Protein: PKH2
Serine/threonine-protein kinase PKH2 (EC 2.7.11.1) (PKB-activating kinase homolog 2)

Gene: PKH2
Organism: Saccharomyces cerevisiae S288C
Interactions: 76
UniProt ID: Q12236

Gene Ontology (top 5):
GO:0000196 - cell integrity MAPK cascade
GO:0004672 - protein kinase activity
GO:0004674 - protein serine/threonine kinase activity
GO:0005524 - ATP binding
GO:0005634 - nucleus

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

1042693

PKH1
Serine/threonine-protein kinase PKH1

2

19

High-throughput

0.743

High

1084657

PKH2
Serine/threonine-protein kinase PKH2

2

19

High-throughput

0.743

High

364812

CDK1
Cyclin-dependent kinase 1

1

9

High-throughput

0.724

High

918726

PIL1
Sphingolipid long chain base-responsive protein PIL1

4

4

Small-scale

0.690

High

1084647

LSP1
Sphingolipid long chain base-responsive protein LSP1

3

4

Small-scale

0.664

High

548929

SCH9
Serine/threonine-protein kinase SCH9

1

19

High-throughput

0.647

High

649687

KCC2
Calcium/calmodulin-dependent protein kinase II

1

16

High-throughput

0.647

High

665863

KPC1
Protein kinase C-like 1

1

18

Small-scale

0.647

High

748789

YPT7
Ypt/Rab-type GTPase YPT7

1

4

High-throughput

0.647

High

803210

RIM4
Meiotic activator RIM4

1

14

High-throughput

0.647

High

865621

DOHH
Deoxyhypusine hydroxylase

1

1

High-throughput

0.647

High

865973

DPH4
Diphthamide biosynthesis protein 4

1

17

High-throughput

0.647

High

925357

CRZ1
Transcriptional regulator CRZ1

1

5

High-throughput

0.647

High

1062354

NOP12
Nucleolar protein 12

1

15

High-throughput

0.618

High

645564

XRN1
5'-3' exoribonuclease 1

2

0

High-throughput

0.569

High

865933

BUD4
Bud site selection protein 4

1

0

High-throughput

0.541

High

793009

ANM1
Protein arginine N-methyltransferase 1

1

3

Small-scale

0.541

High

1059778

FMP45
SUR7 family protein FMP45

1

0

High-throughput

0.518

High

762882

TOR1
Serine/threonine-protein kinase TOR1

1

19

High-throughput

0.515

High

518426

IF4A
ATP-dependent RNA helicase eIF4A

1

15

High-throughput

0.501

High

585155

SYFB
Phenylalanine--tRNA ligase beta subunit

1

1

High-throughput

0.501

High

609250

CLC1
Clathrin light chain

1

1

High-throughput

0.501

High

624471

RDS2
Regulator of drug sensitivity 2

1

1

High-throughput

0.501

High

678354

RSC6
Chromatin structure-remodeling complex protein RSC6

1

1

High-throughput

0.501

High

692531

GYS2
Glycogen [starch] synthase isoform 2

1

2

High-throughput

0.501

High

746696

DRS1
ATP-dependent RNA helicase DRS1

1

17

High-throughput

0.501

High

746763

KPR1
Ribose-phosphate pyrophosphokinase 1

1

9

High-throughput

0.501

High

750802

PRS6A
26S proteasome regulatory subunit 6A

1

10

High-throughput

0.501

High

757916

UBX1
UBX domain-containing protein 1

1

6

High-throughput

0.501

High

811195

TCPZ
T-complex protein 1 subunit zeta

1

20

High-throughput

0.501

High

818397

RTR1
RNA polymerase II subunit B1 CTD phosphatase RTR1

1

2

High-throughput

0.501

High

825356

SHQ1
Protein SHQ1

1

1

High-throughput

0.501

High

1047271

CSM3
Chromosome segregation in meiosis protein 3

1

1

High-throughput

0.501

High

367150

ATPB
ATP synthase subunit beta, mitochondrial

1

7

High-throughput

0.500

High

676996

SRO9
RNA-binding protein SRO9

1

5

High-throughput

0.500

High

808977

HXT6
High-affinity hexose transporter HXT6

1

3

