Protein: MKK1
MAP kinase kinase MKK1/SSP32 (EC 2.7.12.2)

Gene: MKK1
Organism: Saccharomyces cerevisiae S288C
Interactions: 56
UniProt ID: P32490

Gene Ontology (top 5):
GO:0000196 - cell integrity MAPK cascade
GO:0000425 - pexophagy
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0004708 - MAP kinase kinase activity

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

738041

SLT2
Mitogen-activated protein kinase SLT2/MPK1

10

20

Small-scale

0.977

High

738042

BCK1
Serine/threonine-protein kinase BCK1/SLK1/SSP31

3

16

Small-scale

0.857

High

660316

STE11
Serine/threonine-protein kinase STE11

1

17

Small-scale

0.747

High

738052

GIN4
Serine/threonine-protein kinase GIN4

1

17

High-throughput

0.691

High

665790

KPC1
Protein kinase C-like 1

1

17

Small-scale

0.656

High

694115

CDC15
Cell division control protein 15

1

17

High-throughput

0.647

High

738022

PP2C1
Protein phosphatase 2C homolog 1

1

12

Small-scale

0.647

High

654708

SPA2
Protein SPA2

2

11

Small-scale

0.625

High

464576

PBS2
MAP kinase kinase PBS2

1

19

Small-scale

0.618

High

737799

HOG1
Mitogen-activated protein kinase HOG1

1

20

Small-scale

0.618

High

738038

BUD4
Bud site selection protein 4

1

0

High-throughput

0.614

High

738026

YPT31
GTP-binding protein YPT31/YPT8

1

3

High-throughput

0.553

High

523373

HSP71
Heat shock protein SSA1

2

20

High-throughput

0.552

High

544179

SSB1
Ribosome-associated molecular chaperone SSB1

2

20

High-throughput

0.552

High

738025

RGD1
RHO GTPase-activating protein RGD1

1

5

High-throughput

0.536

High

738033

RGD2
Rho-GTPase-activating protein RGD2

1

3

High-throughput

0.515

High

738040

NST1
Stress response protein NST1

1

20

Small-scale

0.515

High

738037

FYV8
Protein FYV8

1

0

High-throughput

0.513

High

738047

SPH1
Protein SPH1

1

5

Small-scale

0.508

High

738018

DRS1
ATP-dependent RNA helicase DRS1

1

16

High-throughput

0.501

High

738019

KPR1
Ribose-phosphate pyrophosphokinase 1

1

2

High-throughput

0.501

High

738028

BZZ1
Protein BZZ1

1

4

High-throughput

0.501

High

738048

MRB1
Methylated RNA-binding protein 1

1

2

High-throughput

0.501

High

366972

ATPB
ATP synthase subunit beta, mitochondrial

1

14

High-throughput

0.500

High

590575

HSP26
Heat shock protein 26

1

2

High-throughput

0.500

High

587293

ABP1
Actin-binding protein

1

9

High-throughput

0.481

High

738036

ARC1
tRNA-aminoacylation cofactor ARC1

1

3

High-throughput

0.481

High

585127

SYFB
Phenylalanine--tRNA ligase beta subunit

1

0

High-throughput

0.480

High

738023

ATG19
Autophagy-related protein 19

1

0

High-throughput

0.480

High

738024

YBY8
Uncharacterized protein YBR138C

1

0

High-throughput

0.480

High

738029

VHR2
Transcription factor VHR2

1

0

High-throughput

0.480

High

738030

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

0

High-throughput

0.480

High

738034

BUD27
Bud site selection protein 27

1

0

High-throughput

0.480

High

738035

WWM1
WW domain-containing protein WWM1

1

0

High-throughput

0.480

High

738046

YL287
Uncharacterized protein YLR287C

1

0

High-throughput

0.480

High

738051

KAD6
Adenylate kinase isoenzyme 6 homolog FAP7

1

0

High-throughput

0.480

High

738049

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

738027

OSH7
Oxysterol-binding protein homolog 7

1

3

High-throughput

0.479

High

609210

CLC1
Clathrin light chain

1

1

High-throughput

0.457

High

647051

RPC2
DNA-directed RNA polymerase III subunit RPC2

1

4

High-throughput

0.457

High

738050

YIG1
Protein YIG1

1

1

High-throughput

0.457

High

425118

OTC
Ornithine carbamoyltransferase

1

9

High-throughput

0.457

High

386630

TBB
Tubulin beta chain

1

20

High-throughput

0.445

High

510306

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

738017

HSP79
Heat shock protein homolog SSE2

1

20

High-throughput

0.445

High

738031

SSB2
Ribosome-associated molecular chaperone SSB2

1

20

High-throughput

0.445

High

738044

GRH1
GRASP65 homolog protein 1

1

2

High-throughput

0.445

High

706512

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.437

High

738043

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.437

High

360779

COX5A
Cytochrome c oxidase subunit 5A, mitochondrial

1

0

High-throughput

0.261

Low

676524

PUT3
Proline utilization trans-activator

1

0

High-throughput

0.261

Low

738020

RE104
Meiotic recombination protein REC104

1

0

High-throughput

0.261

Low

738021

RRP1
Ribosomal RNA-processing protein 1

1

0

High-throughput

0.261

Low

738032

NTA1
Protein N-terminal amidase

1

0

High-throughput

0.261

Low

738039

YG1D
Probable transcriptional regulatory protein HAH1

1

0

High-throughput

0.261

Low

738045

YMI3
Putative uncharacterized protein YML083C

1

0

High-throughput

0.261

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025