Protein: SLD5
DNA replication complex GINS protein SLD5

Gene: SLD5
Organism: Saccharomyces cerevisiae S288C
Interactions: 62
UniProt ID: Q03406

Gene Ontology (top 5):
GO:0000727 - double-strand break repair via break-induced replication
GO:0000811 - GINS complex
GO:0005634 - nucleus
GO:0006261 - DNA-templated DNA replication
GO:0031261 - DNA replication preinitiation complex

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1030397

CTF4
DNA polymerase alpha-binding protein

20

1

Small-scale

0.990

High

1042688

PSF1
DNA replication complex GINS protein PSF1

23

4

Small-scale

0.990

High

1042682

CDC45
Cell division control protein 45

24

3

Small-scale

0.990

High

823317

PSF2
DNA replication complex GINS protein PSF2

18

6

Small-scale

0.986

High

664465

MCM3
DNA replication licensing factor MCM3

19

15

Small-scale

0.984

High

713296

MCM5
Minichromosome maintenance protein 5

17

15

Small-scale

0.984

High

794096

MCM7
DNA replication licensing factor MCM7

15

15

Small-scale

0.983

High

721410

MCM4
DNA replication licensing factor MCM4

15

15

Small-scale

0.982

High

1042686

PSF3
DNA replication complex GINS protein PSF3

14

4

Small-scale

0.981

High

917056

MCM6
DNA replication licensing factor MCM6

15

16

Small-scale

0.979

High

713032

MCM2
DNA replication licensing factor MCM2

11

15

Small-scale

0.970

High

1042676

SLD5
DNA replication complex GINS protein SLD5

5

0

Small-scale

0.860

High

642071

DPOE
DNA polymerase epsilon catalytic subunit A

6

7

Small-scale

0.721

High

1042679

POB3
FACT complex subunit POB3

6

1

Small-scale

0.721

High

1042680

CSM3
Chromosome segregation in meiosis protein 3

11

0

Small-scale

0.721

High

864249

DPB11
DNA replication regulator DPB11

1

0

Small-scale

0.687

High

561329

DPOLA
DNA polymerase alpha catalytic subunit A

10

7

Small-scale

0.686

High

665200

DPB2
DNA polymerase epsilon subunit B

4

1

Small-scale

0.676

High

677698

MRC1
Mediator of replication checkpoint protein 1

5

0

Small-scale

0.672

High

739746

SPT16
FACT complex subunit SPT16

4

0

Small-scale

0.643

High

735406

MCM10
Minichromosome maintenance protein 10

3

2

Small-scale

0.633

High

923794

TOF1
Topoisomerase 1-associated factor 1

3

1

Small-scale

0.633

High

1042685

CDC53
Cell division control protein 53

3

0

Small-scale

0.619

High

1042684

DIA2
Protein DIA2

3

0

Small-scale

0.613

High

647827

RFA1
Replication factor A protein 1

2

1

Small-scale

0.611

High

381235

H2B1
Histone H2B.1

2

1

Small-scale

0.571

High

381613

H2B2
Histone H2B.2

2

1

Small-scale

0.571

High

415241

TOP1
DNA topoisomerase 1

2

0

Small-scale

0.559

High

916741

UFD1
Ubiquitin fusion degradation protein 1

2

0

Small-scale

0.559

High

382307

H4
Histone H4

2

0

Small-scale

0.547

High

690743

DPB3
DNA polymerase epsilon subunit C

2

0

Small-scale

0.547

High

797126

CENPL
Inner kinetochore subunit IML3

1

0

High-throughput

0.486

High

602618

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

864608

CUL8
Cullin-8

1

1

High-throughput

0.479

High

1042687

RIO1
Serine/threonine-protein kinase RIO1

1

0

Small-scale

0.460

High

680011

CDC48
Cell division control protein 48

1

0

Small-scale

0.458

High

754446

NPL4
Nuclear protein localization protein 4

1

0

Small-scale

0.458

High

758515

SLD2
DNA replication regulator SLD2

1

0

Small-scale

0.458

High

803758

RRM3
ATP-dependent DNA helicase RRM3

1

0

Small-scale

0.458

High

910770

SKP1
Suppressor of kinetochore protein 1

1

0

Small-scale

0.458

High

921608

NRD1
Protein NRD1

1

0

Small-scale

0.458

High

1025167

SEN1
Helicase SEN1

1

0

Small-scale

0.458

High

1042681

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.458

High

1042683

RBX1
RING-box protein HRT1

1

0

Small-scale

0.458

High

546066

SSB1
Ribosome-associated molecular chaperone SSB1

1

1

High-throughput

0.445

High

819641

SSB2
Ribosome-associated molecular chaperone SSB2

1

1

High-throughput

0.445

High

521128

PRI1
DNA primase small subunit

1

0

Small-scale

0.426

High

632853

PRI2
DNA primase large subunit

1

0

Small-scale

0.426

High

727281

HS104
Heat shock protein 104

1

0

High-throughput

0.426

High

742276

HSP7F
Heat shock protein homolog SSE1

1

0

High-throughput

0.426

High

793834

DPOA2
DNA polymerase alpha subunit B

1

0

Small-scale

0.426

High

1042678

DPB4
DNA polymerase epsilon subunit D

1

0

Small-scale

0.426

High

1039093

YP077
Uncharacterized protein YPL077C

2

0

High-throughput

0.323

High

1042677

SRC1
Inner nuclear membrane protein SRC1

2

0

High-throughput

0.317

High

796034

LDB7
Chromatin structure-remodeling complex protein RSC14

1

0

High-throughput

0.282

High

850670

IRC6
Increased recombination centers protein 6

1

0

High-throughput

0.265

Low

617845

PGTB1
Geranylgeranyl transferase type-1 subunit beta

1

0

Small-scale

0.249

Low

1035370

TOF2
Topoisomerase 1-associated factor 2

1

0

Small-scale

0.249

Low

923243

ESF2
Pre-rRNA-processing protein ESF2

1

0

High-throughput

0.238

Low

739454

ZUO1
Zuotin

1

0

High-throughput

0.232

Low

826479

DJP1
DnaJ-like protein 1

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025