High-throughput

0.489

High

809003

HXT7
High-affinity hexose transporter HXT7

1

3

High-throughput

0.489

High

672363

RV161
Reduced viability upon starvation protein 161

1

3

High-throughput

0.481

High

1046649

MYO5
Myosin-5

1

15

Small-scale

0.481

High

803334

YAP3
AP-1-like transcription factor YAP3

1

0

High-throughput

0.480

High

863243

DPOD2
DNA polymerase delta small subunit

1

0

High-throughput

0.480

High

866082

NNF1
Kinetochore-associated protein NNF1

1

0

High-throughput

0.480

High

1084658

NKP1
Inner kinetochore subunit NKP1

1

0

High-throughput

0.480

High

408367

GAL1
Galactokinase

1

0

High-throughput

0.479

High

1062760

THI20
Hydroxymethylpyrimidine/phosphomethylpyrimidine kinase THI20

1

0

High-throughput

0.479

High

585520

KCY
Uridylate kinase

1

3

High-throughput

0.479

High

708532

TF2B
Transcription initiation factor IIB

1

3

High-throughput

0.479

High

916540

SAP4
SIT4-associating protein SAP4

1

3

High-throughput

0.479

High

1025067

NUM1
Nuclear migration protein NUM1

1

20

High-throughput

0.479

High

1044841

SCC2
Sister chromatid cohesion protein 2

1

1

High-throughput

0.479

High

805532

ORC6
Origin recognition complex subunit 6

1

0

High-throughput

0.460

High

826934

DSN1
Kinetochore-associated protein DSN1

1

0

High-throughput

0.458

High

866296

BCA2
Branched-chain-amino-acid aminotransferase, cytosolic

1

0

High-throughput

0.458

High

383210

RLA4
Large ribosomal subunit protein P2B

1

2

High-throughput

0.457

High

478435

EI2BG
Translation initiation factor eIF2B subunit gamma

1

2

High-throughput

0.457

High

763550

ATG19
Autophagy-related protein 19

1

1

High-throughput

0.457

High

823100

VPS27
Vacuolar protein sorting-associated protein 27

1

7

Small-scale

0.457

High

849861

BUD27
Bud site selection protein 27

1

2

High-throughput

0.457

High

871582

PFD3
Prefoldin subunit 3

1

1

High-throughput

0.457

High

918256

YG1D
Probable transcriptional regulatory protein HAH1

1

1

High-throughput

0.457

High

1039099

YP077
Uncharacterized protein YPL077C

1

2

High-throughput

0.457

High

1046008

ARA2
D-arabinose 1-dehydrogenase

1

2

High-throughput

0.457

High

1062796

BRX1
Ribosome biogenesis protein BRX1

1

3

High-throughput

0.457

High

1084564

BUG1
Binder of USO1 and GRH1 protein 1

1

1

High-throughput

0.457

High

555177

G6PI
Glucose-6-phosphate isomerase

1

1

High-throughput

0.457

High

510908

HSP77
Import motor subunit, mitochondrial

1

20

High-throughput

0.445

High

824587

6P21
6-phosphofructo-2-kinase 1

1

11

High-throughput

0.445

High

361022

CCPR
Cytochrome c peroxidase, mitochondrial

1

1

High-throughput

0.437

High

739820

SPT16
FACT complex subunit SPT16

1

4

Small-scale

0.437

High

793639

ARA1
D-arabinose dehydrogenase [NAD(P)+] heavy chain

1

1

High-throughput

0.437

High

918305

TIM21
Mitochondrial import inner membrane translocase subunit TIM21

1

0

High-throughput

0.279

Low

781344

DID4
DOA4-independent degradation protein 4

1

0

High-throughput

0.261

Low

1043803

SRC1
Inner nuclear membrane protein SRC1

1

0

High-throughput

0.261

Low

1057092

MDM36
Mitochondrial distribution and morphology protein 36

1

0

High-throughput

0.261

Low

1059419

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.249

Low


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Last updated: 11Aug2025