Protein: PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase (EC 2.1.2.3) (5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase) (AICAR transformylase); Inosine 5'-monophosphate cyclohydrolase (IMP cyclohydrolase) (EC 3.5.4.10) (ATIC) (IMP synthase) (Inosinicase)]

Gene: PUR91, ADE16
Organism: Saccharomyces cerevisiae S288C
Interactions: 37
UniProt ID: P54113

Gene Ontology (top 5):
GO:0003937 - IMP cyclohydrolase activity
GO:0004643 - phosphoribosylaminoimidazolecarboxamide formyltransferase activity
GO:0005829 - cytosol
GO:0006164 - purine nucleotide biosynthetic process
GO:0006189 - 'de novo' IMP biosynthetic process

Download interactions: TXT   MITAB-2.5

Interaction Interactor Experiments Homologs Category Interaction
Score
Confidence

791981

PUR92
Bifunctional purine biosynthesis protein ADE17 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

5

3

High-throughput

0.918

High

926259

PUR91
Bifunctional purine biosynthesis protein ADE16 [Includes: Phosphoribosylaminoimidazolecarboxamide formyltransferase

2

3

High-throughput

0.785

High

743263

PP12
Serine/threonine-protein phosphatase PP1-2

5

1

High-throughput

0.652

High

789810

SOL2
6-phosphogluconolactonase-like protein 2

2

3

High-throughput

0.611

High

545875

SSB1
Ribosome-associated molecular chaperone SSB1

2

4

High-throughput

0.601

High

894389

SOL1
6-phosphogluconolactonase-like protein 1

2

3

High-throughput

0.588

High

850137

RPN11
Ubiquitin carboxyl-terminal hydrolase RPN11

2

0

High-throughput

0.559

High

819479

SSB2
Ribosome-associated molecular chaperone SSB2

2

4

High-throughput

0.552

High

926260

RAD25
General transcription and DNA repair factor IIH helicase/translocase subunit XPB/SSL2

1

0

High-throughput

0.518

High

743710

VATD
V-type proton ATPase subunit D

1

1

High-throughput

0.494

High

926264

LSP1
Sphingolipid long chain base-responsive protein LSP1

1

2

High-throughput

0.494

High

670999

SIS1
Protein SIS1

1

2

High-throughput

0.479

High

795483

ATG8
Autophagy-related protein 8

1

1

High-throughput

0.479

High

806787

RPN10
26S proteasome regulatory subunit RPN10

1

1

High-throughput

0.479

High

926262

MUK1
Protein MUK1

1

0

High-throughput

0.458

High

585997

CSK21
Casein kinase II subunit alpha

1

3

High-throughput

0.445

High

727235

HS104
Heat shock protein 104

1

1

High-throughput

0.445

High

623919

MYO2
Myosin-2

1

2

Small-scale

0.439

High

660238

AATC
Aspartate aminotransferase, cytoplasmic

1

0

High-throughput

0.438

High

805690

YHS2
MIP18 family protein YHR122W

1

0

High-throughput

0.438

High

707880

TF2B
Transcription initiation factor IIB

1

1

High-throughput

0.437

High

918641

PIL1
Sphingolipid long chain base-responsive protein PIL1

1

2

High-throughput

0.437

High

926263

TAF7
Transcription initiation factor TFIID subunit 7

1

1

High-throughput

0.437

High

926265

DBP10
ATP-dependent RNA helicase DBP10

1

1

High-throughput

0.437

High

394802

EF1A
Elongation factor 1-alpha

1

0

High-throughput

0.426

High

926261

REG1
Resistance to glucose repression protein 1

2

0

High-throughput

0.320

High

454475

PHO4
Phosphate system positive regulatory protein PHO4

1

0

High-throughput

0.279

Low

709918

BMH1
Protein BMH1

1

0

High-throughput

0.279

Low

722166

XPO1
Exportin-1

1

0

High-throughput

0.279

Low

798086

SLX1
Structure-specific endonuclease subunit SLX1

1

0

High-throughput

0.269

Low

917787

MPS2
Monopolar spindle protein 2

1

0

Small-scale

0.251

Low

557756

SRS2
ATP-dependent DNA helicase SRS2

1

0

High-throughput

0.249

Low

801760

SRP72
Signal recognition particle subunit SRP72

1

0

High-throughput

0.249

Low

801892

KSP1
Serine/threonine-protein kinase KSP1

1

0

High-throughput

0.249

Low

873359

BPL1
Biotin--protein ligase

1

0

High-throughput

0.249

Low

836837

MPG1
Mannose-1-phosphate guanyltransferase

1

0

High-throughput

0.232

Low


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Last updated: 11Aug2025