Protein: SYFB
Phenylalanine--tRNA ligase beta subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase beta subunit) (PheRS)

Gene: SYFB, FRS1
Organism: Saccharomyces cerevisiae S288C
Interactions: 49
UniProt ID: P15624

Gene Ontology (top 5):
GO:0000287 - magnesium ion binding
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding
GO:0005737 - cytoplasm
GO:0006432 - phenylalanyl-tRNA aminoacylation

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585119

SYFA
Phenylalanine--tRNA ligase alpha subunit

4

8

High-throughput

0.896

High

585137

SSB2
Ribosome-associated molecular chaperone SSB2

2

2

High-throughput

0.552

High

585126

HS104
Heat shock protein 104

2

0

High-throughput

0.547

High

585125

XPO1
Exportin-1

1

3

High-throughput

0.536

High

585139

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

2

High-throughput

0.533

High

585142

BRE5
UBP3-associated protein BRE5

1

0

High-throughput

0.513

High

585143

UBP3
Ubiquitin carboxyl-terminal hydrolase 3

1

0

High-throughput

0.513

High

440820

KIN28
Serine/threonine-protein kinase KIN28

1

1

High-throughput

0.501

High

585145

PKH3
Serine/threonine-protein kinase PKH3

1

1

High-throughput

0.501

High

585155

PKH2
Serine/threonine-protein kinase PKH2

1

1

High-throughput

0.501

High

481846

SYIC
Isoleucine--tRNA ligase, cytoplasmic

1

0

High-throughput

0.493

High

585138

GLDS1
Protein GDS1

1

0

High-throughput

0.493

High

585120

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

585122

KCC4
Probable serine/threonine-protein kinase KCC4

1

0

High-throughput

0.480

High

585123

KCC1
Calcium/calmodulin-dependent protein kinase I

1

0

High-throughput

0.480

High

585127

MKK1
MAP kinase kinase MKK1/SSP32

1

0

High-throughput

0.480

High

585128

ELM1
Serine/threonine-protein kinase ELM1

1

0

High-throughput

0.480

High

585147

CTK1
CTD kinase subunit alpha

1

0

High-throughput

0.480

High

585149

ISR1
Serine/threonine-protein kinase ISR1

1

0

High-throughput

0.480

High

392156

HSP82
ATP-dependent molecular chaperone HSP82

1

1

High-throughput

0.479

High

578765

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

585144

TOM1
E3 ubiquitin-protein ligase TOM1

1

1

High-throughput

0.479

High

399337

CARB
Carbamoyl phosphate synthase arginine-specific large chain

1

0

High-throughput

0.458

High

434784

RS3
Small ribosomal subunit protein uS3

1

0

High-throughput

0.458

High

558554

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

585129

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

High-throughput

0.458

High

585130

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

585131

RPN1
26S proteasome regulatory subunit RPN1

1

0

High-throughput

0.458

High

585140

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

0

High-throughput

0.458

High

585141

PPID
Peptidyl-prolyl cis-trans isomerase CPR6

1

0

High-throughput

0.458

High

585146

RUVB1
RuvB-like protein 1

1

0

High-throughput

0.458

High

585150

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

585156

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

522944

HSP71
Heat shock protein SSA1

1

3

High-throughput

0.445

High

525828

HSP72
Heat shock protein SSA2

1

3

High-throughput

0.445

High

585132

SSZ1
Ribosome-associated complex subunit SSZ1

1

2

High-throughput

0.445

High

585136

HSP7E
Heat shock protein SSC3, mitochondrial

1

2

High-throughput

0.445

High

394188

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

585134

XDJ1
DnaJ protein homolog XDJ1

1

0

High-throughput

0.426

High

585121

SIS1
Protein SIS1

2

0

High-throughput

0.298

High

585157

TECR
Very-long-chain enoyl-CoA reductase

1

0

High-throughput

0.279

Low

585151

HRD1
ERAD-associated E3 ubiquitin-protein ligase HRD1

1

0

High-throughput

0.269

Low

585124

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

585133

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

585135

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

585148

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

585152

AP3D
AP-3 complex subunit delta

1

0

High-throughput

0.249

Low

585153

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

585154

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025