Protein: SYFA
Phenylalanine--tRNA ligase alpha subunit (EC 6.1.1.20) (Phenylalanyl-tRNA synthetase alpha subunit) (PheRS)

Gene: SYFA, FRS2
Organism: Saccharomyces cerevisiae S288C
Interactions: 39
UniProt ID: P15625

Gene Ontology (top 5):
GO:0000049 - tRNA binding
GO:0000287 - magnesium ion binding
GO:0002161 - aminoacyl-tRNA deacylase activity
GO:0004826 - phenylalanine-tRNA ligase activity
GO:0005524 - ATP binding

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

585119

SYFB
Phenylalanine--tRNA ligase beta subunit

4

8

High-throughput

0.896

High

392157

HSP82
ATP-dependent molecular chaperone HSP82

2

1

High-throughput

0.614

High

585180

BRE5
UBP3-associated protein BRE5

1

1

High-throughput

0.536

High

585177

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

1

High-throughput

0.533

High

585161

XPO1
Exportin-1

1

0

High-throughput

0.513

High

585162

KU70
ATP-dependent DNA helicase II subunit 1

1

0

High-throughput

0.513

High

575295

EI2BA
Translation initiation factor eIF2B subunit alpha

1

2

High-throughput

0.489

High

585166

SPT7
SAGA complex subunit SPT7

1

1

High-throughput

0.489

High

585158

PHO85
Cyclin-dependent protein kinase PHO85

1

0

High-throughput

0.480

High

578766

HSC82
ATP-dependent molecular chaperone HSC82

1

1

High-throughput

0.479

High

585163

GSP1
GTP-binding nuclear protein GSP1/CNR1

1

0

Small-scale

0.460

High

558555

CAF20
Cap-associated protein CAF20

1

0

High-throughput

0.458

High

585164

SMY2
Protein SMY2

1

0

High-throughput

0.458

High

585165

PRS6A
26S proteasome regulatory subunit 6A

1

0

High-throughput

0.458

High

585169

ATG8
Autophagy-related protein 8

1

0

High-throughput

0.458

High

585172

TCPG
T-complex protein 1 subunit gamma

1

0

High-throughput

0.458

High

585174

YEY6
MYG1 protein YER156C

1

0

Small-scale

0.458

High

585176

GPP1
Glycerol-1-phosphate phosphohydrolase 1

1

0

High-throughput

0.458

High

585179

HST2
NAD-dependent protein deacetylase HST2

1

0

High-throughput

0.458

High

585185

VAM6
Vacuolar morphogenesis protein 6

1

0

High-throughput

0.458

High

585189

DBP10
ATP-dependent RNA helicase DBP10

1

0

High-throughput

0.458

High

585190

RUVB2
RuvB-like protein 2

1

0

High-throughput

0.458

High

543697

SSB1
Ribosome-associated molecular chaperone SSB1

1

2

High-throughput

0.445

High

585175

SSB2
Ribosome-associated molecular chaperone SSB2

1

2

High-throughput

0.445

High

585168

ANM1
Protein arginine N-methyltransferase 1

1

1

High-throughput

0.437

High

585186

AP3D
AP-3 complex subunit delta

1

1

High-throughput

0.437

High

585183

SEN15
tRNA-splicing endonuclease subunit SEN15

1

0

High-throughput

0.279

Low

585159

SIS1
Protein SIS1

1

0

High-throughput

0.249

Low

585160

TF2B
Transcription initiation factor IIB

1

0

High-throughput

0.249

Low

585167

CENPA
Histone H3-like centromeric protein CSE4

1

0

High-throughput

0.249

Low

585170

RPN10
26S proteasome regulatory subunit RPN10

1

0

High-throughput

0.249

Low

585173

LAA1
AP-1 accessory protein LAA1

1

0

High-throughput

0.249

Low

585182

SCC2
Sister chromatid cohesion protein 2

1

0

High-throughput

0.249

Low

585184

MMS22
E3 ubiquitin-protein ligase substrate receptor MMS22

1

0

High-throughput

0.249

Low

585187

ATG9
Autophagy-related protein 9

1

0

High-throughput

0.249

Low

585188

RRP6
Exosome complex exonuclease RRP6

1

0

High-throughput

0.249

Low

585181

NAF1
H/ACA ribonucleoprotein complex non-core subunit NAF1

1

0

High-throughput

0.238

Low

585171

SPT8
SAGA complex subunit SPT8

1

0

High-throughput

0.232

Low

585178

UBP8
Ubiquitin carboxyl-terminal hydrolase 8

1

0

High-throughput

0.232

Low


Service provided by Combinatics, Japan

Last updated: 11Aug2025