protein uS3

1

7

High-throughput

0.479

High

436041

RS13
Small ribosomal subunit protein uS15

1

4

High-throughput

0.479

High

438539

UBC2
Ubiquitin-conjugating enzyme E2 2

1

17

Small-scale

0.479

High

514709

RS18A
Small ribosomal subunit protein uS13A

1

6

High-throughput

0.479

High

579656

HSC82
ATP-dependent molecular chaperone HSC82

1

20

High-throughput

0.479

High

585714

UBC4
Ubiquitin-conjugating enzyme E2 4

1

17

Small-scale

0.479

High

674705

RS2
Small ribosomal subunit protein uS5

1

7

High-throughput

0.479

High

707505

TF2B
Transcription initiation factor IIB

1

2

High-throughput

0.479

High

795075

NU170
Nucleoporin NUP170

1

4

High-throughput

0.479

High

802256

RS20
Small ribosomal subunit protein uS10

1

7

High-throughput

0.479

High

864602

RS12
Small ribosomal subunit protein eS12

1

2

High-throughput

0.479

High

864607

RS15
Small ribosomal subunit protein uS19

1

2

High-throughput

0.479

High

864608

SLD5
DNA replication complex GINS protein SLD5

1

1

High-throughput

0.479

High

864609

MTQ2
eRF1 methyltransferase catalytic subunit MTQ2

1

1

High-throughput

0.479

High

864610

SCC2
Sister chromatid cohesion protein 2

1

2

High-throughput

0.479

High

864618

RIO1
Serine/threonine-protein kinase RIO1

1

1

High-throughput

0.479

High

864619

SMC6
Structural maintenance of chromosomes protein 6

1

13

High-throughput

0.479

High

747926

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

864620

LAG2
Cullin-associated NEDD8-dissociated protein 1 homolog

1

1

Small-scale

0.457

High

481668

HSP73
Heat shock protein SSA3

1

18

High-throughput

0.445

High

510612

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

524401

HSP71
Heat shock protein SSA1

1

18

High-throughput

0.445

High

545397

SSB1
Ribosome-associated molecular chaperone SSB1

1

19

High-throughput

0.445

High

816278

HSP7E
Heat shock protein SSC3, mitochondrial

1

20

High-throughput

0.445

High

819135

SSB2
Ribosome-associated molecular chaperone SSB2

1

19

High-throughput

0.445

High

433720

RL26A
Large ribosomal subunit protein uL24A

1

6

High-throughput

0.437

High

455141

RS19A
Small ribosomal subunit protein eS19A

1

3

High-throughput

0.437

High

504293

RL31A
Large ribosomal subunit protein eL31A

1

5

High-throughput

0.437

High

512523

RS6A
Small ribosomal subunit protein eS6A

1

6

High-throughput

0.437

High

689541

RS7A
Small ribosomal subunit protein eS7A

1

5

High-throughput

0.437

High

747452

RSSA1
Small ribosomal subunit protein uS2A

1

4

High-throughput

0.437

High

864616

RS10A
Small ribosomal subunit protein eS10A

1

5

High-throughput

0.437

High

863629

PFD1
Prefoldin subunit 1

1

0

High-throughput

0.426

High

864603

SOL1
6-phosphogluconolactonase-like protein 1

1

0

High-throughput

0.426

High

626794

HSP60
Heat shock protein 60, mitochondrial

1

11

High-throughput

0.407

High

428025

PLMT
Phosphatidyl-N-methylethanolamine N-methyltransferase

1

0

High-throughput

0.238

Low


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Last updated: 11Aug2025